NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|281210018|gb|EFA84186|]
View 

hypothetical protein PPL_03261 [Heterostelium album PN500]

Protein Classification

methyltransferase domain-containing protein( domain architecture ID 1004954)

methyltransferase domain-containing protein may be a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK08317 super family cl32293
hypothetical protein; Provisional
 44-271 1.48e-42

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PRK08317:

Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 145.85  E-value: 1.48e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  44 HPATANITRKTKEELTLGEGDKIIDFGCGYGKDLKSFLNRVGPNGEVTGIDNSTAMIDYAKK-KFGDRPTVKLHVFSAEK 122
Cdd:PRK08317   1 LPDFRRYRARTFELLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKErAAGLGPNVEFVRGDADG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018 123 VDLPSNYYDVARCERLLQHVPNPVAVIDEMIRVTKDGGMVAISDTDWTSSKIYCPERLRdvTDRILNTkFN---CHPGVA 199
Cdd:PRK08317  81 LPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDWDTLVWHSGDRAL--MRKILNF-WSdhfADPWLG 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281210018 200 NELFSLV-NPKLKNTKVRGYMIQATSWEFA-KVVTLDLRAKRALDLKVITQEEYNDWVETMKDLDRKGQFYHSI 271
Cdd:PRK08317 158 RRLPGLFrEAGLTDIEVEPYTLIETDLKEAdKGFGLIRAARRAVEAGGISADEADAWLADLAQLARAGEFFFSV 231
 
Name Accession Description Interval E-value
PRK08317 PRK08317
hypothetical protein; Provisional
 44-271 1.48e-42

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 145.85  E-value: 1.48e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  44 HPATANITRKTKEELTLGEGDKIIDFGCGYGKDLKSFLNRVGPNGEVTGIDNSTAMIDYAKK-KFGDRPTVKLHVFSAEK 122
Cdd:PRK08317   1 LPDFRRYRARTFELLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKErAAGLGPNVEFVRGDADG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018 123 VDLPSNYYDVARCERLLQHVPNPVAVIDEMIRVTKDGGMVAISDTDWTSSKIYCPERLRdvTDRILNTkFN---CHPGVA 199
Cdd:PRK08317  81 LPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDWDTLVWHSGDRAL--MRKILNF-WSdhfADPWLG 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281210018 200 NELFSLV-NPKLKNTKVRGYMIQATSWEFA-KVVTLDLRAKRALDLKVITQEEYNDWVETMKDLDRKGQFYHSI 271
Cdd:PRK08317 158 RRLPGLFrEAGLTDIEVEPYTLIETDLKEAdKGFGLIRAARRAVEAGGISADEADAWLADLAQLARAGEFFFSV 231
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 56-171 2.91e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 100.45  E-value: 2.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  56 EELTLGEGDKIIDFGCGYGKDLKSFLNRvgpNGEVTGIDNSTAMIDYAKKKFGDRPT-VKLHVFSAEKVDLPSNYYDVAR 134
Cdd:COG2226   16 AALGLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGLnVEFVVGDAEDLPFPDGSFDLVI 92

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 281210018 135 CERLLQHVPNPVAVIDEMIRVTKDGGMVAISDTDWTS 171
Cdd:COG2226   93 SSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPD 129
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 66-160 3.81e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 88.00  E-value: 3.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018   66 IIDFGCGYGKDLKSFLNRVGpnGEVTGIDNSTAMIDYAKKKFGDR-PTVKLHVFSAEKVDLPSNYYDVARCERLLQHVPN 144
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAgLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*...
gi 281210018  145 P--VAVIDEMIRVTKDGG 160
Cdd:pfam13649  79 PdlEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 65-169 6.23e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 6.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  65 KIIDFGCGYGKDLKSFLNRvgPNGEVTGIDNSTAMIDYAKKKF--GDRPTVKLHVFSAEK-VDLPSNYYDVARCERLLQH 141
Cdd:cd02440    1 RVLDLGCGTGALALALASG--PGARVTGVDISPVALELARKAAaaLLADNVEVLKGDAEElPPEADESFDVIISDPPLHH 78

                         90       100
                 ....*....|....*....|....*....
gi 281210018 142 -VPNPVAVIDEMIRVTKDGGMVAISDTDW 169
Cdd:cd02440   79 lVEDLARFLEEARRLLKPGGVLVLTLVLA 107
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
65-167 5.88e-04

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 40.48  E-value: 5.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018    65 KIIDFGCGYGKDLKSfLNRVGPNGEVTGIDNSTAMIDYAKKK-----FGDRptVKLHVFSAEKVDLPSNYYDVARCErLL 139
Cdd:smart00828   2 RVLDFGCGYGSDLID-LAERHPHLQLHGYTISPEQAEVGRERiralgLQGR--IRIFYRDSAKDPFPDTYDLVFGFE-VI 77

                           90       100
                   ....*....|....*....|....*...
gi 281210018   140 QHVPNPVAVIDEMIRVTKDGGMVAISDT 167
Cdd:smart00828  78 HHIKDKMDLFSNISRHLKDGGHLVLADF 105
 
Name Accession Description Interval E-value
PRK08317 PRK08317
hypothetical protein; Provisional
 44-271 1.48e-42

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 145.85  E-value: 1.48e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  44 HPATANITRKTKEELTLGEGDKIIDFGCGYGKDLKSFLNRVGPNGEVTGIDNSTAMIDYAKK-KFGDRPTVKLHVFSAEK 122
Cdd:PRK08317   1 LPDFRRYRARTFELLAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKErAAGLGPNVEFVRGDADG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018 123 VDLPSNYYDVARCERLLQHVPNPVAVIDEMIRVTKDGGMVAISDTDWTSSKIYCPERLRdvTDRILNTkFN---CHPGVA 199
Cdd:PRK08317  81 LPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTDWDTLVWHSGDRAL--MRKILNF-WSdhfADPWLG 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 281210018 200 NELFSLV-NPKLKNTKVRGYMIQATSWEFA-KVVTLDLRAKRALDLKVITQEEYNDWVETMKDLDRKGQFYHSI 271
Cdd:PRK08317 158 RRLPGLFrEAGLTDIEVEPYTLIETDLKEAdKGFGLIRAARRAVEAGGISADEADAWLADLAQLARAGEFFFSV 231
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 56-171 2.91e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 100.45  E-value: 2.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  56 EELTLGEGDKIIDFGCGYGKDLKSFLNRvgpNGEVTGIDNSTAMIDYAKKKFGDRPT-VKLHVFSAEKVDLPSNYYDVAR 134
Cdd:COG2226   16 AALGLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGLnVEFVVGDAEDLPFPDGSFDLVI 92

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 281210018 135 CERLLQHVPNPVAVIDEMIRVTKDGGMVAISDTDWTS 171
Cdd:COG2226   93 SSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPD 129
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 66-160 3.81e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 88.00  E-value: 3.81e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018   66 IIDFGCGYGKDLKSFLNRVGpnGEVTGIDNSTAMIDYAKKKFGDR-PTVKLHVFSAEKVDLPSNYYDVARCERLLQHVPN 144
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAgLNVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLPD 78

                          90
                  ....*....|....*...
gi 281210018  145 P--VAVIDEMIRVTKDGG 160
Cdd:pfam13649  79 PdlEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 60-166 1.13e-20

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 85.07  E-value: 1.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  60 LGEGDKIIDFGCGYGKDLKSFLNRvgpNGEVTGIDNSTAMIDYAKKKfGDRPTVKLHVFSAEKVDLPSNYYDVARCERLL 139
Cdd:COG2227   22 LPAGGRVLDVGCGTGRLALALARR---GADVTGVDISPEALEIARER-AAELNVDFVQGDLEDLPLEDGSFDLVICSEVL 97

                         90       100
                 ....*....|....*....|....*..
gi 281210018 140 QHVPNPVAVIDEMIRVTKDGGMVAISD 166
Cdd:COG2227   98 EHLPDPAALLRELARLLKPGGLLLLST 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 67-164 5.67e-20

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 82.33  E-value: 5.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018   67 IDFGCGYGKDLKSfLNRVGPNgeVTGIDNSTAMIDYAKKKFGDRPtVKLHVFSAEKVDLPSNYYDVARCERLLQHVPNPV 146
Cdd:pfam08241   1 LDVGCGTGLLTEL-LARLGAR--VTGVDISPEMLELAREKAPREG-LTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPE 76

                          90
                  ....*....|....*...
gi 281210018  147 AVIDEMIRVTKDGGMVAI 164
Cdd:pfam08241  77 RALREIARVLKPGGILII 94
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 60-169 1.82e-18

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 80.15  E-value: 1.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018   60 LGEGDKIIDFGCGYGKDLKSFLNRVGPNGEVTGIDNSTAMIDYAKKKFGDRP--TVKLHVFSAEkvDLPSNY----YDVA 133
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGfdNVEFEQGDIE--ELPELLeddkFDVV 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 281210018  134 RCERLLQHVPNPVAVIDEMIRVTKDGGMVAISDTDW 169
Cdd:pfam13847  79 ISNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDS 114
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
62-166 1.43e-17

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 76.02  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  62 EGDKIIDFGCGYGKDLKSFLNRVgPNGEVTGIDNSTAMIDYAKKKFgdrPTVKLHVFSAEKVDLPSNyYDVARCERLLQH 141
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERF-PGARVTGVDLSPEMLARARARL---PNVRFVVADLRDLDPPEP-FDLVVSNAALHW 75

                         90       100
                 ....*....|....*....|....*
gi 281210018 142 VPNPVAVIDEMIRVTKDGGMVAISD 166
Cdd:COG4106   76 LPDHAALLARLAAALAPGGVLAVQV 100
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 52-167 4.39e-16

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 75.57  E-value: 4.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  52 RKTKEELTLGEGDKIIDFGCGYGKDLKSFLNRVGPNGEVTGIDNSTAMIDYAKKKFGDR---PTVKLHVFSAEKVDLPSN 128
Cdd:PRK00216  41 RKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKTGEVVGLDFSEGMLAVGREKLRDLglsGNVEFVQGDAEALPFPDN 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 281210018 129 YYDVA------RcerllqHVPNPVAVIDEMIRVTKDGGMVAISDT 167
Cdd:PRK00216 121 SFDAVtiafglR------NVPDIDKALREMYRVLKPGGRLVILEF 159
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 67-162 8.79e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 65.85  E-value: 8.79e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018   67 IDFGCGYGKDLKSFLNRVgPNGEVTGIDNSTAMIDYAKKKFGDRP-----TVKLHVFSAEKVDLPSnyYDVARCERLLQH 141
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAL-PGLEYTGLDISPAALEAARERLAALGllnavRVELFQLDLGELDPGS--FDVVVASNVLHH 77

                          90       100
                  ....*....|....*....|.
gi 281210018  142 VPNPVAVIDEMIRVTKDGGMV 162
Cdd:pfam08242  78 LADPRAVLRNIRRLLKPGGVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 59-168 2.84e-13

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 67.25  E-value: 2.84e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  59 TLGEGDKIIDFGCGYGKDLKSFLNRVGpnGEVTGIDNSTAMIDYAKKKFGDR--PTVKLHVFSAEK-VDLPSNYYDVARC 135
Cdd:COG0500   23 RLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAKAglGNVEFLVADLAElDPLPAESFDLVVA 100

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 281210018 136 ERLLQHVP--NPVAVIDEMIRVTKDGGMVAISDTD 168
Cdd:COG0500  101 FGVLHHLPpeEREALLRELARALKPGGVLLLSASD 135
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 58-168 1.70e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 61.29  E-value: 1.70e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018   58 LTLGEGDKIIDFGCGYGKDLKsFLNRVGPngEVTGIDNSTAMIDyakkkfGDRPTVKLHVFSAEKVDLPSNYYDVARCER 137
Cdd:pfam13489  18 PKLPSPGRVLDFGCGTGIFLR-LLRAQGF--SVTGVDPSPIAIE------RALLNVRFDQFDEQEAAVPAGKFDVIVARE 88

                          90       100       110
                  ....*....|....*....|....*....|.
gi 281210018  138 LLQHVPNPVAVIDEMIRVTKDGGMVAISDTD 168
Cdd:pfam13489  89 VLEHVPDPPALLRQIAALLKPGGLLLLSTPL 119
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
48-165 1.70e-10

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 58.86  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  48 ANITRKTKEELTLGEGDKIIDFGCGYGKDLKSFLNRVGpngEVTGIDNSTAMIDYAKKKFGDrptVKLHVFSAEKVDLPS 127
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGY---RLTGVDLSEEMLAKAREKGVY---DRLLVADLADLAEPD 105

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 281210018 128 NYYDVARCERLLQHVPNPVAVIDEMIRVTKDGGMVAIS 165
Cdd:COG4976  106 GRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFS 143
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 44-166 3.87e-10

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 57.25  E-value: 3.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  44 HPATANITRKTKEELTLGEGDKIIDFGCGYGKDLKSFLNRVGpnGEVTGIDNSTAMIDYAKKKF---GDRPTVKLHVFSA 120
Cdd:COG2230   33 EEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYARERAaeaGLADRVEVRLADY 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 281210018 121 EKVDlPSNYYDVARCERLLQHVPNPV--AVIDEMIRVTKDGGMVAISD 166
Cdd:COG2230  111 RDLP-ADGQFDAIVSIGMFEHVGPENypAYFAKVARLLKPGGRLLLHT 157
arsM PRK11873
arsenite methyltransferase;
60-166 2.02e-09

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 56.88  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  60 LGEGDKIIDFGCGYGKDlkSFL--NRVGPNGEVTGIDNSTAMIDYAKK--KFGDRPTVKLHVFSAEKVDLPSNYYDV--A 133
Cdd:PRK11873  75 LKPGETVLDLGSGGGFD--CFLaaRRVGPTGKVIGVDMTPEMLAKARAnaRKAGYTNVEFRLGEIEALPVADNSVDViiS 152

                         90       100       110
                 ....*....|....*....|....*....|...
gi 281210018 134 RCerLLQHVPNPVAVIDEMIRVTKDGGMVAISD 166
Cdd:PRK11873 153 NC--VINLSPDKERVFKEAFRVLKPGGRFAISD 183
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 65-169 6.23e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.74  E-value: 6.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  65 KIIDFGCGYGKDLKSFLNRvgPNGEVTGIDNSTAMIDYAKKKF--GDRPTVKLHVFSAEK-VDLPSNYYDVARCERLLQH 141
Cdd:cd02440    1 RVLDLGCGTGALALALASG--PGARVTGVDISPVALELARKAAaaLLADNVEVLKGDAEElPPEADESFDVIISDPPLHH 78

                         90       100
                 ....*....|....*....|....*....
gi 281210018 142 -VPNPVAVIDEMIRVTKDGGMVAISDTDW 169
Cdd:cd02440   79 lVEDLARFLEEARRLLKPGGVLVLTLVLA 107
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 60-164 4.40e-07

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 49.77  E-value: 4.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  60 LGEGDKIIDFGCGYGKDLKSFLNRVGPNGEVTGIDNSTAMIDYAKK---KFGDRPTVKLHVFSAEKVdLPSNYYDvarce 136
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKnleRFGLPDNVELKLGDIREG-IDEGDVD----- 162

                         90       100
                 ....*....|....*....|....*...
gi 281210018 137 RLLQHVPNPVAVIDEMIRVTKDGGMVAI 164
Cdd:COG2519  163 AVFLDMPDPWEALEAVAKALKPGGVLVA 190
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 54-166 9.26e-06

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 46.67  E-value: 9.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  54 TKE---ELTLGEGDKIIDFGCGYGKDlkSFLNRVGPNGEVTGIDNSTAMIDYA-KKKFGDRPTVKLHVFSAEKVDLPSNY 129
Cdd:PLN02336 255 TKEfvdKLDLKPGQKVLDVGCGIGGG--DFYMAENFDVHVVGIDLSVNMISFAlERAIGRKCSVEFEVADCTKKTYPDNS 332

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 281210018 130 YDVARCERLLQHVPNPVAVIDEMIRVTKDGGMVAISD 166
Cdd:PLN02336 333 FDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLISD 369
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 63-166 1.64e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 45.27  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  63 GDKIIDFGCGYGkDLKSFLN-RVGPNGEVTGIDNSTAMIDYA--KKKFGDRPTVKLHVF-SAEKVDLPSN--YYDVARCE 136
Cdd:PLN02233  74 GDRVLDLCCGSG-DLAFLLSeKVGSDGKVMGLDFSSEQLAVAasRQELKAKSCYKNIEWiEGDATDLPFDdcYFDAITMG 152

                         90       100       110
                 ....*....|....*....|....*....|
gi 281210018 137 RLLQHVPNPVAVIDEMIRVTKDGGMVAISD 166
Cdd:PLN02233 153 YGLRNVVDRLKAMQEMYRVLKPGSRVSILD 182
PRK01683 PRK01683
trans-aconitate 2-methyltransferase; Provisional
 65-164 1.17e-04

trans-aconitate 2-methyltransferase; Provisional


Pssm-ID: 234970  Cd Length: 258  Bit Score: 42.62  E-value: 1.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  65 KIIDFGCGYGKDLKSFLNRVgPNGEVTGIDNSTAMIDYAKKKFGDRPTVKLHVFS---AEKVDLpsnYYDVArcerLLQH 141
Cdd:PRK01683  34 YVVDLGCGPGNSTELLVERW-PAARITGIDSSPAMLAEARSRLPDCQFVEADIASwqpPQALDL---IFANA----SLQW 105

                         90       100
                 ....*....|....*....|...
gi 281210018 142 VPNPVAVIDEMIRVTKDGGMVAI 164
Cdd:PRK01683 106 LPDHLELFPRLVSLLAPGGVLAV 128
PTZ00098 PTZ00098
phosphoethanolamine N-methyltransferase; Provisional
 51-266 5.58e-04

phosphoethanolamine N-methyltransferase; Provisional


Pssm-ID: 173391 [Multi-domain]  Cd Length: 263  Bit Score: 40.72  E-value: 5.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  51 TRKTKEELTLGEGDKIIDFGCGYGKDLKSFLNRVGpnGEVTGIDNSTAMIDYAKKKFGDRPTVKLHVFSAEKVDLPSNYY 130
Cdd:PTZ00098  41 TTKILSDIELNENSKVLDIGSGLGGGCKYINEKYG--AHVHGVDICEKMVNIAKLRNSDKNKIEFEANDILKKDFPENTF 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018 131 DVARCERLLQHVP--NPVAVIDEMIRVTKDGGMVAISDtdwtsskiYCPERLRDVTDR----ILNTKFNCHPgvANELFS 204
Cdd:PTZ00098 119 DMIYSRDAILHLSyaDKKKLFEKCYKWLKPNGILLITD--------YCADKIENWDEEfkayIKKRKYTLIP--IQEYGD 188

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018 205 LVNP-KLKNTKVR---GYMIQATSWEFAKvvtldLRAKRALDLKVITQEEYND----WVETMKDLDRKGQ 266
Cdd:PTZ00098 189 LIKScNFQNVVAKdisDYWLELLQVELKK-----LEEKKEEFLKLYSEKEYNSlkdgWTRKIKDTKRKLQ 253
PKS_MT smart00828
Methyltransferase in polyketide synthase (PKS) enzymes;
65-167 5.88e-04

Methyltransferase in polyketide synthase (PKS) enzymes;


Pssm-ID: 214839 [Multi-domain]  Cd Length: 224  Bit Score: 40.48  E-value: 5.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018    65 KIIDFGCGYGKDLKSfLNRVGPNGEVTGIDNSTAMIDYAKKK-----FGDRptVKLHVFSAEKVDLPSNYYDVARCErLL 139
Cdd:smart00828   2 RVLDFGCGYGSDLID-LAERHPHLQLHGYTISPEQAEVGRERiralgLQGR--IRIFYRDSAKDPFPDTYDLVFGFE-VI 77

                           90       100
                   ....*....|....*....|....*...
gi 281210018   140 QHVPNPVAVIDEMIRVTKDGGMVAISDT 167
Cdd:smart00828  78 HHIKDKMDLFSNISRHLKDGGHLVLADF 105
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 56-105 6.98e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.79  E-value: 6.98e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 281210018  56 EELTLGEGDKIIDFGCGYGKdLKSFLNRVGPNGEVTGIDNSTAMIDYAKK 105
Cdd:COG2813   43 EHLPEPLGGRVLDLGCGYGV-IGLALAKRNPEARVTLVDVNARAVELARA 91
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 62-170 1.04e-03

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 40.10  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281210018  62 EGDKIIDFGCGyGKDLKSFLNRVGpnGEVTGIDNSTAMIDYAKKKFGDRP---TVKLHVFSAEKVDLPSNYYDVARCERL 138
Cdd:PLN02396 131 EGLKFIDIGCG-GGLLSEPLARMG--ATVTGVDAVDKNVKIARLHADMDPvtsTIEYLCTTAEKLADEGRKFDAVLSLEV 207

                         90       100       110
                 ....*....|....*....|....*....|..
gi 281210018 139 LQHVPNPVAVIDEMIRVTKDGGMVAISDTDWT 170
Cdd:PLN02396 208 IEHVANPAEFCKSLSALTIPNGATVLSTINRT 239
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 63-105 2.00e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.34  E-value: 2.00e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 281210018   63 GDKIIDFGCGYGKdLKSFLNRVGPNGEVTGIDNSTAMIDYAKK 105
Cdd:pfam05175  32 SGKVLDLGCGAGV-LGAALAKESPDAELTMVDINARALESARE 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH