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Conserved domains on  [gi|577575287|gb|EUH87482|]
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ferrichrome transport permease fhuB [Staphylococcus aureus M1020]

Protein Classification

FecCD family ABC transporter permease( domain architecture ID 10001816)

FecCD family ABC transporter permease such as iron ABC transporter permease, which is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

CATH:  1.10.3470.10
Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
SCOP:  4002900
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-331 1.94e-95

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440374  Cd Length: 306  Bit Score: 285.43  E-value: 1.94e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  30 STLIGDAKIQASTIIEAIFNYNPSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPALIGLNSGASFAL 109
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 110 ALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRSRRdGFNPMRIILAGAAVSAMLTALSQGIALAFRLNQT--VTFWT 187
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGG-GLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLrsIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 188 AGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIAVAIAGQVAFVGL 267
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577575287 268 MVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISFIGVPYFLYLVKKGG 331
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTIlapAELPVGIVTALIGAPFFLYLLRRRR 306
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-331 1.94e-95

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 285.43  E-value: 1.94e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  30 STLIGDAKIQASTIIEAIFNYNPSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPALIGLNSGASFAL 109
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 110 ALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRSRRdGFNPMRIILAGAAVSAMLTALSQGIALAFRLNQT--VTFWT 187
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGG-GLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLrsIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 188 AGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIAVAIAGQVAFVGL 267
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577575287 268 MVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISFIGVPYFLYLVKKGG 331
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTIlapAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 22-329 3.80e-77

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 238.97  E-value: 3.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287   22 ILLITLFISTLIGDAKIQASTIIEAIFNYNPSNQQQnIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPALIGL 101
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAAL-IVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  102 NSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRSRRdGFNPMRIILAGAAVSAMLTALSQGIALAF--RL 179
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRG-GASPLRLILAGIAVSALLSALTSLLLLLLnpEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  180 NQTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIAVAIA 259
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 577575287  260 GQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYLG---EAPVGAIISFIGVPYFLYLVKK 329
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILspyELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
4-333 1.45e-58

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 199.68  E-value: 1.45e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287   4 RENPTPLKFLSYIIGLSMILLITLFISTLIGDAKIQASTIieaifnynpSNQQQNIINEIRIPRNIAAVIVGMALAVSGA 83
Cdd:PRK10577 346 RVAARRRRVLAWLLALGLLLLLALVVALSFGRDAHGWNWL---------SGQLLDALLPLRLPRLLAALLAGAMLAVAGT 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  84 IIQGVTRNGLADPALIGLNSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRsrRDGFNPMRIILAGAAVS 163
Cdd:PRK10577 417 LLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLAR--RGGFAPERLLLTGIALS 494

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 164 AMLTALSQgIALA---FRLNQTVTfWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMI 240
Cdd:PRK10577 495 ALFTALIQ-LLLAsgdPRAAQLLT-WLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRA 572

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 241 RGICLIIAMILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISF 317
Cdd:PRK10577 573 RLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLlfpYQIPAGLLAAL 652

                        330
                 ....*....|....*.
gi 577575287 318 IGVPYFLYLVKKGGRS 333
Cdd:PRK10577 653 IGAPYFLWLLRRSRRR 668
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 69-327 1.09e-48

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 163.88  E-value: 1.09e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  69 IAAVIVGMALAVSGAIIQGVTRNGLADPALIGLNSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIgrSRRD 148
Cdd:cd06550    2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLL--ASRG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 149 GFNPMRIILAGAAVSAMLTALSQGIALAFRL-NQTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGE 227
Cdd:cd06550   80 GLSPSKLILIGIVLSAFFSAGVILISLLSDDsLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 228 SLAKGLGQNVTMIRGICLIIAMILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL- 306
Cdd:cd06550  160 DLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLl 239

                        250       260
                 ....*....|....*....|..
gi 577575287 307 -GEAPVGAIISFIGVPYFLYLV 327
Cdd:cd06550  240 pSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 30-331 1.94e-95

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 285.43  E-value: 1.94e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  30 STLIGDAKIQASTIIEAIFNYNPSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPALIGLNSGASFAL 109
Cdd:COG0609    1 SLSLGAVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 110 ALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRSRRdGFNPMRIILAGAAVSAMLTALSQGIALAFRLNQT--VTFWT 187
Cdd:COG0609   81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGG-GLSPLRLVLAGVAVSALFSALTSLLLLLADPEQLrsIVFWL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 188 AGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIAVAIAGQVAFVGL 267
Cdd:COG0609  160 MGSLAGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577575287 268 MVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISFIGVPYFLYLVKKGG 331
Cdd:COG0609  240 VVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTIlapAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 22-329 3.80e-77

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 238.97  E-value: 3.80e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287   22 ILLITLFISTLIGDAKIQASTIIEAIFNYNPSNQQQnIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPALIGL 101
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSALLGGDDSLAAL-IVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  102 NSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRSRRdGFNPMRIILAGAAVSAMLTALSQGIALAF--RL 179
Cdd:pfam01032  80 SSGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRG-GASPLRLILAGIAVSALLSALTSLLLLLLnpEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  180 NQTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIAVAIA 259
Cdd:pfam01032 159 LQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVV 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 577575287  260 GQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYLG---EAPVGAIISFIGVPYFLYLVKK 329
Cdd:pfam01032 239 GPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILspyELPVGIVTALIGAPFFIYLLLR 311
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 18-333 7.60e-60

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 195.34  E-value: 7.60e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  18 GLSMILLITLFISTLIGDAKIQASTIIEAIFNYNPSNQQQnIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPA 97
Cdd:COG4779   28 VLLLLLLALAVLALTLGDYPLSPGDVLRALLGEGDPGASF-VVLELRLPRALAALLVGAALGLSGAIFQSLTRNPLASPD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  98 LIGLNSGASFAlALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIgrSRRDGFNPMRIILAGAAVSAMLTALSQGIALAF 177
Cdd:COG4779  107 IIGITAGASAG-AVAAIVVLGGSGLAVALGALAGGLATALLVYLL--AWRGGVSGYRLILVGIGVSAMLTAVNSYLLTRA 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 178 RLN--QTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIA 255
Cdd:COG4779  184 DLEdaQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLVAVALAAVA 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 256 VAIAGQVAFVGLMVPHIARFLIGTDYAKILPlTALLGGILVLVADVIARYL---GEAPVGAIISFIGVPYFLYLVKKGGR 332
Cdd:COG4779  264 TAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLlapVQLPVGVVTGALGGPYLLWLLIRENR 342


                 .
gi 577575287 333 S 333
Cdd:COG4779  343 R 343
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
4-333 1.45e-58

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 199.68  E-value: 1.45e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287   4 RENPTPLKFLSYIIGLSMILLITLFISTLIGDAKIQASTIieaifnynpSNQQQNIINEIRIPRNIAAVIVGMALAVSGA 83
Cdd:PRK10577 346 RVAARRRRVLAWLLALGLLLLLALVVALSFGRDAHGWNWL---------SGQLLDALLPLRLPRLLAALLAGAMLAVAGT 416

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  84 IIQGVTRNGLADPALIGLNSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRsrRDGFNPMRIILAGAAVS 163
Cdd:PRK10577 417 LLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFGWLLAAALLGALAALALILLLAR--RGGFAPERLLLTGIALS 494

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 164 AMLTALSQgIALA---FRLNQTVTfWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMI 240
Cdd:PRK10577 495 ALFTALIQ-LLLAsgdPRAAQLLT-WLSGSTYGVTWAQALPLLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRA 572

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 241 RGICLIIAMILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISF 317
Cdd:PRK10577 573 RLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLlfpYQIPAGLLAAL 652

                        330
                 ....*....|....*.
gi 577575287 318 IGVPYFLYLVKKGGRS 333
Cdd:PRK10577 653 IGAPYFLWLLRRSRRR 668
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
16-331 1.14e-56

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 186.44  E-value: 1.14e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  16 IIGLSMILLITLFISTLIGDAKIQAstiIEAIFNYNPSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLAD 95
Cdd:PRK11228   6 VAALIGLFWLSLFCYSAIPISAADA---LNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPLAS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  96 PALIGLNSGASFALALTYAVLPntsfliLMFAGF---LGAILGGAI----VLMIGRSRRDGFNPMRIILAGAAVSAMLTA 168
Cdd:PRK11228  83 PSLLGINSGAALAMALTSALSP------TPFAGYslaFIAACGGGLswllVMTAGGGWRHTHDRNRLILAGIALSALCMA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 169 LSQ-GIALAFRLNQTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLII 247
Cdd:PRK11228 157 LTRiTLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNML 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 248 AMILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISFIGVPYFL 324
Cdd:PRK11228 237 VLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALafpGELPAGAVLALIGAPCFV 316


                 ....*..
gi 577575287 325 YLVKKGG 331
Cdd:PRK11228 317 WLARRRG 323
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
18-332 7.04e-56

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 184.91  E-value: 7.04e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  18 GLSMILLITLFISTLIGDAKIQASTIIEAIFNYNpSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPA 97
Cdd:PRK10441  15 GLLLLLIIATALSLLIGAKSLPASVVLEALSGTC-QSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  98 LIGLNSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRSRRDGFNPMRIILAGAAVSAMLTALSQGIALaf 177
Cdd:PRK10441  94 LLGVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIAL-- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 178 rLNQTV----TFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAG 253
Cdd:PRK10441 172 -LNPDVydqlRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCG 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 254 IAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL--GEAPVGAIISFIGVPYFLYLVKKGG 331
Cdd:PRK10441 251 SATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLvpGELRVSVVSAFIGAPVLIFLVRRKT 330


                 .
gi 577575287 332 R 332
Cdd:PRK10441 331 R 331
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
16-333 1.45e-54

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 188.89  E-value: 1.45e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  16 IIGLSMILLITLFISTLIGDAKIQASTIIEAIFNYNPSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLAD 95
Cdd:PRK10577  14 ALLLALLLLLALALTLTQLSAALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGALLQQVLRNPLAS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  96 PALIGLNSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIgrSRRDGFNPMRIILAGAAVSAMLTALSQGIAL 175
Cdd:PRK10577  94 PTTLGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFAL--AGGKRLSPLRLVLAGMVVSLYLGALTTLLLL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 176 AFRLN-QTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGI 254
Cdd:PRK10577 172 FNEQYlQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLSAA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 255 AVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYLG-----EAPVGAIISFIGVPYFLYLVKK 329
Cdd:PRK10577 252 VVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAgvggeLLPTGAVTALIGAPLLLWLLPR 331


                 ....
gi 577575287 330 GGRS 333
Cdd:PRK10577 332 LRSA 335
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 15-333 4.81e-51

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 171.96  E-value: 4.81e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  15 YIIGLSMILLITLFISTLIGDAKIQASTIIeaifnynpSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLA 94
Cdd:COG4139   14 WLLLLLLLLLLLFVLSLCAGEVWIPPTQWL--------SEAWQLFVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  95 DPALIGLNSGASFALALTYAVLPN-TSFLILMFAGFLGAILGGAIVLMIGRSRRDGfnpMRIILAGAAV----SAMLTAL 169
Cdd:COG4139   86 EPGLLGISNGAGVGLVLVVLLGGGlLPPWLLSLAAIAGALLVTLLLLAFARRRLSN---ARLLLIGVALgiicSAIMTWA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 170 SQgIALAFRLNQTVtFWTAGGVSGTTWSHLKWAIPLIGIALFIILTIsKQLTILNLGESLAKGLGQNVTMIRGICLIIAM 249
Cdd:COG4139  163 VY-FSSSLDLRQLM-YWMMGSFGGVDWRQLWLLLALLPVLLWLCLQG-KPLNLLLLGENQARQLGLSVHRWRNLLVLATG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 250 ILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYLGEA---PVGAIISFIGVPYFLYL 326
Cdd:COG4139  240 LLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAALLLLADIIARLALSSaelPIGVVTATLGAPVFIWL 319


                 ....*..
gi 577575287 327 VKKGGRS 333
Cdd:COG4139  320 LLRRRKI 326
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 69-327 1.09e-48

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 163.88  E-value: 1.09e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  69 IAAVIVGMALAVSGAIIQGVTRNGLADPALIGLNSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIgrSRRD 148
Cdd:cd06550    2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLL--ASRG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 149 GFNPMRIILAGAAVSAMLTALSQGIALAFRL-NQTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGE 227
Cdd:cd06550   80 GLSPSKLILIGIVLSAFFSAGVILISLLSDDsLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFDE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 228 SLAKGLGQNVTMIRGICLIIAMILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL- 306
Cdd:cd06550  160 DLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTLl 239

                        250       260
                 ....*....|....*....|..
gi 577575287 307 -GEAPVGAIISFIGVPYFLYLV 327
Cdd:cd06550  240 pSELPVGPVTALLGAPYFLYLL 261
btuC PRK09535
cobalamin ABC transporter permease BtuC;
46-329 2.18e-47

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 163.77  E-value: 2.18e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  46 AIFNYNPSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPALIGLNSGASFAlALTYAVLPNTSFLILM 125
Cdd:PRK09535  77 SPFSFAVPETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVG-AVAAIVLPLAVPFGLQ 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 126 FAGFLGAILGGAIVLMIgrSRRDGFNPM-RIILAGAAVSAMLTALSQGIAL-AFRLNQTVTFWTAGGVSGTTWSHLKWAI 203
Cdd:PRK09535 156 AAAFAGALVAAFGVYAI--ATENGRTPVaTLLLAGVAVQTFLGAVISYLLLhSGESLRRAVYWLMGHLHGSTWSDVEVAL 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 204 PLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAK 283
Cdd:PRK09535 234 PVVVVGFVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRI 313

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 577575287 284 ILPLTALLGGILVLVADVIARY-LGEAPVGAIISFIGVPYFLYLVKK 329
Cdd:PRK09535 314 LLPTSALAGASFLVATDTVARSgPAEVPVGIVTAALGAPFFLYLLRT 360
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 15-333 1.06e-46

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 160.89  E-value: 1.06e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  15 YIIGLSMILLITLFISTLIGDAKIQASTIIeaifnynpSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLA 94
Cdd:PRK03784  17 WLLGLSVLLLLALLLSLCAGEQWISPGDWL--------SPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  95 DPALIGLNSGASFALALTYAVLPNT-SFLILMFAGFLGAILggAIVLMIGRSRRDGFNPMRIILAGAAV----SAMLT-A 168
Cdd:PRK03784  89 EPGLLGVSNGAGVALVAAVLLGQGLlPPWALSLCAIAGALL--ITLILLRFARRHRLSTSRLLLAGVALgiicSALMTwA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 169 LSQGIALAFRLnqtVTFWTAGGVSGTTWSHLKWAIPLIgIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIA 248
Cdd:PRK03784 167 VYFSTSLDLRQ---LMYWMMGGFGGVDWRQSWLMLALL-PVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLAT 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 249 MILAGIAVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISFIGVPYFLY 325
Cdd:PRK03784 243 GWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLAlasAELPIGVVTATLGAPVFIW 322


                 ....*...
gi 577575287 326 LVKKGGRS 333
Cdd:PRK03784 323 LLLRSHRA 330
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
16-326 5.46e-46

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 158.67  E-value: 5.46e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  16 IIGLSMILLITLFISTLIGDAKIQASTIIEAifnYNPSNQQQNIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLAD 95
Cdd:PRK09777   6 VIFITLALAGCALLSLRMGVIPLPWRALLTD---WQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLAS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  96 PALIGLNSGASFALALTYAVLPNTSFLILMFAGFLGAILGGAIVLMIGRSRRdgfnPMRIILAGAAVSAMLTALSQGIAL 175
Cdd:PRK09777  83 PDILGVNHAASLASVGALLLFPSLPVMWLPLLAFIGGMAGLILLKMLAGTHQ----PMKLALTGVALSALWASLTDYLML 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 176 AFRLN-QTVTFWTAGGVSGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGI 254
Cdd:PRK09777 159 SRPQDiNNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTAT 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 577575287 255 AVAIAGQVAFVGLMVPHIARFLIGTDYAKILPLTALLGGILVLVADVIARYLG---EAPVGAIISFIGVPYFLYL 326
Cdd:PRK09777 239 GVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHpplELPAGVLTAIIGAPWFFWL 313
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
34-326 5.07e-35

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 130.22  E-value: 5.07e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287  34 GDAKIQASTIIEAIFNYNPSNQQQnIINEIRIPRNIAAVIVGMALAVSGAIIQGVTRNGLADPALIGLNSGAsFALALTY 113
Cdd:PRK10440  30 GAVTLETSQVFAALMGDAPRSMTM-VVTEWRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVMGFNTGA-WSGVLVA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 114 AVLPNTSFLILMFAGFLGAILGGAIVLMIgrSRRDGFNPMRIILAGAAVSAMLTALSQGIALAFRLNQTVT--FWTAGGV 191
Cdd:PRK10440 108 MVLFGQDLTAIALAAMAGGIVTSLLVWLL--AWRNGIDTFRLIIIGIGVRAMLVAFNTWLLLKASLETALTagLWNAGSL 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577575287 192 SGTTWSHLKWAIPLIGIALFIILTISKQLTILNLGESLAKGLGQNVTMIRGICLIIAMILAGIAVAIAGQVAFVGLMVPH 271
Cdd:PRK10440 186 NGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAAATALAGPISFIALVAPH 265

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 577575287 272 IARFLIGTDyAKILPLTALLGGILVLVADVIARYL---GEAPVGAIISFIGVPYFLYL 326
Cdd:PRK10440 266 IARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLfmpYQLPVGVVTVSLGGIYLIVL 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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