NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|528761199|gb|EPY80858|]
View 

hypothetical protein CB1_000794021 [Camelus ferus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Endostatin-like super family cl23985
Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of ...
 293-384 6.27e-37

Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; endostatin XVIII is monomeric and contains a heparin-binding epitope and zinc binding sites while endostatin XV is trimeric and contains neither of these sites; the generation of endostatin or endostatin-like collagen XV/XVIII fragments is catalyzed by proteolytic enzymes within the protease-sensitive hinge region of the C-terminal domain; endostatin inhibits endothelial cell migration in vitro and appears to be highly effective in murine in vivo studies


The actual alignment was detected with superfamily member pfam06482:

Pssm-ID: 474121  Cd Length: 169  Bit Score: 132.18  E-value: 6.27e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528761199  293 LHLVALNTPFSGDIR----ADFQCFQQARAAGLLSTYRAFLSSHLQDLSTVVRKAERYSLPIVNLKpGLVLSD------- 361
Cdd:pfam06482   1 LHLIALNTPQSGDMRgirgADFLCFQQARAAGLKGTFRAFLSSRLQDLYSIVRKADRENVPIVNLK-DEVLFDswesifs 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 528761199  362 ---------IPLPSFTG------NAMPRSMpqLHHGND 384
Cdd:pfam06482  80 gsggqmkpnVPIYSFDGrdvlrdPAWPQKM--VWHGST 115
Collagen_trimer pfam20010
Collagen trimerization domain; This small domain mediate trimerization in various collagen ...
 230-276 3.06e-21

Collagen trimerization domain; This small domain mediate trimerization in various collagen proteins.


:

Pssm-ID: 466257  Cd Length: 49  Bit Score: 86.12  E-value: 3.06e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 528761199  230 VTALSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGEL 276
Cdd:pfam20010   1 VTVFQNYDTMLQKTHRVPEGTLVYVREREELYIRVRNGWRKIQLGEL 47
 
Name Accession Description Interval E-value
Endostatin pfam06482
Collagenase NC10 and Endostatin; NC10 stands for Non-helical region 10 and is taken from Swiss: ...
 293-384 6.27e-37

Collagenase NC10 and Endostatin; NC10 stands for Non-helical region 10 and is taken from Swiss:P39059. A mutation in this region in Swiss:P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to.


Pssm-ID: 461931  Cd Length: 169  Bit Score: 132.18  E-value: 6.27e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528761199  293 LHLVALNTPFSGDIR----ADFQCFQQARAAGLLSTYRAFLSSHLQDLSTVVRKAERYSLPIVNLKpGLVLSD------- 361
Cdd:pfam06482   1 LHLIALNTPQSGDMRgirgADFLCFQQARAAGLKGTFRAFLSSRLQDLYSIVRKADRENVPIVNLK-DEVLFDswesifs 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 528761199  362 ---------IPLPSFTG------NAMPRSMpqLHHGND 384
Cdd:pfam06482  80 gsggqmkpnVPIYSFDGrdvlrdPAWPQKM--VWHGST 115
Endostatin-like cd00247
Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of ...
 293-361 2.22e-36

Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; endostatin XVIII is monomeric and contains a heparin-binding epitope and zinc binding sites while endostatin XV is trimeric and contains neither of these sites; the generation of endostatin or endostatin-like collagen XV/XVIII fragments is catalyzed by proteolytic enzymes within the protease-sensitive hinge region of the C-terminal domain; endostatin inhibits endothelial cell migration in vitro and appears to be highly effective in murine in vivo studies


Pssm-ID: 238151  Cd Length: 171  Bit Score: 130.92  E-value: 2.22e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528761199 293 LHLVALNTPFSGDIR----ADFQCFQQARAAGLLSTYRAFLSSHLQDLSTVVRKAERYSLPIVNLKpGLVLSD 361
Cdd:cd00247    4 LHLVALNTPLSGDMRgirgADFQCFQQARAAGLKGTFRAFLSSRLQDLYSIVRRADRDSLPIVNLK-GEVLFN 75
Collagen_trimer pfam20010
Collagen trimerization domain; This small domain mediate trimerization in various collagen ...
 230-276 3.06e-21

Collagen trimerization domain; This small domain mediate trimerization in various collagen proteins.


Pssm-ID: 466257  Cd Length: 49  Bit Score: 86.12  E-value: 3.06e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 528761199  230 VTALSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGEL 276
Cdd:pfam20010   1 VTVFQNYDTMLQKTHRVPEGTLVYVREREELYIRVRNGWRKIQLGEL 47
 
Name Accession Description Interval E-value
Endostatin pfam06482
Collagenase NC10 and Endostatin; NC10 stands for Non-helical region 10 and is taken from Swiss: ...
 293-384 6.27e-37

Collagenase NC10 and Endostatin; NC10 stands for Non-helical region 10 and is taken from Swiss:P39059. A mutation in this region in Swiss:P39060 is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent angiogenesis inhibitor. Endostatin also binds a zinc ion near the N-terminus; this is likely to be of structural rather than functional importance according to.


Pssm-ID: 461931  Cd Length: 169  Bit Score: 132.18  E-value: 6.27e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 528761199  293 LHLVALNTPFSGDIR----ADFQCFQQARAAGLLSTYRAFLSSHLQDLSTVVRKAERYSLPIVNLKpGLVLSD------- 361
Cdd:pfam06482   1 LHLIALNTPQSGDMRgirgADFLCFQQARAAGLKGTFRAFLSSRLQDLYSIVRKADRENVPIVNLK-DEVLFDswesifs 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 528761199  362 ---------IPLPSFTG------NAMPRSMpqLHHGND 384
Cdd:pfam06482  80 gsggqmkpnVPIYSFDGrdvlrdPAWPQKM--VWHGST 115
Endostatin-like cd00247
Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of ...
 293-361 2.22e-36

Endostatin-like domain; the angiogenesis inhibitor endostatin is a C-terminal fragment of collagen XV/XVIII, a proteoglycan/collagen found in vessel walls and basement membranes; this domain has a compact globular fold similar to that of C-type lectins; endostatin XVIII is monomeric and contains a heparin-binding epitope and zinc binding sites while endostatin XV is trimeric and contains neither of these sites; the generation of endostatin or endostatin-like collagen XV/XVIII fragments is catalyzed by proteolytic enzymes within the protease-sensitive hinge region of the C-terminal domain; endostatin inhibits endothelial cell migration in vitro and appears to be highly effective in murine in vivo studies


Pssm-ID: 238151  Cd Length: 171  Bit Score: 130.92  E-value: 2.22e-36
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 528761199 293 LHLVALNTPFSGDIR----ADFQCFQQARAAGLLSTYRAFLSSHLQDLSTVVRKAERYSLPIVNLKpGLVLSD 361
Cdd:cd00247    4 LHLVALNTPLSGDMRgirgADFQCFQQARAAGLKGTFRAFLSSRLQDLYSIVRRADRDSLPIVNLK-GEVLFN 75
Collagen_trimer pfam20010
Collagen trimerization domain; This small domain mediate trimerization in various collagen ...
 230-276 3.06e-21

Collagen trimerization domain; This small domain mediate trimerization in various collagen proteins.


Pssm-ID: 466257  Cd Length: 49  Bit Score: 86.12  E-value: 3.06e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 528761199  230 VTALSNMDDMLQKAHLVIEGTFIYLRDSTEFFIRVRDGWKKLQLGEL 276
Cdd:pfam20010   1 VTVFQNYDTMLQKTHRVPEGTLVYVREREELYIRVRNGWRKIQLGEL 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH