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Conserved domains on  [gi|578538705|gb|EUN75187|]
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APC family amino acid-polyamine-organocation transporter [Staphylococcus aureus M0888]

Protein Classification

APC family permease( domain architecture ID 11425014)

APC (amino acid/polyamine/organocation) family permease is involved in the uptake of a specific amino acid and/or polyamine substrate with the concomitant import of a proton

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
28-458 1.88e-60

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


:

Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 207.44  E-value: 1.88e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  28 KGLAILSSDALSSVAYGPEQILITLSVVGAVATWYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWG 107
Cdd:COG0531   11 RKLGLFDLVALGVGAIIGAGIFVLPGLAAGLAGPAAILAWLIAGLLALLVALSYAELASAFPRAGGAYTYARRALGPLLG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 108 LLAGGSLLVDYILTVAVSISSGADAFVAAFPslYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIGLVILIFI 187
Cdd:COG0531   91 FLAGWALLLSYVLAVAAVAVAFGGYLSSLFP--AGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 188 GTFRVATGDIQPHMHASVGtavpgvtLFLLLKAFSSGASSLTGVEAISNAVTNFREPsANNAVKTLIAMGSILAFLLVGI 267
Cdd:COG0531  169 GLFAFDPANFTPFLPAGGG-------LSGVLAALALAFFAFTGFEAIANLAEEAKNP-KRNIPRAIILSLLIVGVLYILV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 268 VGLayVYGIMPQTE----TTVLSQLAMQIFGdNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGD 343
Cdd:COG0531  241 SLA--LTGVVPYDElaasGAPLADAAEAVFG-PWGAILIALGALLSLLGALNASILGASRLLYAMARDGLLPKVFAKVHP 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 344 RLGY-SNSIIILGVLAIILIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVI----KWIHERPKNWLSKLsVNLLGGIVTf 418
Cdd:COG0531  318 RFGTpVNAILLTGVIALLLLLLGAASFTALASLASVGVLLAYLLVALAVIVlrrrRPDLPRPFRVPLPL-IPILGILLC- 395
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 578538705 419 iVFMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAE 458
Cdd:COG0531  396 -LFLLYLLGPGALLIGLVLLAIGLLLYLLYRRRHPKLLKE 434
 
Name Accession Description Interval E-value
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
28-458 1.88e-60

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 207.44  E-value: 1.88e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  28 KGLAILSSDALSSVAYGPEQILITLSVVGAVATWYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWG 107
Cdd:COG0531   11 RKLGLFDLVALGVGAIIGAGIFVLPGLAAGLAGPAAILAWLIAGLLALLVALSYAELASAFPRAGGAYTYARRALGPLLG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 108 LLAGGSLLVDYILTVAVSISSGADAFVAAFPslYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIGLVILIFI 187
Cdd:COG0531   91 FLAGWALLLSYVLAVAAVAVAFGGYLSSLFP--AGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 188 GTFRVATGDIQPHMHASVGtavpgvtLFLLLKAFSSGASSLTGVEAISNAVTNFREPsANNAVKTLIAMGSILAFLLVGI 267
Cdd:COG0531  169 GLFAFDPANFTPFLPAGGG-------LSGVLAALALAFFAFTGFEAIANLAEEAKNP-KRNIPRAIILSLLIVGVLYILV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 268 VGLayVYGIMPQTE----TTVLSQLAMQIFGdNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGD 343
Cdd:COG0531  241 SLA--LTGVVPYDElaasGAPLADAAEAVFG-PWGAILIALGALLSLLGALNASILGASRLLYAMARDGLLPKVFAKVHP 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 344 RLGY-SNSIIILGVLAIILIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVI----KWIHERPKNWLSKLsVNLLGGIVTf 418
Cdd:COG0531  318 RFGTpVNAILLTGVIALLLLLLGAASFTALASLASVGVLLAYLLVALAVIVlrrrRPDLPRPFRVPLPL-IPILGILLC- 395
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 578538705 419 iVFMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAE 458
Cdd:COG0531  396 -LFLLYLLGPGALLIGLVLLAIGLLLYLLYRRRHPKLLKE 434
AA_permease_2 pfam13520
Amino acid permease;
37-446 1.57e-28

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 118.57  E-value: 1.57e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705   37 ALSSVAYGPEQILITLSVVGAVATWYtlpIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLV 116
Cdd:pfam13520  10 VIGSVIGSGIFVAPLVASGGPALIVW---GWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  117 DYILTVAVSISSGADAFVAAFPSLYG----HKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIGLVILIFIGTFRV 192
Cdd:pfam13520  87 AYVLGLASSASVAASYLLSALGPDLVpttwLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGLVT 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  193 ATGDIQPHMHASVGTAVPGVTLFLLLkAFSSGASSLTGVEAISNAVTNFREPsanNAVKTLIAMGSILAFLlvGIVGLAY 272
Cdd:pfam13520 167 ADGGGFNLLSGEWHTFFPDGWPGVFA-GFLGVLWSFTGFESAANVSEEVKKR---NVPKAIFIGVIIVGVL--YILVNIA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  273 VYGIMPQTETTVLS------QLAMQIFGDNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMP--RMFTVRGDR 344
Cdd:pfam13520 241 FFGVVPDDEIALSSglgqvaALLFQAVGGKWGAIIVVILLALSLLGAVNTAIVGASRLLYALARDGVLPfsRFFAKVNKF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  345 LGYSNSIIILGVLAIILIIVFDGMTED---LIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLS-VNLLGGI-VTFI 419
Cdd:pfam13520 321 GSPIRAIILTAILSLILLLLFLLSPAAynaLLSLSAYGYLLSYLLPIIGLLILRKKRPDLGRIPGRWpVAIFGILfSLFL 400
                         410       420
                  ....*....|....*....|....*..
gi 578538705  420 VFMILLITKFSQVWPILIFLPFVVIFF 446
Cdd:pfam13520 401 IVALFFPPVGPATGSSLNYAIILIVAF 427
2A0303 TIGR00906
cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides ...
66-386 5.00e-06

cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273330 [Multi-domain]  Cd Length: 557  Bit Score: 49.43  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705   66 IAGAVLILLAALimSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYIltvaVSISSGADAFVAAFPSLYGHKV 145
Cdd:TIGR00906  69 LISGLAAVLSGF--CYAEFGARVPKAGSAYLYSYVTVGELWAFITGWNLILEYV----IGTAAVARSWSAYFDELLNKQI 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  146 --------------------LIACLLVLFILILNLRGLTESATVlsypVYLF-IIGLVILIFIGTFRVATGDIQpHMHAS 204
Cdd:TIGR00906 143 gqfrrtyfklnydglaeypdFFAVCLILLLAVLLSFGVKESAWV----NKIFtAINILVLLFVIIAGFTKADVA-NWSIT 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  205 VGTAVPGVTLFLLLKAFSSGAS---SLTGVEAISNAVTNFREPSANNAVKTLIAMGSI-LAFLLVGivglAYVYGIMP-- 278
Cdd:TIGR00906 218 EEKGAGGFMPYGFTGVLSGAATcffAFIGFDAIATTGEEVKNPQRAIPIGIVTSLLVCfVAYFLMS----AALTLMMPyy 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  279 QTETTVLSQLAMQIFGDNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYS-NSIIILGVL 357
Cdd:TIGR00906 294 LLDPDAPFPVAFEYVGWDPAKYIVAVGALCGMSTSLLGGMFPLPRVIYAMARDGLLFKWLAQINSKTKTPiNATVVSGAI 373
                         330       340
                  ....*....|....*....|....*....
gi 578538705  358 AIILIIVFDgmTEDLIPLYAVGVFIPFTL 386
Cdd:TIGR00906 374 AALMAFLFD--LKALVDLLSIGTLLAYSL 400
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
56-447 7.14e-03

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 39.08  E-value: 7.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  56 GAVATWYTlpIAGAVLILLAALIMSYRqiIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYILTVAVSISSGADAFVA 135
Cdd:cd10322   67 GLSAIWYI--LGAALGALLLALFLAPR--LRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILST 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 136 AFPSLYGHKVLIACLLVLFILILN-LRGLTESATVLSYPVYLFIIGLVILIFIGTFRVATGDI----QPHMHASVGTAVP 210
Cdd:cd10322  143 LLGIPYTVAVIIAAVIVILYTVFGgMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALaaalPALLLALGPGGGL 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 211 GVTLFLLLkAFSSGASSLTGVEAISNAVTNFREPSANNAVKTLIAMGSILAFLLVGIVGLAYVYGIMPQTETTVLSQLAM 290
Cdd:cd10322  223 GWSTILSL-ILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPDLALPTLIN 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 291 QIFGDnaafyfVQATTVMILVLAANTGFTAFPMLAAS--MSKDKYMPRMFTVRGDR--LGYSN-SIIILGVLAIILIIVF 365
Cdd:cd10322  302 SLLPP------GLAGLVLAGLLAAAMSTADSLLLAAStlFTRDIYKPLINPKASDKklLRVSRiAVVVVGVLALLLALLP 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 366 DGMTEDLI---PLYAVGVFIPFTLAQFGmvikwiherpkNWLSKLSV--NLLGGIVTFIVFMILLITKFSQVWPILIFLP 440
Cdd:cd10322  376 PSILLLLSlaaGLLAAALFPPLLGGLFW-----------KRATKAGAiaGIIVGLIVTLVWLLLPLASPLGIDPIIPALL 444

                 ....*..
gi 578538705 441 FVVIFFL 447
Cdd:cd10322  445 VSLIVFV 451
 
Name Accession Description Interval E-value
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
28-458 1.88e-60

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 207.44  E-value: 1.88e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  28 KGLAILSSDALSSVAYGPEQILITLSVVGAVATWYTLPIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWG 107
Cdd:COG0531   11 RKLGLFDLVALGVGAIIGAGIFVLPGLAAGLAGPAAILAWLIAGLLALLVALSYAELASAFPRAGGAYTYARRALGPLLG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 108 LLAGGSLLVDYILTVAVSISSGADAFVAAFPslYGHKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIGLVILIFI 187
Cdd:COG0531   91 FLAGWALLLSYVLAVAAVAVAFGGYLSSLFP--AGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 188 GTFRVATGDIQPHMHASVGtavpgvtLFLLLKAFSSGASSLTGVEAISNAVTNFREPsANNAVKTLIAMGSILAFLLVGI 267
Cdd:COG0531  169 GLFAFDPANFTPFLPAGGG-------LSGVLAALALAFFAFTGFEAIANLAEEAKNP-KRNIPRAIILSLLIVGVLYILV 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 268 VGLayVYGIMPQTE----TTVLSQLAMQIFGdNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGD 343
Cdd:COG0531  241 SLA--LTGVVPYDElaasGAPLADAAEAVFG-PWGAILIALGALLSLLGALNASILGASRLLYAMARDGLLPKVFAKVHP 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 344 RLGY-SNSIIILGVLAIILIIVFDGMTEDLIPLYAVGVFIPFTLAQFGMVI----KWIHERPKNWLSKLsVNLLGGIVTf 418
Cdd:COG0531  318 RFGTpVNAILLTGVIALLLLLLGAASFTALASLASVGVLLAYLLVALAVIVlrrrRPDLPRPFRVPLPL-IPILGILLC- 395
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 578538705 419 iVFMILLITKFSQVWPILIFLPFVVIFFLKINKHYRDIAE 458
Cdd:COG0531  396 -LFLLYLLGPGALLIGLVLLAIGLLLYLLYRRRHPKLLKE 434
AA_permease_2 pfam13520
Amino acid permease;
37-446 1.57e-28

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 118.57  E-value: 1.57e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705   37 ALSSVAYGPEQILITLSVVGAVATWYtlpIAGAVLILLAALIMSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLV 116
Cdd:pfam13520  10 VIGSVIGSGIFVAPLVASGGPALIVW---GWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWF 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  117 DYILTVAVSISSGADAFVAAFPSLYG----HKVLIACLLVLFILILNLRGLTESATVLSYPVYLFIIGLVILIFIGTFRV 192
Cdd:pfam13520  87 AYVLGLASSASVAASYLLSALGPDLVpttwLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGLVT 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  193 ATGDIQPHMHASVGTAVPGVTLFLLLkAFSSGASSLTGVEAISNAVTNFREPsanNAVKTLIAMGSILAFLlvGIVGLAY 272
Cdd:pfam13520 167 ADGGGFNLLSGEWHTFFPDGWPGVFA-GFLGVLWSFTGFESAANVSEEVKKR---NVPKAIFIGVIIVGVL--YILVNIA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  273 VYGIMPQTETTVLS------QLAMQIFGDNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMP--RMFTVRGDR 344
Cdd:pfam13520 241 FFGVVPDDEIALSSglgqvaALLFQAVGGKWGAIIVVILLALSLLGAVNTAIVGASRLLYALARDGVLPfsRFFAKVNKF 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  345 LGYSNSIIILGVLAIILIIVFDGMTED---LIPLYAVGVFIPFTLAQFGMVIKWIHERPKNWLSKLS-VNLLGGI-VTFI 419
Cdd:pfam13520 321 GSPIRAIILTAILSLILLLLFLLSPAAynaLLSLSAYGYLLSYLLPIIGLLILRKKRPDLGRIPGRWpVAIFGILfSLFL 400
                         410       420
                  ....*....|....*....|....*..
gi 578538705  420 VFMILLITKFSQVWPILIFLPFVVIFF 446
Cdd:pfam13520 401 IVALFFPPVGPATGSSLNYAIILIVAF 427
2A0303 TIGR00906
cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides ...
66-386 5.00e-06

cationic amino acid transport permease; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273330 [Multi-domain]  Cd Length: 557  Bit Score: 49.43  E-value: 5.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705   66 IAGAVLILLAALimSYRQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYIltvaVSISSGADAFVAAFPSLYGHKV 145
Cdd:TIGR00906  69 LISGLAAVLSGF--CYAEFGARVPKAGSAYLYSYVTVGELWAFITGWNLILEYV----IGTAAVARSWSAYFDELLNKQI 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  146 --------------------LIACLLVLFILILNLRGLTESATVlsypVYLF-IIGLVILIFIGTFRVATGDIQpHMHAS 204
Cdd:TIGR00906 143 gqfrrtyfklnydglaeypdFFAVCLILLLAVLLSFGVKESAWV----NKIFtAINILVLLFVIIAGFTKADVA-NWSIT 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  205 VGTAVPGVTLFLLLKAFSSGAS---SLTGVEAISNAVTNFREPSANNAVKTLIAMGSI-LAFLLVGivglAYVYGIMP-- 278
Cdd:TIGR00906 218 EEKGAGGFMPYGFTGVLSGAATcffAFIGFDAIATTGEEVKNPQRAIPIGIVTSLLVCfVAYFLMS----AALTLMMPyy 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  279 QTETTVLSQLAMQIFGDNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDRLGYS-NSIIILGVL 357
Cdd:TIGR00906 294 LLDPDAPFPVAFEYVGWDPAKYIVAVGALCGMSTSLLGGMFPLPRVIYAMARDGLLFKWLAQINSKTKTPiNATVVSGAI 373
                         330       340
                  ....*....|....*....|....*....
gi 578538705  358 AIILIIVFDgmTEDLIPLYAVGVFIPFTL 386
Cdd:TIGR00906 374 AALMAFLFD--LKALVDLLSIGTLLAYSL 400
2A0304 TIGR00907
amino acid permease (GABA permease); [Transport and binding proteins, Amino acids, peptides ...
52-335 1.60e-04

amino acid permease (GABA permease); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273331 [Multi-domain]  Cd Length: 482  Bit Score: 44.35  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705   52 LSVVGAVATWYTLPIAGAVLILLAAlimSYRQIIYAYPKGGG-----------------AYMVSKTNLGEKWGLLAGGSL 114
Cdd:TIGR00907  41 LSSGGAMSIVWGWIIAGAGSICIAL---SLAELSSAYPTSGGqyfwsaklapprqmpfaSWMTGWFNLAGQVAGTASTDL 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  115 LVDYILTVAVSISSGADAFVaafPSLYgHKVLIACLLVLFILILN------LRGLTESATVLSYPVYLFIIGLVILIFIG 188
Cdd:TIGR00907 118 SVAQLILGIVSLTTPGREYI---PTRW-HIFGIMIGIHLIHALINslptkwLPRITSSAAYWSLLGFLTICITLLACKSP 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  189 TF---RVATGDIQPhmhaSVGTAVPGVTLFLLlkAFSSGASSLTGVEAISNAVTNFREPSAN--NAVKTLIAMGSILAFL 263
Cdd:TIGR00907 194 KFndgKFVFTNFNN----STGGWKPGGFAFLL--GLLNPAWSMTGYDGTAHMAEEIENPEVVgpRAIIGAVAIGIVTGFC 267
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578538705  264 LvgIVGLAYVYGIMP----QTETTVLSQLAMQIFGDNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMP 335
Cdd:TIGR00907 268 F--NIVLFFSMGDIDslisSTTGQPIAQIFYNALGNKAGAIFLLCLILVTSFFCAITCMTANSRMIYAFSRDGGLP 341
AA_permease pfam00324
Amino acid permease;
48-427 1.49e-03

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 41.54  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705   48 ILITLSVVGAVATWYTLPIAGaVLILLAALIMSyrQIIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYILTVA--VS 125
Cdd:pfam00324  19 SGSVLGQAGPAGALLGYLISG-VVIFLVMLSLG--EISTNGPVSGGFYTYASRFLGPSLGFATGWNYWLSWITVLAleLT 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  126 ISSGADAFVAAFPSLYGHKVLIACLLVLFILI--LNLRGLTESATVLSY----PVYLFIIGLVILIFIGTFRVATGDIQP 199
Cdd:pfam00324  96 AASILIQFWELVPDIPYLWVWGAVFLVLLTIInlVGVKWYGEAEFWFALikiiAIIGFIIVGIILLSGGNPNDGAIFRYL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  200 HMHASVGTAVPGVTLFLLLkAFSSGASSLTGVEAISNAVTNFREP------SANNAVKTLIAMGSILAFLLVGIVGLAYV 273
Cdd:pfam00324 176 GDNGGKNNFPPGFGKGFIS-VFVIAFFAFTGIELVGIAAGEVKNPeksipkAILQVIWRITIFYILSLLAIGLLVPWNDP 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  274 YGIMPQTETTVLSQLAMQIFGDNAAFYFVQATTVMILVLAANTGFTAFPMLAASMSKDKYMPRMFTVRGDR----LGYSN 349
Cdd:pfam00324 255 GLLNDSASAASPFVIFFKFLGISGLAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAPKFLKKVDKRgvplRAILV 334
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578538705  350 SIIILGVLAIILIIVFDGMTEDLIPLYAVGVFIPFTLAQFG-MVIKWIHERPKNWLSKLSVNLLGGIVTFIVFMILLIT 427
Cdd:pfam00324 335 SMVISLLALLLASLNPAIVFNFLLAISGLSGLIVWGLISLShLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIII 413
SLC5sbd cd10322
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ...
56-447 7.14e-03

Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.


Pssm-ID: 271357 [Multi-domain]  Cd Length: 454  Bit Score: 39.08  E-value: 7.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705  56 GAVATWYTlpIAGAVLILLAALIMSYRqiIYAYPKGGGAYMVSKTNLGEKWGLLAGGSLLVDYILTVAVSISSGADAFVA 135
Cdd:cd10322   67 GLSAIWYI--LGAALGALLLALFLAPR--LRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILST 142
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 136 AFPSLYGHKVLIACLLVLFILILN-LRGLTESATVLSYPVYLFIIGLVILIFIGTFRVATGDI----QPHMHASVGTAVP 210
Cdd:cd10322  143 LLGIPYTVAVIIAAVIVILYTVFGgMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGGGGFSALaaalPALLLALGPGGGL 222
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 211 GVTLFLLLkAFSSGASSLTGVEAISNAVTNFREPSANNAVKTLIAMGSILAFLLVGIVGLAYVYGIMPQTETTVLSQLAM 290
Cdd:cd10322  223 GWSTILSL-ILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARALFPDLENPDLALPTLIN 301
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 291 QIFGDnaafyfVQATTVMILVLAANTGFTAFPMLAAS--MSKDKYMPRMFTVRGDR--LGYSN-SIIILGVLAIILIIVF 365
Cdd:cd10322  302 SLLPP------GLAGLVLAGLLAAAMSTADSLLLAAStlFTRDIYKPLINPKASDKklLRVSRiAVVVVGVLALLLALLP 375
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578538705 366 DGMTEDLI---PLYAVGVFIPFTLAQFGmvikwiherpkNWLSKLSV--NLLGGIVTFIVFMILLITKFSQVWPILIFLP 440
Cdd:cd10322  376 PSILLLLSlaaGLLAAALFPPLLGGLFW-----------KRATKAGAiaGIIVGLIVTLVWLLLPLASPLGIDPIIPALL 444

                 ....*..
gi 578538705 441 FVVIFFL 447
Cdd:cd10322  445 VSLIVFV 451
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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