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Conserved domains on  [gi|342880055|gb|EGU81266|]
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hypothetical protein FOXB_08222 [Fusarium oxysporum f. sp. conglutinans Fo5176]

Protein Classification

RNase_H_Dikarya_like domain-containing protein( domain architecture ID 10195359)

RNase_H_Dikarya_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNase_H_Dikarya_like cd13934
Fungal (dikarya) Ribonuclease H, uncharacterized; This family contains dikarya RNase H, many ...
 70-221 2.08e-74

Fungal (dikarya) Ribonuclease H, uncharacterized; This family contains dikarya RNase H, many of which are uncharacterized. Ribonuclease H (RNase H) enzymes are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. It is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. An important RNase H function is to remove Okazaki fragments during DNA replication.


:

Pssm-ID: 260014 [Multi-domain]  Cd Length: 153  Bit Score: 222.07  E-value: 2.08e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  70 IAVDGACRGNGTPDAKAAIGVFVGETSSFNRCLLLRQ---VPVTNQIAELNAGIVALEQAMEILRtkaLGEEPLHKVVIK 146
Cdd:cd13934    2 VYIDGACRNNGRPDARAGYGVYFGPDSSYNVSGRLEDtggHPQTSQRAELRAAIAALRFRSWIID---PDGEGLKTVVIA 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342880055 147 ADSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLVEDLNASNVEVLFWHVPRDMNKEADKLANQAFN 221
Cdd:cd13934   79 TDSEYVVKGATEWIPKWKRNGWRTSKGKPVKNRDLFELLLDEIEDLEEGGVEVQFWHVPRELNKEADRLAKAAAE 153
 
Name Accession Description Interval E-value
RNase_H_Dikarya_like cd13934
Fungal (dikarya) Ribonuclease H, uncharacterized; This family contains dikarya RNase H, many ...
 70-221 2.08e-74

Fungal (dikarya) Ribonuclease H, uncharacterized; This family contains dikarya RNase H, many of which are uncharacterized. Ribonuclease H (RNase H) enzymes are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. It is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. An important RNase H function is to remove Okazaki fragments during DNA replication.


Pssm-ID: 260014 [Multi-domain]  Cd Length: 153  Bit Score: 222.07  E-value: 2.08e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  70 IAVDGACRGNGTPDAKAAIGVFVGETSSFNRCLLLRQ---VPVTNQIAELNAGIVALEQAMEILRtkaLGEEPLHKVVIK 146
Cdd:cd13934    2 VYIDGACRNNGRPDARAGYGVYFGPDSSYNVSGRLEDtggHPQTSQRAELRAAIAALRFRSWIID---PDGEGLKTVVIA 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342880055 147 ADSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLVEDLNASNVEVLFWHVPRDMNKEADKLANQAFN 221
Cdd:cd13934   79 TDSEYVVKGATEWIPKWKRNGWRTSKGKPVKNRDLFELLLDEIEDLEEGGVEVQFWHVPRELNKEADRLAKAAAE 153
RnhA COG0328
Ribonuclease HI [Replication, recombination and repair];
66-219 8.49e-29

Ribonuclease HI [Replication, recombination and repair];


Pssm-ID: 440097 [Multi-domain]  Cd Length: 136  Bit Score: 104.93  E-value: 8.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  66 DCIFIAVDGACRGNGTPdakAAIGVFV---GETSSFNRCLLLrqvpVTNQIAELNAGIVALEqameilrtkALGEEPLHK 142
Cdd:COG0328    1 KMIEIYTDGACRGNPGP---GGWGAVIrygGEEKELSGGLGD----TTNNRAELTALIAALE---------ALKELGPCE 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055 143 VVIKADSEYLVKGMTEWVFKWETNGYRnakrdPVKNSDLFKRLNRLvedlnASNVEVLFWHVPR----DMNKEADKLANQ 218
Cdd:COG0328   65 VEIYTDSQYVVNQITGWIHGWKKNGWK-----PVKNPDLWQRLDEL-----LARHKVTFEWVKGhaghPGNERADALANK 134


                 .
gi 342880055 219 A 219
Cdd:COG0328  135 A 135
rnhA PRK00203
ribonuclease H; Reviewed
 68-219 1.28e-21

ribonuclease H; Reviewed


Pssm-ID: 178927 [Multi-domain]  Cd Length: 150  Bit Score: 86.80  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  68 IFIAVDGACRGNGTPDAKAAIGVFVG---ETSSFNRClllrqvpVTNQIAELNAGIVALEqameilrtkALgEEPLhKVV 144
Cdd:PRK00203   4 VEIYTDGACLGNPGPGGWGAILRYKGhekELSGGEAL-------TTNNRMELMAAIEALE---------AL-KEPC-EVT 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 342880055 145 IKADSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLVedlNASNVEvLFW---HVPRDMNKEADKLANQA 219
Cdd:PRK00203  66 LYTDSQYVRQGITEWIHGWKKNGWKTADKKPVKNVDLWQRLDAAL---KRHQIK-WHWvkgHAGHPENERCDELARAG 139
RNase_H pfam00075
RNase H; RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral ...
 70-219 3.49e-21

RNase H; RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.


Pssm-ID: 395028 [Multi-domain]  Cd Length: 141  Bit Score: 85.51  E-value: 3.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055   70 IAVDGACRGNGTPdAKAAIGVFvgetssFNRCLLLRQVP--VTNQIAELNAGIVALeqameilrtKALGEEPlhKVVIKA 147
Cdd:pfam00075   6 VYTDGSCLGNPGP-GGAGAVLY------RGHENISAPLPgrTTNNRAELQAVIEAL---------KALKSPS--KVNIYT 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 342880055  148 DSEYLVKGMTEWVFKWETNGYRNA-KRDPVKNSDLFKRLNRLvedlnASNVEVLFWHVPRDM----NKEADKLANQA 219
Cdd:pfam00075  68 DSQYVIGGITQWVHGWKKNGWPTTsEGKPVKNKDLWQLLKAL-----CKKHQVYWQWVKGHAgnpgNEMADRLAKQG 139
 
Name Accession Description Interval E-value
RNase_H_Dikarya_like cd13934
Fungal (dikarya) Ribonuclease H, uncharacterized; This family contains dikarya RNase H, many ...
 70-221 2.08e-74

Fungal (dikarya) Ribonuclease H, uncharacterized; This family contains dikarya RNase H, many of which are uncharacterized. Ribonuclease H (RNase H) enzymes are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. It is widely present in various organisms, including bacteria, archaea and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. An important RNase H function is to remove Okazaki fragments during DNA replication.


Pssm-ID: 260014 [Multi-domain]  Cd Length: 153  Bit Score: 222.07  E-value: 2.08e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  70 IAVDGACRGNGTPDAKAAIGVFVGETSSFNRCLLLRQ---VPVTNQIAELNAGIVALEQAMEILRtkaLGEEPLHKVVIK 146
Cdd:cd13934    2 VYIDGACRNNGRPDARAGYGVYFGPDSSYNVSGRLEDtggHPQTSQRAELRAAIAALRFRSWIID---PDGEGLKTVVIA 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342880055 147 ADSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLVEDLNASNVEVLFWHVPRDMNKEADKLANQAFN 221
Cdd:cd13934   79 TDSEYVVKGATEWIPKWKRNGWRTSKGKPVKNRDLFELLLDEIEDLEEGGVEVQFWHVPRELNKEADRLAKAAAE 153
RNase_HI_eukaryote_like cd09280
Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic ...
 72-219 2.88e-43

Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts; Ribonuclease H (RNase H) is classified into two families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. RNase H is widely present in various organisms, including bacteria, archaea and eukaryote and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. Eukaryotic RNase H is longer and more complex than in prokaryotes. Almost all eukaryotic RNase HI have highly conserved regions at their N-termini called hybrid binding domain (HBD). It is speculated that the HBD contributes to binding the RNA/DNA hybrid. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability, but RNase H is essential in higher eukaryotes. RNase H knockout mice lack mitochondrial DNA replication and die as embryos.


Pssm-ID: 260012 [Multi-domain]  Cd Length: 145  Bit Score: 142.32  E-value: 2.88e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  72 VDGACRGNGTPDAKAAIGVFVGETSSFNRCLLLRQVPVTNQIAELNAGIVALEQAMeilrtkalgEEPLHKVVIKADSEY 151
Cdd:cd09280    4 TDGSCLNNGKPGARAGIGVYFGPGDPRNVSEPLPGRKQTNNRAELLAVIHALEQAP---------EEGIRKLEIRTDSKY 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 342880055 152 LVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLvedLNASNVEVLFWHVP----RDMNKEADKLANQA 219
Cdd:cd09280   75 AINCITKWIPKWKKNGWKTSKGKPVKNQDLIKELDKL---LRKRGIKVKFEHVKghsgDPGNEEADRLAREG 143
RnhA COG0328
Ribonuclease HI [Replication, recombination and repair];
66-219 8.49e-29

Ribonuclease HI [Replication, recombination and repair];


Pssm-ID: 440097 [Multi-domain]  Cd Length: 136  Bit Score: 104.93  E-value: 8.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  66 DCIFIAVDGACRGNGTPdakAAIGVFV---GETSSFNRCLLLrqvpVTNQIAELNAGIVALEqameilrtkALGEEPLHK 142
Cdd:COG0328    1 KMIEIYTDGACRGNPGP---GGWGAVIrygGEEKELSGGLGD----TTNNRAELTALIAALE---------ALKELGPCE 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055 143 VVIKADSEYLVKGMTEWVFKWETNGYRnakrdPVKNSDLFKRLNRLvedlnASNVEVLFWHVPR----DMNKEADKLANQ 218
Cdd:COG0328   65 VEIYTDSQYVVNQITGWIHGWKKNGWK-----PVKNPDLWQRLDEL-----LARHKVTFEWVKGhaghPGNERADALANK 134


                 .
gi 342880055 219 A 219
Cdd:COG0328  135 A 135
RNase_HI_prokaryote_like cd09278
RNase HI family found mainly in prokaryotes; Ribonuclease H (RNase H) is classified into two ...
 68-219 1.08e-24

RNase HI family found mainly in prokaryotes; Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD), residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Prokaryotic RNase H varies greatly in domain structures and substrate specificities. Prokaryotes and some single-cell eukaryotes do not require RNase H for viability.


Pssm-ID: 260010 [Multi-domain]  Cd Length: 139  Bit Score: 94.47  E-value: 1.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  68 IFIAVDGACRGNGTPDAKAAIGVFVGET---SSFNRClllrqvpVTNQIAELNAGIVALEQAmeilrtkalgeEPLHKVV 144
Cdd:cd09278    2 IVIYTDGACLGNPGPGGWAAVIRYGDHEkelSGGEPG-------TTNNRMELTAAIEALEAL-----------KEPCPVT 63

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 342880055 145 IKADSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLvedLNASNVEvLFW---HVPRDMNKEADKLANQA 219
Cdd:cd09278   64 IYTDSQYVINGITKWIKGWKKNGWKTADGKPVKNRDLWQELDAL---LAGHKVT-WEWvkgHAGHPGNERADRLANKA 137
rnhA PRK00203
ribonuclease H; Reviewed
 68-219 1.28e-21

ribonuclease H; Reviewed


Pssm-ID: 178927 [Multi-domain]  Cd Length: 150  Bit Score: 86.80  E-value: 1.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  68 IFIAVDGACRGNGTPDAKAAIGVFVG---ETSSFNRClllrqvpVTNQIAELNAGIVALEqameilrtkALgEEPLhKVV 144
Cdd:PRK00203   4 VEIYTDGACLGNPGPGGWGAILRYKGhekELSGGEAL-------TTNNRMELMAAIEALE---------AL-KEPC-EVT 65

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 342880055 145 IKADSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLVedlNASNVEvLFW---HVPRDMNKEADKLANQA 219
Cdd:PRK00203  66 LYTDSQYVRQGITEWIHGWKKNGWKTADKKPVKNVDLWQRLDAAL---KRHQIK-WHWvkgHAGHPENERCDELARAG 139
RNase_H pfam00075
RNase H; RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral ...
 70-219 3.49e-21

RNase H; RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.


Pssm-ID: 395028 [Multi-domain]  Cd Length: 141  Bit Score: 85.51  E-value: 3.49e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055   70 IAVDGACRGNGTPdAKAAIGVFvgetssFNRCLLLRQVP--VTNQIAELNAGIVALeqameilrtKALGEEPlhKVVIKA 147
Cdd:pfam00075   6 VYTDGSCLGNPGP-GGAGAVLY------RGHENISAPLPgrTTNNRAELQAVIEAL---------KALKSPS--KVNIYT 67

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 342880055  148 DSEYLVKGMTEWVFKWETNGYRNA-KRDPVKNSDLFKRLNRLvedlnASNVEVLFWHVPRDM----NKEADKLANQA 219
Cdd:pfam00075  68 DSQYVIGGITQWVHGWKKNGWPTTsEGKPVKNKDLWQLLKAL-----CKKHQVYWQWVKGHAgnpgNEMADRLAKQG 139
RNase_H_like cd06222
Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of ...
 70-217 8.00e-17

Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Ribonuclease H (RNase H) enzymes are divided into two major families, Type 1 and Type 2, based on amino acid sequence similarities and biochemical properties. RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner in the presence of divalent cations. It is widely present in various organisms, including bacteria, archaea, and eukaryotes. Most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site residues and have the same catalytic mechanism and functions in cells. RNase H is involved in DNA replication, repair and transcription. An important RNase H function is to remove Okazaki fragments during DNA replication. RNase H inhibitors have been explored as anti-HIV drug targets since RNase H inactivation inhibits reverse transcription. This model also includes the Prp8 domain IV, which adopts the RNase fold but shows low sequence homology; domain IV is implicated in key spliceosomal interactions.


Pssm-ID: 259998 [Multi-domain]  Cd Length: 121  Bit Score: 73.50  E-value: 8.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  70 IAVDGACRGNGTPDAKAAI-----GVFVGETSSFNRClllrqvpVTNQIAELNAGIVALEQAMEIlrtkalgeePLHKVV 144
Cdd:cd06222    1 INVDGSCRGNPGPAGIGGVlrdheGGWLGGFALKIGA-------PTALEAELLALLLALELALDL---------GYLKVI 64

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 342880055 145 IKADSEYLVKGMTEWVFKWETNGyrnakrdpvknsDLFKRLNRLVEDlnasNVEVLFWHVPRDMNKEADKLAN 217
Cdd:cd06222   65 IESDSKYVVDLINSGSFKWSPNI------------LLIEDILLLLSR----FWSVKISHVPREGNQVADALAK 121
RNase_HI_like cd09279
RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Ribonuclease ...
 68-219 1.09e-16

RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Ribonuclease H (RNase H) is classified into two evolutionarily unrelated families, type 1 (prokaryotic RNase HI, eukaryotic RNase H1 and viral RNase H) and type 2 (prokaryotic RNase HII and HIII, and eukaryotic RNase H2). RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner. RNase H is involved in DNA replication, repair and transcription. RNase H is widely present in various organisms, including bacteria, archaea and eukaryotes and most prokaryotic and eukaryotic genomes contain multiple RNase H genes. Despite the lack of amino acid sequence homology, type 1 and type 2 RNase H share a main-chain fold and steric configurations of the four acidic active-site (DEDD) residues and have the same catalytic mechanism and functions in cells. One of the important functions of RNase H is to remove Okazaki fragments during DNA replication. Most archaeal genomes contain only type 2 RNase H (RNase HII); however, a few contain RNase HI as well. Although archaeal RNase HI sequences conserve the DEDD active-site motif, they lack other common features important for catalytic function, such as the basic protrusion region. Archaeal RNase HI homologs are more closely related to retroviral RNase HI than bacterial and eukaryotic type I RNase H in enzymatic properties.


Pssm-ID: 260011 [Multi-domain]  Cd Length: 128  Bit Score: 73.28  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  68 IFIAVDGACRGNGTPdakAAIGVFVgeTSSFNRCLLLRQ---VPVTNQIAELNAGIVALEQAmeilrtKALGEEplhKVV 144
Cdd:cd09279    1 WTLYFDGASRGNPGP---AGAGVVI--YSPGGEVLELSErlgFPATNNEAEYEALIAGLELA------LELGAE---KLE 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342880055 145 IKADSEYLVKGMTewvfkwetngyrnaKRDPVKNSDLfKRLNRLVEDLNASNVEVLFWHVPRDMNKEADKLANQA 219
Cdd:cd09279   67 IYGDSQLVVNQLN--------------GEYKVKNERL-KPLLEKVLELLAKFELVELKWIPREQNKEADALANQA 126
PRK06548 PRK06548
ribonuclease H; Provisional
 110-222 8.21e-12

ribonuclease H; Provisional


Pssm-ID: 75628 [Multi-domain]  Cd Length: 161  Bit Score: 61.37  E-value: 8.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055 110 TNQIAELNAgivaleqAMEILRTKALGEEPlhkVVIKADSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKRLNRLV 189
Cdd:PRK06548  41 TNNIAELTA-------VRELLIATRHTDRP---ILILSDSKYVINSLTKWVYSWKMRKWRKADGKPVLNQEIIQEIDSLM 110

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 342880055 190 EDLNASnvevLFW---HVPRDMNKEADKLANQAFNS 222
Cdd:PRK06548 111 ENRNIR----MSWvnaHTGHPLNEAADSLARQAANN 142
PRK08719 PRK08719
ribonuclease H; Reviewed
 70-219 8.61e-11

ribonuclease H; Reviewed


Pssm-ID: 236334 [Multi-domain]  Cd Length: 147  Bit Score: 57.95  E-value: 8.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  70 IAVDGACRGNGTPDAKAAIGVFVGETSS--FNRCLLLRQVPVTNQIAELNAGIVALEQAMEilrtkalGEeplhkvVIKA 147
Cdd:PRK08719   7 IYIDGAAPNNQHGCVRGGIGLVVYDEAGeiVDEQSITVNRYTDNAELELLALIEALEYARD-------GD------VIYS 73

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342880055 148 DSEYLVKGMTEWVFKWETNGYRNAKRDPVKNSDLFKrlnrLVEDLNASN-VEVLF--WHVPRDMNKEADKLANQA 219
Cdd:PRK08719  74 DSDYCVRGFNEWLDTWKQKGWRKSDKKPVANRDLWQ----QVDELRARKyVEVEKvtAHSGIEGNEAADMLAQAA 144
RVT_3 pfam13456
Reverse transcriptase-like; This domain is found in plants and appears to be part of a ...
 72-219 2.10e-06

Reverse transcriptase-like; This domain is found in plants and appears to be part of a retrotransposon.


Pssm-ID: 433223 [Multi-domain]  Cd Length: 123  Bit Score: 45.33  E-value: 2.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055   72 VDGACRGNGTPDAKAAI-----GVFVGETS-SFNRCLllrqvpvTNQIAELNAGIVALEQAMEilrtkaLGeepLHKVVI 145
Cdd:pfam13456   2 FDGAFKCDSGLAGAGVVirdpnGNVLLAGQkKLGPGA-------SVLEAEAQALIIGLQLAWK------LG---IRHLIV 65

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 342880055  146 KADSEYLVKGMTEwvfKWETNGYRNAKRDPVKnsDLFKRLnrlvedlnasnVEVLFWHVPRDMNKEADKLANQA 219
Cdd:pfam13456  66 EGDSATVVQLING---RSPKQSKLANLLDEIR--KLLKRF-----------ESVSFEHIPREQNRVADTLAKMA 123
PRK07238 PRK07238
bifunctional RNase H/acid phosphatase; Provisional
 70-219 2.25e-04

bifunctional RNase H/acid phosphatase; Provisional


Pssm-ID: 180903 [Multi-domain]  Cd Length: 372  Bit Score: 41.50  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 342880055  70 IAVDGACRGNGTPDAKAAIgVFVGETSSfnrclLLRQVP-----VTNQIAELNAGIVALEQAMEILRTKalgeeplhkVV 144
Cdd:PRK07238   5 VEADGGSRGNPGPAGYGAV-VWDADRGE-----VLAERAeaigrATNNVAEYRGLIAGLEAAAELGATE---------VE 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 342880055 145 IKADSEYLVKGMTEwvfKWEtngyrnakrdpVKNSDLfKRLNRLVEDLNASNVEVLFWHVPRDMNKEADKLANQA 219
Cdd:PRK07238  70 VRMDSKLVVEQMSG---RWK-----------VKHPDM-KPLAAQARELASQFGRVTYTWIPRARNAHADRLANEA 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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