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Conserved domains on  [gi|578703719|gb|EUP37241|]
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acetyl-CoA carboxylase, biotin carboxyl carrier protein [Staphylococcus aureus M1555]

Protein Classification

acetyl-CoA carboxylase biotin carboxyl carrier protein( domain architecture ID 11423502)

acetyl-CoA carboxylase biotin carboxyl carrier protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

CATH:  2.40.50.100
Gene Ontology:  GO:0003989|GO:0006633|GO:0009317
PubMed:  1370469
SCOP:  4002909
TCDB:  3.B.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-154 1.80e-51

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 160.45  E-value: 1.80e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719   9 LIEILDKSTLTEINIEDTKGKVTLKKEketeiitPQISQMPVEAAAMPMPQAQSTDSNKTEAPKPtsdNHKTINAPMVGT 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRG-------GAAAAAPVAAPAAAAPAAAAPAAAAAAAAAS---GGGAVKSPMVGT 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578703719  89 FYKSPSPDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:COG0511   71 FYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-154 1.80e-51

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 160.45  E-value: 1.80e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719   9 LIEILDKSTLTEINIEDTKGKVTLKKEketeiitPQISQMPVEAAAMPMPQAQSTDSNKTEAPKPtsdNHKTINAPMVGT 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRG-------GAAAAAPVAAPAAAAPAAAAPAAAAAAAAAS---GGGAVKSPMVGT 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578703719  89 FYKSPSPDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:COG0511   71 FYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-154 3.77e-45

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 144.98  E-value: 3.77e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719    1 MNFKEIKELIEILDKSTLTEINIEDtkGKVTLKKEKETEIITPQISQMPVEAAAMPMP--QAQSTDSNKTEAPKPTSD-N 77
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKE--EEFSVRLSKAAAAASFSVVQQAAAPVPAQVPaqSSAAVPAPAPAAPAPAADiK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578703719   78 HKTINAPMVGTFYKSPSPDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:TIGR00531  79 GHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 43-151 3.77e-29

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 107.62  E-value: 3.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  43 PQISQMPVE-AAAMPMPQAQSTDSNKTEA-PKPT---SDNHKTINAPMVGTFYKSPSPDEEAYVQVGDTVSNETTVCILE 117
Cdd:PLN02983 157 PPHAMPPASpPAAQPAPSAPASSPPPTPAsPPPAkapKSSHPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIE 236

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578703719 118 AMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLF 151
Cdd:PLN02983 237 AMKLMNEIEADQSGTIVEILAEDGKPVSVDTPLF 270
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 80-153 1.65e-23

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 87.09  E-value: 1.65e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578703719  80 TINAPMVGTFYKSpspdeeaYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:cd06850    1 EVTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 79-153 1.84e-18

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 74.56  E-value: 1.84e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578703719   79 KTINAPMVGTFYKSPspDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:pfam00364   1 TEIKSPMIGESVREG--VVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
 
Name Accession Description Interval E-value
AccB COG0511
Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier ...
 9-154 1.80e-51

Biotin carboxyl carrier protein [Lipid transport and metabolism]; Biotin carboxyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440277 [Multi-domain]  Cd Length: 136  Bit Score: 160.45  E-value: 1.80e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719   9 LIEILDKSTLTEINIEDTKGKVTLKKEketeiitPQISQMPVEAAAMPMPQAQSTDSNKTEAPKPtsdNHKTINAPMVGT 88
Cdd:COG0511    1 LIELLEESGLTELEVEEGEYKVRIKRG-------GAAAAAPVAAPAAAAPAAAAPAAAAAAAAAS---GGGAVKSPMVGT 70

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578703719  89 FYKSPSPDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:COG0511   71 FYRAPSPGAKPFVKVGDKVKAGDTLCIIEAMKMMNEIEAPVSGTVVEILVENGQPVEYGQPLFVIE 136
BCCP TIGR00531
acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify ...
 1-154 3.77e-45

acetyl-CoA carboxylase, biotin carboxyl carrier protein; This model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase.The gene name is accB or fabE. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 273123 [Multi-domain]  Cd Length: 155  Bit Score: 144.98  E-value: 3.77e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719    1 MNFKEIKELIEILDKSTLTEINIEDtkGKVTLKKEKETEIITPQISQMPVEAAAMPMP--QAQSTDSNKTEAPKPTSD-N 77
Cdd:TIGR00531   1 MNIREIKELIKLVEESGITELELKE--EEFSVRLSKAAAAASFSVVQQAAAPVPAQVPaqSSAAVPAPAPAAPAPAADiK 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578703719   78 HKTINAPMVGTFYKSPSPDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:TIGR00531  79 GHIVRSPMVGTFYRAPSPDAKPFVEVGDKVNKGQTVCIVEAMKMMNEIEAEKAGTVVAILVENGQPVEYGEPLIVIE 155
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 43-151 3.77e-29

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 107.62  E-value: 3.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  43 PQISQMPVE-AAAMPMPQAQSTDSNKTEA-PKPT---SDNHKTINAPMVGTFYKSPSPDEEAYVQVGDTVSNETTVCILE 117
Cdd:PLN02983 157 PPHAMPPASpPAAQPAPSAPASSPPPTPAsPPPAkapKSSHPPLKSPMAGTFYRSPAPGEPPFVKVGDKVQKGQVVCIIE 236

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578703719 118 AMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLF 151
Cdd:PLN02983 237 AMKLMNEIEADQSGTIVEILAEDGKPVSVDTPLF 270
PRK09282 PRK09282
pyruvate carboxylase subunit B; Validated
 29-154 2.68e-26

pyruvate carboxylase subunit B; Validated


Pssm-ID: 236449 [Multi-domain]  Cd Length: 592  Bit Score: 103.38  E-value: 2.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  29 KVTLKKEKETEIITPQISQMPVEAAAMPMPQAQSTDSNKTEAPKPtsdnhktINAPMVGTFYKspspdeeAYVQVGDTVS 108
Cdd:PRK09282 480 KIEGVKAEGKRPFYLRVDGMPEEVVVEPLKEIVVGGRPRASAPGA-------VTSPMPGTVVK-------VKVKEGDKVK 545

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 578703719 109 NETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:PRK09282 546 AGDTVLVLEAMKMENEIQAPVDGTVKEILVKEGDRVNPGDVLMEIE 591
biotinyl_domain cd06850
The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all ...
 80-153 1.65e-23

The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, oxaloacetate decarboxylase, methylmalonyl-CoA decarboxylase, transcarboxylase and urea amidolyase. This domain functions in transferring CO2 from one subsite to another, allowing carboxylation, decarboxylation, or transcarboxylation. During this process, biotin is covalently attached to a specific lysine.


Pssm-ID: 133459 [Multi-domain]  Cd Length: 67  Bit Score: 87.09  E-value: 1.65e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578703719  80 TINAPMVGTFYKSpspdeeaYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:cd06850    1 EVTAPMPGTVVKV-------LVKEGDKVEAGQPLAVLEAMKMENEVTAPVAGVVKEILVKEGDQVEAGQLLVVI 67
PRK07051 PRK07051
biotin carboxyl carrier domain-containing protein;
79-153 7.93e-23

biotin carboxyl carrier domain-containing protein;


Pssm-ID: 180811 [Multi-domain]  Cd Length: 80  Bit Score: 85.83  E-value: 7.93e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578703719  79 KTINAPMVGTFYKSPSPDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:PRK07051   4 HEIVSPLPGTFYRRPSPDAPPYVEVGDAVAAGDVVGLIEVMKQFTEVEAEAAGRVVEFLVEDGEPVEAGQVLARI 78
Biotin_lipoyl pfam00364
Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue ...
 79-153 1.84e-18

Biotin-requiring enzyme; This family covers two Prosite entries, the conserved lysine residue binds biotin in one group and lipoic acid in the other. Note that the HMM does not currently recognize the Glycine cleavage system H proteins.


Pssm-ID: 395290 [Multi-domain]  Cd Length: 73  Bit Score: 74.56  E-value: 1.84e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578703719   79 KTINAPMVGTFYKSPspDEEAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:pfam00364   1 TEIKSPMIGESVREG--VVEWLVKVGDKVKAGQPLAEVEAMKMEMEIPAPVAGVVKEILVPEGDTVEVGDPLAKI 73
PRK14040 PRK14040
oxaloacetate decarboxylase subunit alpha;
58-153 7.83e-13

oxaloacetate decarboxylase subunit alpha;


Pssm-ID: 237592 [Multi-domain]  Cd Length: 593  Bit Score: 64.57  E-value: 7.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  58 PQAQSTDSNKTEAPKPTSDNHKTINAPMVGTFYKspspdeeAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEIL 137
Cdd:PRK14040 504 PAAPAAAPAAAAAAAPAAAAGEPVTAPLAGNIFK-------VIVTEGQTVAEGDVLLILEAMKMETEIRAAQAGTVRGIA 576

                         90
                 ....*....|....*.
gi 578703719 138 VEDGQMVEYGQPLFKV 153
Cdd:PRK14040 577 VKEGDAVAVGDTLLTL 592
PRK06549 PRK06549
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 39-154 5.07e-12

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235826 [Multi-domain]  Cd Length: 130  Bit Score: 59.44  E-value: 5.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  39 EIITPQISQMPVEAAAMPMPQAqSTDSNKTEAPKP---TSDNHKTINAPMVGTFYKspspdeeAYVQVGDTVSNETTVCI 115
Cdd:PRK06549  20 EIGAPAQAAAPAQPASTPVPVP-TEASPQVEAQAPqpaAAAGADAMPSPMPGTILK-------VLVAVGDQVTENQPLLI 91

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578703719 116 LEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:PRK06549  92 LEAMKMENEIVASSAGTVTAIHVTPGQVVNPGDGLITIG 130
PycA COG1038
Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the ...
 61-153 2.18e-11

Pyruvate carboxylase [Energy production and conversion]; Pyruvate carboxylase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440660 [Multi-domain]  Cd Length: 1144  Bit Score: 60.48  E-value: 2.18e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719   61 QSTDSNKTEAPKPTSDNHKTINAPMVGTFYKspspdeeAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVED 140
Cdd:COG1038  1059 RSVKVTVASREKADPGNPGHIGAPMPGTVVK-------VLVKEGDEVKKGDPLLTIEAMKMETTITAPRDGTVKEVLVKE 1131

                          90
                  ....*....|...
gi 578703719  141 GQMVEYGQPLFKV 153
Cdd:COG1038  1132 GDQVEAGDLLIEL 1144
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 47-150 3.89e-11

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 57.56  E-value: 3.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  47 QMPVEAAAMPMPQAQSTDSNKTEAPKPTSDNHKTINAPMVGTFYKspspdeeAYVQVGDTVSNETTVCILEAMKLFNEIQ 126
Cdd:PRK05641  53 PTPAPAPAPAVPSAPTPVAPAAPAPAPASAGENVVTAPMPGKILR-------ILVREGQQVKVGQGLLILEAMKMENEIP 125

                         90       100
                 ....*....|....*....|....
gi 578703719 127 AEISGEIVEILVEDGQMVEYGQPL 150
Cdd:PRK05641 126 APKDGVVKKILVKEGDTVDTGQPL 149
PRK12999 PRK12999
pyruvate carboxylase; Reviewed
 61-154 8.22e-10

pyruvate carboxylase; Reviewed


Pssm-ID: 237263 [Multi-domain]  Cd Length: 1146  Bit Score: 55.91  E-value: 8.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719   61 QSTDSNKTEAPK--PTSDNHktINAPMVGTFYKspspdeeAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILV 138
Cdd:PRK12999 1059 RSVKSTVAAREKadPGNPGH--VGAPMPGSVVT-------VLVKEGDEVKAGDPLAVIEAMKMETTITAPVDGTVKRVLV 1129

                          90
                  ....*....|....*.
gi 578703719  139 EDGQMVEYGQPLFKVK 154
Cdd:PRK12999 1130 KAGDQVEAGDLLVELE 1145
Biotinyl_lipoyl_domains cd06663
Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the ...
 80-153 2.60e-09

Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl, or methylamine, respectively, between components of the complex/protein via a biotinyl or lipoyl group, which is covalently attached to a highly conserved lysine residue.


Pssm-ID: 133456 [Multi-domain]  Cd Length: 73  Bit Score: 50.90  E-value: 2.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  80 TINAPM------VGTFYKspspdeeAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:cd06663    1 TILIPDlaqhlgDGTVVK-------WLKKVGDKVKKGDVLAEIEAMKATSDVEAPKSGTVKKVLVKEGTKVEGDTPLVKI 73
lipoyl_domain cd06849
Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. ...
 100-153 7.93e-07

Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid dehydrogenase (BCDH), contain at least three different enzymes, 2-oxo acid dehydrogenase (E1), dihydrolipoyl acyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) and play a key role in redox regulation. E2, the central component of the complex, catalyzes the transfer of the acyl group of CoA from E1 to E3 via reductive acetylation of a lipoyl group covalently attached to a lysine residue.


Pssm-ID: 133458 [Multi-domain]  Cd Length: 74  Bit Score: 44.32  E-value: 7.93e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578703719 100 YVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:cd06849   21 LVKEGDSVEEGDVLAEVETDKATVEVEAPAAGVLAKILVEEGDTVPVGQVIAVI 74
AceF COG0508
Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component ...
 100-153 4.76e-06

Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component [Energy production and conversion]; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440274 [Multi-domain]  Cd Length: 77  Bit Score: 42.36  E-value: 4.76e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578703719 100 YVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:COG0508   23 LVKEGDTVKEGDPLAEVETDKATMEVPAPAAGVLLEILVKEGDTVPVGAVIAVI 76
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 101-154 5.41e-06

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 44.67  E-value: 5.41e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578703719 101 VQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:PTZ00144  66 KKVGDYVKEDEVICIIETDKVSVDIRAPASGVITKIFAEEGDTVEVGAPLSEID 119
EmrA COG1566
Multidrug resistance efflux pump EmrA [Defense mechanisms];
125-153 8.47e-06

Multidrug resistance efflux pump EmrA [Defense mechanisms];


Pssm-ID: 441174 [Multi-domain]  Cd Length: 331  Bit Score: 44.27  E-value: 8.47e-06
                         10        20
                 ....*....|....*....|....*....
gi 578703719 125 IQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:COG1566   48 VAAKVSGRVTEVLVKEGDRVKKGQVLARL 76
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 101-154 2.32e-05

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 42.89  E-value: 2.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578703719 101 VQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:PRK11855 140 VKVGDTVEEDQSLITVETDKATMEIPSPVAGVVKEIKVKVGDKVSVGSLLVVIE 193
PRK14042 PRK14042
pyruvate carboxylase subunit B; Provisional
 100-154 2.36e-05

pyruvate carboxylase subunit B; Provisional


Pssm-ID: 172536 [Multi-domain]  Cd Length: 596  Bit Score: 43.17  E-value: 2.36e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578703719 100 YVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:PRK14042 540 HVSAGDEVKAGQAVLVIEAMKMETEIKAPANGVVAEILCQKGDKVTPGQVLIRVE 594
PRK08225 PRK08225
acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 80-150 5.22e-05

acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 181304 [Multi-domain]  Cd Length: 70  Bit Score: 39.39  E-value: 5.22e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578703719  80 TINAPMVGTFYKspspdeeAYVQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPL 150
Cdd:PRK08225   3 KVYASMAGNVWK-------IVVKVGDTVEEGQDVVILESMKMEIPIVAEEAGTVKKINVQEGDFVNEGDVL 66
AcrA COG0845
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ...
 124-153 5.91e-05

Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];


Pssm-ID: 440606 [Multi-domain]  Cd Length: 324  Bit Score: 41.85  E-value: 5.91e-05
                         10        20        30
                 ....*....|....*....|....*....|
gi 578703719 124 EIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:COG0845   25 EVRARVSGRVEEVLVDEGDRVKKGQVLARL 54
Biotin_lipoyl_2 pfam13533
Biotin-lipoyl like;
124-154 1.07e-04

Biotin-lipoyl like;


Pssm-ID: 433286  Cd Length: 50  Bit Score: 37.81  E-value: 1.07e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 578703719  124 EIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:pfam13533   4 KIASPVSGKVVAVNVKEGQQVKKGDVLATLD 34
PDHac_trf_long TIGR01348
pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model ...
 46-154 1.52e-04

pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; This model describes a subset of pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase specifically close by both phylogenetic and per cent identity (UPGMA) trees. Members of this set include two or three copies of the lipoyl-binding domain. E. coli AceF is a member of this model, while mitochondrial and some other bacterial forms belong to a separate model. [Energy metabolism, Pyruvate dehydrogenase]


Pssm-ID: 273566 [Multi-domain]  Cd Length: 546  Bit Score: 40.63  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719   46 SQMPVEA---AAMPMPQAQSTDSNKTEAP--KPTSDNHKTINAPMVGTFYKSPSPdeEAYVQVGDTVSNETTVCILEAMK 120
Cdd:TIGR01348  79 AQAQAEAkkeAAPAPTAGAPAPAAQAQAApaAGQSSGVQEVTVPDIGDIEKVTVI--EVLVKVGDTVSADQSLITLESDK 156

                          90       100       110
                  ....*....|....*....|....*....|....
gi 578703719  121 LFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:TIGR01348 157 ASMEVPAPASGVVKSVKVKVGDSVPTGDLILTLS 190
sucB TIGR01347
2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This ...
 103-153 2.17e-04

2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); This model describes the TCA cycle 2-oxoglutarate system E2 component, dihydrolipoamide succinyltransferase. It is closely related to the pyruvate dehydrogenase E2 component, dihydrolipoamide acetyltransferase. The seed for this model includes mitochondrial and Gram-negative bacterial forms. Mycobacterial candidates are highly derived, differ in having and extra copy of the lipoyl-binding domain at the N-terminus. They score below the trusted cutoff, but above the noise cutoff and above all examples of dihydrolipoamide acetyltransferase. [Energy metabolism, TCA cycle]


Pssm-ID: 273565 [Multi-domain]  Cd Length: 403  Bit Score: 40.10  E-value: 2.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578703719  103 VGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:TIGR01347  24 VGDTVKRDENIVEIETDKVVLEVPSPADGVLQEILFKEGDTVESGQVLAIL 74
PRK11855 PRK11855
dihydrolipoamide acetyltransferase; Reviewed
 101-154 2.54e-04

dihydrolipoamide acetyltransferase; Reviewed


Pssm-ID: 237000 [Multi-domain]  Cd Length: 547  Bit Score: 39.81  E-value: 2.54e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578703719 101 VQVGDTVSNETTVCILEAMKLFNEIQAEISGEIVEILVEDGQMVEYGQPLFKVK 154
Cdd:PRK11855  23 VKEGDTVEEDQPLVTVETDKATMEIPSPAAGVVKEIKVKVGDTVSVGGLLAVIE 76
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
 124-152 7.47e-04

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 38.56  E-value: 7.47e-04
                          10        20
                  ....*....|....*....|....*....
gi 578703719  124 EIQAEISGEIVEILVEDGQMVEYGQPLFK 152
Cdd:pfam00529  22 AVQPQVSGIVTRVLVKEGDRVKAGDVLFQ 50
aceF PRK11854
pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated
 50-147 1.31e-03

pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated


Pssm-ID: 236999 [Multi-domain]  Cd Length: 633  Bit Score: 38.06  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578703719  50 VEAAAMPMPQAQSTDSNKTEAPKPTSDNhKTINAPMVGTfykspspDE----EAYVQVGDTVSNETTVCILEAMKLFNEI 125
Cdd:PRK11854 179 VAGEAPAAAPAAAEAAAPAAAPAAAAGV-KDVNVPDIGG-------DEvevtEVMVKVGDKVEAEQSLITVEGDKASMEV 250

                         90       100
                 ....*....|....*....|..
gi 578703719 126 QAEISGEIVEILVEDGQMVEYG 147
Cdd:PRK11854 251 PAPFAGTVKEIKVNVGDKVKTG 272
RND_mfp TIGR01730
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ...
 124-153 3.46e-03

RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273776 [Multi-domain]  Cd Length: 322  Bit Score: 36.52  E-value: 3.46e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 578703719  124 EIQAEISGEIVEILVEDGQMVEYGQPLFKV 153
Cdd:TIGR01730  28 DLAAEVAGKITKISVREGQKVKKGQVLARL 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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