NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578156426|gb|EUL17016|]
View 

cold shock-like protein CspLA [Staphylococcus aureus M0488]

Protein Classification

cold-shock protein( domain architecture ID 10003418)

cold-shock protein (Csp) such as bacterial CspA and CspB involved in cold stress response

CATH:  2.40.50.140
Gene Ontology:  GO:0003676
PubMed:  9371456|12530521

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CspC COG1278
Cold shock protein, CspA family [Transcription];
1-66 2.56e-32

Cold shock protein, CspA family [Transcription];


:

Pssm-ID: 440889  Cd Length: 67  Bit Score: 105.66  E-value: 2.56e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578156426  1 MNNGTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:COG1278   1 MATGTVKWFNAEKGFGFITPDDGGeDVFVHISALQRSGFRTLREGQRVEFEVEQGDKGPQAVNVRVL 67
 
Name Accession Description Interval E-value
CspC COG1278
Cold shock protein, CspA family [Transcription];
1-66 2.56e-32

Cold shock protein, CspA family [Transcription];


Pssm-ID: 440889  Cd Length: 67  Bit Score: 105.66  E-value: 2.56e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578156426  1 MNNGTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:COG1278   1 MATGTVKWFNAEKGFGFITPDDGGeDVFVHISALQRSGFRTLREGQRVEFEVEQGDKGPQAVNVRVL 67
CSD pfam00313
'Cold-shock' DNA-binding domain;
3-66 1.61e-28

'Cold-shock' DNA-binding domain;


Pssm-ID: 278729  Cd Length: 66  Bit Score: 96.16  E-value: 1.61e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578156426   3 NGTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:pfam00313  2 TGTVKWFNAKKGFGFITPEDGDkDVFVHFSAIQGDGFRSLQEGQKVEFEVVEGTKGPQAANVTKP 66
CSP_CDS cd04458
Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in ...
 4-64 7.91e-27

Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.


Pssm-ID: 239905  Cd Length: 65  Bit Score: 91.87  E-value: 7.91e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578156426  4 GTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQ 64
Cdd:cd04458   3 GTVKWFDDEKGFGFITPDDGGeDVFVHISALEGDGFRSLEEGDRVEFELEEGDKGPQAVNVR 64
cspE PRK09507
cold shock-like protein CspE;
4-66 1.00e-22

cold shock-like protein CspE;


Pssm-ID: 169931  Cd Length: 69  Bit Score: 81.62  E-value: 1.00e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578156426  4 GTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:PRK09507  6 GNVKWFNESKGFGFITPEDGSkDVFVHFSAIQTNGFKTLAEGQRVEFEITNGAKGPSAANVIAL 69
CSP smart00357
Cold shock protein domain; RNA-binding domain that functions as a RNA-chaperone in bacteria ...
 4-64 2.44e-15

Cold shock protein domain; RNA-binding domain that functions as a RNA-chaperone in bacteria and is involved in regulating translation in eukaryotes. Contains sub-family of RNA-binding domains in the Rho transcription termination factor.


Pssm-ID: 214633 [Multi-domain]  Cd Length: 64  Bit Score: 63.00  E-value: 2.44e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578156426    4 GTVKWFNaeKGFGFIEQENGG-DVFVHFSGIaSDGYKTLEEGQKVTFEIT--EGQRGDQAVNVQ 64
Cdd:smart00357  2 GVVKWFN--KGFGFIRPDDGGkDVFVHPSQI-QGGLKSLREGDEVEFKVVspEGGEKPEAENVV 62
retron_eff_Se72 NF038236
retron Se72 family effector protein; Members of this family are cold shock domain-containing ...
 4-66 8.70e-12

retron Se72 family effector protein; Members of this family are cold shock domain-containing proteins encoded adjacent to reverse transcriptases found in Se72-type retron systems, and considered effector proteins contributing to phage resistance.


Pssm-ID: 439537  Cd Length: 62  Bit Score: 53.73  E-value: 8.70e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578156426  4 GTVKWFNAEKGFGFIEQENGGDVFVHFSGIASDGYkTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:NF038236  1 GTVNAYDPFKGFGFIRREKGKDVFFFYDDINDEGD-DIIEGDKVSFEVRKTPKGPRAYNIKKV 62
 
Name Accession Description Interval E-value
CspC COG1278
Cold shock protein, CspA family [Transcription];
1-66 2.56e-32

Cold shock protein, CspA family [Transcription];


Pssm-ID: 440889  Cd Length: 67  Bit Score: 105.66  E-value: 2.56e-32
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578156426  1 MNNGTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:COG1278   1 MATGTVKWFNAEKGFGFITPDDGGeDVFVHISALQRSGFRTLREGQRVEFEVEQGDKGPQAVNVRVL 67
CSD pfam00313
'Cold-shock' DNA-binding domain;
3-66 1.61e-28

'Cold-shock' DNA-binding domain;


Pssm-ID: 278729  Cd Length: 66  Bit Score: 96.16  E-value: 1.61e-28
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578156426   3 NGTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:pfam00313  2 TGTVKWFNAKKGFGFITPEDGDkDVFVHFSAIQGDGFRSLQEGQKVEFEVVEGTKGPQAANVTKP 66
CSP_CDS cd04458
Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in ...
 4-64 7.91e-27

Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. CSP expression is up-regulated by an abrupt drop in growth temperature. CSP's are also expressed under normal condition at lower level. The function of cold-shock proteins is not fully understood. They preferentially bind poly-pyrimidine region of single-stranded RNA and DNA. CSP's are thought to bind mRNA and regulate ribosomal translation, mRNA degradation, and the rate of transcription termination. The human Y-box protein, which contains a CSD, regulates transcription and translation of genes that contain the Y-box sequence in their promoters. This specific ssDNA-binding properties of CSD are required for the binding of Y-box protein to the promoter's Y-box sequence, thereby regulating transcription.


Pssm-ID: 239905  Cd Length: 65  Bit Score: 91.87  E-value: 7.91e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578156426  4 GTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQ 64
Cdd:cd04458   3 GTVKWFDDEKGFGFITPDDGGeDVFVHISALEGDGFRSLEEGDRVEFELEEGDKGPQAVNVR 64
cspE PRK09507
cold shock-like protein CspE;
4-66 1.00e-22

cold shock-like protein CspE;


Pssm-ID: 169931  Cd Length: 69  Bit Score: 81.62  E-value: 1.00e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578156426  4 GTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:PRK09507  6 GNVKWFNESKGFGFITPEDGSkDVFVHFSAIQTNGFKTLAEGQRVEFEITNGAKGPSAANVIAL 69
PRK10354 PRK10354
RNA chaperone/antiterminator CspA;
4-66 1.51e-22

RNA chaperone/antiterminator CspA;


Pssm-ID: 182402  Cd Length: 70  Bit Score: 81.18  E-value: 1.51e-22
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578156426  4 GTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:PRK10354  7 GIVKWFNADKGFGFITPDDGSkDVFVHFSAIQNDGYKSLDEGQKVSFTIESGAKGPAAGNVTSL 70
PRK09890 PRK09890
cold shock protein CspG; Provisional
 4-66 2.76e-20

cold shock protein CspG; Provisional


Pssm-ID: 77467  Cd Length: 70  Bit Score: 75.57  E-value: 2.76e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578156426  4 GTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:PRK09890  7 GLVKWFNADKGFGFITPDDGSkDVFVHFTAIQSNEFRTLNENQKVEFSIEQGQRGPAAANVVTL 70
PRK09937 PRK09937
cold shock-like protein CspD;
1-60 9.69e-19

cold shock-like protein CspD;


Pssm-ID: 77494  Cd Length: 74  Bit Score: 72.07  E-value: 9.69e-19
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578156426  1 MNNGTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQA 60
Cdd:PRK09937  1 MEKGTVKWFNNAKGFGFICPEGGGeDIFAHYSTIQMDGYRTLKAGQSVQFDVHQGPKGNHA 61
PRK14998 PRK14998
cold shock-like protein CspD; Provisional
 1-60 9.98e-18

cold shock-like protein CspD; Provisional


Pssm-ID: 184960  Cd Length: 73  Bit Score: 69.31  E-value: 9.98e-18
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578156426  1 MNNGTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQA 60
Cdd:PRK14998  1 METGTVKWFNNAKGFGFICPEGGGeDIFAHYSTIQMDGYRTLKAGQSVRFDVHQGPKGNHA 61
PRK10943 PRK10943
cold shock-like protein CspC; Provisional
 4-66 1.84e-17

cold shock-like protein CspC; Provisional


Pssm-ID: 170841  Cd Length: 69  Bit Score: 68.56  E-value: 1.84e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578156426  4 GTVKWFNAEKGFGFIEQENGG-DVFVHFSGIASDGYKTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:PRK10943  6 GQVKWFNESKGFGFITPADGSkDVFVHFSAIQGNGFKTLAEGQNVEFEIQDGQKGPAAVNVTAI 69
CSP smart00357
Cold shock protein domain; RNA-binding domain that functions as a RNA-chaperone in bacteria ...
 4-64 2.44e-15

Cold shock protein domain; RNA-binding domain that functions as a RNA-chaperone in bacteria and is involved in regulating translation in eukaryotes. Contains sub-family of RNA-binding domains in the Rho transcription termination factor.


Pssm-ID: 214633 [Multi-domain]  Cd Length: 64  Bit Score: 63.00  E-value: 2.44e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578156426    4 GTVKWFNaeKGFGFIEQENGG-DVFVHFSGIaSDGYKTLEEGQKVTFEIT--EGQRGDQAVNVQ 64
Cdd:smart00357  2 GVVKWFN--KGFGFIRPDDGGkDVFVHPSQI-QGGLKSLREGDEVEFKVVspEGGEKPEAENVV 62
retron_eff_Se72 NF038236
retron Se72 family effector protein; Members of this family are cold shock domain-containing ...
 4-66 8.70e-12

retron Se72 family effector protein; Members of this family are cold shock domain-containing proteins encoded adjacent to reverse transcriptases found in Se72-type retron systems, and considered effector proteins contributing to phage resistance.


Pssm-ID: 439537  Cd Length: 62  Bit Score: 53.73  E-value: 8.70e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578156426  4 GTVKWFNAEKGFGFIEQENGGDVFVHFSGIASDGYkTLEEGQKVTFEITEGQRGDQAVNVQTV 66
Cdd:NF038236  1 GTVNAYDPFKGFGFIRREKGKDVFFFYDDINDEGD-DIIEGDKVSFEVRKTPKGPRAYNIKKV 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH