NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|579304348|gb|EUT55700|]
View 

polysaccharide biosynthesis protein [Staphylococcus aureus M0116]

Protein Classification

polysaccharide biosynthesis protein( domain architecture ID 10192027)

polysaccharide biosynthesis protein similar to Bacillus subtilis sporulation protein YkvU, Lipid II flippase MurJ, and uncharacterized membrane protein YabM, which are involved in cell wall metabolism; belongs to the multidrug and toxic compound extrusion (MATE)-like transporter superfamily

Gene Ontology:  GO:0016020|GO:0009252
PubMed:  31866287|33774036

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 11-425 4.72e-82

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


:

Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 261.25  E-value: 4.72e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  11 VVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAKA-------VA 83
Cdd:cd13124    1 LILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGArrifrvsLI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  84 YIQLVGILLFIAIFVFANNIA-HMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIV 162
Cdd:cd13124   81 LLLILGLVFFLLLFFGAPFLAqLLLGDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIVILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 163 TIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLVA----------HRPFKFKMVNNTAKIVWKQFALSVLIFAISQLIV 232
Cdd:cd13124  161 LAYLLLPVGGGLYYAAAGATFGAVIGALAGLLVLLYyyrkkrrelkRLLRKSPRSKISTKEILKELLSYAIPITLSSLIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 233 ILWQVIDSVTIIKSLQAIRVPFDVAITEKGVY-DRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKI 311
Cdd:cd13124  241 PLLQLIDSFTVPRRLQAAGLSESEATALYGILtGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 312 TILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIIL 391
Cdd:cd13124  321 TLLIGLPAAVGLAVLAEPINTLLFGDSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVL 400

                        410       420       430
                 ....*....|....*....|....*....|....
gi 579304348 392 IRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHL 425
Cdd:cd13124  401 IPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
 
Name Accession Description Interval E-value
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 11-425 4.72e-82

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 261.25  E-value: 4.72e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  11 VVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAKA-------VA 83
Cdd:cd13124    1 LILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGArrifrvsLI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  84 YIQLVGILLFIAIFVFANNIA-HMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIV 162
Cdd:cd13124   81 LLLILGLVFFLLLFFGAPFLAqLLLGDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIVILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 163 TIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLVA----------HRPFKFKMVNNTAKIVWKQFALSVLIFAISQLIV 232
Cdd:cd13124  161 LAYLLLPVGGGLYYAAAGATFGAVIGALAGLLVLLYyyrkkrrelkRLLRKSPRSKISTKEILKELLSYAIPITLSSLIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 233 ILWQVIDSVTIIKSLQAIRVPFDVAITEKGVY-DRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKI 311
Cdd:cd13124  241 PLLQLIDSFTVPRRLQAAGLSESEATALYGILtGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 312 TILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIIL 391
Cdd:cd13124  321 TLLIGLPAAVGLAVLAEPINTLLFGDSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVL 400

                        410       420       430
                 ....*....|....*....|....*....|....
gi 579304348 392 IRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHL 425
Cdd:cd13124  401 IPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 1-499 3.03e-80

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 259.71  E-value: 3.03e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348   1 MKHKEAFNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAK 80
Cdd:COG5841    1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  81 A-------VAYIQLVGILLFIAIFVFANNIAHM-MGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIE 152
Cdd:COG5841   81 ArrifrvsLLLLLILGLVFFLLLFFGAPFIARLlLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQVIE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 153 QVIRVGIIIVTIVIFVDRGwtIYEAGTIAILASTIGFLGSSIYLVA-------HRPFKFKMVNNTAKIVWKQFALSVLIF 225
Cdd:COG5841  161 QIVRVIFILLLAYLLLPYG--LEYAAAGATFGAVIGALAGLLVLLYyyrkrkkKLKRLLEKSKTKSKESSKDILKELLRI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 226 AI----SQLIVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYD-RGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVL 300
Cdd:COG5841  239 AIpitlSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILSgMAQPLVNLPTVLATALATSLVPAISEAFAKKDRKL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 301 MNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAG 380
Cdd:COG5841  319 VRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPEGGGILAILAPSAIFLSLQQVTTGILQGLGKQKIPVINLLIG 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 381 LVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHLH-AMRRFFINVVLGMVFMSIVV---QCVLNIVTTH 456
Cdd:COG5841  399 LLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKlDLRRRLLKPLLASLIMGIVVlllYRLLSLFLPE 478

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 579304348 457 GRFTGLIELLCAAVLGIIALFFYIFRFNVLTYKELTYLPFGSK 499
Cdd:COG5841  479 SRLGALLATLIAVLVGAIVYLLLLLKLGLITKEELRRLPKGGK 521
spore_V_B TIGR02900
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ...
 7-422 4.19e-21

stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]


Pssm-ID: 274343 [Multi-domain]  Cd Length: 488  Bit Score: 96.21  E-value: 4.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348    7 FNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAK------ 80
Cdd:TIGR02900   2 LKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNikkilk 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348   81 -AVAYIQLVGILLFIAIFVFANNIAH-MMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVG 158
Cdd:TIGR02900  82 vSLIFTLIWSLIVTAIVFLLSPFIAStLLKDERSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVIEQIVRIS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  159 IIIVTIVIFVdrGWTIYEAGTIAILASTIGFLGSSIYLVA----HRPFKFKMVNNTAKIVWKQFALSVLIFAI----SQL 230
Cdd:TIGR02900 162 VVALLISAFL--PYGLEYAVAGAYLSLVLGELVSLLYLYFffkrKKSFSIRFPFFDYKSEGKALLFDLFSVSLpltlSRF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  231 IVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYDRGA-SFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASL 309
Cdd:TIGR02900 240 IGSLLYFLETLLVPQRLVIAGVTYREATSLYGKLSGMAmPLLTFPAVITSSLSTALVPDISEAMAKKNYSSIEKRINQAI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  310 KITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNI 389
Cdd:TIGR02900 320 KISLLLGLITTVILLVIPDELGALFYGRPDAGNFIRVLAPSFPFLYFSAPLQSILQGLGKQKVALRNSLIGAIVKIILLF 399

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 579304348  390 ILIRLS--GIIGASISTVVSLIIFgTIIHIAVTRK 422
Cdd:TIGR02900 400 VLTSIPsiNIYGYAITFIITSVLV-TILNLAEIKK 433
Polysacc_synt_C pfam14667
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ...
 344-485 1.42e-12

Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.


Pssm-ID: 434111 [Multi-domain]  Cd Length: 141  Bit Score: 64.90  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  344 LSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKY 423
Cdd:pfam14667   2 LQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRYL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 579304348  424 HLHAMRRFFINVVLGMVFMSIVVQCVLNIVTTHgrFTGLIELLCAAVLGIIALFFYIFRFNV 485
Cdd:pfam14667  82 GLRLLLRRLLKPLLAALVMGIVVYLLLLLLGLL--LGLALALLLAVLVGALVYLLLLLLLKL 141
 
Name Accession Description Interval E-value
MATE_SpoVB_like cd13124
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ...
 11-425 4.72e-82

Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240529 [Multi-domain]  Cd Length: 434  Bit Score: 261.25  E-value: 4.72e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  11 VVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAKA-------VA 83
Cdd:cd13124    1 LILTIAGLISKILGAIYRIPLQNIIGDEGMGLYQMAYPIYGIFLTLATAGIPVAISKLVAEYNALGDYKGArrifrvsLI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  84 YIQLVGILLFIAIFVFANNIA-HMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIV 162
Cdd:cd13124   81 LLLILGLVFFLLLFFGAPFLAqLLLGDPRLAPVIRALAPAILIVPLLSVLRGYFQGLQNMTPTAVSQVIEQIVRVIVILV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 163 TIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLVA----------HRPFKFKMVNNTAKIVWKQFALSVLIFAISQLIV 232
Cdd:cd13124  161 LAYLLLPVGGGLYYAAAGATFGAVIGALAGLLVLLYyyrkkrrelkRLLRKSPRSKISTKEILKELLSYAIPITLSSLIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 233 ILWQVIDSVTIIKSLQAIRVPFDVAITEKGVY-DRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKI 311
Cdd:cd13124  241 PLLQLIDSFTVPRRLQAAGLSESEATALYGILtGRAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKELRRRINQALRL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 312 TILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIIL 391
Cdd:cd13124  321 TLLIGLPAAVGLAVLAEPINTLLFGDSEGGLILQILAPSILFLSLQQVTAAILQGLGKVKIPVINLLIGLLVKIVLNYVL 400

                        410       420       430
                 ....*....|....*....|....*....|....
gi 579304348 392 IRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHL 425
Cdd:cd13124  401 IPIFGIYGAAIATVIGFLVAALLNLRALKKLLGF 434
SpoVB COG5841
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ...
 1-499 3.03e-80

Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444543 [Multi-domain]  Cd Length: 532  Bit Score: 259.71  E-value: 3.03e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348   1 MKHKEAFNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAK 80
Cdd:COG5841    1 MKKQSFLKGALILTAAGLISKILGAIYRIPLQNIIGDEGFGLYQMAYPIYGLFLTLATAGIPVAISKLVAEYNALGDYKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  81 A-------VAYIQLVGILLFIAIFVFANNIAHM-MGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIE 152
Cdd:COG5841   81 ArrifrvsLLLLLILGLVFFLLLFFGAPFIARLlLGDPRAYYSLRALAPALLIVPVMSVLRGYFQGLQNMTPTAVSQVIE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 153 QVIRVGIIIVTIVIFVDRGwtIYEAGTIAILASTIGFLGSSIYLVA-------HRPFKFKMVNNTAKIVWKQFALSVLIF 225
Cdd:COG5841  161 QIVRVIFILLLAYLLLPYG--LEYAAAGATFGAVIGALAGLLVLLYyyrkrkkKLKRLLEKSKTKSKESSKDILKELLRI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 226 AI----SQLIVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYD-RGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVL 300
Cdd:COG5841  239 AIpitlSSLVLPLFQLIDSFTVPRRLQAAGLSASEATSLYGILSgMAQPLVNLPTVLATALATSLVPAISEAFAKKDRKL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 301 MNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAG 380
Cdd:COG5841  319 VRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPEGGGILAILAPSAIFLSLQQVTTGILQGLGKQKIPVINLLIG 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 381 LVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKYHLH-AMRRFFINVVLGMVFMSIVV---QCVLNIVTTH 456
Cdd:COG5841  399 LLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKlDLRRRLLKPLLASLIMGIVVlllYRLLSLFLPE 478

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|...
gi 579304348 457 GRFTGLIELLCAAVLGIIALFFYIFRFNVLTYKELTYLPFGSK 499
Cdd:COG5841  479 SRLGALLATLIAVLVGAIVYLLLLLKLGLITKEELRRLPKGGK 521
spore_V_B TIGR02900
stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial ...
 7-422 4.19e-21

stage V sporulation protein B; SpoVB is the stage V sporulation protein B of the bacterial endopore formation program in Bacillus subtilis and various other Firmcutes. It is nearly universal among endospore-formers. Paralogs with rather high sequence similarity to SpoVB exist, including YkvU in B. subtilis and a number of proteins in the genus Clostridium. [Cellular processes, Sporulation and germination]


Pssm-ID: 274343 [Multi-domain]  Cd Length: 488  Bit Score: 96.21  E-value: 4.19e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348    7 FNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAK------ 80
Cdd:TIGR02900   2 LKGTFILTIANLITRILGFIFRIVLSRILGAEGVGLYGMAMPIYFLFITLTTGGLPVAISKFVAEASAKNDRKNikkilk 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348   81 -AVAYIQLVGILLFIAIFVFANNIAH-MMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVG 158
Cdd:TIGR02900  82 vSLIFTLIWSLIVTAIVFLLSPFIAStLLKDERSLYSLLVICPAMPFIALSSVLKGYFQGISNMKPPAYIQVIEQIVRIS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  159 IIIVTIVIFVdrGWTIYEAGTIAILASTIGFLGSSIYLVA----HRPFKFKMVNNTAKIVWKQFALSVLIFAI----SQL 230
Cdd:TIGR02900 162 VVALLISAFL--PYGLEYAVAGAYLSLVLGELVSLLYLYFffkrKKSFSIRFPFFDYKSEGKALLFDLFSVSLpltlSRF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  231 IVILWQVIDSVTIIKSLQAIRVPFDVAITEKGVYDRGA-SFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASL 309
Cdd:TIGR02900 240 IGSLLYFLETLLVPQRLVIAGVTYREATSLYGKLSGMAmPLLTFPAVITSSLSTALVPDISEAMAKKNYSSIEKRINQAI 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  310 KITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNI 389
Cdd:TIGR02900 320 KISLLLGLITTVILLVIPDELGALFYGRPDAGNFIRVLAPSFPFLYFSAPLQSILQGLGKQKVALRNSLIGAIVKIILLF 399

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 579304348  390 ILIRLS--GIIGASISTVVSLIIFgTIIHIAVTRK 422
Cdd:TIGR02900 400 VLTSIPsiNIYGYAITFIITSVLV-TILNLAEIKK 433
MATE_Wzx_like cd13128
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 7-410 1.89e-16

Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240533 [Multi-domain]  Cd Length: 402  Bit Score: 81.05  E-value: 1.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348   7 FNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEA---YAKAVA 83
Cdd:cd13128    2 AKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEKIreiISTSLV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  84 YIQLVGILLFIAIFVFANNIAHmmGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVT 163
Cdd:cd13128   82 LKLILGILALLLLFLFAFLIAF--YDPELVLLLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALIL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 164 IVIfvdrGWTIYEAGTIAILASTIGFLGSSIYLVAHRPFKFKMVNNtaKIVWKQFALSVLIFAISQLIVILWQVIDSVTI 243
Cdd:cd13128  160 VLL----GGGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSFD--LKLAKELLRFSIPLALSGIFSLIYTRIDTIML 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 244 ikslQAIRVPFDVaitekGVYDRGASFIQMGLIVTTTFSFALIPLLSDAIKmNNQVLMNRYANASLKITILISTAAGIGL 323
Cdd:cd13128  234 ----GYFLGDAAV-----GIYNAAYRIAELLLFIPSAISTALFPRISELYK-NDKDELKKLLKKSFKYLFLISLPIAIGL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 324 INLLPLMNGVFF--KTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLSGIIGAS 401
Cdd:cd13128  304 FLFAEPIITLLFgeEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAA 383


                 ....*....
gi 579304348 402 ISTVVSLII 410
Cdd:cd13128  384 IATLISEFI 392
Polysacc_synt_C pfam14667
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ...
 344-485 1.42e-12

Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.


Pssm-ID: 434111 [Multi-domain]  Cd Length: 141  Bit Score: 64.90  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  344 LSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKY 423
Cdd:pfam14667   2 LQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRYL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 579304348  424 HLHAMRRFFINVVLGMVFMSIVVQCVLNIVTTHgrFTGLIELLCAAVLGIIALFFYIFRFNV 485
Cdd:pfam14667  82 GLRLLLRRLLKPLLAALVMGIVVYLLLLLLGLL--LGLALALLLAVLVGALVYLLLLLLLKL 141
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 4-411 5.06e-12

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 67.28  E-value: 5.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348   4 KEAFNGVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEA---YAK 80
Cdd:COG2244    2 KKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELrrlLST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  81 AVAYIQLVGILLFIAIFVFANNIAHMMGDSHLTPMIQAASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVirvgii 160
Cdd:COG2244   82 ALLLRLLLSLLLALLLLLLAPFIAALLGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSL------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 161 ivtivifvdrgwtiyeagTIAILASTIGFLGSSIYLVAhrpfkfkmvnntAKIVWKQFALSVLIFAISQLIVILwqvids 240
Cdd:COG2244  156 ------------------LSLLLALLLALLGLGLWGLV------------LKYSLPLLLSGLLGLLLTNLDRLL------ 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 241 VTIIKSLQAIrvpfdvaitekGVYDRGASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAG 320
Cdd:COG2244  200 LGALLGPAAV-----------GIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLA 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 321 IGLINLLPLMNGVFFKTN--DLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLSGII 398
Cdd:COG2244  269 LGLALLAPPLLSLLFGPEyaEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLV 348

                        410
                 ....*....|...
gi 579304348 399 GASISTVVSLIIF 411
Cdd:COG2244  349 GAAIATLLSYLVL 361
Polysacc_synt pfam01943
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ...
 9-234 1.19e-11

Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.


Pssm-ID: 426523 [Multi-domain]  Cd Length: 274  Bit Score: 65.02  E-value: 1.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348    9 GVVVLTAALIVIKILSAVYRIPYQNILGDTGLYAYQQVYPIVALGMILSMNAIPSAITQNIGKYHSDEAYAKAVAYIQLV 88
Cdd:pfam01943   4 NVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELVSLYWLNALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348   89 GILLFIAIFVFANNIAHMMGDSHLTPMIQAASLSF-IFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVTIVIF 167
Cdd:pfam01943  84 VKLVLVLLFLLLPLIAAFLGLPELAVLYRILALMFlLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIAVFLP 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 579304348  168 VDrgwtIYEAGTIAILASTIGFLGSSIYLVA--HRPFKFKMVNNTAKIV---WKQFALSVLIFAISQLIVIL 234
Cdd:pfam01943 164 GD----IVAALLYQVLAALVGGIIALAVLRKifRPRFVFPSLKLVRKLLsfgAPLFISSLAISLYTYIDSIL 231
MurJ COG0728
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ...
 276-480 8.01e-09

Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440492 [Multi-domain]  Cd Length: 503  Bit Score: 57.85  E-value: 8.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 276 IVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAGIGLINL-LPLMNGVF----FKTNDLTLT---LSVY 347
Cdd:COG0728  273 LFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLaEPIVRLLFergaFTAEDTALTalaLAAY 352

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 348 MITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAVTRKYH--- 424
Cdd:COG0728  353 ALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLLRRRLGglp 432

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 579304348 425 LHAMRRFFINVVLGMVFMSIVVQCVLNIVTTHGRFTGLIELLCAAVLGIIALFFYI 480
Cdd:COG0728  433 LRGILRTLLKLLLASLVMGAVLWLLLRLLGDWLGGGLLGRLLALALLILVGAAVYF 488
MATE_tuaB_like cd13127
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 46-423 3.49e-05

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240532 [Multi-domain]  Cd Length: 406  Bit Score: 45.94  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  46 VYPIVALGMILSMNAIPSAITQnigKYHSDEAYAKAVAYIQL-VGILLFIAIFVFANNIAHMMGDSHLTPMIQAASLSFI 124
Cdd:cd13127   41 ATVFIAFAQLFSDLGLSSALIQ---RKDLTEEDLSTVFWLNLlLGLLLYLLLFLLAPLIAAFYNEPELIPLLRVLSLSFL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 125 FIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVTIVIfvdrGWTIYEAGTIAILASTIGFLGSSIYlVAHRP--- 201
Cdd:cd13127  118 LSGLGSVPRALLQRELRFKKLAIIELISTLVSGVVAIVLALL----GFGVWALVAQQLVGALVSTVLLWIL-SRWRPrls 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 202 FKFKMVNNTAKIVWKQFALSVLIFAISQlivilwqvIDSVTIIKSLQAirvpfdvaiTEKGVYDRGASFIQMGL-IVTTT 280
Cdd:cd13127  193 FSLASLKELLSFGSKLLGSNLLNYFSRN--------LDNLIIGKFLGA---------AALGYYSRAYRLALLPVqNITGP 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 281 FSFALIPLLSDAikMNNQVLMNRYANASLKITILIStaagiglinlLPLMNGVFFKTNDLTLTL-------SVYMITVIC 353
Cdd:cd13127  256 ITRVLFPALSRL--QDDPERLRRAYLKALRLLALIT----------FPLMVGLALLAEPLVLLLlgekwlpAVPILQILA 323

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 579304348 354 VSLIM-----MDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLsGIIGASISTVVSLIIFgTIIHIAVTRKY 423
Cdd:cd13127  324 LAGLFqplssLNGSLLLALGRTDLLLKLGLIKAVLTVLALLIGIPY-GIIGVAIAYVIASLLS-FPLNLYLAGRL 396
MATE_MurJ_like cd13123
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ...
 276-410 6.58e-04

MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240528 [Multi-domain]  Cd Length: 420  Bit Score: 42.05  E-value: 6.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 276 IVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAGIGLINL-LPLMNGVF----FKTNDLTLT---LSVY 347
Cdd:cd13123  266 IFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLaEPIVRLLFergaFTAEDTLMTasaLAAY 345

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 579304348 348 MITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLSGIIGASISTVVSLII 410
Cdd:cd13123  346 ALGLPAFALVKLLSRAFYALKDTKTPVKIAVIAVAVNILLNLLLIKPLGHVGLALATSLSAWV 408
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
267-431 2.56e-03

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 40.13  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 267 GASFIQMGLIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTA-AGIGLINLLPLMNgvFFKTNDLTLT-- 343
Cdd:COG0534   49 AFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLlTLLGLLFAPPLLR--LLGADPEVLAla 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 344 ---LSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILI---RLsGIIGASISTVVSLIIFGTIIHI 417
Cdd:COG0534  127 rdyLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIfggGL-GVAGAALATVISQAVSALLLLY 205

                        170
                 ....*....|....
gi 579304348 418 AVTRKYHLHAMRRF 431
Cdd:COG0534  206 YLFRKRSLLRLRLR 219
MATE_like_10 cd13125
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ...
 301-445 2.80e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240530 [Multi-domain]  Cd Length: 409  Bit Score: 40.22  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 301 MNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITVICVSLIMMDMALLQAQHAVRPIFVGMTAG 380
Cdd:cd13125   72 LARVWSTAFRITLILSILGGLLLLLFSKPLSSLLFGDIDYSWVFILLGLALPLFALNNLLLAILNGLKEIKRYALINIIS 151

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 579304348 381 LVIKFILNIILIRLSGIIGASISTVVSLIIFGTIIHIAV------TRKYHLHAMRRFFINVVLGMVFMSIV 445
Cdd:cd13125  152 SLIGLLVSVLLVYFYGLKGALLALVLNQSLIFLVTLIYSrkqpwfKLKYLWGRLDKDIIKKLLKFSLMALV 222
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
 46-419 3.06e-03

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 40.00  E-value: 3.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348  46 VYPIVALGMILSMnAIPSAITQNIGKYHSDEAYAKAVAYIQL---VGILLFIAIFVFANNIAHMMGDSHLTPM-----IQ 117
Cdd:cd12082   40 IALLIALGVGLSV-GTSALISQAIGAGDEEKARRVLVQSIVLailLGLLLAALLLFFSPLILSLLGAEEEVIElaatyLT 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 118 AASLSFIFIGMLGVLRGYYQSANNMTVPAISQVIEQVIRVGIIIVTIVIFVDRGWTIYEAGTIAILASTIGFLGSSIYLV 197
Cdd:cd12082  119 ILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIFGLGPPELGIAGAALATVISYVIGALLLLIYLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 198 AHRP---FKFKMVNNTAKIVWKQFALSVLIFAISQLIVILWQVIDSVTIIKSlqairvpfdvAITEKGVYDRGASFIQMG 274
Cdd:cd12082  199 KGKKilkFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFG----------GAAALAAYTVAFRIASLA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 579304348 275 LIVTTTFSFALIPLLSDAIKMNNQVLMNRYANASLKITILISTAAGIGLINLLPLMNGVFFKTNDLTLTLSVYMITV--- 351
Cdd:cd12082  269 FMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILaiy 348

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 579304348 352 --ICVSLIMMDMALLQAQHAVRPIFVGMTAGLVIKFILNIILIRLS-GIIGASISTVVSLIIFGTIIHIAV 419
Cdd:cd12082  349 ylFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGlGLYGIWLALVISLILAALVLLLFF 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH