NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|579532723|gb|EUV79730|]
View 

methicillin resistance regulatory protein MecI [Staphylococcus aureus M0232]

Protein Classification

BlaI/MecI/CopY family transcriptional regulator( domain architecture ID 12048869)

BlaI/MecI/CopY family transcriptional regulator similar to Bacillus licheniformis penicillinase repressor that constitutively blocks expression of beta-lactamase and regulates genes involved in antibiotic resistance

CATH:  1.10.10.10
Gene Ontology:  GO:0045892|GO:0003677
SCOP:  4000185

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 8-122 1.67e-41

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


:

Pssm-ID: 427620  Cd Length: 115  Bit Score: 133.11  E-value: 1.67e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579532723    8 ISMAEWDVMNIIWDKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTFL 87
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKDGRAFIYSPLVSREEYKAGQVKQLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 579532723   88 NKLYGGDMKSLVLNFAKNEELNNKEIEELRDILND 122
Cdd:pfam03965  81 DRFFGGSVPALVANFVEREKLSPDDIEELRQLLDQ 115
 
Name Accession Description Interval E-value
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 8-122 1.67e-41

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 133.11  E-value: 1.67e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579532723    8 ISMAEWDVMNIIWDKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTFL 87
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKDGRAFIYSPLVSREEYKAGQVKQLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 579532723   88 NKLYGGDMKSLVLNFAKNEELNNKEIEELRDILND 122
Cdd:pfam03965  81 DRFFGGSVPALVANFVEREKLSPDDIEELRQLLDQ 115
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-126 1.08e-33

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 113.73  E-value: 1.08e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579532723   4 KQVEISMAEWDVMNIIWDKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTA 83
Cdd:COG3682    1 KMKKLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 579532723  84 KTFLNKLYGGDMKSLVLNFAKNEELNNKEIEELRDILNDISKK 126
Cdd:COG3682   81 RDLLDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKKKK 123
CopY_TcrY TIGR02698
copper transport repressor, CopY/TcrY family; This family includes metal-fist type ...
 7-121 1.53e-15

copper transport repressor, CopY/TcrY family; This family includes metal-fist type transcriptional repressors of copper transport systems such as copYZAB of Enterococcus hirae and tcrYAZB (transferble copper resistance) of an Enterocuccus faecium plasmid. High levels of copper can displace zinc and prevent binding by the repressor, activating efflux by copper resistance transporters. The most closely related proteins excluded by this model are antibiotic resistance regulators including the methicillin resistance regulatory protein MecI. [Transport and binding proteins, Cations and iron carrying compounds, Regulatory functions, DNA interactions]


Pssm-ID: 131745  Cd Length: 130  Bit Score: 67.44  E-value: 1.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579532723    7 EISMAEWDVMNIIWDKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTF 86
Cdd:TIGR02698   1 SISDAEWEVMRVVWTLGETTSRDIIRILAEKKDWSDSTIKTLLGRLVDKGCLTTEKEGRKFIYTALVSEDEAVENAAQEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 579532723   87 LNKLYGGDMKSLVLNFAKNEELNNKEIEELRDILN 121
Cdd:TIGR02698  81 FSRICSRKVGAVIADLIEESPLSQTDIEKLEKLLS 115
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
8-65 3.24e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 3.24e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 579532723     8 ISMAEWDVMNIIWDKKSVSaneiVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSEN 65
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLS----VSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPE 61
 
Name Accession Description Interval E-value
Penicillinase_R pfam03965
Penicillinase repressor; The penicillinase repressor negatively regulates expression of the ...
 8-122 1.67e-41

Penicillinase repressor; The penicillinase repressor negatively regulates expression of the penicillinase gene. The N-terminal region of this protein is involved in operator recognition, while the C-terminal is responsible for dimerization of the protein.


Pssm-ID: 427620  Cd Length: 115  Bit Score: 133.11  E-value: 1.67e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579532723    8 ISMAEWDVMNIIWDKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTFL 87
Cdd:pfam03965   1 LGEAEAEVMEILWALGPATVKEVVEELPEPKDWAYSTVKTLLTRLVKKGLLSREKDGRAFIYSPLVSREEYKAGQVKQLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 579532723   88 NKLYGGDMKSLVLNFAKNEELNNKEIEELRDILND 122
Cdd:pfam03965  81 DRFFGGSVPALVANFVEREKLSPDDIEELRQLLDQ 115
CopY COG3682
Transcriptional regulator, CopY/TcrY family [Transcription];
4-126 1.08e-33

Transcriptional regulator, CopY/TcrY family [Transcription];


Pssm-ID: 442898  Cd Length: 125  Bit Score: 113.73  E-value: 1.08e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579532723   4 KQVEISMAEWDVMNIIWDKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTA 83
Cdd:COG3682    1 KMKKLTEAELEVMQVLWELGPATVREVLEALPEERGWAYTTVLTLLRRLEEKGFLSREKEGRAYVYRPLVSREEYQAQEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 579532723  84 KTFLNKLYGGDMKSLVLNFAKNEELNNKEIEELRDILNDISKK 126
Cdd:COG3682   81 RDLLDRFFGGSLKALVAAFVEEEKLSPEELEELRKLLDEKKKK 123
CopY_TcrY TIGR02698
copper transport repressor, CopY/TcrY family; This family includes metal-fist type ...
 7-121 1.53e-15

copper transport repressor, CopY/TcrY family; This family includes metal-fist type transcriptional repressors of copper transport systems such as copYZAB of Enterococcus hirae and tcrYAZB (transferble copper resistance) of an Enterocuccus faecium plasmid. High levels of copper can displace zinc and prevent binding by the repressor, activating efflux by copper resistance transporters. The most closely related proteins excluded by this model are antibiotic resistance regulators including the methicillin resistance regulatory protein MecI. [Transport and binding proteins, Cations and iron carrying compounds, Regulatory functions, DNA interactions]


Pssm-ID: 131745  Cd Length: 130  Bit Score: 67.44  E-value: 1.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579532723    7 EISMAEWDVMNIIWDKKSVSANEIVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSENIYFYSSNIKEDDIKMKTAKTF 86
Cdd:TIGR02698   1 SISDAEWEVMRVVWTLGETTSRDIIRILAEKKDWSDSTIKTLLGRLVDKGCLTTEKEGRKFIYTALVSEDEAVENAAQEL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 579532723   87 LNKLYGGDMKSLVLNFAKNEELNNKEIEELRDILN 121
Cdd:TIGR02698  81 FSRICSRKVGAVIADLIEESPLSQTDIEKLEKLLS 115
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
8-65 3.24e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 37.19  E-value: 3.24e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 579532723     8 ISMAEWDVMNIIWDKKSVSaneiVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSEN 65
Cdd:smart00347   8 LTPTQFLVLRILYEEGPLS----VSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPE 61
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 8-65 8.43e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.22  E-value: 8.43e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 579532723    8 ISMAEWDVMNIIWDKKSVSaneiVVEIQKYKEVSDKTIRTLITRLYKKEIIKRYKSEN 65
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLT----VSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPE 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH