NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|260158853|gb|EEW93921|]
View 

hypothetical protein HMPREF0446_00803 [Granulicatella elegans ATCC 700633]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 48-108 1.20e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 83.66  E-value: 1.20e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDEIRDFF 108
Cdd:NF033788  16 ILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 48-108 1.20e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 83.66  E-value: 1.20e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDEIRDFF 108
Cdd:NF033788  16 ILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
48-111 1.88e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.39  E-value: 1.88e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDEIRDFFNQL 111
Cdd:COG0640   25 ILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
48-111 1.29e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.01  E-value: 1.29e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260158853    48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDEIRDFFNQL 111
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 48-103 7.33e-13

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 58.85  E-value: 7.33e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDE 103
Cdd:cd00090   12 ILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 48-86 2.24e-09

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 48.98  E-value: 2.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 260158853   48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNIL 86
Cdd:pfam01022   7 ILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 31-97 1.59e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 48.66  E-value: 1.59e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 260158853  31 KSLRILTKFTDNKQINIIFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYY 97
Cdd:PRK10141   5 LPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 61-97 1.24e-03

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 35.08  E-value: 1.24e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 260158853  61 DIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYY 97
Cdd:NF033789  26 EIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYY 62
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 48-108 1.20e-22

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 83.66  E-value: 1.20e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDEIRDFF 108
Cdd:NF033788  16 ILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
48-111 1.88e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.39  E-value: 1.88e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDEIRDFFNQL 111
Cdd:COG0640   25 ILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLEWL 88
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
48-111 1.29e-18

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 73.01  E-value: 1.29e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 260158853    48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDEIRDFFNQL 111
Cdd:smart00418   2 ILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 48-103 7.33e-13

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 58.85  E-value: 7.33e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDE 103
Cdd:cd00090   12 ILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAE 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 48-86 2.24e-09

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 48.98  E-value: 2.24e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 260158853   48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNIL 86
Cdd:pfam01022   7 ILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 31-97 1.59e-08

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 48.66  E-value: 1.59e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 260158853  31 KSLRILTKFTDNKQINIIFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYY 97
Cdd:PRK10141   5 LPLQLFKILSDETRLGIVLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHY 71
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
46-103 1.65e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 46.80  E-value: 1.65e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 260158853  46 NIIFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYYFIKDDE 103
Cdd:COG3398  101 RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPE 158
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 50-93 2.90e-04

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 35.98  E-value: 2.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 260158853   50 YLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRREGK 93
Cdd:pfam12840  18 ALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
48-104 5.09e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 36.48  E-value: 5.09e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 260158853  48 IFYLLAVEELCVCDIACLLNLSMASTSHHLRKLANQNILGTRRE----GKIIYYFIKDDEI 104
Cdd:COG4189   24 ILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKpgkrGRQKICYLRVDKI 84
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 61-97 1.24e-03

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 35.08  E-value: 1.24e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 260158853  61 DIACLLNLSMASTSHHLRKLANQNILGTRREGKIIYY 97
Cdd:NF033789  26 EIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYY 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH