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Conserved domains on  [gi|281405619|gb|EFB36299|]
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hypothetical protein PREVCOP_04188 [Segatella copri DSM 18205]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CysN super family cl34513
Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family [Inorganic ion transport and ...
 14-59 1.41e-20

Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family [Inorganic ion transport and metabolism]; Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family is part of the Pathway/BioSystem: Cysteine biosynthesis


The actual alignment was detected with superfamily member COG2895:

Pssm-ID: 442140 [Multi-domain]  Cd Length: 430  Bit Score: 82.44  E-value: 1.41e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281405619  14 LSLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALDISSLT 59
Cdd:COG2895  143 ASLLGIRHVVVAVNKMDLVDYSEEVFEEIVADYRAFAAKLGLEDIT 188
 
Name Accession Description Interval E-value
CysN COG2895
Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family [Inorganic ion transport and ...
 14-59 1.41e-20

Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family [Inorganic ion transport and metabolism]; Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 442140 [Multi-domain]  Cd Length: 430  Bit Score: 82.44  E-value: 1.41e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281405619  14 LSLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALDISSLT 59
Cdd:COG2895  143 ASLLGIRHVVVAVNKMDLVDYSEEVFEEIVADYRAFAAKLGLEDIT 188
PRK05506 PRK05506
bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional
 15-60 3.68e-18

bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional


Pssm-ID: 180120 [Multi-domain]  Cd Length: 632  Bit Score: 76.12  E-value: 3.68e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281405619  15 SLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALDISSLTT 60
Cdd:PRK05506 153 SLLGIRHVVLAVNKMDLVDYDQEVFDEIVADYRAFAAKLGLHDVTF 198
CysN_ATPS cd04166
CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; CysN_ATPS ...
 14-59 9.31e-18

CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which catalyzes ATP hydrolysis, is a member of the ATP pyrophosphatase (ATP PPase) family. CysN hydrolysis of GTP is required for CysD hydrolysis of ATP; however, CysN hydrolysis of GTP is not dependent on CysD hydrolysis of ATP. CysN is an example of lateral gene transfer followed by acquisition of new function. In many organisms, an ATPS exists which is not GTP-dependent and shares no sequence or structural similarity to CysN.


Pssm-ID: 206729 [Multi-domain]  Cd Length: 209  Bit Score: 72.60  E-value: 9.31e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281405619  14 LSLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALDISSLT 59
Cdd:cd04166  126 ASLLGIRHVVVAVNKMDLVDYDEEVFEEIKADYLAFAASLGIEDIT 171
 
Name Accession Description Interval E-value
CysN COG2895
Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family [Inorganic ion transport and ...
 14-59 1.41e-20

Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family [Inorganic ion transport and metabolism]; Sulfate adenylyltransferase subunit 1, EFTu-like GTPase family is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 442140 [Multi-domain]  Cd Length: 430  Bit Score: 82.44  E-value: 1.41e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281405619  14 LSLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALDISSLT 59
Cdd:COG2895  143 ASLLGIRHVVVAVNKMDLVDYSEEVFEEIVADYRAFAAKLGLEDIT 188
PRK05506 PRK05506
bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional
 15-60 3.68e-18

bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional


Pssm-ID: 180120 [Multi-domain]  Cd Length: 632  Bit Score: 76.12  E-value: 3.68e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281405619  15 SLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALDISSLTT 60
Cdd:PRK05506 153 SLLGIRHVVLAVNKMDLVDYDQEVFDEIVADYRAFAAKLGLHDVTF 198
CysN_ATPS cd04166
CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; CysN_ATPS ...
 14-59 9.31e-18

CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which catalyzes ATP hydrolysis, is a member of the ATP pyrophosphatase (ATP PPase) family. CysN hydrolysis of GTP is required for CysD hydrolysis of ATP; however, CysN hydrolysis of GTP is not dependent on CysD hydrolysis of ATP. CysN is an example of lateral gene transfer followed by acquisition of new function. In many organisms, an ATPS exists which is not GTP-dependent and shares no sequence or structural similarity to CysN.


Pssm-ID: 206729 [Multi-domain]  Cd Length: 209  Bit Score: 72.60  E-value: 9.31e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 281405619  14 LSLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALDISSLT 59
Cdd:cd04166  126 ASLLGIRHVVVAVNKMDLVDYDEEVFEEIKADYLAFAASLGIEDIT 171
cysN PRK05124
sulfate adenylyltransferase subunit 1; Provisional
 15-54 7.33e-15

sulfate adenylyltransferase subunit 1; Provisional


Pssm-ID: 235349 [Multi-domain]  Cd Length: 474  Bit Score: 66.48  E-value: 7.33e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 281405619  15 SLLGIPHILVAINKMDLVDFSKDVYDKIVADYKKMSEALD 54
Cdd:PRK05124 156 TLLGIKHLVVAVNKMDLVDYSEEVFERIREDYLTFAEQLP 195
PRK12317 PRK12317
elongation factor 1-alpha; Reviewed
 17-49 3.85e-08

elongation factor 1-alpha; Reviewed


Pssm-ID: 237055 [Multi-domain]  Cd Length: 425  Bit Score: 47.61  E-value: 3.85e-08
                         10        20        30
                 ....*....|....*....|....*....|...
gi 281405619  17 LGIPHILVAINKMDLVDFSKDVYDKIVADYKKM 49
Cdd:PRK12317 137 LGINQLIVAINKMDAVNYDEKRYEEVKEEVSKL 169
TEF1 COG5256
Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and ...
 17-49 1.10e-07

Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]; Translation elongation factor EF-1alpha (GTPase) is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 444074 [Multi-domain]  Cd Length: 423  Bit Score: 46.08  E-value: 1.10e-07
                         10        20        30
                 ....*....|....*....|....*....|...
gi 281405619  17 LGIPHILVAINKMDLVDFSKDVYDKIVADYKKM 49
Cdd:COG5256  136 LGINQLIVAVNKMDAVNYSEKRYEEVKEEVSKL 168
EF1_alpha cd01883
Elongation Factor 1-alpha (EF1-alpha) protein family; EF1 is responsible for the GTP-dependent ...
 17-53 4.02e-06

Elongation Factor 1-alpha (EF1-alpha) protein family; EF1 is responsible for the GTP-dependent binding of aminoacyl-tRNAs to the ribosomes. EF1 is composed of four subunits: the alpha chain which binds GTP and aminoacyl-tRNAs, the gamma chain that probably plays a role in anchoring the complex to other cellular components and the beta and delta (or beta') chains. This subfamily is the alpha subunit, and represents the counterpart of bacterial EF-Tu for the archaea (aEF1-alpha) and eukaryotes (eEF1-alpha). eEF1-alpha interacts with the actin of the eukaryotic cytoskeleton and may thereby play a role in cellular transformation and apoptosis. EF-Tu can have no such role in bacteria. In humans, the isoform eEF1A2 is overexpressed in 2/3 of breast cancers and has been identified as a putative oncogene. This subfamily also includes Hbs1, a G protein known to be important for efficient growth and protein synthesis under conditions of limiting translation initiation in yeast, and to associate with Dom34. It has been speculated that yeast Hbs1 and Dom34 proteins may function as part of a complex with a role in gene expression.


Pssm-ID: 206670 [Multi-domain]  Cd Length: 219  Bit Score: 41.71  E-value: 4.02e-06
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 281405619  17 LGIPHILVAINKMDLV--DFSKDVYDKIVadyKKMSEAL 53
Cdd:cd01883  135 LGVKQLIVAVNKMDDVtvNWSQERYDEIK---KKVSPFL 170
SelB COG3276
Selenocysteine-specific translation elongation factor SelB [Translation, ribosomal structure ...
 14-33 1.55e-05

Selenocysteine-specific translation elongation factor SelB [Translation, ribosomal structure and biogenesis]; Selenocysteine-specific translation elongation factor SelB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 442507 [Multi-domain]  Cd Length: 630  Bit Score: 40.28  E-value: 1.55e-05
                         10        20
                 ....*....|....*....|
gi 281405619  14 LSLLGIPHILVAINKMDLVD 33
Cdd:COG3276   99 LDLLGIKRGIVVLTKADLVD 118
PTZ00141 PTZ00141
elongation factor 1- alpha; Provisional
 17-48 8.86e-05

elongation factor 1- alpha; Provisional


Pssm-ID: 185474 [Multi-domain]  Cd Length: 446  Bit Score: 38.19  E-value: 8.86e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 281405619  17 LGIPHILVAINKMDL--VDFSKDVYDKI---VADYKK 48
Cdd:PTZ00141 143 LGVKQMIVCINKMDDktVNYSQERYDEIkkeVSAYLK 179
SelB cd04171
SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; ...
 14-52 1.19e-04

SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of SelB recognizes this hairpin, while the N-terminal part binds GTP and tRNA in analogy with elongation factor Tu (EF-Tu). It specifically recognizes the selenocysteine charged tRNAsec, which has a UCA anticodon, in an EF-Tu like manner. This allows insertion of selenocysteine at in-frame UGA stop codons. In E. coli SelB binds GTP, selenocysteyl-tRNAsec, and a stem-loop structure immediately downstream of the UGA codon (the SECIS sequence). The absence of active SelB prevents the participation of selenocysteyl-tRNAsec in translation. Archaeal and animal mechanisms of selenocysteine incorporation are more complex. Although the SECIS elements have different secondary structures and conserved elements between archaea and eukaryotes, they do share a common feature. Unlike in E. coli, these SECIS elements are located in the 3' UTRs. This group contains bacterial SelBs, as well as, one from archaea.


Pssm-ID: 206734 [Multi-domain]  Cd Length: 170  Bit Score: 37.20  E-value: 1.19e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 281405619  14 LSLLGIPHILVAINKMDLVD--FSKDVYDKIVADYKKMSEA 52
Cdd:cd04171   98 LELLGIKKGLVVLTKADLVDedRLELVEEEILELLAGTFLA 138
TufA COG0050
Translation elongation factor EF-Tu, a GTPase [Translation, ribosomal structure and biogenesis] ...
 18-33 3.74e-03

Translation elongation factor EF-Tu, a GTPase [Translation, ribosomal structure and biogenesis]; Translation elongation factor EF-Tu, a GTPase is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439820 [Multi-domain]  Cd Length: 396  Bit Score: 33.59  E-value: 3.74e-03
                         10
                 ....*....|....*.
gi 281405619  18 GIPHILVAINKMDLVD 33
Cdd:COG0050  127 GVPYIVVFLNKCDMVD 142
GTP_translation_factor cd00881
GTP translation factor family primarily contains translation initiation, elongation and ...
 10-48 6.89e-03

GTP translation factor family primarily contains translation initiation, elongation and release factors; The GTP translation factor family consists primarily of translation initiation, elongation, and release factors, which play specific roles in protein translation. In addition, the family includes Snu114p, a component of the U5 small nuclear riboprotein particle which is a component of the spliceosome and is involved in excision of introns, TetM, a tetracycline resistance gene that protects the ribosome from tetracycline binding, and the unusual subfamily CysN/ATPS, which has an unrelated function (ATP sulfurylase) acquired through lateral transfer of the EF1-alpha gene and development of a new function.


Pssm-ID: 206647 [Multi-domain]  Cd Length: 183  Bit Score: 32.65  E-value: 6.89e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 281405619  10 RNASLSLLGIPHILVAINKMDLVDFSKdvYDKIVADYKK 48
Cdd:cd00881  105 EHLNIALAGGLPIIVAVNKIDRVGEED--FDEVLREIKE 141
EF_Tu cd01884
Elongation Factor Tu (EF-Tu) GTP-binding proteins; EF-Tu subfamily. This subfamily includes ...
 17-33 9.01e-03

Elongation Factor Tu (EF-Tu) GTP-binding proteins; EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors. The eukaryotic counterpart, eukaryotic translation elongation factor 1 (eEF-1 alpha), is excluded from this family. EF-Tu is one of the most abundant proteins in bacteria, as well as, one of the most highly conserved, and in a number of species the gene is duplicated with identical function. When bound to GTP, EF-Tu can form a complex with any (correctly) aminoacylated tRNA except those for initiation and for selenocysteine, in which case EF-Tu is replaced by other factors. Transfer RNA is carried to the ribosome in these complexes for protein translation.


Pssm-ID: 206671 [Multi-domain]  Cd Length: 195  Bit Score: 32.17  E-value: 9.01e-03
                         10
                 ....*....|....*..
gi 281405619  17 LGIPHILVAINKMDLVD 33
Cdd:cd01884  116 VGVPYIVVFLNKADMVD 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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