NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|407623942|gb|EKF50733|]
View 

putative membrane protein [Lactococcus garvieae DCC43]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
DUF6056 pfam19528
Family of unknown function (DUF6056); This family of integral membrane proteins is ...
19-468 7.67e-122

Family of unknown function (DUF6056); This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 448 and 528 amino acids in length. There is a conserved NYL sequence motif.


:

Pssm-ID: 437360  Cd Length: 444  Bit Score: 370.83  E-value: 7.67e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942   19 NVLRTIITLAILSLTFIFILNLNHYTGYTGDDFLYHFIYTGawpsehLSEYHNLSDYISAVYTHMTLWNARMTSIIFEIL 98
Cdd:pfam19528   1 MKNKKKIFVLILLIFFLLILVLNYLTPLTADDYLYSFVWDG------VRRITSFGDIIVSQYNHYFTWNGRSVAHFIVQL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942   99 AMQMPKSIFNILNASIYVLVGLLLNVVVSGKKAFLKFLHLALTFLLMWFFIPGMGSTVLWVSGAANYLWATVIILLFLLP 178
Cdd:pfam19528  75 FLLIGKILFNILNALVFVLLVLLIYRHARGKKKKYNPSLLLLILLLLWFFLPAFGQTVLWLSGSCNYLWTSVIILGFLLP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  179 YRFNVSTK----RGWEEFYLPVLGLLAGLTNEVGGATTVLLALIFTVYNLKKsgsGNTVA--QILGTVAVAFGFGTQVIL 252
Cdd:pfam19528 155 YRYLKNKKerknNKLLAILMFLLGILAGWSNENTSGGVILIVLLFLLYYKYK---KKKLPlwMITGLLGALIGFLFLVLA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  253 SSGSAETQNYGASTGLGQRFLDILSG----TAHYSGFLLLPIVVFGVLLYFNRdqLQEKACNLWHGGIIFLISGLAGCFA 328
Cdd:pfam19528 232 PGNFVRADAEGTEENHLGLLLLVLARflkiTLNLRENYLLLLLIFVVLLILLF--LKKKNKKVFLLSLLFFLGGLATAYA 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  329 ILASPIIPARLWVASNILFIIALLMmfeAWQELRAQSSWTNVPLCIAILCLTFVSLPSYDYNLKDIKNSYEYFYTAQTIA 408
Cdd:pfam19528 310 MIASPEFPARAFFGAVIFLIIAILI---LLRDLAELESLLRKIAAILIVVLTILFIFSYIEAYADLARSYREYNEREAYI 386
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  409 QKAKEEGKTSARVPGIPMTSNGYNAYFGTPYLVAsehPEKEWSNTWFAKYYGLEKVYLDD 468
Cdd:pfam19528 387 QEQKAKGEKDVVVPPIRPPKNRYSAYYGLSDIGT---DPKAWINKWYAKYYGLKSIKGVP 443
MucBP_2 pfam17965
Mucin binding domain; This domain is found in bacterial cell surface proteins that interact ...
545-607 7.02e-03

Mucin binding domain; This domain is found in bacterial cell surface proteins that interact with mucins. The archetypal member of this family is the Mub-R5 B1 domain. This domain has a beta-grasp fold.


:

Pssm-ID: 465592 [Multi-domain]  Cd Length: 75  Bit Score: 35.76  E-value: 7.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 407623942  545 NALIRYIDVNKDEIVATEQITSPYNEVYDISHAST------AGYEtLISN--PKSYVF---NKRYDQTIDIHVK 607
Cdd:pfam17965   2 TATITYIDDTTGQTLSTDTLTGKTGETIDYTTADTikelepKGYV-LVSDgfPAGTTTfdaDDATDQTYTVHLK 74
 
Name Accession Description Interval E-value
DUF6056 pfam19528
Family of unknown function (DUF6056); This family of integral membrane proteins is ...
19-468 7.67e-122

Family of unknown function (DUF6056); This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 448 and 528 amino acids in length. There is a conserved NYL sequence motif.


Pssm-ID: 437360  Cd Length: 444  Bit Score: 370.83  E-value: 7.67e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942   19 NVLRTIITLAILSLTFIFILNLNHYTGYTGDDFLYHFIYTGawpsehLSEYHNLSDYISAVYTHMTLWNARMTSIIFEIL 98
Cdd:pfam19528   1 MKNKKKIFVLILLIFFLLILVLNYLTPLTADDYLYSFVWDG------VRRITSFGDIIVSQYNHYFTWNGRSVAHFIVQL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942   99 AMQMPKSIFNILNASIYVLVGLLLNVVVSGKKAFLKFLHLALTFLLMWFFIPGMGSTVLWVSGAANYLWATVIILLFLLP 178
Cdd:pfam19528  75 FLLIGKILFNILNALVFVLLVLLIYRHARGKKKKYNPSLLLLILLLLWFFLPAFGQTVLWLSGSCNYLWTSVIILGFLLP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  179 YRFNVSTK----RGWEEFYLPVLGLLAGLTNEVGGATTVLLALIFTVYNLKKsgsGNTVA--QILGTVAVAFGFGTQVIL 252
Cdd:pfam19528 155 YRYLKNKKerknNKLLAILMFLLGILAGWSNENTSGGVILIVLLFLLYYKYK---KKKLPlwMITGLLGALIGFLFLVLA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  253 SSGSAETQNYGASTGLGQRFLDILSG----TAHYSGFLLLPIVVFGVLLYFNRdqLQEKACNLWHGGIIFLISGLAGCFA 328
Cdd:pfam19528 232 PGNFVRADAEGTEENHLGLLLLVLARflkiTLNLRENYLLLLLIFVVLLILLF--LKKKNKKVFLLSLLFFLGGLATAYA 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  329 ILASPIIPARLWVASNILFIIALLMmfeAWQELRAQSSWTNVPLCIAILCLTFVSLPSYDYNLKDIKNSYEYFYTAQTIA 408
Cdd:pfam19528 310 MIASPEFPARAFFGAVIFLIIAILI---LLRDLAELESLLRKIAAILIVVLTILFIFSYIEAYADLARSYREYNEREAYI 386
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  409 QKAKEEGKTSARVPGIPMTSNGYNAYFGTPYLVAsehPEKEWSNTWFAKYYGLEKVYLDD 468
Cdd:pfam19528 387 QEQKAKGEKDVVVPPIRPPKNRYSAYYGLSDIGT---DPKAWINKWYAKYYGLKSIKGVP 443
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
138-355 2.61e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 138 LALTFLLMWFFIPgmgstvlwVSGAANYLWATVIILLFLLPYRFnvstkrgweeFYLPVLGLLAGLTN------------ 205
Cdd:COG2211   91 LALSFVLLFTAPD--------LSPTGKLIYALVTYLLLGLAYTL----------VNIPYSALGAELTPdyeertrlsswr 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 206 EVGGATTVLLALIFTVYNLKKSGSGNTVA-QILGTVAVAFGFGTQVILSSGSAETQNYGASTglgQRFLDILSGTAHYSG 284
Cdd:COG2211  153 FAFAGLGGLLASVLPPPLVAAFGGDAALGyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK---VSLKESLKALLKNRP 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 285 FLLLPIVVF----------GVLLYFNRDQLQEKAcnlwhgGIIFLISGLAGCFAILASPIIPA--------RLWVASNIL 346
Cdd:COG2211  230 FLLLLLAYLlfflalalvaALLLYYFKYVLGLSA------ALVGLLLALYFLAALLGAPLWPRlakrfgkkKAFIIGLLL 303

                 ....*....
gi 407623942 347 FIIALLMMF 355
Cdd:COG2211  304 AALGLLLLF 312
MucBP_2 pfam17965
Mucin binding domain; This domain is found in bacterial cell surface proteins that interact ...
545-607 7.02e-03

Mucin binding domain; This domain is found in bacterial cell surface proteins that interact with mucins. The archetypal member of this family is the Mub-R5 B1 domain. This domain has a beta-grasp fold.


Pssm-ID: 465592 [Multi-domain]  Cd Length: 75  Bit Score: 35.76  E-value: 7.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 407623942  545 NALIRYIDVNKDEIVATEQITSPYNEVYDISHAST------AGYEtLISN--PKSYVF---NKRYDQTIDIHVK 607
Cdd:pfam17965   2 TATITYIDDTTGQTLSTDTLTGKTGETIDYTTADTikelepKGYV-LVSDgfPAGTTTfdaDDATDQTYTVHLK 74
 
Name Accession Description Interval E-value
DUF6056 pfam19528
Family of unknown function (DUF6056); This family of integral membrane proteins is ...
19-468 7.67e-122

Family of unknown function (DUF6056); This family of integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria and viruses. Proteins in this family are typically between 448 and 528 amino acids in length. There is a conserved NYL sequence motif.


Pssm-ID: 437360  Cd Length: 444  Bit Score: 370.83  E-value: 7.67e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942   19 NVLRTIITLAILSLTFIFILNLNHYTGYTGDDFLYHFIYTGawpsehLSEYHNLSDYISAVYTHMTLWNARMTSIIFEIL 98
Cdd:pfam19528   1 MKNKKKIFVLILLIFFLLILVLNYLTPLTADDYLYSFVWDG------VRRITSFGDIIVSQYNHYFTWNGRSVAHFIVQL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942   99 AMQMPKSIFNILNASIYVLVGLLLNVVVSGKKAFLKFLHLALTFLLMWFFIPGMGSTVLWVSGAANYLWATVIILLFLLP 178
Cdd:pfam19528  75 FLLIGKILFNILNALVFVLLVLLIYRHARGKKKKYNPSLLLLILLLLWFFLPAFGQTVLWLSGSCNYLWTSVIILGFLLP 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  179 YRFNVSTK----RGWEEFYLPVLGLLAGLTNEVGGATTVLLALIFTVYNLKKsgsGNTVA--QILGTVAVAFGFGTQVIL 252
Cdd:pfam19528 155 YRYLKNKKerknNKLLAILMFLLGILAGWSNENTSGGVILIVLLFLLYYKYK---KKKLPlwMITGLLGALIGFLFLVLA 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  253 SSGSAETQNYGASTGLGQRFLDILSG----TAHYSGFLLLPIVVFGVLLYFNRdqLQEKACNLWHGGIIFLISGLAGCFA 328
Cdd:pfam19528 232 PGNFVRADAEGTEENHLGLLLLVLARflkiTLNLRENYLLLLLIFVVLLILLF--LKKKNKKVFLLSLLFFLGGLATAYA 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  329 ILASPIIPARLWVASNILFIIALLMmfeAWQELRAQSSWTNVPLCIAILCLTFVSLPSYDYNLKDIKNSYEYFYTAQTIA 408
Cdd:pfam19528 310 MIASPEFPARAFFGAVIFLIIAILI---LLRDLAELESLLRKIAAILIVVLTILFIFSYIEAYADLARSYREYNEREAYI 386
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  409 QKAKEEGKTSARVPGIPMTSNGYNAYFGTPYLVAsehPEKEWSNTWFAKYYGLEKVYLDD 468
Cdd:pfam19528 387 QEQKAKGEKDVVVPPIRPPKNRYSAYYGLSDIGT---DPKAWINKWYAKYYGLKSIKGVP 443
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
138-355 2.61e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 138 LALTFLLMWFFIPgmgstvlwVSGAANYLWATVIILLFLLPYRFnvstkrgweeFYLPVLGLLAGLTN------------ 205
Cdd:COG2211   91 LALSFVLLFTAPD--------LSPTGKLIYALVTYLLLGLAYTL----------VNIPYSALGAELTPdyeertrlsswr 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 206 EVGGATTVLLALIFTVYNLKKSGSGNTVA-QILGTVAVAFGFGTQVILSSGSAETQNYGASTglgQRFLDILSGTAHYSG 284
Cdd:COG2211  153 FAFAGLGGLLASVLPPPLVAAFGGDAALGyRLTALIFAVLGLLAFLLTFFGTKERPVPEEEK---VSLKESLKALLKNRP 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 285 FLLLPIVVF----------GVLLYFNRDQLQEKAcnlwhgGIIFLISGLAGCFAILASPIIPA--------RLWVASNIL 346
Cdd:COG2211  230 FLLLLLAYLlfflalalvaALLLYYFKYVLGLSA------ALVGLLLALYFLAALLGAPLWPRlakrfgkkKAFIIGLLL 303

                 ....*....
gi 407623942 347 FIIALLMMF 355
Cdd:COG2211  304 AALGLLLLF 312
Collagen_mid pfam15984
Bacterial collagen, middle region; Collagen_mid is the conserved central region of bacterial ...
195-277 1.31e-03

Bacterial collagen, middle region; Collagen_mid is the conserved central region of bacterial collagen triple helix repeat proteins.


Pssm-ID: 435053 [Multi-domain]  Cd Length: 198  Bit Score: 40.78  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942  195 PVLGLLAGLTNEVGGATTvllaliftvynlkksGSGNTVAQILGTVAVAfGFGTQV------ILSSGSAETQNYGASTGL 268
Cdd:pfam15984  82 PVTTPLGGTVSTLGGAVT---------------GGGTTLGTALSTGPVQ-QLTQQVssaitpITSTVTGTTQTVGAATGL 145

                  ....*....
gi 407623942  269 GQRFLDILS 277
Cdd:pfam15984 146 GAPVNGLLG 154
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
135-385 6.27e-03

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 39.74  E-value: 6.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 135 FLHLALTFLLMwfFIPGMGstvlwVSGAAnylWATVI-------ILLFLL-----PYRFNVSTKRGWEEFYLPVL--GLL 200
Cdd:COG0534  168 VLNIVLDPLLI--FGGGLG-----VAGAA---LATVIsqavsalLLLYYLfrkrsLLRLRLRDLRPDRKILKRILriGLP 237
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 201 AGLTNEVGGATTVLLALIFTVYnlkksGS--------GNTVAQILGTVAVAFGFGTQVILSsgsaetQNYGAstGLGQRF 272
Cdd:COG0534  238 AGLQQLAESLGFLVLNALVARL-----GTaavaaygiALRIESLAFMPALGLGQAAQPLVG------QNLGA--GDYDRA 304
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407623942 273 LDILSGTAHYSGFLLlpiVVFGVLLYFNRDQlqekacnlwhggiiflisgLAGCFaiLASPIIparLWVASNILFIIALL 352
Cdd:COG0534  305 RRAARLALLLALGIG---LLLALLLFLFPEP-------------------IIGLF--TDDPEV---IALAATYLRIAALF 357
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 407623942 353 MMFEAWQE-----LRAqSSWTNVPLCIAILCLTFVSLP 385
Cdd:COG0534  358 QPFDGLQFvlsgaLRG-AGDTRFPMIISLLRLWLVRLP 394
MucBP_2 pfam17965
Mucin binding domain; This domain is found in bacterial cell surface proteins that interact ...
545-607 7.02e-03

Mucin binding domain; This domain is found in bacterial cell surface proteins that interact with mucins. The archetypal member of this family is the Mub-R5 B1 domain. This domain has a beta-grasp fold.


Pssm-ID: 465592 [Multi-domain]  Cd Length: 75  Bit Score: 35.76  E-value: 7.02e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 407623942  545 NALIRYIDVNKDEIVATEQITSPYNEVYDISHAST------AGYEtLISN--PKSYVF---NKRYDQTIDIHVK 607
Cdd:pfam17965   2 TATITYIDDTTGQTLSTDTLTGKTGETIDYTTADTikelepKGYV-LVSDgfPAGTTTfdaDDATDQTYTVHLK 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure