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Conserved domains on  [gi|378731727|gb|EHY58186|]
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hypothetical protein HMPREF1120_06198 [Exophiala dermatitidis NIH/UT8656]

Protein Classification

telomere length and silencing 1 family protein( domain architecture ID 10537165)

telomere length and silencing 1 (TLS1) family protein similar to human TLS1 homolog, also called hepatocellular carcinoma-associated antigen 59, that is involved in the regulation of telomeric heterochromatin assembly and control of telomere length

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hep_59 pfam07052
Hepatocellular carcinoma-associated antigen 59; This family represents a conserved region ...
 111-213 2.03e-09

Hepatocellular carcinoma-associated antigen 59; This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 (HCA59). Family members are found in a variety of eukaryotes, such as fission yeast where telomere length and silencing protein 1 (Tls1) is required for telomeric heterochromatin assembly as well as telomere length control. Homologs in Arabidopsis are known as Cop1 suppressor 2 (CSU2). Csu2 inhibits constitutive photomorphogenic 1 (COP1) E3 ubiquitin ligase activity. Furthermore, CSU2 is required for primary root development under normal light growth condition.


:

Pssm-ID: 462074  Cd Length: 102  Bit Score: 54.29  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731727  111 RFVSSTGQaINVDQHMVAFIDAELARRRnrtvspsNDAQQQNTEKDSEVETPPDKPHTE-----STIQSASATSNVPTLS 185
Cdd:pfam07052   1 RFTKQTGT-RDVDKHMMKYIEEELAKRK-------GQQQDENEGDEGSASSKSEDPIDElyalpEHLKRSSKKESEEALS 72

                          90       100
                  ....*....|....*....|....*...
gi 378731727  186 hPATVRQLTEVDLGDSAHEINLARIQAA 213
Cdd:pfam07052  73 -NQMLTGIPEVDLGIEAKLKNIEETEKA 99
 
Name Accession Description Interval E-value
Hep_59 pfam07052
Hepatocellular carcinoma-associated antigen 59; This family represents a conserved region ...
 111-213 2.03e-09

Hepatocellular carcinoma-associated antigen 59; This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 (HCA59). Family members are found in a variety of eukaryotes, such as fission yeast where telomere length and silencing protein 1 (Tls1) is required for telomeric heterochromatin assembly as well as telomere length control. Homologs in Arabidopsis are known as Cop1 suppressor 2 (CSU2). Csu2 inhibits constitutive photomorphogenic 1 (COP1) E3 ubiquitin ligase activity. Furthermore, CSU2 is required for primary root development under normal light growth condition.


Pssm-ID: 462074  Cd Length: 102  Bit Score: 54.29  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731727  111 RFVSSTGQaINVDQHMVAFIDAELARRRnrtvspsNDAQQQNTEKDSEVETPPDKPHTE-----STIQSASATSNVPTLS 185
Cdd:pfam07052   1 RFTKQTGT-RDVDKHMMKYIEEELAKRK-------GQQQDENEGDEGSASSKSEDPIDElyalpEHLKRSSKKESEEALS 72

                          90       100
                  ....*....|....*....|....*...
gi 378731727  186 hPATVRQLTEVDLGDSAHEINLARIQAA 213
Cdd:pfam07052  73 -NQMLTGIPEVDLGIEAKLKNIEETEKA 99
 
Name Accession Description Interval E-value
Hep_59 pfam07052
Hepatocellular carcinoma-associated antigen 59; This family represents a conserved region ...
 111-213 2.03e-09

Hepatocellular carcinoma-associated antigen 59; This family represents a conserved region approximately 100 residues long within mammalian hepatocellular carcinoma-associated antigen 59 (HCA59). Family members are found in a variety of eukaryotes, such as fission yeast where telomere length and silencing protein 1 (Tls1) is required for telomeric heterochromatin assembly as well as telomere length control. Homologs in Arabidopsis are known as Cop1 suppressor 2 (CSU2). Csu2 inhibits constitutive photomorphogenic 1 (COP1) E3 ubiquitin ligase activity. Furthermore, CSU2 is required for primary root development under normal light growth condition.


Pssm-ID: 462074  Cd Length: 102  Bit Score: 54.29  E-value: 2.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 378731727  111 RFVSSTGQaINVDQHMVAFIDAELARRRnrtvspsNDAQQQNTEKDSEVETPPDKPHTE-----STIQSASATSNVPTLS 185
Cdd:pfam07052   1 RFTKQTGT-RDVDKHMMKYIEEELAKRK-------GQQQDENEGDEGSASSKSEDPIDElyalpEHLKRSSKKESEEALS 72

                          90       100
                  ....*....|....*....|....*...
gi 378731727  186 hPATVRQLTEVDLGDSAHEINLARIQAA 213
Cdd:pfam07052  73 -NQMLTGIPEVDLGIEAKLKNIEETEKA 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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