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Conserved domains on  [gi|579306262|gb|EUT57580|]
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membrane protein [Staphylococcus aureus M0118]

Protein Classification

M50 family metallopeptidase( domain architecture ID 10598497)

M50 family metallopeptidase cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms; belongs to the site-2 protease (S2P) class of zinc metalloproteases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_M50B pfam13398
Peptidase M50B-like; This is a family of bacterial and plant peptidases in the same family as ...
 28-240 4.03e-34

Peptidase M50B-like; This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.


:

Pssm-ID: 433175  Cd Length: 194  Bit Score: 121.53  E-value: 4.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579306262   28 AIHQYRHKPVLNYLdvilNYIPVLTHEFGHVLFNKLAGGRAKDLVIVTSprerqqtlQQGFAITQSR-HLAGQWLTTIGG 106
Cdd:pfam13398   1 ALVVVWPPPILRPF----RLLVTFFHELGHALAALLTGGRVKGIELHSD--------GSGVTVSRGRpGGLGMILTLPAG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579306262  107 YLMPPIMLLIGLASSHYQIPSFFIFTYLLIFIYFLILTsRKGSPIVVITLISIMLYFILKdenIVEIQLLVTMSYQYILG 186
Cdd:pfam13398  69 YLGPALWGLLLILLSFSGRARALLWLGVLLLLVLLLYV-RNLFGLVLVLLTGGLLLAVWW---LAPPQLLAFFALFLGVF 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 579306262  187 VLLGEVLQsswtIAKLtFQRPSPQWDGSALKELSHVPIFIYSTIWIIFNLYAVN 240
Cdd:pfam13398 145 LLLGAVRD----IDDL-IRRRAPDSDADQLARLTGLPAWLWGVLWLLVSLGFLA 193
 
Name Accession Description Interval E-value
Peptidase_M50B pfam13398
Peptidase M50B-like; This is a family of bacterial and plant peptidases in the same family as ...
 28-240 4.03e-34

Peptidase M50B-like; This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.


Pssm-ID: 433175  Cd Length: 194  Bit Score: 121.53  E-value: 4.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579306262   28 AIHQYRHKPVLNYLdvilNYIPVLTHEFGHVLFNKLAGGRAKDLVIVTSprerqqtlQQGFAITQSR-HLAGQWLTTIGG 106
Cdd:pfam13398   1 ALVVVWPPPILRPF----RLLVTFFHELGHALAALLTGGRVKGIELHSD--------GSGVTVSRGRpGGLGMILTLPAG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579306262  107 YLMPPIMLLIGLASSHYQIPSFFIFTYLLIFIYFLILTsRKGSPIVVITLISIMLYFILKdenIVEIQLLVTMSYQYILG 186
Cdd:pfam13398  69 YLGPALWGLLLILLSFSGRARALLWLGVLLLLVLLLYV-RNLFGLVLVLLTGGLLLAVWW---LAPPQLLAFFALFLGVF 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 579306262  187 VLLGEVLQsswtIAKLtFQRPSPQWDGSALKELSHVPIFIYSTIWIIFNLYAVN 240
Cdd:pfam13398 145 LLLGAVRD----IDDL-IRRRAPDSDADQLARLTGLPAWLWGVLWLLVSLGFLA 193
 
Name Accession Description Interval E-value
Peptidase_M50B pfam13398
Peptidase M50B-like; This is a family of bacterial and plant peptidases in the same family as ...
 28-240 4.03e-34

Peptidase M50B-like; This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.


Pssm-ID: 433175  Cd Length: 194  Bit Score: 121.53  E-value: 4.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579306262   28 AIHQYRHKPVLNYLdvilNYIPVLTHEFGHVLFNKLAGGRAKDLVIVTSprerqqtlQQGFAITQSR-HLAGQWLTTIGG 106
Cdd:pfam13398   1 ALVVVWPPPILRPF----RLLVTFFHELGHALAALLTGGRVKGIELHSD--------GSGVTVSRGRpGGLGMILTLPAG 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579306262  107 YLMPPIMLLIGLASSHYQIPSFFIFTYLLIFIYFLILTsRKGSPIVVITLISIMLYFILKdenIVEIQLLVTMSYQYILG 186
Cdd:pfam13398  69 YLGPALWGLLLILLSFSGRARALLWLGVLLLLVLLLYV-RNLFGLVLVLLTGGLLLAVWW---LAPPQLLAFFALFLGVF 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 579306262  187 VLLGEVLQsswtIAKLtFQRPSPQWDGSALKELSHVPIFIYSTIWIIFNLYAVN 240
Cdd:pfam13398 145 LLLGAVRD----IDDL-IRRRAPDSDADQLARLTGLPAWLWGVLWLLVSLGFLA 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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