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Conserved domains on  [gi|431903140|gb|ELK09316|]
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Breast cancer type 2 susceptibility protein like protein [Pteropus alecto]

Protein Classification

single-stranded DNA-binding protein( domain architecture ID 11101627)

single-stranded DNA (ssDNA)-binding protein plays a key role in DNA replication, recombination, and repair

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2842-3092 5.00e-103

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


:

Pssm-ID: 239940  Cd Length: 251  Bit Score: 331.34  E-value: 5.00e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2842 PLSSLFSDGGNTACVDVVIQRAYPVQWVEKTSSGLYIFRNEREEEKEAAKYAETQQRKLEALFTKIQAEFEEQEENISRQ 2921
Cdd:cd04494     1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2922 CLPSRALTRQQVRALQDGAELYEAVRAAPDPAYLESYFSEEQLRALNNHRQMLNDKKQAQIQLEFRKAVESAEQGDQVSS 3001
Cdd:cd04494    81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLSK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 3002 RDVTTMWKLRIISYEKKGKDSIILSIWRPSSDLYSLLREGQRCRIYHLATSKPKNKSGRANLQLTATKRTQYQQLPASDG 3081
Cdd:cd04494   161 RDVTPVWKLRVTDYRSKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                         250
                  ....*....|.
gi 431903140 3082 ILVQVYQPRRP 3092
Cdd:cd04494   241 ELFQPFQPRKA 251
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2493-2705 2.87e-97

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462700  Cd Length: 187  Bit Score: 311.97  E-value: 2.87e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2493 SLQNARDMQDMRIKKKHGQCVCPQPGSLSLARASGMPRVPLRAAVGGRPPSACPPEQLYMYGVSKHCVKINSKNAESFQF 2572
Cdd:pfam09169    3 NLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESFQF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2573 HIQDYFGKESLRAGKGIQLADGGWLVPSDDGKAGKEEFYRALCDTPGVDPKLISRVWVYNHYRWIIWKLAAMEFAFPKEF 2652
Cdd:pfam09169   83 FDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPKEF 162

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 431903140  2653 ASRCLNPETVLLQLKHrqvenatwwdrpcgtvptsaqpvasvpsRYDIEIDRS 2705
Cdd:pfam09169  163 GRRCLTPERVLLQLKY----------------------------RYDVEIDKS 187
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 3090-3224 5.78e-76

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


:

Pssm-ID: 462679  Cd Length: 139  Bit Score: 248.73  E-value: 5.78e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  3090 RRPLPFPQLSNPDFQPPCAEVDLIGFVISVVRKIGLAPLVYLSDECHNLLAVKFWIDLN----EEIIKPHVLIAASNLQW 3165
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 431903140  3166 RPDSKSGIPTLFAGDFSVFSASPKEGHFQETFHKMRNAIENVDRFCNEAENKLMQILHA 3224
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2708-2833 1.68e-62

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


:

Pssm-ID: 462678  Cd Length: 123  Bit Score: 209.73  E-value: 1.68e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2708 SAIKKIMERDDTAAKTLVLCVSEVILSSTHLSETHSGKTSSaeasKAAVVELTDGWYAIRAQLDPPLSALLQTGRLGVGQ 2787
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGSGTVDN----TKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 431903140  2788 KVVTHGAELLGPPEACSPLEASETLMLKISANSTRPACWDAKLGFC 2833
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQ 122
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1227-1254 2.56e-08

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 51.68  E-value: 2.56e-08
                           10        20
                   ....*....|....*....|....*...
gi 431903140  1227 FRGFYSARGTKLNVSSEALQKAKKLFSD 1254
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1682-1710 1.08e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 50.14  E-value: 1.08e-07
                           10        20
                   ....*....|....*....|....*....
gi 431903140  1682 SVLAFYTGHGRKISVRETSLLEARKWLRE 1710
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1438-1464 1.99e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 49.37  E-value: 1.99e-07
                           10        20
                   ....*....|....*....|....*..
gi 431903140  1438 ISFQTASGKKISVSKDSLNKVVNFFDQ 1464
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1996-2022 2.45e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 46.29  E-value: 2.45e-06
                           10        20
                   ....*....|....*....|....*..
gi 431903140  1996 CGIFSTAGGKSVQVSGTALQKARQIFS 2022
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2065-2093 1.38e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.98  E-value: 1.38e-05
                           10        20
                   ....*....|....*....|....*....
gi 431903140  2065 PFSGFSTASGKQVSVSESAFIKVKGMLAD 2093
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1015-1043 9.75e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 41.66  E-value: 9.75e-05
                           10        20
                   ....*....|....*....|....*....
gi 431903140  1015 FGNGFRTASNKEIRLSEHNIKKSKVLFKD 1043
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1540-1564 1.25e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


:

Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.58  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*
gi 431903140  1540 FHTASGKRVKIAKESLDKVENLFDE 1564
Cdd:pfam00634    5 FQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2842-3092 5.00e-103

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 331.34  E-value: 5.00e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2842 PLSSLFSDGGNTACVDVVIQRAYPVQWVEKTSSGLYIFRNEREEEKEAAKYAETQQRKLEALFTKIQAEFEEQEENISRQ 2921
Cdd:cd04494     1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2922 CLPSRALTRQQVRALQDGAELYEAVRAAPDPAYLESYFSEEQLRALNNHRQMLNDKKQAQIQLEFRKAVESAEQGDQVSS 3001
Cdd:cd04494    81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLSK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 3002 RDVTTMWKLRIISYEKKGKDSIILSIWRPSSDLYSLLREGQRCRIYHLATSKPKNKSGRANLQLTATKRTQYQQLPASDG 3081
Cdd:cd04494   161 RDVTPVWKLRVTDYRSKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                         250
                  ....*....|.
gi 431903140 3082 ILVQVYQPRRP 3092
Cdd:cd04494   241 ELFQPFQPRKA 251
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2493-2705 2.87e-97

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 311.97  E-value: 2.87e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2493 SLQNARDMQDMRIKKKHGQCVCPQPGSLSLARASGMPRVPLRAAVGGRPPSACPPEQLYMYGVSKHCVKINSKNAESFQF 2572
Cdd:pfam09169    3 NLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESFQF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2573 HIQDYFGKESLRAGKGIQLADGGWLVPSDDGKAGKEEFYRALCDTPGVDPKLISRVWVYNHYRWIIWKLAAMEFAFPKEF 2652
Cdd:pfam09169   83 FDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPKEF 162

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 431903140  2653 ASRCLNPETVLLQLKHrqvenatwwdrpcgtvptsaqpvasvpsRYDIEIDRS 2705
Cdd:pfam09169  163 GRRCLTPERVLLQLKY----------------------------RYDVEIDKS 187
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 3090-3224 5.78e-76

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 248.73  E-value: 5.78e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  3090 RRPLPFPQLSNPDFQPPCAEVDLIGFVISVVRKIGLAPLVYLSDECHNLLAVKFWIDLN----EEIIKPHVLIAASNLQW 3165
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 431903140  3166 RPDSKSGIPTLFAGDFSVFSASPKEGHFQETFHKMRNAIENVDRFCNEAENKLMQILHA 3224
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2708-2833 1.68e-62

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 209.73  E-value: 1.68e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2708 SAIKKIMERDDTAAKTLVLCVSEVILSSTHLSETHSGKTSSaeasKAAVVELTDGWYAIRAQLDPPLSALLQTGRLGVGQ 2787
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGSGTVDN----TKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 431903140  2788 KVVTHGAELLGPPEACSPLEASETLMLKISANSTRPACWDAKLGFC 2833
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQ 122
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2720-2832 1.75e-39

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 142.75  E-value: 1.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2720 AAKTLVLCVSEVILSSThlsethsgktssaEASKAAVVELTDGWYAIRAQLDPPLSALLQTGRLGVGQKVVTHGAELLGP 2799
Cdd:cd04493     1 ASRLMVLCVSGINSEER-------------LSPHMPIIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                          90       100       110
                  ....*....|....*....|....*....|...
gi 431903140 2800 PEACSPLEASETLMLKISANSTRPACWDAKLGF 2832
Cdd:cd04493    68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 3111-3205 2.07e-39

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 142.93  E-value: 2.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 3111 DLIGFVISVVRKI-GLAPLVYLSDECHNLLAVKFWIDL----NEEIIKPHVLIAASNLQWRPDSKSGIPTLFAGDFSVFS 3185
Cdd:cd04495     1 DTVGVVISVGKPIeGKFPAVYLADECLNLLCVKFWSSLeqyaYEDVVKRRVLLAASNLQWRTESTSGVPTLFAGEYSTFS 80

                          90       100
                  ....*....|....*....|
gi 431903140 3186 ASPKEGHFQETFHKMRNAIE 3205
Cdd:cd04495    81 ANPKESHLQEEFNNLKHLIE 100
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1227-1254 2.56e-08

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 51.68  E-value: 2.56e-08
                           10        20
                   ....*....|....*....|....*...
gi 431903140  1227 FRGFYSARGTKLNVSSEALQKAKKLFSD 1254
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1682-1710 1.08e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 50.14  E-value: 1.08e-07
                           10        20
                   ....*....|....*....|....*....
gi 431903140  1682 SVLAFYTGHGRKISVRETSLLEARKWLRE 1710
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1438-1464 1.99e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 49.37  E-value: 1.99e-07
                           10        20
                   ....*....|....*....|....*..
gi 431903140  1438 ISFQTASGKKISVSKDSLNKVVNFFDQ 1464
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2869-2910 5.99e-07

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 48.51  E-value: 5.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 431903140  2869 VEKTSSGLYIFRNEREEEKEAAKYAETQQRKLEALFTKIQAE 2910
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQAE 42
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1996-2022 2.45e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 46.29  E-value: 2.45e-06
                           10        20
                   ....*....|....*....|....*..
gi 431903140  1996 CGIFSTAGGKSVQVSGTALQKARQIFS 2022
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2065-2093 1.38e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.98  E-value: 1.38e-05
                           10        20
                   ....*....|....*....|....*....
gi 431903140  2065 PFSGFSTASGKQVSVSESAFIKVKGMLAD 2093
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1015-1043 9.75e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 41.66  E-value: 9.75e-05
                           10        20
                   ....*....|....*....|....*....
gi 431903140  1015 FGNGFRTASNKEIRLSEHNIKKSKVLFKD 1043
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1540-1564 1.25e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.58  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*
gi 431903140  1540 FHTASGKRVKIAKESLDKVENLFDE 1564
Cdd:pfam00634    5 FQTASGKKISVSEESLQKAKKLFRD 29
 
Name Accession Description Interval E-value
BRCA2DBD_OB2 cd04494
BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the ...
 2842-3092 5.00e-103

BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239940  Cd Length: 251  Bit Score: 331.34  E-value: 5.00e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2842 PLSSLFSDGGNTACVDVVIQRAYPVQWVEKTSSGLYIFRNEREEEKEAAKYAETQQRKLEALFTKIQAEFEEQEENISRQ 2921
Cdd:cd04494     1 PLSSLYDSGGLVGCVDVIILRVYPLQWVEKTSEGGSVFRSERAEEREARLHAQRQQKKLEALFSKIQEEFEKEEEDNNQR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2922 CLPSRALTRQQVRALQDGAELYEAVRAAPDPAYLESYFSEEQLRALNNHRQMLNDKKQAQIQLEFRKAVESAEQGDQVSS 3001
Cdd:cd04494    81 RPRSRTRTRQNVTDLQDGAELYEALEAAADPSFLEAELSEEQLEALSNYQQLQNEKKQARLQEEFRKAVEEALKEEGLSK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 3002 RDVTTMWKLRIISYEKKGKDSIILSIWRPSSDLYSLLREGQRCRIYHLATSKPKNKSGRANLQLTATKRTQYQQLPASDG 3081
Cdd:cd04494   161 RDVTPVWKLRVTDYRSKPEKSGLLSIWRPTEDLRSLLTEGKRYRIYGLATSNSKKRSGNEEVQLTATKKTRYQPLPVSQR 240

                         250
                  ....*....|.
gi 431903140 3082 ILVQVYQPRRP 3092
Cdd:cd04494   241 ELFQPFQPRKA 251
BRCA-2_helical pfam09169
BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix ...
 2493-2705 2.87e-97

BRCA2, helical; Members of this family adopt a helical structure, consisting of a four-helix cluster core (alpha 1, alpha 8, alpha 9, alpha 10) and two successive beta-hairpins (beta 1 to beta 4). An approx. 50-amino acid segment that contains four short helices (alpha 2 to alpha 4), meanders around the surface of the core structure. In BRCA2, the alpha 9 and alpha 10 helices pack with BRCA-2_OB1 (pfam09103) through van der Waals contacts involving hydrophobic and aromatic residues, and also through side-chain and backbone hydrogen bonds. The domain binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462700  Cd Length: 187  Bit Score: 311.97  E-value: 2.87e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2493 SLQNARDMQDMRIKKKHGQCVCPQPGSLSLARASGMPRVPLRAAVGGRPPSACPPEQLYMYGVSKHCVKINSKNAESFQF 2572
Cdd:pfam09169    3 NLLLARDLQDMRIKKKSRQIIRPQPGSLYLKKSSVVRRISLKAAVGGCPPSHYSEKQLYYGGVCKVSLIIASENAESFQF 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2573 HIQDYFGKESLRAGKGIQLADGGWLVPSDDGKAGKEEFYRALCDTPGVDPKLISRVWVYNHYRWIIWKLAAMEFAFPKEF 2652
Cdd:pfam09169   83 FDDDFFGKEFLLNGGGIQLADGGLLIPNDGGVAGKEEFYRALCDTPGVDPKLISAWWVYNHYRWIVWKLAAMERFFPKEF 162

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 431903140  2653 ASRCLNPETVLLQLKHrqvenatwwdrpcgtvptsaqpvasvpsRYDIEIDRS 2705
Cdd:pfam09169  163 GRRCLTPERVLLQLKY----------------------------RYDVEIDKS 187
BRCA-2_OB3 pfam09104
BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB ...
 3090-3224 5.78e-76

BRCA2, oligonucleotide/oligosaccharide-binding, domain 3; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB3 has a pronounced groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for strong ssDNA binding.


Pssm-ID: 462679  Cd Length: 139  Bit Score: 248.73  E-value: 5.78e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  3090 RRPLPFPQLSNPDFQPPCAEVDLIGFVISVVRKIGLAPLVYLSDECHNLLAVKFWIDLN----EEIIKPHVLIAASNLQW 3165
Cdd:pfam09104    1 REVTPFSDLLNPSFQPPCGEVDLVGVVVSVVKKQGLAPLVYLSDECMNLLAVKFWSDLNqyayEDIVKPRALIAASNLQW 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 431903140  3166 RPDSKSGIPTLFAGDFSVFSASPKEGHFQETFHKMRNAIENVDRFCNEAENKLMQILHA 3224
Cdd:pfam09104   81 RRESSSPIPTLYAGELSVFSANPKEGHLQEAFNDLKNLVENPENFFEDAEEKLSHLLNS 139
BRCA-2_OB1 pfam09103
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB ...
 2708-2833 1.68e-62

BRCA2, oligonucleotide/oligosaccharide-binding, domain 1; Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.


Pssm-ID: 462678  Cd Length: 123  Bit Score: 209.73  E-value: 1.68e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140  2708 SAIKKIMERDDTAAKTLVLCVSEVILSSTHLSETHSGKTSSaeasKAAVVELTDGWYAIRAQLDPPLSALLQTGRLGVGQ 2787
Cdd:pfam09103    1 SALRKILERDDSASKPMVLCVSAIISSESNSEETGSGTVDN----TKAILELTDGWYSIKAVLDAPLTRLVRRGKIRVGQ 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 431903140  2788 KVVTHGAELLGPPEACSPLEASETLMLKISANSTRPACWDAKLGFC 2833
Cdd:pfam09103   77 KLAICGAELVGSKEPCSPLEAPDSVRLKISANSTRRARWDAKLGFQ 122
BRCA2DBD_OB1 cd04493
BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the ...
 2720-2832 1.75e-39

BRCA2DBD_OB1: A subfamily of OB folds corresponding to the first OB fold (OB1) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA). BRCA2DBD OB1 binds DNA weakly.


Pssm-ID: 239939  Cd Length: 100  Bit Score: 142.75  E-value: 1.75e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 2720 AAKTLVLCVSEVILSSThlsethsgktssaEASKAAVVELTDGWYAIRAQLDPPLSALLQTGRLGVGQKVVTHGAELLGP 2799
Cdd:cd04493     1 ASRLMVLCVSGINSEER-------------LSPHMPIIELTDGWYSIRAQLDPPLTNLVRKGKLRVGQKLRICGAELLGS 67

                          90       100       110
                  ....*....|....*....|....*....|...
gi 431903140 2800 PEACSPLEASETLMLKISANSTRPACWDAKLGF 2832
Cdd:cd04493    68 ANPCSPLEAPDSVRLKINANSTRRARWDARLGF 100
BRCA2DBD_OB3 cd04495
BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the ...
 3111-3205 2.07e-39

BRCA2DBD_OB3: A subfamily of OB folds corresponding to the third OB fold (OB3) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated repair of double-strand DNA breaks. It stimulates the displacement of Replication protein A (RPA), the most abundant eukaryotic ssDNA binding protein. It also facilitates filament formation. Mutations that map throughout the BRCA2 protein are associated with breast cancer susceptibility. BRCA2 is a large nuclear protein and its most conserved region is the C-terminal BRCA2DBD. BRCA2DBD binds ssDNA in vitro, and is composed of five structural domains, three of which are OB folds (OB1, OB2, and OB3). BRCA2DBD OB2 and OB3 are arranged in tandem, and their mode of binding can be considered qualitatively similar to two OB folds of RPA1, DBD-A and DBD-B (the major DBDs of RPA).


Pssm-ID: 239941  Cd Length: 100  Bit Score: 142.93  E-value: 2.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 431903140 3111 DLIGFVISVVRKI-GLAPLVYLSDECHNLLAVKFWIDL----NEEIIKPHVLIAASNLQWRPDSKSGIPTLFAGDFSVFS 3185
Cdd:cd04495     1 DTVGVVISVGKPIeGKFPAVYLADECLNLLCVKFWSSLeqyaYEDVVKRRVLLAASNLQWRTESTSGVPTLFAGEYSTFS 80

                          90       100
                  ....*....|....*....|
gi 431903140 3186 ASPKEGHFQETFHKMRNAIE 3205
Cdd:cd04495    81 ANPKESHLQEEFNNLKHLIE 100
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1227-1254 2.56e-08

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 51.68  E-value: 2.56e-08
                           10        20
                   ....*....|....*....|....*...
gi 431903140  1227 FRGFYSARGTKLNVSSEALQKAKKLFSD 1254
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1682-1710 1.08e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 50.14  E-value: 1.08e-07
                           10        20
                   ....*....|....*....|....*....
gi 431903140  1682 SVLAFYTGHGRKISVRETSLLEARKWLRE 1710
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1438-1464 1.99e-07

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 49.37  E-value: 1.99e-07
                           10        20
                   ....*....|....*....|....*..
gi 431903140  1438 ISFQTASGKKISVSKDSLNKVVNFFDQ 1464
Cdd:pfam00634    3 LGFQTASGKKISVSEESLQKAKKLFRD 29
Tower pfam09121
Tower; Members of this family adopt a secondary structure consisting of a pair of long, ...
 2869-2910 5.99e-07

Tower; Members of this family adopt a secondary structure consisting of a pair of long, antiparallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their end. The 3HB contains a helix-turn-helix motif and is similar to the DNA binding domains of the bacterial site-specific recombinases, and of eukaryotic Myb and homeodomain transcription factors. The Tower domain has an important role in the tumour suppressor function of BRCA2, and is essential for appropriate binding of BRCA2 to DNA.


Pssm-ID: 462684  Cd Length: 42  Bit Score: 48.51  E-value: 5.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 431903140  2869 VEKTSSGLYIFRNEREEEKEAAKYAETQQRKLEALFTKIQAE 2910
Cdd:pfam09121    1 MEKKPDGGFVFRNERAEEKEARRYAEAQQKALEALFAKIQAE 42
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1996-2022 2.45e-06

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 46.29  E-value: 2.45e-06
                           10        20
                   ....*....|....*....|....*..
gi 431903140  1996 CGIFSTAGGKSVQVSGTALQKARQIFS 2022
Cdd:pfam00634    2 FLGFQTASGKKISVSEESLQKAKKLFR 28
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 2065-2093 1.38e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 43.98  E-value: 1.38e-05
                           10        20
                   ....*....|....*....|....*....
gi 431903140  2065 PFSGFSTASGKQVSVSESAFIKVKGMLAD 2093
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1015-1043 9.75e-05

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 41.66  E-value: 9.75e-05
                           10        20
                   ....*....|....*....|....*....
gi 431903140  1015 FGNGFRTASNKEIRLSEHNIKKSKVLFKD 1043
Cdd:pfam00634    1 SFLGFQTASGKKISVSEESLQKAKKLFRD 29
BRCA2 pfam00634
BRCA2 repeat; The alignment covers only the most conserved region of the repeat.
 1540-1564 1.25e-03

BRCA2 repeat; The alignment covers only the most conserved region of the repeat.


Pssm-ID: 459881  Cd Length: 29  Bit Score: 38.58  E-value: 1.25e-03
                           10        20
                   ....*....|....*....|....*
gi 431903140  1540 FHTASGKRVKIAKESLDKVENLFDE 1564
Cdd:pfam00634    5 FQTASGKKISVSEESLQKAKKLFRD 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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