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Conserved domains on  [gi|527302915|gb|EPT03695|]
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hypothetical protein FOMPIDRAFT_1158516 [Fomitopsis schrenkii]

Protein Classification

CIAPIN1 domain-containing protein( domain architecture ID 13433036)

CIAPIN1 (cytokine-induced apoptosis inhibitor 1) domain-containing protein similar to anamorsin that is a component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 205-309 1.33e-38

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


:

Pssm-ID: 398662  Cd Length: 99  Bit Score: 132.01  E-value: 1.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915  205 RPEVCPPvtaGAPRRKKACKNCTCGLAELEAEELKSsKVVLLDGAVDgqTVEVSQSEkerLVAAAAAAPKATSSCGNCYL 284
Cdd:pfam05093   4 TPPECEP---NGKKRRKACKDCTCGLKELEEAEDAA-QRALQDKALG--KVKFTEDD---LTEIDFTVQGKTGSCGSCAL 74

                          90       100
                  ....*....|....*....|....*
gi 527302915  285 GDAFRCSECPYRGLPAFKPGEKVEI 309
Cdd:pfam05093  75 GDAFRCSGCPYLGLPAFKPGEEVTI 99
COG5636 super family cl35031
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
89-315 3.38e-27

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


The actual alignment was detected with superfamily member COG5636:

Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 107.54  E-value: 3.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915  89 ALAPRISTLLAQLLTGLEPLGTLHLLHLGD-ALPSLPSELTLAGFKILaplSDGTLITQKPAHTAAAPLKSAPATALPLR 167
Cdd:COG5636   63 KLNQTVSIPLKKKKTNLQSGSKLPTFKKASsSTSNLPKKADHSRQPIV---KETDSFKPPSFKMTTEPKVYRVVDDLMED 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915 168 RKADPDRKASKKALWTLNAPSTPTIDAESLLT--AEDR--ERPEvCPPVTAgapRRKKACKNCTCGLAELEAEELKSSKv 243
Cdd:COG5636  140 KEELRKLLRSKAQYMMRKDTDPRTIMEDELLDedSEDKaiQRSE-CPPSKT---KKKRACKDCTCGLKEEEENEIVRTR- 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527302915 244 vlldgavdgQTVEVSQSEKERLVAAAAAAPKATSSCGNCYLGDAFRCSECPYRGLPAFKPGEKVEIDFGMDD 315
Cdd:COG5636  215 ---------QDKVVKFTEDELTEIDFTIDGKKVSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMNLDN 277
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 205-309 1.33e-38

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 132.01  E-value: 1.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915  205 RPEVCPPvtaGAPRRKKACKNCTCGLAELEAEELKSsKVVLLDGAVDgqTVEVSQSEkerLVAAAAAAPKATSSCGNCYL 284
Cdd:pfam05093   4 TPPECEP---NGKKRRKACKDCTCGLKELEEAEDAA-QRALQDKALG--KVKFTEDD---LTEIDFTVQGKTGSCGSCAL 74

                          90       100
                  ....*....|....*....|....*
gi 527302915  285 GDAFRCSECPYRGLPAFKPGEKVEI 309
Cdd:pfam05093  75 GDAFRCSGCPYLGLPAFKPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
89-315 3.38e-27

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 107.54  E-value: 3.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915  89 ALAPRISTLLAQLLTGLEPLGTLHLLHLGD-ALPSLPSELTLAGFKILaplSDGTLITQKPAHTAAAPLKSAPATALPLR 167
Cdd:COG5636   63 KLNQTVSIPLKKKKTNLQSGSKLPTFKKASsSTSNLPKKADHSRQPIV---KETDSFKPPSFKMTTEPKVYRVVDDLMED 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915 168 RKADPDRKASKKALWTLNAPSTPTIDAESLLT--AEDR--ERPEvCPPVTAgapRRKKACKNCTCGLAELEAEELKSSKv 243
Cdd:COG5636  140 KEELRKLLRSKAQYMMRKDTDPRTIMEDELLDedSEDKaiQRSE-CPPSKT---KKKRACKDCTCGLKEEEENEIVRTR- 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527302915 244 vlldgavdgQTVEVSQSEKERLVAAAAAAPKATSSCGNCYLGDAFRCSECPYRGLPAFKPGEKVEIDFGMDD 315
Cdd:COG5636  215 ---------QDKVVKFTEDELTEIDFTIDGKKVSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMNLDN 277
DRE2_N pfam16803
Fe-S cluster assembly protein DRE2 N-terminus; This is the N-terminal domain of the fungal ...
 55-156 3.01e-04

Fe-S cluster assembly protein DRE2 N-terminus; This is the N-terminal domain of the fungal Fe-S cluster assembly protein DRE2.


Pssm-ID: 435591  Cd Length: 129  Bit Score: 39.86  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915   55 VDKYMVDRLVDGATTLTPSTFASVHVaLSPPEYEA--LAPR--ISTLLAQL-----LTGLEPlgTLHLLHLGDALpslps 125
Cdd:pfam16803  31 TDQQMIDRLAAGLVSLPANTYDLILY-LTPEDAPDslLFPRklISVLFDALkpggkLRGQDG--TFDGAEKLEAL----- 102

                          90       100       110
                  ....*....|....*....|....*....|.
gi 527302915  126 eltLAGFkILAPLSDGTLITQKPAHTAAAPL 156
Cdd:pfam16803 103 ---LAGF-VIENEDDGGWVKPDQSEEVAVPL 129
 
Name Accession Description Interval E-value
CIAPIN1 pfam05093
Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named ...
 205-309 1.33e-38

Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis; Anamorsin, subsequently named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1, in humans is the homolog of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS). CIAPIN1 is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis. Dre2 has been found to interact with the yeast reductase Tah18, forming a tight cytosolic complex implicated in the response to high levels of oxidative stress.


Pssm-ID: 398662  Cd Length: 99  Bit Score: 132.01  E-value: 1.33e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915  205 RPEVCPPvtaGAPRRKKACKNCTCGLAELEAEELKSsKVVLLDGAVDgqTVEVSQSEkerLVAAAAAAPKATSSCGNCYL 284
Cdd:pfam05093   4 TPPECEP---NGKKRRKACKDCTCGLKELEEAEDAA-QRALQDKALG--KVKFTEDD---LTEIDFTVQGKTGSCGSCAL 74

                          90       100
                  ....*....|....*....|....*
gi 527302915  285 GDAFRCSECPYRGLPAFKPGEKVEI 309
Cdd:pfam05093  75 GDAFRCSGCPYLGLPAFKPGEEVTI 99
COG5636 COG5636
Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];
89-315 3.38e-27

Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown];


Pssm-ID: 227923 [Multi-domain]  Cd Length: 284  Bit Score: 107.54  E-value: 3.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915  89 ALAPRISTLLAQLLTGLEPLGTLHLLHLGD-ALPSLPSELTLAGFKILaplSDGTLITQKPAHTAAAPLKSAPATALPLR 167
Cdd:COG5636   63 KLNQTVSIPLKKKKTNLQSGSKLPTFKKASsSTSNLPKKADHSRQPIV---KETDSFKPPSFKMTTEPKVYRVVDDLMED 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915 168 RKADPDRKASKKALWTLNAPSTPTIDAESLLT--AEDR--ERPEvCPPVTAgapRRKKACKNCTCGLAELEAEELKSSKv 243
Cdd:COG5636  140 KEELRKLLRSKAQYMMRKDTDPRTIMEDELLDedSEDKaiQRSE-CPPSKT---KKKRACKDCTCGLKEEEENEIVRTR- 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 527302915 244 vlldgavdgQTVEVSQSEKERLVAAAAAAPKATSSCGNCYLGDAFRCSECPYRGLPAFKPGEKVEIDFGMDD 315
Cdd:COG5636  215 ---------QDKVVKFTEDELTEIDFTIDGKKVSACGNCYLGDAFRCSGCPYLGLPAFEPGDVVSFSMNLDN 277
DRE2_N pfam16803
Fe-S cluster assembly protein DRE2 N-terminus; This is the N-terminal domain of the fungal ...
 55-156 3.01e-04

Fe-S cluster assembly protein DRE2 N-terminus; This is the N-terminal domain of the fungal Fe-S cluster assembly protein DRE2.


Pssm-ID: 435591  Cd Length: 129  Bit Score: 39.86  E-value: 3.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 527302915   55 VDKYMVDRLVDGATTLTPSTFASVHVaLSPPEYEA--LAPR--ISTLLAQL-----LTGLEPlgTLHLLHLGDALpslps 125
Cdd:pfam16803  31 TDQQMIDRLAAGLVSLPANTYDLILY-LTPEDAPDslLFPRklISVLFDALkpggkLRGQDG--TFDGAEKLEAL----- 102

                          90       100       110
                  ....*....|....*....|....*....|.
gi 527302915  126 eltLAGFkILAPLSDGTLITQKPAHTAAAPL 156
Cdd:pfam16803 103 ---LAGF-VIENEDDGGWVKPDQSEEVAVPL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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