|
Name |
Accession |
Description |
Interval |
E-value |
| XerD |
COG4974 |
Site-specific recombinase XerD [Replication, recombination and repair]; |
64-348 |
2.42e-44 |
|
Site-specific recombinase XerD [Replication, recombination and repair];
Pssm-ID: 443999 [Multi-domain] Cd Length: 291 Bit Score: 154.00 E-value: 2.42e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 64 FFDRLKNE-NLSARSIEKRTTEYNTHIK--ERFGNIPIGKITTTQCTAFRNYLLnDAGLSVDYARSVWAGFKAVINYAKK 140
Cdd:COG4974 10 FLEELKREkGLSPNTIKAYRRDLRRFLRflEELGKIPLAEITPEDIRAYLNYLR-ERGLSPSTINRYLAALRSFFRYAVR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 141 HYKLLYDPTLSVTPIPRTKPQAKFITREEFDEKVEQITNDTS-----RQLTRLLFYSGLRIGEALALQWKDydkikgeid 215
Cdd:COG4974 89 EGLLEDNPAAKVKLPKKPRKLPRVLTEEEIEALLEALDTETPeglrdRALLLLLYATGLRVSELLGLKWSD--------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 216 vnkkINLSNRKIEYNLKKESSKGIIPVPNLIREMLKNMYNESSKRykyfDENY-FIFGGLEPIRYVTYSYHFKSVF---- 290
Cdd:COG4974 160 ----IDLDRGTIRVRRGKGGKERTVPLSPEALEALREYLEERRPR----DSDYlFPTRRGRPLSRRAIRKILKRLAkrag 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 291 --PNLKIHHLRHSYASYLINNGVDMYLLMELMRHSNITeTIQTYSHLYTDKKHQAMSIFD 348
Cdd:COG4974 232 ipKRVTPHSLRHTFATHLLEAGVDLRTVQELLGHSSIS-TTQIYTHVSDEELREAVEKLH 290
|
|
| INT_ICEBs1_C_like |
cd01189 |
C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; ... |
167-334 |
8.16e-30 |
|
C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.
Pssm-ID: 271189 [Multi-domain] Cd Length: 147 Bit Score: 111.50 E-value: 8.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 167 REEFDE--KVEQITNDTSRQLTRLLFYSGLRIGEALALQWKDYDKIKGEIDVNK--KINLSNRKIEYNLKKESSKGIIPV 242
Cdd:cd01189 1 PEELKKllEALKKRGDRYYLLFLLALLTGLRRGELLALTWSDIDFENGTIRINRtlVRKKKGGYVIKPPKTKSSIRTIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 243 PNLIREMLKNMynessKRYKYFDENYfifgGLEPIRyvtysyhfksvfpnlkIHHLRHSYASYLINNGVDMYLLMELMRH 322
Cdd:cd01189 81 PDELIELLKEL-----KAFKKLLKKA----GLPRIT----------------PHDLRHTFASLLLEAGVPLKVIAERLGH 135
|
170
....*....|..
gi 577646932 323 SNITETIQTYSH 334
Cdd:cd01189 136 SDISTTLDVYAH 147
|
|
| Phage_integrase |
pfam00589 |
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ... |
182-336 |
6.24e-16 |
|
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.
Pssm-ID: 395471 [Multi-domain] Cd Length: 169 Bit Score: 74.66 E-value: 6.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 182 SRQLTRLLFYSGLRIGEALALQWKDydkikgeidvnkkINLSNRKIEYNLKKESSKGIIPVPNLIREMLKNMYnesSKRY 261
Cdd:pfam00589 23 DKALLELLYATGLRISELCSLRWSD-------------IDFENGVIRVHRGKGNKERTVPLSDAALELLKEWL---SKRL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 262 KYFDENYFIFGGL--EPIRYVTYSYHFKSVFPNLKI------HHLRHSYASYLINNGVDMYLLMELMRHSNITETiQTYS 333
Cdd:pfam00589 87 LEAPKSDYLFASKrgKPLSRQTVRKIFKRAGKEAGLelplhpHMLRHSFATHLLEAGVDLRVVQKLLGHSSISTT-QIYT 165
|
...
gi 577646932 334 HLY 336
Cdd:pfam00589 166 HVA 168
|
|
| xerC |
PRK00236 |
site-specific tyrosine recombinase XerC; Reviewed |
64-341 |
2.04e-08 |
|
site-specific tyrosine recombinase XerC; Reviewed
Pssm-ID: 234698 [Multi-domain] Cd Length: 297 Bit Score: 54.78 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 64 FFDRLKNE-NLSARSIEkrttEYNTHIK------ERFGNIPIGKITTTQctaFRNYL--LNDAGLSvdyARSV---WAGF 131
Cdd:PRK00236 13 FLEYLRVErGLSPHTLR----AYRRDLRaflaflEEHGISSLQDLDAAD---LRSFLarRRRQGLS---ARSLarrLSAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 132 KAVINYAKKHYKLLYDPTLSV-TP-IPRTKPqaKFITREEFDEKVEQITNDT---SRQLTRL-LFY-SGLRIGEALALQW 204
Cdd:PRK00236 83 RSFYRWLVRRGLLKANPAAGLrAPkIPKRLP--KPLDVDQAKRLLDAIDEDDplaLRDRAILeLLYgSGLRLSELVGLDI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 205 KDYDKIKGEIDVNKKINlsnrkieynlkKESskgIIPVPNLIREMLKNmYNESSKRYKYFDENYFI--FGG-LEP--IRY 279
Cdd:PRK00236 161 DDLDLASGTLRVLGKGN-----------KER---TVPLGRAAREALEA-YLALRPLFLPDDDALFLgaRGGrLSPrvVQR 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 577646932 280 VTYSY-HFKSVFPNLKIHHLRHSYASYLINNGVDMYLLMELMRHSNITETiQTYSHLytDKKH 341
Cdd:PRK00236 226 RVKKLgKKAGLPSHITPHKLRHSFATHLLESGGDLRAVQELLGHASLSTT-QIYTHV--DFQH 285
|
|
| Arm-DNA-bind_4 |
pfam14657 |
Arm DNA-binding domain; This family includes AP2-like domains found in a variety of phage ... |
11-51 |
6.07e-08 |
|
Arm DNA-binding domain; This family includes AP2-like domains found in a variety of phage integrase proteins. These domains bind to Arm DNA sites.
Pssm-ID: 464242 Cd Length: 44 Bit Score: 48.28 E-value: 6.07e-08
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 577646932 11 KWYFSIR-YKDVYGNNKRKMKRGFERKKDAKLAESEFIQNVK 51
Cdd:pfam14657 1 TWYFQVYgYDDITGKRKQKTKRGFKTKKEAKEAEAEFIKKIS 42
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| XerD |
COG4974 |
Site-specific recombinase XerD [Replication, recombination and repair]; |
64-348 |
2.42e-44 |
|
Site-specific recombinase XerD [Replication, recombination and repair];
Pssm-ID: 443999 [Multi-domain] Cd Length: 291 Bit Score: 154.00 E-value: 2.42e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 64 FFDRLKNE-NLSARSIEKRTTEYNTHIK--ERFGNIPIGKITTTQCTAFRNYLLnDAGLSVDYARSVWAGFKAVINYAKK 140
Cdd:COG4974 10 FLEELKREkGLSPNTIKAYRRDLRRFLRflEELGKIPLAEITPEDIRAYLNYLR-ERGLSPSTINRYLAALRSFFRYAVR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 141 HYKLLYDPTLSVTPIPRTKPQAKFITREEFDEKVEQITNDTS-----RQLTRLLFYSGLRIGEALALQWKDydkikgeid 215
Cdd:COG4974 89 EGLLEDNPAAKVKLPKKPRKLPRVLTEEEIEALLEALDTETPeglrdRALLLLLYATGLRVSELLGLKWSD--------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 216 vnkkINLSNRKIEYNLKKESSKGIIPVPNLIREMLKNMYNESSKRykyfDENY-FIFGGLEPIRYVTYSYHFKSVF---- 290
Cdd:COG4974 160 ----IDLDRGTIRVRRGKGGKERTVPLSPEALEALREYLEERRPR----DSDYlFPTRRGRPLSRRAIRKILKRLAkrag 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 291 --PNLKIHHLRHSYASYLINNGVDMYLLMELMRHSNITeTIQTYSHLYTDKKHQAMSIFD 348
Cdd:COG4974 232 ipKRVTPHSLRHTFATHLLEAGVDLRTVQELLGHSSIS-TTQIYTHVSDEELREAVEKLH 290
|
|
| XerC |
COG4973 |
Site-specific recombinase XerC [Replication, recombination and repair]; |
64-343 |
1.95e-30 |
|
Site-specific recombinase XerC [Replication, recombination and repair];
Pssm-ID: 443998 [Multi-domain] Cd Length: 287 Bit Score: 116.98 E-value: 1.95e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 64 FFDRLKNENLSARSIEKRTTEYNTHIKE-RFGNIPIGKITTTQctaFRNYL--LNDAGLSVDYARSVWAGFKAVINYAKK 140
Cdd:COG4973 11 YLEHLRERRLSPKTLEAYRRDLRRLIPLlGDADLPLEELTPAD---VRRFLarLHRRGLSPRTLNRRLSALRSFFNWAVR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 141 HYKLLYDPTLSVTPIPRTKPQAKFITREEFDEKVEQITNDTS----RQLTRLLFYSGLRIGEALALQWKDYDKIKGEIDV 216
Cdd:COG4973 88 EGLLEANPAAGVKAPKAPRKLPRALTVDELAQLLDALADDPLavrdRAIVELLYSTGLRLGELVGLDWEDVDLDAGEVRV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 217 nkkinlsnrkieynLKKESSKGIIPVPNLIREMLKNmYNESSKRYKYFDENY-FIFGGLEPIRYVTYSYHFKS------V 289
Cdd:COG4973 168 --------------RGKTGKSRTVPLGPKALAALRE-WLAVRPELAAPDEGAlFPSRRGTRLSPRNVQKRLRRlakkagL 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 577646932 290 FPNLKIHHLRHSYASYLINNGVDMYLLMELMRHSNITeTIQTYSHLytDKKHQA 343
Cdd:COG4973 233 PKHVHPHDLRHSFATHLLESGGDLRAVQELLGHASIS-TTQIYTHL--DFQHLA 283
|
|
| INT_ICEBs1_C_like |
cd01189 |
C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; ... |
167-334 |
8.16e-30 |
|
C-terminal catalytic domain of integrases from bacterial phages and conjugate transposons; This family of tyrosine based site-specific integrases is has origins in bacterial phages and conjugate transposons. One member is the integrase from Bacillus subtilis conjugative transposon ICEBs1. ICEBs1 can be excised and transfered to various recipients in response to DNA damage or high concentrations of potential mating partners. The family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.
Pssm-ID: 271189 [Multi-domain] Cd Length: 147 Bit Score: 111.50 E-value: 8.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 167 REEFDE--KVEQITNDTSRQLTRLLFYSGLRIGEALALQWKDYDKIKGEIDVNK--KINLSNRKIEYNLKKESSKGIIPV 242
Cdd:cd01189 1 PEELKKllEALKKRGDRYYLLFLLALLTGLRRGELLALTWSDIDFENGTIRINRtlVRKKKGGYVIKPPKTKSSIRTIPL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 243 PNLIREMLKNMynessKRYKYFDENYfifgGLEPIRyvtysyhfksvfpnlkIHHLRHSYASYLINNGVDMYLLMELMRH 322
Cdd:cd01189 81 PDELIELLKEL-----KAFKKLLKKA----GLPRIT----------------PHDLRHTFASLLLEAGVPLKVIAERLGH 135
|
170
....*....|..
gi 577646932 323 SNITETIQTYSH 334
Cdd:cd01189 136 SDISTTLDVYAH 147
|
|
| FimB |
COG0582 |
Integrase/recombinase, includes phage integrase [Replication, recombination and repair, ... |
69-344 |
1.69e-21 |
|
Integrase/recombinase, includes phage integrase [Replication, recombination and repair, Mobilome: prophages, transposons];
Pssm-ID: 440347 [Multi-domain] Cd Length: 391 Bit Score: 94.34 E-value: 1.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 69 KNENLSARSIEKRTTEYNTHIKERFGNIPIGKITTTQCTAFRNYLLndAGLSVDYARSVWAGFKAVINYAKKHYKLLYDP 148
Cdd:COG0582 110 KKPEWKEKTAAQVRRTLEKHIFPVLGDRPIAEITPPDLLAVLRPIE--ARGAPETARRVRQRLRQVFRYAVARGLIERNP 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 149 TLSVT---PIPRTKPQAkFITREEFDEKVEQITNDTSRQLTR----LLFYSGLRIGEALALQWKDydkikgeidvnkkIN 221
Cdd:COG0582 188 AADLKgalPKPKVKHHP-ALTPEELPELLRALDAYRGSPVTRlalrLLLLTGVRPGELRGARWSE-------------ID 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 222 LSNRKIEYNlkKESSKG----IIPVPNLIREMLKNMYnESSKRYKYfdenyfIF----GGLEPIRYVTYSYHFKSV-FPN 292
Cdd:COG0582 254 LEAALWTIP--AERMKTrrphIVPLSRQALEILKELK-PLTGDSEY------VFpsrrGPKKPMSENTLNKALRRMgYGR 324
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 577646932 293 LKIHHLRHSYASYLINNGVDMYLLMELMRHSNITETIQTYSH-LYTDKKHQAM 344
Cdd:COG0582 325 FTPHGFRHTASTLLNEAGFPPDVIERQLAHKDGNKVRAAYNRaDYLEERREMM 377
|
|
| INT_Rci_Hp1_C |
cd00796 |
Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal ... |
161-334 |
3.62e-21 |
|
Shufflon-specific DNA recombinase Rci and Bacteriophage Hp1_like integrase, C-terminal catalytic domain; Rci protein is a tyrosine recombinase specifically involved in Shufflon type of DNA rearrangement in bacteria. The shufflon of plasmid R64 consists of four invertible DNA segments which are separated and flanked by seven 19-bp repeat sequences. RCI recombinase facilitates the site-specific recombination between any inverted repeats results in an inversion of the DNA segment(s) either independently or in groups. HP1 integrase promotes site-specific recombination of the HP1 genome into that of Haemophilus influenza. Bacteriophage Hp1_like integrases are tyrosine based site specific recombinases. They belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.
Pssm-ID: 271177 [Multi-domain] Cd Length: 162 Bit Score: 88.54 E-value: 3.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 161 QAKFITREEFDEKVEQITNDTSRQL---TRLLFYSGLRIGEALALQWKDydkikgeidvnkkINLSNRKIEynlkKESSK 237
Cdd:cd00796 1 RDRFLTEDEEARLLAALEESTNPHLrliVLLALYTGARRGEILSLRWDD-------------IDLEVGLIV----LPETK 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 238 G----IIPVPNLIREMLKNMYNESSKRYKYFdenyfiFGGLEPIRYVTYSYHFKSVF-----PNLKIHHLRHSYASYLIN 308
Cdd:cd00796 64 NgkprTVPLSDEAIAILKELKRKRGKDGFFV------DGRFFGIPIASLRRAFKKARkraglEDLRFHDLRHTFASRLVQ 137
|
170 180
....*....|....*....|....*.
gi 577646932 309 NGVDMYLLMELMRHSNItETIQTYSH 334
Cdd:cd00796 138 AGVPIKTVAKILGHSSI-KMTMRYAH 162
|
|
| DNA_BRE_C |
cd00397 |
DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme ... |
185-332 |
1.80e-20 |
|
DNA breaking-rejoining enzymes, C-terminal catalytic domain; The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine based site-specific recombinases (integrases) that share the same fold in their catalytic domain containing conserved active site residues. The best-studied members of this diverse superfamily include Human topoisomerase I, the bacteriophage lambda integrase, the bacteriophage P1 Cre recombinase, the yeast Flp recombinase, and the bacterial XerD/C recombinases. Their overall reaction mechanism is essentially identical and involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. The enzymes differ in that topoisomerases cleave and then rejoin the same 5' and 3' termini, whereas a site-specific recombinase transfers a 5' hydroxyl generated by recombinase cleavage to a new 3' phosphate partner located in a different duplex region. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.
Pssm-ID: 271175 [Multi-domain] Cd Length: 167 Bit Score: 87.15 E-value: 1.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 185 LTRLLFYSGLRIGEALALQWKDYDKIKGEIDVNKKInlsnrkieynlKKESSKGIIPVPNLIREMLKNMYNESSKRYKYF 264
Cdd:cd00397 22 ILLLLLETGLRISELLALKVKDIDLDNGTIRVRGKK-----------TKGGKERTVPLPKELAEELKEYLKERRDKRGPL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577646932 265 DENYFIFGGLEPIRYVTYSYH---------FKSVFPNLKIHHLRHSYASYLINNGVDMYLLMELMRHSNITeTIQTY 332
Cdd:cd00397 91 LKSLYLNKLFGTKLGERLSRRtlrrifkkaGIEAGRKITPHSLRHTFATNLLENGVDIKVVQKLLGHSSIS-TTQRY 166
|
|
| Phage_integrase |
pfam00589 |
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered ... |
182-336 |
6.24e-16 |
|
Phage integrase family; Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase are Arg-173, His-289, Arg-292 and Tyr-324.
Pssm-ID: 395471 [Multi-domain] Cd Length: 169 Bit Score: 74.66 E-value: 6.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 182 SRQLTRLLFYSGLRIGEALALQWKDydkikgeidvnkkINLSNRKIEYNLKKESSKGIIPVPNLIREMLKNMYnesSKRY 261
Cdd:pfam00589 23 DKALLELLYATGLRISELCSLRWSD-------------IDFENGVIRVHRGKGNKERTVPLSDAALELLKEWL---SKRL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 262 KYFDENYFIFGGL--EPIRYVTYSYHFKSVFPNLKI------HHLRHSYASYLINNGVDMYLLMELMRHSNITETiQTYS 333
Cdd:pfam00589 87 LEAPKSDYLFASKrgKPLSRQTVRKIFKRAGKEAGLelplhpHMLRHSFATHLLEAGVDLRVVQKLLGHSSISTT-QIYT 165
|
...
gi 577646932 334 HLY 336
Cdd:pfam00589 166 HVA 168
|
|
| INT_IntI_C |
cd01193 |
Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases ... |
163-335 |
4.29e-13 |
|
Integron integrase and similar protiens, C-terminal catalytic domain; Integron integrases mediate site-specific DNA recombination between a proximal primary site (attI) and a secondary target site (attC) found within mobile gene cassettes encoding resistance or virulence factors. Unlike other site specific recombinases, the attC sites lack sequence conservation. Integron integrase exhibits broader DNA specificity by recognizing the non-conserved attC sites. The structure shows that DNA target site recognition are not dependent on canonical DNA but on the position of two flipped-out bases that interact in cis and in trans with the integrase. Integron-integrases are present in many natural occurring mobile elements, including transposons and conjugative plasmids. Vibrio, Shewanella, Xanthomonas, and Pseudomonas species harbor chromosomal super-integrons. All integron-integrases carry large inserts unlike the TnpF ermF-like proteins also seen in this group.
Pssm-ID: 271193 [Multi-domain] Cd Length: 176 Bit Score: 66.53 E-value: 4.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 163 KFITREEfdekVEQITNDTSRQLTR----LLFYSGLRIGEALALQWKDYDKIKGEIDVnkkinlsnrkieynlkkESSKG 238
Cdd:cd01193 4 VVLSPDE----VRRILGALTELRHRlilsLLYGAGLRISELLRLRVKDIDFERGVIRV-----------------RQGKG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 239 ----IIPVPNLIREMLKNmYNESSKRYKYFDENYFIFGGLEPIRYVTYSYHF--KSVFPNLK-------------IHHLR 299
Cdd:cd01193 63 gkdrVVPLPEKLLEPLRR-YLKSARPKEELDPAEGRAGVLDPRTGVERRHHIseTTVQRALKkaveqagitkrvtPHTLR 141
|
170 180 190
....*....|....*....|....*....|....*.
gi 577646932 300 HSYASYLINNGVDMYLLMELMRHSNItETIQTYSHL 335
Cdd:cd01193 142 HSFATHLLEAGTDIRTIQELLGHSDL-STTMIYTHV 176
|
|
| INTN1_C_like |
cd01185 |
Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal ... |
177-340 |
1.18e-12 |
|
Integrase IntN1 of Bacteroides mobilizable transposon NBU1 and similar proteins, C-terminal catalytic domain; IntN1 is a tyrosine recombinase for the integration and excision of Bacteroides mobilizable transposon NBU1 from the host chromosome. IntN1 does not require strict homology between the recombining sites seen with other tyrosine recombinases. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.
Pssm-ID: 271185 [Multi-domain] Cd Length: 161 Bit Score: 64.98 E-value: 1.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 177 ITNDTSRQLTRLLF----YSGLRIGEALALQWKDYDKIKGeidvnkkinlsNRKIEYNLKKESSKGIIPVPNLIREMLKn 252
Cdd:cd01185 11 LSDTSRLELVRDMFlfscYTGLRFSDLKNLTWKNIVEASG-----------RTWIRYRRKKTGKPVTVPLLPVAREILE- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 253 mynesskRYKYFDENYFIFGGLEpirYVTYSYHFKSVFPNLKIH-----HL-RHSYASYLINNGVDMYLLMELMRHSNIT 326
Cdd:cd01185 79 -------KYKDDRSEGKLFPVLS---NQKINRYLKEIAKIAGIDkhltfHVaRHTFATLLLLKGVDIETISKLLGHSSIK 148
|
170
....*....|....
gi 577646932 327 ETiQTYSHLYTDKK 340
Cdd:cd01185 149 TT-QIYAKIVDSKK 161
|
|
| INT_tnpA_C_Tn554 |
cd01186 |
Putative Transposase A from transposon Tn554, C-terminal catalytic domain; This family ... |
165-335 |
1.60e-11 |
|
Putative Transposase A from transposon Tn554, C-terminal catalytic domain; This family includes putative Transposase A from transposon Tn554. It belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.
Pssm-ID: 271186 [Multi-domain] Cd Length: 184 Bit Score: 62.43 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 165 ITREEFDEKVEQITNDTSRQLTRLLFYSGLRIGEALALQWKDYDKIKGEIDVNKKINLSNRKIeynlKKESSKGIIPVpn 244
Cdd:cd01186 2 LTPREVQELINACNNLRDKFLLALLYETGLRIGEALGLRIEDIDMADNQIELVPREDNTNEAR----AKSMRERRIPV-- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 245 liREMLKNMYNE--SSKRYKYFDENYFIF----GG--LEPIRYVTYSYHFKSVFPNLKI----HHLRHSYASYLINNGVD 312
Cdd:cd01186 76 --SQDLIDLYADylTYIYCEEAEFSITVFvnvkGGnqGKAMNYSDVYDLVRRLKKRTGIdftpHMFRHTHATALIRAGWS 153
|
170 180
....*....|....*....|...
gi 577646932 313 MYLLMELMRHSNITETIQTYSHL 335
Cdd:cd01186 154 IEVVARRLGHAHVQTTLNTYGHL 176
|
|
| INT_XerDC_C |
cd00798 |
XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in ... |
189-341 |
7.61e-11 |
|
XerD and XerC integrases, C-terminal catalytic domains; XerDC-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid inheritance. They share the same fold in their catalytic domain containing six conserved active site residues and the overall reaction mechanism with the DNA breaking-rejoining enzyme superfamily. In Escherichia coli, the Xer site-specific recombination system acts to convert dimeric chromosomes, which are formed by homologous recombination to monomers. Two related recombinases, XerC and XerD, bind cooperatively to a recombination site present in the E. coli chromosome. Each recombinase catalyzes the exchange of one pair of DNA strand in a reaction that proceeds through a Holliday junction intermediate. These enzymes can bridge two different and well-separated DNA sequences called arm- and core-sites. The C-terminal domain binds, cleaves, and re-ligates DNA strands at the core-sites, while the N-terminal domain is largely responsible for high-affinity binding to the arm-type sites.
Pssm-ID: 271179 [Multi-domain] Cd Length: 172 Bit Score: 60.22 E-value: 7.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 189 LFY-SGLRIGEALALQWKDYDKIKGEIDVNKKINlsnrkieynlkKESskgIIPVPNLIREMLKNMYNESSKRYKYFDEN 267
Cdd:cd00798 27 LLYaSGLRVSELVGLDLSDVDLDEGLVRVTGKGN-----------KER---LVPFGSYAVEALEEYLEERRPLLLKKKPP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 268 YFIF-----GGLEP-------IRYVTYSYHFKSVFPnlkiHHLRHSYASYLINNGVDMYLLMELMRHSNITETiQTYSHL 335
Cdd:cd00798 93 DALFlnkrgKRLSRrgvwrilKKYAERAGLPKHVSP----HTLRHSFATHLLEGGADLRVVQELLGHASLSTT-QIYTHV 167
|
....*.
gi 577646932 336 ytDKKH 341
Cdd:cd00798 168 --SFER 171
|
|
| INT_C_like_1 |
cd01184 |
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ... |
185-334 |
1.63e-09 |
|
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain containing six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.
Pssm-ID: 271184 [Multi-domain] Cd Length: 180 Bit Score: 56.55 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 185 LTRLLFYSGLRIGEALALQWKDYDKIKGeIDVnkkINLSNRKIEYNLKKESSKGIIPV-PNLIR----EMLKNMynESSK 259
Cdd:cd01184 28 LPLIGLYTGARLNEICQLRVDDIKEEDG-IWC---IDINDDAEGRRLKTKASRRLVPIhPRLIElgflDYVEAL--RADG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 260 RYKYFDENYFIFGGlepiRYVTYSYHFKSVFPNLKIHH--------LRHSYASYLINNGVDMYLLMELMRHSNITETIQT 331
Cdd:cd01184 102 KLFLFPEKRDKDGK----YSKAASKWFNRLLRKLGIKDderksfhsFRHTFITALKRAGVPEELIAQIVGHSRGGVTHDT 177
|
...
gi 577646932 332 YSH 334
Cdd:cd01184 178 YGK 180
|
|
| xerC |
PRK00236 |
site-specific tyrosine recombinase XerC; Reviewed |
64-341 |
2.04e-08 |
|
site-specific tyrosine recombinase XerC; Reviewed
Pssm-ID: 234698 [Multi-domain] Cd Length: 297 Bit Score: 54.78 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 64 FFDRLKNE-NLSARSIEkrttEYNTHIK------ERFGNIPIGKITTTQctaFRNYL--LNDAGLSvdyARSV---WAGF 131
Cdd:PRK00236 13 FLEYLRVErGLSPHTLR----AYRRDLRaflaflEEHGISSLQDLDAAD---LRSFLarRRRQGLS---ARSLarrLSAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 132 KAVINYAKKHYKLLYDPTLSV-TP-IPRTKPqaKFITREEFDEKVEQITNDT---SRQLTRL-LFY-SGLRIGEALALQW 204
Cdd:PRK00236 83 RSFYRWLVRRGLLKANPAAGLrAPkIPKRLP--KPLDVDQAKRLLDAIDEDDplaLRDRAILeLLYgSGLRLSELVGLDI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 205 KDYDKIKGEIDVNKKINlsnrkieynlkKESskgIIPVPNLIREMLKNmYNESSKRYKYFDENYFI--FGG-LEP--IRY 279
Cdd:PRK00236 161 DDLDLASGTLRVLGKGN-----------KER---TVPLGRAAREALEA-YLALRPLFLPDDDALFLgaRGGrLSPrvVQR 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 577646932 280 VTYSY-HFKSVFPNLKIHHLRHSYASYLINNGVDMYLLMELMRHSNITETiQTYSHLytDKKH 341
Cdd:PRK00236 226 RVKKLgKKAGLPSHITPHKLRHSFATHLLESGGDLRAVQELLGHASLSTT-QIYTHV--DFQH 285
|
|
| Arm-DNA-bind_4 |
pfam14657 |
Arm DNA-binding domain; This family includes AP2-like domains found in a variety of phage ... |
11-51 |
6.07e-08 |
|
Arm DNA-binding domain; This family includes AP2-like domains found in a variety of phage integrase proteins. These domains bind to Arm DNA sites.
Pssm-ID: 464242 Cd Length: 44 Bit Score: 48.28 E-value: 6.07e-08
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 577646932 11 KWYFSIR-YKDVYGNNKRKMKRGFERKKDAKLAESEFIQNVK 51
Cdd:pfam14657 1 TWYFQVYgYDDITGKRKQKTKRGFKTKKEAKEAEAEFIKKIS 42
|
|
| int |
PHA02601 |
integrase; Provisional |
1-346 |
1.35e-07 |
|
integrase; Provisional
Pssm-ID: 222904 [Multi-domain] Cd Length: 333 Bit Score: 52.42 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 1 MPVYKDGNtGKWYFSIRykdVYGNNKRKMKRGFERKKDAKLAESEFI----QNVKYGYS-DNQPF-EYI--FFDrLKNEN 72
Cdd:PHA02601 1 MAVRKLKD-GKWLCEIY---PNGRDGKRIRKRFATKGEALAFENYTMaevdDKEWVGEKeDRRRLsELLqiWWD-LHGQT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 73 LSARSIEKRTTEYNTHIkerFGNIPIGKITTTQCTAFRNYLLNDaGLSVDYARSV--------WAGFKAVINYAKKHYKL 144
Cdd:PHA02601 76 LEDGKARLAKLLILCKG---LGDPIASEFTAKDFADYRARRLSG-EFKVNKGRPIkpatvnreLAYLSAVFNELIKLGKW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 145 -LYDPTLSVTPIPRTKPQAKFITREEFDEKVEQITNDTSRQL---TRLLFYSGLRIGEALALqwkdydkikgeidvnKKI 220
Cdd:PHA02601 152 sGPNPLDGIRPFKEAEPELAFLTKEEIERLLDACDGSRSPDLgliAKICLATGARWSEAETL---------------KRS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 221 NLSNRKIEYNLKKESSKGIIPVPNLIREMLknmyneSSKRYKYFDENYFIFGglepiRYVtysyhfKSVFPNL----KIH 296
Cdd:PHA02601 217 QISPYKITFVKTKGKKNRTVPISEELYKML------PKRRGRLFKDAYESFE-----RAV------KRAGIDLpegqATH 279
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 577646932 297 HLRHSYASYLINNGVDMYLLMELMRHSNITETIQtYSHLYTDKKHQAMSI 346
Cdd:PHA02601 280 VLRHTFASHFMMNGGNILVLQRILGHATIEMTMA-YAHFAPDHLEDAVSL 328
|
|
| xerD |
PRK00283 |
tyrosine recombinase; |
296-338 |
2.86e-06 |
|
tyrosine recombinase;
Pssm-ID: 234713 [Multi-domain] Cd Length: 299 Bit Score: 48.26 E-value: 2.86e-06
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 577646932 296 HHLRHSYASYLINNGVDMYLLMELMRHSNITETiQTYSHLYTD 338
Cdd:PRK00283 245 HVLRHAFATHLLNHGADLRVVQELLGHSDISTT-QIYTHVATE 286
|
|
| INT_C_like_5 |
cd01195 |
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine ... |
166-334 |
5.52e-04 |
|
Uncharacterized site-specific tyrosine recombinase, C-terminal catalytic domain; Tyrosine recombinase (integrase) belongs to a DNA breaking-rejoining enzyme superfamily. The catalytic domain contains six conserved active site residues. The recombination reaction involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA. Many DNA breaking-rejoining enzymes also have N-terminal domains, which show little sequence or structure similarity.
Pssm-ID: 271195 [Multi-domain] Cd Length: 170 Bit Score: 40.15 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 166 TREEFDEKVEQITNDTS-----RQLTRLLFYSGLRIGEALALQWKDYDKIKGEIDVNKKINLsnrkieynlkkesSKGII 240
Cdd:cd01195 1 SREEARQRLDAADRHTAkgkrdEALVRLLLDNALRRSEAVALDVEDLEKEHRRLRILGKGKK-------------QREVV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 241 PVPNLIREMLKNMYNESSKR----YKYFDENyfIFGG-LEP---IRYVTYSYHFKSVFPNLKIHHLRHSYASYLINNGVD 312
Cdd:cd01195 68 TLPPTTREALAAWLAARGEAegplFVSLDRA--SRGRrLSPqavYRIVRRLAERIGLGKRLSPHGLRHSAITLALDAGAG 145
|
170 180
....*....|....*....|...
gi 577646932 313 MY-LLMELMRHSNItETIQTYSH 334
Cdd:cd01195 146 LIrKVQDFSRHADL-RTLQVYDD 167
|
|
| INT_P4_C |
cd00801 |
Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in ... |
179-344 |
7.99e-04 |
|
Bacteriophage P4 integrase, C-terminal catalytic domain; P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. The P4 integrase mediates integrative and excisive site-specific recombination between two sites, called attachment sites, located on the phage genome and the bacterial chromosome. The phage attachment site is often found adjacent to the integrase gene, while the host attachment sites are typically situated near tRNA genes. This family belongs to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The catalytic domain contains six conserved active site residues. Their overall reaction mechanism involves cleavage of a single strand of a DNA duplex by nucleophilic attack of a conserved tyrosine to give a 3' phosphotyrosyl protein-DNA adduct. In the second rejoining step, a terminal 5' hydroxyl attacks the covalent adduct to release the enzyme and generate duplex DNA.
Pssm-ID: 271182 [Multi-domain] Cd Length: 180 Bit Score: 39.95 E-value: 7.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 179 NDTSRQLTRLLFYSGLRIGEALALQWKdydkikgEIDVNKKInlsnrkieYNLKKESSKG----IIPVPNLIREMLKNmy 254
Cdd:cd00801 18 SPPTKLALRLLLLTGQRIGELARARWS-------EIDLEEKT--------WTIPAERTKNkrphRVPLSDQALEILEE-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 255 nesskRYKYFDENYFIFGGL----EPIRYVTYSYHFKSVFPNLKI---HHLRHSYASYLINNGVDMYLLMELMRHSNITE 327
Cdd:cd00801 81 -----LKEFTGDSGYLFPSRrkkkKPISENTINKALKRLGYKGKEftpHDLRRTFSTLLNELGIDPEVIERLLNHVLGGV 155
|
170
....*....|....*...
gi 577646932 328 TIQTYSH-LYTDKKHQAM 344
Cdd:cd00801 156 VRAAYNRyDYLEERREAL 173
|
|
| Phage_int_SAM_3 |
pfam14659 |
Phage integrase, N-terminal SAM-like domain; This domain is found in a variety of phage ... |
60-113 |
1.30e-03 |
|
Phage integrase, N-terminal SAM-like domain; This domain is found in a variety of phage integrase proteins.
Pssm-ID: 464243 [Multi-domain] Cd Length: 55 Bit Score: 36.37 E-value: 1.30e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 577646932 60 FEYIFFDRLKNeNLSARSIEKRTTEYNTHIKERFGNIPIGKITTTQCTAFRNYL 113
Cdd:pfam14659 3 FYEIWLEDYKP-RVKPSTYATYKRIIKNHILPYFGNMKLSKITPADIQKFQNKL 55
|
|
| xerS |
PRK05084 |
site-specific tyrosine recombinase XerS; Reviewed |
188-344 |
6.58e-03 |
|
site-specific tyrosine recombinase XerS; Reviewed
Pssm-ID: 235339 [Multi-domain] Cd Length: 357 Bit Score: 37.98 E-value: 6.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 188 LLFYSGLRIGEALALQWKDYDKIKGEIDVNKKINlsnrkieynlKKESskgiIPVPNLIREMLKNMYNESSKRYKYfDEN 267
Cdd:PRK05084 203 LILGSGLRVSELVNLDLSDLNLKQMTIDVTRKGG----------KRDS----VNIAPFALPYLEEYLKIRASRYKA-EKQ 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577646932 268 YFIF------GGLEPIRYVT-------YSYHFKSvfpNLKIHHLRHSYASYLINNGVDMYLLMELMRHSNiTETIQTYSH 334
Cdd:PRK05084 268 EKALfltkyrGKPNRISARAiekmvakYSEAFGV---RLTPHKLRHTLATRLYDATKDQVLVADQLGHTS-TETTDLYTH 343
|
170
....*....|
gi 577646932 335 LYTDKKHQAM 344
Cdd:PRK05084 344 IVNDEQKEAL 353
|
|
| |
