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Conserved domains on  [gi|507743900|gb|EOS02986|]
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hypothetical protein C799_00543 [Bacteroides thetaiotaomicron dnLKV9]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10455355)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  9445404|10521532|12691742|12200473|10508766
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 7-169 6.10e-31

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


:

Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 114.80  E-value: 6.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900    7 SVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYvlkfVDKGYSLTYIYQE-NSGQSVAINKALKL 85
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEY----AKKDPRVRVIRLPeNRGKAGARNAGLRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   86 VRGDYLVWPDSDDFYaSSNAISKMVSILDKSEDSVSMVRCLPVYLNENLIFHHKMESNENLHNEYLFeDCILGKCYFLSG 165
Cdd:pfam00535  77 ATGDYIAFLDADDEV-PPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGL-RLLGLNLPFLIG 154


                  ....
gi 507743900  166 GYMV 169
Cdd:pfam00535 155 GFAL 158
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 7-169 6.10e-31

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 114.80  E-value: 6.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900    7 SVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYvlkfVDKGYSLTYIYQE-NSGQSVAINKALKL 85
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEY----AKKDPRVRVIRLPeNRGKAGARNAGLRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   86 VRGDYLVWPDSDDFYaSSNAISKMVSILDKSEDSVSMVRCLPVYLNENLIFHHKMESNENLHNEYLFeDCILGKCYFLSG 165
Cdd:pfam00535  77 ATGDYIAFLDADDEV-PPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGL-RLLGLNLPFLIG 154


                  ....
gi 507743900  166 GYMV 169
Cdd:pfam00535 155 GFAL 158
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-120 4.32e-28

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 108.25  E-value: 4.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   5 LVSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYvlkfVDKGYSLTYIY-QENSGQSVAINKAL 83
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILREL----AAKDPRIRVIRlERNRGKGAARNAGL 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 507743900  84 KLVRGDYLVWPDSDDFYaSSNAISKMVSILDKSEDSV 120
Cdd:COG0463   79 AAARGDYIAFLDADDQL-DPEKLEELVAALEEGPADL 114
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 8-130 2.56e-27

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 104.90  E-value: 2.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVDKgysLTYIYQENSGQSVAINKALKLVR 87
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRV---IRVINEENQGLAAARNAGLKAAR 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 507743900  88 GDYLVWPDSDDFYaSSNAISKMVSILDKSEDsVSMVRCLPVYL 130
Cdd:cd00761   78 GEYILFLDADDLL-LPDWLERLVAELLADPE-ADAVGGPGNLL 118
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-98 4.59e-20

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 88.95  E-value: 4.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   2 SSRLVSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVDkgysLTYIYQENSGQSVAINK 81
Cdd:PRK10073   4 STPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPH----VRLLHQANAGVSVARNT 79

                         90
                 ....*....|....*..
gi 507743900  82 ALKLVRGDYLVWPDSDD 98
Cdd:PRK10073  80 GLAVATGKYVAFPDADD 96
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
7-104 7.26e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 47.10  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   7 SVITPCYNAGSFIHRLLDSILDQ---DYLYLEMYIVDDGSTDNTKSVVDEYVLKFvDKGYSLTYIYQENSGQSVAINKAL 83
Cdd:NF038302   4 TVAIPTYNGANRLPEVLERLRSQigtESLSWEIIVVDNNSTDNTAQVVQEYQKNW-PSPYPLRYCFEPQQGAAFARQRAI 82

                         90       100
                 ....*....|....*....|.
gi 507743900  84 KLVRGDYLVWPDsDDFYASSN 104
Cdd:NF038302  83 QEAKGELIGFLD-DDNLPAPN 102
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 7-169 6.10e-31

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 114.80  E-value: 6.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900    7 SVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYvlkfVDKGYSLTYIYQE-NSGQSVAINKALKL 85
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEY----AKKDPRVRVIRLPeNRGKAGARNAGLRA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   86 VRGDYLVWPDSDDFYaSSNAISKMVSILDKSEDSVSMVRCLPVYLNENLIFHHKMESNENLHNEYLFeDCILGKCYFLSG 165
Cdd:pfam00535  77 ATGDYIAFLDADDEV-PPDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGL-RLLGLNLPFLIG 154


                  ....
gi 507743900  166 GYMV 169
Cdd:pfam00535 155 GFAL 158
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-120 4.32e-28

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 108.25  E-value: 4.32e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   5 LVSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYvlkfVDKGYSLTYIY-QENSGQSVAINKAL 83
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILREL----AAKDPRIRVIRlERNRGKGAARNAGL 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 507743900  84 KLVRGDYLVWPDSDDFYaSSNAISKMVSILDKSEDSV 120
Cdd:COG0463   79 AAARGDYIAFLDADDQL-DPEKLEELVAALEEGPADL 114
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 8-130 2.56e-27

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 104.90  E-value: 2.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVDKgysLTYIYQENSGQSVAINKALKLVR 87
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRV---IRVINEENQGLAAARNAGLKAAR 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 507743900  88 GDYLVWPDSDDFYaSSNAISKMVSILDKSEDsVSMVRCLPVYL 130
Cdd:cd00761   78 GEYILFLDADDLL-LPDWLERLVAELLADPE-ADAVGGPGNLL 118
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 7-119 1.06e-24

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 99.16  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   7 SVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKfvdkgysLTYIYQEN-SGQSVAINKALKL 85
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGTVDIIKKYEDK-------ITYWISEPdKGIYDAMNKGIAL 73

                         90       100       110
                 ....*....|....*....|....*....|....
gi 507743900  86 VRGDYLVWPDSDDFYAsSNAISKMVSILDKSEDS 119
Cdd:cd06433   74 ATGDIIGFLNSDDTLL-PGALLAVVAAFAEHPEV 106
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 6-117 9.56e-22

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 93.27  E-value: 9.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   6 VSVITPCYNAGSFIHRLLDSILDQDY--LYLEMYIVDDGSTDNTKSVVDEYVLKFVDkgysLTYIYQE-NSGQSVAINKA 82
Cdd:COG1215   31 VSVIIPAYNEEAVIEETLRSLLAQDYpkEKLEVIVVDDGSTDETAEIARELAAEYPR----VRVIERPeNGGKAAALNAG 106

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507743900  83 LKLVRGDYLVWPDSDDFYaSSNAISKMVSILDKSE 117
Cdd:COG1215  107 LKAARGDIVVFLDADTVL-DPDWLRRLVAAFADPG 140
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 2-98 4.59e-20

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 88.95  E-value: 4.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   2 SSRLVSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVDkgysLTYIYQENSGQSVAINK 81
Cdd:PRK10073   4 STPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPH----VRLLHQANAGVSVARNT 79

                         90
                 ....*....|....*..
gi 507743900  82 ALKLVRGDYLVWPDSDD 98
Cdd:PRK10073  80 GLAVATGKYVAFPDADD 96
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
2-111 2.73e-19

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 84.27  E-value: 2.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   2 SSRLVSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVdkgyslTYIYQ-ENSGQSVAIN 80
Cdd:COG1216    1 MRPKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAFPRV------RVIRNpENLGFAAARN 74

                         90       100       110
                 ....*....|....*....|....*....|.
gi 507743900  81 KALKLVRGDYLVWPDSDDFyASSNAISKMVS 111
Cdd:COG1216   75 LGLRAAGGDYLLFLDDDTV-VEPDWLERLLA 104
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 8-110 3.47e-17

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 78.04  E-value: 3.47e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYvlkFVDKGYSLTYIY-QENSGQSVAINKALKLV 86
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEEL---AALYIRRVLVVRdKENGGKAGALNAGLRHA 77

                         90       100
                 ....*....|....*....|....
gi 507743900  87 RGDYLVWPDSDDFYAsSNAISKMV 110
Cdd:cd06423   78 KGDIVVVLDADTILE-PDALKRLV 100
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 5-120 6.95e-17

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 78.81  E-value: 6.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   5 LVSVITPCYNAGSFIHRLLDSILDQDYLY--LEMYIVDDGSTDNTKSVVDEYVLKFVdkgySLTYIYQENSGQSVAINKA 82
Cdd:cd02525    1 FVSIIIPVRNEEKYIEELLESLLNQSYPKdlIEIIVVDGGSTDGTREIVQEYAAKDP----RIRLIDNPKRIQSAGLNIG 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 507743900  83 LKLVRGDYLVWPDSDDFYaSSNAISKMV-SILDKSEDSV 120
Cdd:cd02525   77 IRNSRGDIIIRVDAHAVY-PKDYILELVeALKRTGADNV 114
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 6-131 8.26e-15

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 73.00  E-value: 8.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   6 VSVITPCYNAGSFIHRLLDSILDQDYL--YLEMYIVDDGSTDNTksvvDEYVLKFVDKGYSLtYIYQENSGQSVAINKAL 83
Cdd:cd06439   31 VTIIIPAYNEEAVIEAKLENLLALDYPrdRLEIIVVSDGSTDGT----AEIAREYADKGVKL-LRFPERRGKAAALNRAL 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 507743900  84 KLVRGDYLVWPDSDDFYaSSNAISKMVSILdkSEDSVSMVRCLPVYLN 131
Cdd:cd06439  106 ALATGEIVVFTDANALL-DPDALRLLVRHF--ADPSVGAVSGELVIVD 150
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 13-158 8.76e-14

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 69.20  E-value: 8.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900  13 YNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVlkfvdKGYSLTYIYQENSG-QSVAIN--KALKLVRGD 89
Cdd:cd04196    7 YNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKEYI-----DKDPFIIILIRNGKnLGVARNfeSLLQAADGD 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507743900  90 YLVWPDSDDFYAsSNAISKMVSILDKSEDSVsMV--RCLPVYLNENLIFHHKMESNE----NLHNEYLFEDCILG 158
Cdd:cd04196   82 YVFFCDQDDIWL-PDKLERLLKAFLKDDKPL-LVysDLELVDENGNPIGESFFEYQKikpgTSFNNLLFQNVVTG 154
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 8-124 2.16e-12

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 64.90  E-value: 2.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSI---LDQDYLYlEMYIVDDGSTDNTKSVVDEYVLKF-VDKGYSLtyiyQENSGQSVAINKAL 83
Cdd:cd04179    1 VVIPAYNEEENIPELVERLlavLEEGYDY-EIIVVDDGSTDGTAEIARELAARVpRVRVIRL----SRNFGKGAAVRAGF 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 507743900  84 KLVRGDYLVWPDSDDFYaSSNAISKMVS-ILDKSEDSVSMVR 124
Cdd:cd04179   76 KAARGDIVVTMDADLQH-PPEDIPKLLEkLLEGGADVVIGSR 116
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 4-98 4.15e-11

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 62.00  E-value: 4.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900    4 RLVSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVDKGysLTYIYQEN----SGQSVAI 79
Cdd:pfam13641   2 PDVSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETLDVAEEIAARFPDVR--LRVIRNARllgpTGKSRGL 79

                          90
                  ....*....|....*....
gi 507743900   80 NKALKLVRGDYLVWPDSDD 98
Cdd:pfam13641  80 NHGFRAVKSDLVVLHDDDS 98
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 5-119 5.18e-11

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 61.06  E-value: 5.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   5 LVSVITPCYNA-GSFIHRLLDSILDQDYLYLEMYIVDDGSTDN-TKSVVDEYVLKfvDKGYSLTYIyQENSGQSVAINKA 82
Cdd:cd04184    2 LISIVMPVYNTpEKYLREAIESVRAQTYPNWELCIADDASTDPeVKRVLKKYAAQ--DPRIKVVFR-EENGGISAATNSA 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 507743900  83 LKLVRGDYLVWPDSDDfYASSNAISKMVSILDKSEDS 119
Cdd:cd04184   79 LELATGEFVALLDHDD-ELAPHALYEVVKALNEHPDA 114
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-97 1.37e-10

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 60.38  E-value: 1.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILDQDYLY--LEMYIVDDGSTDNTKSVVdEYVLKFVDKG-YSLTYIYQENSGQSVAINKALK 84
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLSALDYPKekFEVILVDDHSTDGTVQIL-EFAAAKPNFQlKILNNSRVSISGKKNALTTAIK 79

                         90
                 ....*....|...
gi 507743900  85 LVRGDYLVWPDSD 97
Cdd:cd04192   80 AAKGDWIVTTDAD 92
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-92 3.92e-10

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 57.95  E-value: 3.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVDkgysltYIYQENSGQSVAINKALKLVR 87
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVELLRELFPEVRL------IRNGENLGFGAGNNQGIREAK 74


                 ....*
gi 507743900  88 GDYLV 92
Cdd:cd04186   75 GDYVL 79
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 8-98 3.26e-09

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 56.31  E-value: 3.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILDQDYL-YLEMYIVDDGSTDNTKSVVDEYVLKFVDKGYSLTYIyQENSGQSV----AINKA 82
Cdd:cd06913    1 IILPVHNGEQWLDECLESVLQQDFEgTLELSVFNDASTDKSAEIIEKWRKKLEDSGVIVLVG-SHNSPSPKgvgyAKNQA 79

                         90
                 ....*....|....*.
gi 507743900  83 LKLVRGDYLVWPDSDD 98
Cdd:cd06913   80 IAQSSGRYLCFLDSDD 95
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 8-102 3.51e-09

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 55.66  E-value: 3.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVdkgYSLTYIYQENSG-QSVAI-NKALKL 85
Cdd:cd06420    1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEETKELIEEFKSQFP---IPIKHVWQEDEGfRKAKIrNKAIAA 77

                         90       100
                 ....*....|....*....|..
gi 507743900  86 VRGDYLVWPDSD-----DFYAS 102
Cdd:cd06420   78 AKGDYLIFIDGDciphpDFIAD 99
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 8-124 6.89e-08

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 51.71  E-value: 6.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRL---LDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVD-KGYSLTyiyqENSGQSVAINKAL 83
Cdd:cd04187    1 IVVPVYNEEENLPELyerLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDPRvKVIRLS----RNFGQQAALLAGL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 507743900  84 KLVRGDYLVWPDSD--DfyaSSNAISKMVSILDKSEDSVSMVR 124
Cdd:cd04187   77 DHARGDAVITMDADlqD---PPELIPEMLAKWEEGYDVVYGVR 116
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
5-98 1.83e-07

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 51.53  E-value: 1.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   5 LVSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKsvVDEYVLKFVDKgySLTYIYQE-NSGQSVAINKAL 83
Cdd:PRK10018   6 LISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCSTSWEQ--LQQYVTALNDP--RITYIHNDiNSGACAVRNQAI 81

                         90
                 ....*....|....*
gi 507743900  84 KLVRGDYLVWPDSDD 98
Cdd:PRK10018  82 MLAQGEYITGIDDDD 96
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 6-124 2.38e-07

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 50.75  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   6 VSVITPCYNAGSFIHRLLDSILDQ-DylylEMYIVDDGSTDNTKSVVDEYVLKFVDkgysltyiyQENSGQSVAINKALK 84
Cdd:cd02511    2 LSVVIITKNEERNIERCLESVKWAvD----EIIVVDSGSTDRTVEIAKEYGAKVYQ---------RWWDGFGAQRNFALE 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 507743900  85 LVRGDYLVWPDSDDfYASSNAISKMVSIL-DKSEDSVSMVR 124
Cdd:cd02511   69 LATNDWVLSLDADE-RLTPELADEILALLaTDDYDGYYVPR 108
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 8-97 2.48e-07

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 50.64  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNAGSFIHRLLDSILD-----QDYLYlEMYIVDDGSTDNTKSVVDEYVLKFVDKGYSLTyiYQENSGQSVAINKA 82
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAVEyleerPSFSY-EIIVVDDGSKDGTAEVARKLARKNPALIRVLT--LPKNRGKGGAVRAG 77

                         90
                 ....*....|....*
gi 507743900  83 LKLVRGDYLVWPDSD 97
Cdd:cd04188   78 MLAARGDYILFADAD 92
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 7-98 4.31e-06

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 46.92  E-value: 4.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   7 SVITPCYNAGS--FIHRLLDSILDQDYLYLEMYIVDDGS-TDNTKSVVDEYVLKFVDKGYSLtyiyQENSGQSVAINKAL 83
Cdd:cd04195    1 SVLMSVYIKEKpeFLREALESILKQTLPPDEVVLVKDGPvTQSLNEVLEEFKRKLPLKVVPL----EKNRGLGKALNEGL 76

                         90
                 ....*....|....*
gi 507743900  84 KLVRGDYLVWPDSDD 98
Cdd:cd04195   77 KHCTYDWVARMDTDD 91
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
7-104 7.26e-06

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 47.10  E-value: 7.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   7 SVITPCYNAGSFIHRLLDSILDQ---DYLYLEMYIVDDGSTDNTKSVVDEYVLKFvDKGYSLTYIYQENSGQSVAINKAL 83
Cdd:NF038302   4 TVAIPTYNGANRLPEVLERLRSQigtESLSWEIIVVDNNSTDNTAQVVQEYQKNW-PSPYPLRYCFEPQQGAAFARQRAI 82

                         90       100
                 ....*....|....*....|.
gi 507743900  84 KLVRGDYLVWPDsDDFYASSN 104
Cdd:NF038302  83 QEAKGELIGFLD-DDNLPAPN 102
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 6-92 9.87e-06

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 46.02  E-value: 9.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   6 VSVITPCYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEYVLKFVdkgysltyiyQENSGQSVAINKALKL 85
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGTVAIARSAGVVVI----------SSPKGRARQMNAGAAA 70


                 ....*..
gi 507743900  86 VRGDYLV 92
Cdd:cd02522   71 ARGDWLL 77
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 7-119 1.15e-05

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 46.30  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   7 SVITPCYNAGSFIHRLLDSIL---------DQDYLYlEMYIVDDGSTDNTKSVVDEYVLKFVDKGYSLTYI-YQENSGQS 76
Cdd:PTZ00260  73 SIVIPAYNEEDRLPKMLKETIkylesrsrkDPKFKY-EIIIVNDGSKDKTLKVAKDFWRQNINPNIDIRLLsLLRNKGKG 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 507743900  77 VAINKALKLVRGDYLVWPDSD---DFyassNAISKMVSILDKSEDS 119
Cdd:PTZ00260 152 GAVRIGMLASRGKYILMVDADgatDI----DDFDKLEDIMLKIEQN 193
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 8-97 1.21e-04

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 42.52  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITPCYNA----GSFIHRLLDSILDQDYlylEMYIVDDGSTDNTKSVVDEYVLKFvdkGYSLTYIYQENSGQSVAINKAL 83
Cdd:cd06442    1 IIIPTYNEreniPELIERLDAALKGIDY---EIIVVDDNSPDGTAEIVRELAKEY---PRVRLIVRPGKRGLGSAYIEGF 74

                         90
                 ....*....|....
gi 507743900  84 KLVRGDYLVWPDSD 97
Cdd:cd06442   75 KAARGDVIVVMDAD 88
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 8-108 1.38e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 42.24  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   8 VITpcYNAGSFIHRLLDSILDQDYLYLEMYIVDDGSTDNTKSVVDEyvLKFVDKgysLTYIYQ-ENSGQSVAINKALKLV 86
Cdd:cd04185    3 VVT--YNRLDLLKECLDALLAQTRPPDHIIVIDNASTDGTAEWLTS--LGDLDN---IVYLRLpENLGGAGGFYEGVRRA 75

                         90       100
                 ....*....|....*....|....
gi 507743900  87 --RGDYLVWPDSDDFYASSNAISK 108
Cdd:cd04185   76 yeLGYDWIWLMDDDAIPDPDALEK 99
CESA_CaSu_A2 cd06437
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit ...
 5-142 2.39e-04

Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.


Pssm-ID: 133059 [Multi-domain]  Cd Length: 232  Bit Score: 41.91  E-value: 2.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   5 LVSVITPCYNAGSFIHRLLDSILDQDYL--YLEMYIVDDgSTDNTKSVVDEYVLKFVDKGYSLTYIYQEN-SG-QSVAIN 80
Cdd:cd06437    2 MVTVQLPVFNEKYVVERLIEAACALDYPkdRLEIQVLDD-STDETVRLAREIVEEYAAQGVNIKHVRRADrTGyKAGALA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507743900  81 KALKLVRGDYLVWPDSdDFYASSNAISKMVSILDKSEdsVSMVRCLPVYLNENLIFHHKMES 142
Cdd:cd06437   81 EGMKVAKGEYVAIFDA-DFVPPPDFLQKTPPYFADPK--LGFVQTRWGHINANYSLLTRVQA 139
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 7-154 1.22e-03

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 39.95  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900    7 SVITPCYNaGSFIHRLLDSILDQDYLYLEMY---IVDDGSTDNTKSVVDEyvLKFVDKGYSLTYIYQENSGQSVAINKAL 83
Cdd:pfam10111   1 SVVIPVYN-GEKTHWIQERILNQTFQYDPEFeliIINDGSTDKTLEEVSS--IKDHNLQVYYPNAPDTTYSLAASRNRGT 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507743900   84 KLVRGDYLVWPDSDDFYASSN--AISKMVSILDKSEDSVSMVrCLPVYlnenlifHHKMESNENLHN-EYLFED 154
Cdd:pfam10111  78 SHAIGEYISFIDGDCLWSPDKfeKQLKIATSLALQENIQAAV-VLPVT-------DLNDESSNFLRRgGDLTAS 143
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 6-124 2.46e-03

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 39.33  E-value: 2.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   6 VSVITPCYNAGSFIHRLLD------SILDQDYlylEMYIVDDGSTDNTKSVVDEYVLKfvDKGYSLTYIYQENSGQSVAI 79
Cdd:PRK10714   8 VSVVIPVYNEQESLPELIRrttaacESLGKEY---EILLIDDGSSDNSAEMLVEAAQA--PDSHIVAILLNRNYGQHSAI 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 507743900  80 NKALKLVRGDYLVWPDSdDFYASSNAISKMVSILDKSEDSVSMVR 124
Cdd:PRK10714  83 MAGFSHVTGDLIITLDA-DLQNPPEEIPRLVAKADEGYDVVGTVR 126
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 4-97 2.50e-03

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 38.91  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   4 RLVSVITPCYNAG---SFIHRLLDSILdQDYLYLEMYIVDDGSTDNTKSVVDEyvlkfvdkgysLTYIYQENS------- 73
Cdd:PLN02726   9 MKYSIIVPTYNERlniALIVYLIFKAL-QDVKDFEIIVVDDGSPDGTQDVVKQ-----------LQKVYGEDRillrprp 76

                         90       100
                 ....*....|....*....|....*..
gi 507743900  74 ---GQSVAINKALKLVRGDYLVWPDSD 97
Cdd:PLN02726  77 gklGLGTAYIHGLKHASGDFVVIMDAD 103
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 7-96 3.04e-03

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 38.72  E-value: 3.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507743900   7 SVITPCYN-AGSFIHRLLDSILDQD--YLYLEMYIVDDGST-DNTKSVVDEYVLKFVDKgysLTYI-YQENSGQSVAINK 81
Cdd:cd02510    1 SVIIIFHNeALSTLLRTVHSVINRTppELLKEIILVDDFSDkPELKLLLEEYYKKYLPK---VKVLrLKKREGLIRARIA 77

                         90
                 ....*....|....*
gi 507743900  82 ALKLVRGDYLVWPDS 96
Cdd:cd02510   78 GARAATGDVLVFLDS 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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