|
Name |
Accession |
Description |
Interval |
E-value |
| PLP_SbnA_fam |
TIGR03945 |
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a ... |
6-310 |
3.28e-169 |
|
2,3-diaminopropionate biosynthesis protein SbnA; Members of this family include SbnA, a protein of the staphyloferrin B biosynthesis operon of Staphylococcus aureus. SbnA and SbnB together appear to synthesize 2,3-diaminopropionate, a precursor of certain siderophores and other secondary metabolites. SbnA is a pyridoxal phosphate-dependent enzyme. [Cellular processes, Biosynthesis of natural products]
Pssm-ID: 274872 [Multi-domain] Cd Length: 304 Bit Score: 472.07 E-value: 3.28e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 6 VLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLALVAKMK 85
Cdd:TIGR03945 1 ILSLIGNTPLVKLERLFPDAPFRLFAKLEGFNPGGSIKDRPALYILEAAIKRGRITPGTTIIESSSGNLGIALAMICAYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 86 GYKMICVVDPKISKVNLNLIKSYGAQVHMVDVSDEHGNYLKARLVIAQDLANSIDGAYWPNQYNNPENPEAYVHTLVQEI 165
Cdd:TIGR03945 81 GLRFICVVDPNISPQNLKLLRAYGAEVEKVTEPDETGGYLGTRIARVRELLASIPDAYWPNQYANPDNPRAHYHGTGREI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 166 YDDFnDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIFGGKPGVRRLLGIGNAIVPGNVNRSLYDDLSYV 245
Cdd:TIGR03945 161 ARAF-PTLDYLFVGVSTTGTLMGCSRRLRERGPNTKVIAVDAVGSVIFGGPPGRRHIPGLGASVVPELLDESLIDDVVHV 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 228783582 246 NDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDRGDRYYNTIFSDEWL 310
Cdd:TIGR03945 240 PEYDTVAGCRRLARREGILAGGSSGTVVAAIKRLLPRIPEGSTVVAILPDRGERYLDTVYNDEWV 304
|
|
| CysK |
COG0031 |
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ... |
1-303 |
1.15e-144 |
|
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis
Pssm-ID: 439802 [Multi-domain] Cd Length: 301 Bit Score: 409.82 E-value: 1.15e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 1 MIHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLAL 80
Cdd:COG0031 2 RIYDSILELIGNTPLVRLNRLSPGPGAEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPGGTIVEATSGNTGIGLAM 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 81 VAKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMVDvSDEHGNYLKARlviAQDLANSIDGAYWPNQYNNPENPEAYVHT 160
Cdd:COG0031 82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTP-GAEGMKGAIDK---AEELAAETPGAFWPNQFENPANPEAHYET 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 161 LVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIF-GGKPGVRRLLGIGNAIVPGNVNRSLY 239
Cdd:COG0031 158 TGPEIWEQTDGKVDAFVAGVGTGGTITGVGRYLKERNPDIKIVAVEPEGSPLLsGGEPGPHKIEGIGAGFVPKILDPSLI 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 228783582 240 DDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDRGDRYYNT 303
Cdd:COG0031 238 DEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAKRLGPGKTIVTILPDSGERYLST 301
|
|
| CBS_like |
cd01561 |
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ... |
11-300 |
3.39e-133 |
|
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.
Pssm-ID: 107204 [Multi-domain] Cd Length: 291 Bit Score: 380.32 E-value: 3.39e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 11 GDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLALVAKMKGYKMI 90
Cdd:cd01561 1 GNTPLVRLNRLSPGTGAEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPGTTIIEPTSGNTGIGLAMVAAAKGYRFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 91 CVVDPKISKVNLNLIKSYGAQVHMVDVSDEHGnyLKARLVIAQDLANSIDGAYWPNQYNNPENPEAYVHTLVQEIYDDFN 170
Cdd:cd01561 81 IVMPETMSEEKRKLLRALGAEVILTPEAEADG--MKGAIAKARELAAETPNAFWLNQFENPANPEAHYETTAPEIWEQLD 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 171 DTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIF-GGKPGVRRLLGIGNAIVPGNVNRSLYDDLSYVNDAD 249
Cdd:cd01561 159 GKVDAFVAGVGTGGTITGVARYLKEKNPNVRIVGVDPVGSVLFsGGPPGPHKIEGIGAGFIPENLDRSLIDEVVRVSDEE 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 228783582 250 AFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDRGDRY 300
Cdd:cd01561 239 AFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLGPGKTIVTILPDSGERY 289
|
|
| cysKM |
TIGR01136 |
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ... |
6-303 |
3.61e-97 |
|
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273463 Cd Length: 299 Bit Score: 289.18 E-value: 3.61e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 6 VLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLALVAKMK 85
Cdd:TIGR01136 1 IEELIGNTPLVRLNRLAPGCDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGDTIIEATSGNTGIALAMVAAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 86 GYKMICVVDPKISKVNLNLIKSYGAQVHMVDvsDEHGnyLKARLVIAQDLANSIDGAYWPNQYNNPENPEAYVHTLVQEI 165
Cdd:TIGR01136 81 GYKLILTMPETMSLERRKLLRAYGAELILTP--GEEG--MKGAIDKAEELAAETNKYVMLDQFENPANPEAHYKTTGPEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 166 YDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVD-AVGSVIFGGKPGVRRLLGIGNAIVPGNVNRSLYDDLSY 244
Cdd:TIGR01136 157 WRDTDGRIDHFVAGVGTGGTITGVGRYLKEQNPNIQIVAVEpAESPVLSGGEPGPHKIQGIGAGFIPKILDLSLIDEVIT 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 245 VNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKL-PKSKKVLAILPDRGDRYYNT 303
Cdd:TIGR01136 237 VSDEDAIETARRLAREEGILVGISSGAAVAAALKLAKRLeNADKVIVAILPDTGERYLST 296
|
|
| cysK |
TIGR01139 |
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ... |
6-303 |
6.09e-94 |
|
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273465 Cd Length: 298 Bit Score: 281.18 E-value: 6.09e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 6 VLSLIGDTPIVKINKlVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLALVAKMK 85
Cdd:TIGR01139 1 ISELIGNTPLVRLNR-IEGCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 86 GYKMICVVDPKISKVNLNLIKSYGAQVHMVDvsdehGNY-LKARLVIAQDLANSIDGAYW-PNQYNNPENPEAYVHTLVQ 163
Cdd:TIGR01139 80 GYKLILTMPETMSIERRKLLKAYGAELVLTP-----GAEgMKGAIAKAEEIAASTPNSYFmLQQFENPANPEIHRKTTGP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 164 EIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGS-VIFGGKPGVRRLLGIGNAIVPGNVNRSLYDDL 242
Cdd:TIGR01139 155 EIWRDTDGKLDAFVAGVGTGGTITGVGEVLKEQKPNIKIVAVEPAESpVLSGGKPGPHKIQGIGAGFIPKNLNRSVIDEV 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228783582 243 SYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDRGDRYYNT 303
Cdd:TIGR01139 235 ITVSDEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPEPDKLIVVILPSTGERYLST 295
|
|
| cysta_beta |
TIGR01137 |
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ... |
2-313 |
1.76e-92 |
|
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]
Pssm-ID: 273464 [Multi-domain] Cd Length: 455 Bit Score: 282.46 E-value: 1.76e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 2 IHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLALV 81
Cdd:TIGR01137 1 ILDNILDLIGNTPLVRLNKVSKGLKCELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPGDTIIEPTSGNTGIGLALV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 82 AKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMV------DVSDEHGNylkarlvIAQDLANSIDGAYWPNQYNNPENPE 155
Cdd:TIGR01137 81 AAIKGYKCIIVLPEKMSSEKVDVLRALGAEIVRTptaaafDSPESHIG-------VAKRLVREIPGAHILDQYRNPSNPL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 156 AYVHTLVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIFGGKPGVR------RLLGIGNAI 229
Cdd:TIGR01137 154 AHYDTTGPEILEQCEGKLDMFVAGVGTGGTITGIARYLKESCPGCRIVGADPEGSILAQPEELNQtgrtpyKVEGIGYDF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 230 VPGNVNRSLYDDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLI-DKLPKSKKVLAILPDRGDRYYNTIFSDE 308
Cdd:TIGR01137 234 IPTVLDRKVVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAeDELQEGQRCVVLLPDSIRNYMTKFLNDE 313
|
....*
gi 228783582 309 WLVEH 313
Cdd:TIGR01137 314 WMLDN 318
|
|
| PRK10717 |
PRK10717 |
cysteine synthase A; Provisional |
1-319 |
5.71e-85 |
|
cysteine synthase A; Provisional
Pssm-ID: 182672 [Multi-domain] Cd Length: 330 Bit Score: 259.02 E-value: 5.71e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 1 MIHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLAL 80
Cdd:PRK10717 2 KIFEDVSDTIGNTPLIRLNRASEATGCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGTIVEGTAGNTGIGLAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 81 VAKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMVD---VSDEhGNYLKARLVIAQDLANS-IDGAYWPNQYNNPENPEA 156
Cdd:PRK10717 82 VAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPaapYANP-NNYVKGAGRLAEELVASePNGAIWANQFDNPANREA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 157 YVHTLVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIFG-------GKPGVRRLLGIGNAI 229
Cdd:PRK10717 161 HYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKIVLADPTGSALYSyyktgelKAEGSSITEGIGQGR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 230 VPGNVNRSLYDDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDRGDRYYNTIFSDEW 309
Cdd:PRK10717 241 ITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLARELGPGHTIVTILCDSGERYQSKLFNPDF 320
|
330
....*....|
gi 228783582 310 LVEHDIELPQ 319
Cdd:PRK10717 321 LREKGLPVPR 330
|
|
| PALP |
pfam00291 |
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ... |
6-295 |
2.69e-80 |
|
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.
Pssm-ID: 459749 [Multi-domain] Cd Length: 295 Bit Score: 246.07 E-value: 2.69e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 6 VLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAEnsgQLKPGGTIVESSSGNLAIGLALVAKMK 85
Cdd:pfam00291 1 ISLGIGPTPLVRLPRLSKELGVDVYLKLESLNPTGSFKDRGALNLLLRLK---EGEGGKTVVEASSGNHGRALAAAAARL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 86 GYKMICVVDPKISKVNLNLIKSYGAQVHMVDvsdehGNYLKARLvIAQDLANSIDGAYWPNQYNNPENPEAYvHTLVQEI 165
Cdd:pfam00291 78 GLKVTIVVPEDAPPGKLLLMRALGAEVVLVG-----GDYDEAVA-AARELAAEGPGAYYINQYDNPLNIEGY-GTIGLEI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 166 YDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIFGG----------KPGVRRLLGIGNAIVPGNVN 235
Cdd:pfam00291 151 LEQLGGDPDAVVVPVGGGGLIAGIARGLKELGPDVRVIGVEPEGAPALARslaagrpvpvPVADTIADGLGVGDEPGALA 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 228783582 236 RSLYDDLS----YVNDADAFFITRELVSKEGILVGGSSGAVVCAA-LRLIDKLPKSKKVLAILPD 295
Cdd:pfam00291 231 LDLLDEYVgevvTVSDEEALEAMRLLARREGIVVEPSSAAALAALkLALAGELKGGDRVVVVLTG 295
|
|
| Trp-synth-beta_II |
cd00640 |
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ... |
13-296 |
8.90e-75 |
|
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.
Pssm-ID: 107202 [Multi-domain] Cd Length: 244 Bit Score: 230.09 E-value: 8.90e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGqLKPGGTIVESSSGNLAIGLALVAKMKGYKMICV 92
Cdd:cd00640 1 TPLVRLKRLSKLGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEG-KLPKGVIIESTGGNTGIALAAAAARLGLKCTIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 93 VDPKISKVNLNLIKSYGAQVHMVDvsdehgNYLKARLVIAQDLANSIDGAYWPNQYNNPENPEAYVhTLVQEIYDDFND- 171
Cdd:cd00640 80 MPEGASPEKVAQMRALGAEVVLVP------GDFDDAIALAKELAEEDPGAYYVNQFDNPANIAGQG-TIGLEILEQLGGq 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 172 TLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDavgsvifggkPGVRRllgignaivpgnvnrslyddlsyVNDADAF 251
Cdd:cd00640 153 KPDAVVVPVGGGGNIAGIARALKELLPNVKVIGVE----------PEVVT-----------------------VSDEEAL 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 228783582 252 FITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDR 296
Cdd:cd00640 200 EAIRLLAREEGILVEPSSAAALAAALKLAKKLGKGKTVVVILTGG 244
|
|
| cysM |
TIGR01138 |
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ... |
6-303 |
1.52e-70 |
|
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]
Pssm-ID: 130208 [Multi-domain] Cd Length: 290 Bit Score: 220.94 E-value: 1.52e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 6 VLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLALVAKMK 85
Cdd:TIGR01138 2 IEQTVGNTPLVRLQRMGPENGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAALK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 86 GYKMICVVDPKISKVNLNLIKSYGAQVHMVDvsDEHGnyLKARLVIAQDLANSIDGAYWpNQYNNPENPEAYVHTLVQEI 165
Cdd:TIGR01138 82 GYRMKLLMPDNMSQERKAAMRAYGAELILVT--KEEG--MEGARDLALELANRGEGKLL-DQFNNPDNPYAHYTSTGPEI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 166 YDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVD-AVGSVIfggkPGVRRllgIGNAIVPGNVNRSLYDDLSY 244
Cdd:TIGR01138 157 WQQTGGRITHFVSSMGTTGTIMGVSRFLKEQNPPVQIVGLQpEEGSSI----PGIRR---WPTEYLPGIFDASLVDRVLD 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 228783582 245 VNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSkKVLAILPDRGDRYYNT 303
Cdd:TIGR01138 230 IHQRDAENTMRELAVREGIFCGVSSGGAVAAALRLARELPDA-VVVAIICDRGDRYLST 287
|
|
| cysM |
PRK11761 |
cysteine synthase CysM; |
1-303 |
6.05e-67 |
|
cysteine synthase CysM;
Pssm-ID: 236972 Cd Length: 296 Bit Score: 212.04 E-value: 6.05e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 1 MIHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLAL 80
Cdd:PRK11761 1 MAYPTLEDTIGNTPLVKLQRLPPDRGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPGDTLIEATSGNTGIALAM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 81 VAKMKGYKMICVVDPKISKVNLNLIKSYGAQVhmVDVSDEHGnylkarLVIAQDLANSI--DGAYWP-NQYNNPENPEAY 157
Cdd:PRK11761 81 IAAIKGYRMKLIMPENMSQERRAAMRAYGAEL--ILVPKEQG------MEGARDLALQMqaEGEGKVlDQFANPDNPLAH 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 158 VHTLVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVD-AVGSVIfggkPGVRRLlgiGNAIVPGNVNR 236
Cdd:PRK11761 153 YETTGPEIWRQTEGRITHFVSSMGTTGTIMGVSRYLKEQNPAVQIVGLQpEEGSSI----PGIRRW---PEEYLPKIFDA 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 228783582 237 SLYDDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVlAILPDRGDRYYNT 303
Cdd:PRK11761 226 SRVDRVLDVSQQEAENTMRRLAREEGIFCGVSSGGAVAAALRIARENPNAVIV-AIICDRGDRYLST 291
|
|
| PLN00011 |
PLN00011 |
cysteine synthase |
1-318 |
2.23e-63 |
|
cysteine synthase
Pssm-ID: 177651 Cd Length: 323 Bit Score: 203.70 E-value: 2.23e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 1 MIHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPG-GTIVESSSGNLAIGLA 79
Cdd:PLN00011 6 LIKNDVTELIGNTPMVYLNNIVDGCVARIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEATAGNTGIGLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 80 LVAKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMVDVSDEhgnyLKARLVIAQDLANSIDGAYWPNQYNNPENPEAYVH 159
Cdd:PLN00011 86 CIGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIG----LKGMLEKAEEILSKTPGGYIPQQFENPANPEIHYR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 160 TLVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGS-VIFGGKPGVRRLLGIGNAIVPGNVNRSL 238
Cdd:PLN00011 162 TTGPEIWRDSAGKVDILVAGVGTGGTATGVGKFLKEKNKDIKVCVVEPVESaVLSGGQPGPHLIQGIGSGIIPFNLDLTI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 239 YDDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRlIDKLPKS--KKVLAILPDRGDRYYNTIFSDEwlVEHDIE 316
Cdd:PLN00011 242 VDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALK-VAKRPENagKLIVVIFPSGGERYLSTKLFES--VRYEAE 318
|
...
gi 228783582 317 -LP 318
Cdd:PLN00011 319 nLP 321
|
|
| PLN02565 |
PLN02565 |
cysteine synthase |
2-307 |
2.88e-58 |
|
cysteine synthase
Pssm-ID: 166206 Cd Length: 322 Bit Score: 190.52 E-value: 2.88e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 2 IHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTI-VESSSGNLAIGLAL 80
Cdd:PLN02565 5 IAKDVTELIGKTPLVYLNNVVDGCVARIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVlIEPTSGNTGIGLAF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 81 VAKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMVDVSDEhgnyLKARLVIAQDLANSIDGAYWPNQYNNPENPEAYVHT 160
Cdd:PLN02565 85 MAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKG----MKGAVQKAEEILAKTPNSYILQQFENPANPKIHYET 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 161 LVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIF-GGKPGVRRLLGIGNAIVPGNVNRSLY 239
Cdd:PLN02565 161 TGPEIWKGTGGKVDAFVSGIGTGGTITGAGKYLKEQNPDIKLYGVEPVESAVLsGGKPGPHKIQGIGAGFIPGVLDVDLL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 240 DDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRlIDKLPKS--KKVLAILPDRGDRYYNTIFSD 307
Cdd:PLN02565 241 DEVVQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIK-IAKRPENagKLIVVIFPSFGERYLSSVLFE 309
|
|
| PLN02556 |
PLN02556 |
cysteine synthase/L-3-cyanoalanine synthase |
2-322 |
1.36e-56 |
|
cysteine synthase/L-3-cyanoalanine synthase
Pssm-ID: 178171 [Multi-domain] Cd Length: 368 Bit Score: 187.47 E-value: 1.36e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 2 IHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGT-IVESSSGNLAIGLAL 80
Cdd:PLN02556 49 IKTDASQLIGKTPLVYLNKVTEGCGAYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGKTtLIEPTSGNMGISLAF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 81 VAKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMVDVSDEHGNYLKArlviAQDLANSIDGAYWPNQYNNPENPEAYVHT 160
Cdd:PLN02556 129 MAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKK----AYELLESTPDAFMLQQFSNPANTQVHFET 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 161 LVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVD-AVGSVIFGGKPGVRRLLGIGNAIVPGNVNRSLY 239
Cdd:PLN02556 205 TGPEIWEDTLGQVDIFVMGIGSGGTVSGVGKYLKSKNPNVKIYGVEpAESNVLNGGKPGPHHITGNGVGFKPDILDMDVM 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 240 DDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIdKLP--KSKKVLAILPDRGDRYYNTIFSDEWLVEHDIEL 317
Cdd:PLN02556 285 EKVLEVSSEDAVNMARELALKEGLMVGISSGANTVAALRLA-KMPenKGKLIVTVHPSFGERYLSSVLFQELRKEAENMQ 363
|
....*
gi 228783582 318 PQSIN 322
Cdd:PLN02556 364 PVSVD 368
|
|
| PLN03013 |
PLN03013 |
cysteine synthase |
2-303 |
2.32e-54 |
|
cysteine synthase
Pssm-ID: 178587 [Multi-domain] Cd Length: 429 Bit Score: 183.44 E-value: 2.32e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 2 IHDDVLSLIGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTI-VESSSGNLAIGLAL 80
Cdd:PLN03013 113 IADNVSQLIGKTPMVYLNSIAKGCVANIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVlVEPTSGNTGIGLAF 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 81 VAKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMVDVSDEHGNYLKArlviAQDLANSIDGAYWPNQYNNPENPEAYVHT 160
Cdd:PLN03013 193 IAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQK----AEEILKNTPDAYMLQQFDNPANPKIHYET 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 161 LVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGS-VIFGGKPGVRRLLGIGNAIVPGNVNRSLY 239
Cdd:PLN03013 269 TGPEIWDDTKGKVDIFVAGIGTGGTITGVGRFIKEKNPKTQVIGVEPTESdILSGGKPGPHKIQGIGAGFIPKNLDQKIM 348
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 228783582 240 DDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDRGDRYYNT 303
Cdd:PLN03013 349 DEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASGRDIYT 412
|
|
| PLN02356 |
PLN02356 |
phosphateglycerate kinase |
10-313 |
1.11e-35 |
|
phosphateglycerate kinase
Pssm-ID: 215204 Cd Length: 423 Bit Score: 133.58 E-value: 1.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 10 IGDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPGGTIVESSSGNLAIGLALVAKMKGYKM 89
Cdd:PLN02356 51 IGNTPLIRINSLSEATGCEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPGGVVTEGSAGSTAISLATVAPAYGCKC 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 90 ICVVDPKISKVNLNLIKSYGAQVHMV-DVS----DEHGNYLKARLVIAQDLA---------------------------- 136
Cdd:PLN02356 131 HVVIPDDVAIEKSQILEALGATVERVrPVSithkDHYVNIARRRALEANELAskrrkgsetdgihlektngciseeeken 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 137 ----NSIDGAYWPNQYNNPENPEAYVHTLVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVI 212
Cdd:PLN02356 211 slfsSSCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQEKNPNIKCFLIDPPGSGL 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 213 FGG-KPGV---------RRLL--------GIGNAIVPGNVNRSLYDDLSYVNDADAFFITRELVSKEGILVGGSSGAVVC 274
Cdd:PLN02356 291 FNKvTRGVmytreeaegRRLKnpfdtiteGIGINRLTQNFLMAKLDGAFRGTDKEAVEMSRYLLKNDGLFVGSSSAMNCV 370
|
330 340 350
....*....|....*....|....*....|....*....
gi 228783582 275 AALRLIDKLPKSKKVLAILPDRGDRYYNTIFSDEWLVEH 313
Cdd:PLN02356 371 GAVRVAQSLGPGHTIVTILCDSGMRHLSKFHDPQYLSQH 409
|
|
| ThrC |
COG0498 |
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ... |
11-293 |
9.98e-26 |
|
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis
Pssm-ID: 440264 [Multi-domain] Cd Length: 394 Bit Score: 105.67 E-value: 9.98e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 11 GDTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLkpggTIVESSSGNLAIGLALVAKMKGYKMI 90
Cdd:COG0498 65 GGTPLVKAPRLADELGKNLYVKEEGHNPTGSFKDRAMQVAVSLALERGAK----TIVCASSGNGSAALAAYAARAGIEVF 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 91 CVVdP--KISKVNLNLIKSYGAQVHMVDvsdehGNYLKA-RLV--IAQD----LANSIdgaywpnqynnpeNP---EAYV 158
Cdd:COG0498 141 VFV-PegKVSPGQLAQMLTYGAHVIAVD-----GNFDDAqRLVkeLAADeglyAVNSI-------------NParlEGQK 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 159 hTLVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLN--------PsvKVMAVDAVGSV-----IFGGKPGVRRL--- 222
Cdd:COG0498 202 -TYAFEIAEQLGRVPDWVVVPTGNGGNILAGYKAFKELKelglidrlP--RLIAVQATGCNpiltaFETGRDEYEPErpe 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 223 -----LGIGNaivPGNVNRSLYD------DLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLID--KLPKSKKV 289
Cdd:COG0498 279 tiapsMDIGN---PSNGERALFAlresggTAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLRKLREegEIDPDEPV 355
|
....
gi 228783582 290 LAIL 293
Cdd:COG0498 356 VVLS 359
|
|
| Thr-synth_1 |
cd01563 |
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ... |
4-293 |
5.34e-25 |
|
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.
Pssm-ID: 107206 [Multi-domain] Cd Length: 324 Bit Score: 102.67 E-value: 5.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 4 DDVLSLI-GDTPIVKINKLVPPESAQ-LYVKLEGFNPGGSSKDRVAKRVIEYAENSGQlkpgGTIVESSSGNLAIGLALV 81
Cdd:cd01563 13 DDIVSLGeGNTPLVRAPRLGERLGGKnLYVKDEGLNPTGSFKDRGMTVAVSKAKELGV----KAVACASTGNTSASLAAY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 82 AKMKGYKMICVVDPKISKVNLNLIKSYGAQVHMVDvsdehGNYLKArLVIAQDLANsiDGAYWPNQYNNPENPEAYvHTL 161
Cdd:cd01563 89 AARAGIKCVVFLPAGKALGKLAQALAYGATVLAVE-----GNFDDA-LRLVRELAE--ENWIYLSNSLNPYRLEGQ-KTI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 162 VQEIYDDFNDTL-DWIVCPVGTAGLITGVAKGMKKL------NPSVKVMAVDAVGS-----VIFGGKPGVRRL------- 222
Cdd:cd01563 160 AFEIAEQLGWEVpDYVVVPVGNGGNITAIWKGFKELkelgliDRLPRMVGVQAEGAapivrAFKEGKDDIEPVenpetia 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 223 --LGIGNaivPGNVNRSLYddlsYVNDADAFFIT----------RELVSKEGILVGGSSGAVVCAALRLIDK--LPKSKK 288
Cdd:cd01563 240 taIRIGN---PASGPKALR----AVRESGGTAVAvsdeeileaqKLLARTEGIFVEPASAASLAGLKKLREEgiIDKGER 312
|
....*
gi 228783582 289 VLAIL 293
Cdd:cd01563 313 VVVVL 317
|
|
| thrC |
TIGR00260 |
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ... |
5-293 |
1.11e-16 |
|
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 272986 [Multi-domain] Cd Length: 327 Bit Score: 79.35 E-value: 1.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 5 DVLSLI-GDTPIVKINKLVPP-ESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLkpggTIVESSSGNLAIGLALVA 82
Cdd:TIGR00260 14 DLVDLGeGVTPLFRAPALAANvGIKNLYVKELGHNPTLSFKDRGMAVALTKALELGND----TVLCASTGNTGAAAAAYA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 83 KMKGYKMICVV-DPKISKVNLNLIKSYGAQVHMVDvsdehGNYLKarlviAQDLANSIDG---AYWPNQYNN-PENPEAY 157
Cdd:TIGR00260 90 GKAGLKVVVLYpAGKISLGKLAQALGYNAEVVAID-----GNFDD-----AQRLVKQLFEdkpALGLNSANSiPYRLEGQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 158 VhTLVQEIYDDFN-DTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSVIFGGKPGVRRLLG------------ 224
Cdd:TIGR00260 160 K-TYAFEAVEQLGwEAPDKVVVPVPNSGNFGAIWKGFKEKKMLGLDSLPVKRGIQAEGAADIVRAFLEggqwepietpet 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 225 IGNAI---VPGNVNRSLydDLSY--------VNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDK--LPKSKKVLA 291
Cdd:TIGR00260 239 LSTAMdigNPANWPRAL--EAFRrsngyaedLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLKLVEKgtADPAERVVC 316
|
..
gi 228783582 292 IL 293
Cdd:TIGR00260 317 AL 318
|
|
| PRK08638 |
PRK08638 |
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB; |
13-293 |
1.41e-16 |
|
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
Pssm-ID: 236317 [Multi-domain] Cd Length: 333 Bit Score: 79.01 E-value: 1.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKpggTIVESSSGNLAIGLALVAKMKGYKMIcV 92
Cdd:PRK08638 28 TPLPRSNYLSERCKGEIFLKLENMQRTGSFKIRGAFNKLSSLTDAEKRK---GVVACSAGNHAQGVALSCALLGIDGK-V 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 93 VDPK---ISKVNLNliKSYGAQVHMvdvsdeHGNYLKARLVIAQDLANSiDGAYWPNQYNNPEnPEAYVHTLVQEIYDDF 169
Cdd:PRK08638 104 VMPKgapKSKVAAT--CGYGAEVVL------HGDNFNDTIAKVEEIVEE-EGRTFIPPYDDPK-VIAGQGTIGLEILEDL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 170 NDtLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDA-----VGSVIFGGKPGVRRL---LGIGNAI-VPGN----VNR 236
Cdd:PRK08638 174 WD-VDTVIVPIGGGGLIAGIAVALKSINPTIHIIGVQSenvhgMAASFYAGEITTHRTtgtLADGCDVsRPGNltyeIVR 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 228783582 237 SLYDDLSYVNDADAFFITRELVSKEGILVGGsSGAVVCAALRL--IDKLPKSKKVLAIL 293
Cdd:PRK08638 253 ELVDDIVLVSEDEIRNAMKDLIQRNKVVTEG-AGALATAALLSgkLDQYIQNKKVVAII 310
|
|
| Thr-dehyd |
cd01562 |
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ... |
13-293 |
2.08e-16 |
|
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.
Pssm-ID: 107205 [Multi-domain] Cd Length: 304 Bit Score: 78.30 E-value: 2.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVK---INKLVppeSAQLYVKLEGFNPGGSSKDRVA-KRVIEYAENsgQLKPGgtIVESSSGNLAIGLALVAKMKGYK 88
Cdd:cd01562 18 TPLLTsptLSELL---GAEVYLKCENLQKTGSFKIRGAyNKLLSLSEE--ERAKG--VVAASAGNHAQGVAYAAKLLGIP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 89 MICVVdPKI-SKVNLNLIKSYGAQVhmvdVsdEHGNYLKARLVIAQDLAnSIDGAYWPNQYNNPenpeaYV----HTLVQ 163
Cdd:cd01562 91 ATIVM-PETaPAAKVDATRAYGAEV----V--LYGEDFDEAEAKARELA-EEEGLTFIHPFDDP-----DViagqGTIGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 164 EIYDDFNDtLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGSvifggkPGVRRLLgIGNAIVPGNVNRSLYDDLS 243
Cdd:cd01562 158 EILEQVPD-LDAVFVPVGGGGLIAGIATAVKALSPNTKVIGVEPEGA------PAMAQSL-AAGKPVTLPEVDTIADGLA 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 228783582 244 yVN--DADAFFITRELV-------------------SKEGILVGGSsGAVVCAALRLIDKLPKSKKVLAIL 293
Cdd:cd01562 230 -VKrpGELTFEIIRKLVddvvtvsedeiaaamlllfEREKLVAEPA-GALALAALLSGKLDLKGKKVVVVL 298
|
|
| IlvA |
COG1171 |
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ... |
27-293 |
3.08e-16 |
|
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440784 [Multi-domain] Cd Length: 327 Bit Score: 78.15 E-value: 3.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 27 AQLYVKLEGFNPGGSSKDR-VAKRVIEYAENSGQLkpggTIVESSSGNLAIGLALVAKMKGYK-MICVvdPKI-SKVNLN 103
Cdd:COG1171 39 AEVYLKLENLQPTGSFKLRgAYNALASLSEEERAR----GVVAASAGNHAQGVAYAARLLGIPaTIVM--PETaPAVKVA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 104 LIKSYGAQVHmvdvsdEHGNYLKARLVIAQDLANSiDGAYwpnqynnpenpeaYVH------------TLVQEIYDDFND 171
Cdd:COG1171 113 ATRAYGAEVV------LHGDTYDDAEAAAAELAEE-EGAT-------------FVHpfddpdviagqgTIALEILEQLPD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 172 tLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVG------SVIfGGKP-------------GVRRllgignaivPG 232
Cdd:COG1171 173 -LDAVFVPVGGGGLIAGVAAALKALSPDIRVIGVEPEGaaamyrSLA-AGEPvtlpgvdtiadglAVGR---------PG 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 228783582 233 N----VNRSLYDDLSYVNDADAFFITRELVSKEGILVGGsSGAVVCAALRLIDKLPKSKKVLAIL 293
Cdd:COG1171 242 EltfeILRDLVDDIVTVSEDEIAAAMRLLLERTKIVVEP-AGAAALAALLAGKERLKGKRVVVVL 305
|
|
| PRK06815 |
PRK06815 |
threonine/serine dehydratase; |
27-293 |
1.39e-14 |
|
threonine/serine dehydratase;
Pssm-ID: 180709 [Multi-domain] Cd Length: 317 Bit Score: 73.19 E-value: 1.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 27 AQLYVKLEGFNPGGSSKDRVAKRVIEyAENSGQLKPGgtIVESSSGNLAIGLALVAKMKGYKMICVVDPKISKVNLNLIK 106
Cdd:PRK06815 35 CEVYLKCEHLQHTGSFKFRGASNKLR-LLNEAQRQQG--VITASSGNHGQGVALAAKLAGIPVTVYAPEQASAIKLDAIR 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 107 SYGAQVHMVDVsDEHGNYLKARLVIAQdlansiDGAYWPNQYNNPEnPEAYVHTLVQEIYDDFNDtLDWIVCPVGTAGLI 186
Cdd:PRK06815 112 ALGAEVRLYGG-DALNAELAARRAAEQ------QGKVYISPYNDPQ-VIAGQGTIGMELVEQQPD-LDAVFVAVGGGGLI 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 187 TGVAKGMKKLNPSVKVMAV-----DAVGSVIFGGK---PGVRRLLGIGNA--IVPGNVN----RSLYDDLSYVNDADAFF 252
Cdd:PRK06815 183 SGIATYLKTLSPKTEIIGCwpansPSLYTSLEAGEiveVAEQPTLSDGTAggVEPGAITfplcQQLIDQKVLVSEEEIKE 262
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 228783582 253 ITRELVSKEGILVGGSSGAVVCAALRLIDKLpKSKKVLAIL 293
Cdd:PRK06815 263 AMRLIAETDRWLIEGAAGVALAAALKLAPRY-QGKKVAVVL 302
|
|
| PLN02970 |
PLN02970 |
serine racemase |
13-210 |
3.09e-14 |
|
serine racemase
Pssm-ID: 215524 [Multi-domain] Cd Length: 328 Bit Score: 72.40 E-value: 3.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIV---KINKLVPpesAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSgQLKPGgtIVESSSGNLAIGLALVAKMKGYKM 89
Cdd:PLN02970 28 TPVLtssSLDALAG---RSLFFKCECFQKGGAFKFRGACNAIFSLSDD-QAEKG--VVTHSSGNHAAALALAAKLRGIPA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 90 ICVVDPKISKVNLNLIKSYGAQVHMVDvsdehgNYLKARLVIAQDLANSIdGAYWPNQYNNPenpeaYV----HTLVQEI 165
Cdd:PLN02970 102 YIVVPKNAPACKVDAVIRYGGIITWCE------PTVESREAVAARVQQET-GAVLIHPYNDG-----RVisgqGTIALEF 169
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 228783582 166 YDDFNDtLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVGS 210
Cdd:PLN02970 170 LEQVPE-LDVIIVPISGGGLISGIALAAKAIKPSIKIIAAEPKGA 213
|
|
| PRK06450 |
PRK06450 |
threonine synthase; Validated |
11-278 |
1.33e-12 |
|
threonine synthase; Validated
Pssm-ID: 180565 [Multi-domain] Cd Length: 338 Bit Score: 67.45 E-value: 1.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 11 GDTPIVKINKLvppesaqlYVKLEGFNPGGSSKDRVAKRVIEYAENSGQlkpgGTIVESSSGNLAIGLALVAKMKGYKMI 90
Cdd:PRK06450 57 GRTPLIKKGNI--------WFKLDFLNPTGSYKDRGSVTLISYLAEKGI----KQISEDSSGNAGASIAAYGAAAGIEVK 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 91 CVVDPKISKVNLNLIKSYGAQVHMVDVSDEHgnylkarlvIAQDLANSidGAYWPNQYNNPENPEAyVHTLVQEIYDDFN 170
Cdd:PRK06450 125 IFVPETASGGKLKQIESYGAEVVRVRGSRED---------VAKAAENS--GYYYASHVLQPQFRDG-IRTLAYEIAKDLD 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 171 DTL-DWIVCPVGTAGLITGVAKGMKKLNPS-----------VKVMAVDAVGSVIFGGK--PGvRRLLGIGNAIVPGN--V 234
Cdd:PRK06450 193 WKIpNYVFIPVSAGTLLLGVYSGFKHLLDSgvisempkivaVQTEQVSPLCAKFKGISytPP-DKVTSIADALVSTRpfL 271
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 228783582 235 NRSLYDDLSYVNDA-----DAFFITRELVSKEGILVGGSSgAVVCAALR 278
Cdd:PRK06450 272 LDYMVKALSEYGECivvsdNEIVEAWKELAKKGLLVEYSS-ATVYAAYK 319
|
|
| L-Ser-dehyd |
cd06448 |
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ... |
13-210 |
4.33e-12 |
|
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
Pssm-ID: 107209 Cd Length: 316 Bit Score: 65.78 E-value: 4.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVKINKLVPPESAQLYVKLEGFNPGGSSKDR-VAKRVIEYAENSGQLKPGgtIVESSSGNLAIGLALVAKMKGYKMIC 91
Cdd:cd06448 2 TPLIESTALSKTAGCNVFLKLENLQPSGSFKIRgIGHLCQKSAKQGLNECVH--VVCSSGGNAGLAAAYAARKLGVPCTI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 92 VVdPKISKVNL-NLIKSYGAQVHMV-DVSDEHGNYLKARLViaqdlANSIDGAYWPnQYNNPENPEAYVhTLVQEIYDDF 169
Cdd:cd06448 80 VV-PESTKPRVvEKLRDEGATVVVHgKVWWEADNYLREELA-----ENDPGPVYVH-PFDDPLIWEGHS-SMVDEIAQQL 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 228783582 170 --NDTLDWIVCPVGTAGLITGVAKGMKKLNPS-VKVMAVDAVGS 210
Cdd:cd06448 152 qsQEKVDAIVCSVGGGGLLNGIVQGLERNGWGdIPVVAVETEGA 195
|
|
| PRK06381 |
PRK06381 |
threonine synthase; Validated |
11-296 |
7.35e-12 |
|
threonine synthase; Validated
Pssm-ID: 235789 Cd Length: 319 Bit Score: 65.11 E-value: 7.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 11 GDTPIVKINKLvpPE---SAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQlkpgGTIVESSSGNLAIGLALVAKMKGY 87
Cdd:PRK06381 14 GGTPLLRARKL--EEelgLRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY----SGITVGTCGNYGASIAYFARLYGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 88 KMICVVDPKISKVNLNLIKSYGAQVHMVDvsdehGNYLKARLVIAQD-LANSIDGAYwPNQYNNPENPEAYvHTLVQEIY 166
Cdd:PRK06381 88 KAVIFIPRSYSNSRVKEMEKYGAEIIYVD-----GKYEEAVERSRKFaKENGIYDAN-PGSVNSVVDIEAY-SAIAYEIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 167 DDFNDTLDWIVCPVGTAGLITGVAKGMKKL--NPSVKVMAVDAVGSVIFGG------KPGVRRLLGIGNA-IVPGNVN-- 235
Cdd:PRK06381 161 EALGDVPDAVAVPVGNGTTLAGIYHGFRRLydRGKTSRMPRMIGVSTSGGNqivesfKRGSSEVVDLEVDeIRETAVNep 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 228783582 236 -------------RSLYDD---LSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDKLPKSKKVLAILPDR 296
Cdd:PRK06381 241 lvsyrsfdgdnalEAIYDShgyAFGFSDDEMVKYAELLRRMEGLNALPASASALAALVKYLKKNGVNDNVVAVITGR 317
|
|
| PRK08329 |
PRK08329 |
threonine synthase; Validated |
13-209 |
3.90e-11 |
|
threonine synthase; Validated
Pssm-ID: 236244 [Multi-domain] Cd Length: 347 Bit Score: 63.31 E-value: 3.90e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVKINKlvppesaQLYVKLEGFNPGGSSKDR-----VAKrvieyaensgqLKPGGT--IVESSSGNLAIGLALVAKMK 85
Cdd:PRK08329 65 TPTVKRSI-------KVYFKLDYLQPTGSFKDRgtyvtVAK-----------LKEEGIneVVIDSSGNAALSLALYSLSE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 86 GYKMICVVDPKISKVNLNLIKSYGAQVHMVD-----VSDEHGNYLKArlviaqdlansiDGAYWPNQYNNPENPEAyVHT 160
Cdd:PRK08329 127 GIKVHVFVSYNASKEKISLLSRLGAELHFVEgdrmeVHEEAVKFSKR------------NNIPYVSHWLNPYFLEG-TKT 193
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 228783582 161 LVQEIYDDFNdTLDWIVCPVGTAGLITGVAKGMKKL------NPSVKVMAVDAVG 209
Cdd:PRK08329 194 IAYEIYEQIG-VPDYAFVPVGSGTLFLGIWKGFKELhemgeiSKMPKLVAVQAEG 247
|
|
| PRK06608 |
PRK06608 |
serine/threonine dehydratase; |
13-204 |
3.65e-10 |
|
serine/threonine dehydratase;
Pssm-ID: 235842 [Multi-domain] Cd Length: 338 Bit Score: 60.17 E-value: 3.65e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVK---INKLVPPEsaqLYVKLEGFNPGGSSKDR-VAKRVIEYAENSgqlKPGGTIVESSSGNLAIGLALVAKMKGYK 88
Cdd:PRK06608 24 TPIVHsesLNEMLGHE---IFFKVESLQKTGAFKVRgVLNHLLELKEQG---KLPDKIVAYSTGNHGQAVAYASKLFGIK 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 89 MICVVDPKISKVNLNLIKSYGAQVHMVDVSDEHGNYLKArlviAQDlansiDGAYWPNQYNNpENPEAYVHTLVQEIYDD 168
Cdd:PRK06608 98 TRIYLPLNTSKVKQQAALYYGGEVILTNTRQEAEEKAKE----DEE-----QGFYYIHPSDS-DSTIAGAGTLCYEALQQ 167
|
170 180 190
....*....|....*....|....*....|....*.
gi 228783582 169 FNDTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMA 204
Cdd:PRK06608 168 LGFSPDAIFASCGGGGLISGTYLAKELISPTSLLIG 203
|
|
| PRK12483 |
PRK12483 |
threonine dehydratase; Reviewed |
28-210 |
5.58e-10 |
|
threonine dehydratase; Reviewed
Pssm-ID: 237111 [Multi-domain] Cd Length: 521 Bit Score: 60.20 E-value: 5.58e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 28 QLYVKLEGFNPGGSSKDRVAKRviEYAENSGQLKPGGTIVeSSSGNLAIGLALVAKMKGYKMICVVDPKISKVNLNLIKS 107
Cdd:PRK12483 53 QVLLKREDLQPVFSFKIRGAYN--KMARLPAEQLARGVIT-ASAGNHAQGVALAAARLGVKAVIVMPRTTPQLKVDGVRA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 108 YGAQVHMvdvsdeHGNYLKARLVIAQDLANSiDGAYWPNQYNNPENPeAYVHTLVQEIYDDFNDTLDWIVCPVGTAGLIT 187
Cdd:PRK12483 130 HGGEVVL------HGESFPDALAHALKLAEE-EGLTFVPPFDDPDVI-AGQGTVAMEILRQHPGPLDAIFVPVGGGGLIA 201
|
170 180
....*....|....*....|...
gi 228783582 188 GVAKGMKKLNPSVKVMAVDAVGS 210
Cdd:PRK12483 202 GIAAYVKYVRPEIKVIGVEPDDS 224
|
|
| PRK05638 |
PRK05638 |
threonine synthase; Validated |
11-297 |
3.31e-09 |
|
threonine synthase; Validated
Pssm-ID: 235539 [Multi-domain] Cd Length: 442 Bit Score: 57.51 E-value: 3.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 11 GDTPIVKiNKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQlkpGGTIVeSSSGNLAIGLALVAKMKGYKMI 90
Cdd:PRK05638 65 GGTPLIR-ARISEKLGENVYIKDETRNPTGSFRDRLATVAVSYGLPYAA---NGFIV-ASDGNAAASVAAYSARAGKEAF 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 91 CVVDPKISKVNLNLIKSYGAQVhmvdvsDEHGNYLKARLVIAQDLANsIDGAYWPNQYNNPENPEAyVHTLVQEIYDDFN 170
Cdd:PRK05638 140 VVVPRKVDKGKLIQMIAFGAKI------IRYGESVDEAIEYAEELAR-LNGLYNVTPEYNIIGLEG-QKTIAFELWEEIN 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 171 DTLdwIVCPVGTAGLITGVAKGMKKL------NPSVKVMAVDA-----VGSVIFGGKPGVRRLLGIG----NAIVPGNVN 235
Cdd:PRK05638 212 PTH--VIVPTGSGSYLYSIYKGFKELleigviEEIPKLIAVQTercnpIASEILGNKTKCNETKALGlyvkNPVMKEYVS 289
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 228783582 236 RSL--YDDLSYVNDADAFFITRELVSKEGILVGGSSGAVVCAALRLIDK--LPKSKKVLAILPDRG 297
Cdd:PRK05638 290 EAIkeSGGTAVVVNEEEIMAGEKLLAKEGIFAELSSAVVMPALLKLGEEgyIEKGDKVVLVVTGSG 355
|
|
| PLN02550 |
PLN02550 |
threonine dehydratase |
12-206 |
4.25e-09 |
|
threonine dehydratase
Pssm-ID: 178165 [Multi-domain] Cd Length: 591 Bit Score: 57.62 E-value: 4.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 12 DTPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSgQLKPGgtIVESSSGNLAIGLALVAKMKGYKMIC 91
Cdd:PLN02550 109 ESPLQLAKKLSERLGVKVLLKREDLQPVFSFKLRGAYNMMAKLPKE-QLDKG--VICSSAGNHAQGVALSAQRLGCDAVI 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 92 VVDPKISKVNLNLIKSYGAQVHMV-DVSDEHGNYLKARlviAQDlansiDGAYWPNQYNNPEnPEAYVHTLVQEIYDDFN 170
Cdd:PLN02550 186 AMPVTTPEIKWQSVERLGATVVLVgDSYDEAQAYAKQR---ALE-----EGRTFIPPFDHPD-VIAGQGTVGMEIVRQHQ 256
|
170 180 190
....*....|....*....|....*....|....*.
gi 228783582 171 DTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVD 206
Cdd:PLN02550 257 GPLHAIFVPVGGGGLIAGIAAYVKRVRPEVKIIGVE 292
|
|
| PRK08813 |
PRK08813 |
threonine dehydratase; Provisional |
17-278 |
7.21e-08 |
|
threonine dehydratase; Provisional
Pssm-ID: 236339 [Multi-domain] Cd Length: 349 Bit Score: 53.09 E-value: 7.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 17 KINKLVPP------ESAQLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKPggtIVESSSGNLAIGLALVAKMKGYKMI 90
Cdd:PRK08813 32 RLRRYLSPtplhyaERFGVWLKLENLQRTGSYKVRGALNALLAGLERGDERP---VICASAGNHAQGVAWSAYRLGVQAI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 91 CVVDPKISKVNLNLIKSYGAQVHmvdvsdEHGNYLKARLVIAQDLANSiDGAYWPNQYNNPEnPEAYVHTLVQEIYDDFN 170
Cdd:PRK08813 109 TVMPHGAPQTKIAGVAHWGATVR------QHGNSYDEAYAFARELADQ-NGYRFLSAFDDPD-VIAGQGTVGIELAAHAP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 171 DTldwIVCPVGTAGLITGVAKGMKKLNPSV---KVMAVDAVGSVIFGGKPGVRRLLGIGNAI---VPGNVNR----SLYD 240
Cdd:PRK08813 181 DV---VIVPIGGGGLASGVALALKSQGVRVvgaQVEGVDSMARAIRGDLREIAPVATLADGVkvkIPGFLTRrlcsSLLD 257
|
250 260 270
....*....|....*....|....*....|....*...
gi 228783582 241 DLSYVNDADAFFITRELVSKEGILVGGsSGAVVCAALR 278
Cdd:PRK08813 258 DVVIVREAELRETLVRLALEEHVIAEG-AGALALAAGR 294
|
|
| PRK09224 |
PRK09224 |
threonine ammonia-lyase IlvA; |
59-210 |
2.22e-07 |
|
threonine ammonia-lyase IlvA;
Pssm-ID: 236417 [Multi-domain] Cd Length: 504 Bit Score: 52.06 E-value: 2.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 59 QLKPGgtIVESSSGNLAIGLALVAKMKGYKMICVV---DPKIsKVNLnlIKSYGAQVHMvdvsdeHGN-----YLKA-RL 129
Cdd:PRK09224 66 QLARG--VITASAGNHAQGVALSAARLGIKAVIVMpvtTPDI-KVDA--VRAFGGEVVL------HGDsfdeaYAHAiEL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 130 VIAQDLAnsidgaywpnqynnpenpeaYVH------------TLVQEIYDDFNDTLDWIVCPVGTAGLITGVAKGMKKLN 197
Cdd:PRK09224 135 AEEEGLT--------------------FIHpfddpdviagqgTIAMEILQQHPHPLDAVFVPVGGGGLIAGVAAYIKQLR 194
|
170
....*....|...
gi 228783582 198 PSVKVMAVDAVGS 210
Cdd:PRK09224 195 PEIKVIGVEPEDS 207
|
|
| PRK08246 |
PRK08246 |
serine/threonine dehydratase; |
13-210 |
1.01e-06 |
|
serine/threonine dehydratase;
Pssm-ID: 181319 [Multi-domain] Cd Length: 310 Bit Score: 49.57 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVKINkLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIEYAEnsgqlKPGGTIVESSSGNLAIGLALVAKMKGYKMICV 92
Cdd:PRK08246 24 TPVLEAD-GAGFGPAPVWLKLEHLQHTGSFKARGAFNRLLAAP-----VPAAGVVAASGGNAGLAVAYAAAALGVPATVF 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 93 VDPKISKVNLNLIKSYGAQVhmVDVSDEHGNYLKARLVIAQDlansiDGAYWPNQYNNPENPeAYVHTLVQEIYDDFNDt 172
Cdd:PRK08246 98 VPETAPPAKVARLRALGAEV--VVVGAEYADALEAAQAFAAE-----TGALLCHAYDQPEVL-AGAGTLGLEIEEQAPG- 168
|
170 180 190
....*....|....*....|....*....|....*...
gi 228783582 173 LDWIVCPVGTAGLITGVAKGMKklnPSVKVMAVDAVGS 210
Cdd:PRK08246 169 VDTVLVAVGGGGLIAGIAAWFE---GRARVVAVEPEGA 203
|
|
| eutB |
PRK07476 |
threonine dehydratase; Provisional |
13-293 |
2.35e-05 |
|
threonine dehydratase; Provisional
Pssm-ID: 236025 [Multi-domain] Cd Length: 322 Bit Score: 45.34 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 13 TPIVKINKLVPPESAQLYVKLEGFNPGGSSKDRVAKRVIeyAENSGQLKPGGtIVESSSGNLAIGLALVAKMKGYK-MIC 91
Cdd:PRK07476 20 TPLVASASLSARAGVPVWLKLETLQPTGSFKLRGATNAL--LSLSAQERARG-VVTASTGNHGRALAYAARALGIRaTIC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 92 ----VVDPKISKvnlnlIKSYGAQVHMVDVSDEHGNYLKARLVIAQDLAnsidgaYWPnqynnP-ENPE--AYVHTLVQE 164
Cdd:PRK07476 97 msrlVPANKVDA-----IRALGAEVRIVGRSQDDAQAEVERLVREEGLT------MVP-----PfDDPRiiAGQGTIGLE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 165 IYDDFNDtLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVD-----AVGSVIFGGKP----GVRRLL-----GIG--NA 228
Cdd:PRK07476 161 ILEALPD-VATVLVPLSGGGLASGVAAAVKAIRPAIRVIGVSmergaAMHASLAAGRPvqveEVPTLAdslggGIGldNR 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 228783582 229 iVPGNVNRSLYDDLSYVNDAD-------AFFITRELVskEGilvggsSGAVVCAALrLIDKL-PKSKKVLAIL 293
Cdd:PRK07476 240 -YTFAMCRALLDDVVLLDEAEiaagirhAYREERLVV--EG------AGAVGIAAL-LAGKIaARDGPIVVVV 302
|
|
| PRK08197 |
PRK08197 |
threonine synthase; Validated |
11-119 |
2.50e-04 |
|
threonine synthase; Validated
Pssm-ID: 181283 [Multi-domain] Cd Length: 394 Bit Score: 42.30 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 228783582 11 GDTPIVKINKLVPPESA-QLYVKLEGFNPGGSSKDRVAKRVIEYAENSGQLKpggtIVESSSGNLAIGLALVAKMKGYKM 89
Cdd:PRK08197 78 GMTPLLPLPRLGKALGIgRLWVKDEGLNPTGSFKARGLAVGVSRAKELGVKH----LAMPTNGNAGAAWAAYAARAGIRA 153
|
90 100 110
....*....|....*....|....*....|..
gi 228783582 90 ICVVDPKISKVNLNLIKSYGAQVHMVD--VSD 119
Cdd:PRK08197 154 TIFMPADAPEITRLECALAGAELYLVDglISD 185
|
|
| PRK08639 |
PRK08639 |
threonine dehydratase; Validated |
160-209 |
1.05e-03 |
|
threonine dehydratase; Validated
Pssm-ID: 236318 [Multi-domain] Cd Length: 420 Bit Score: 40.56 E-value: 1.05e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 228783582 160 TLVQEIYDDFN--DTLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDAVG 209
Cdd:PRK08639 165 TVAVEILEQLEkeGSPDYVFVPVGGGGLISGVTTYLKERSPKTKIIGVEPAG 216
|
|
| PRK07334 |
PRK07334 |
threonine dehydratase; Provisional |
160-207 |
4.03e-03 |
|
threonine dehydratase; Provisional
Pssm-ID: 235994 [Multi-domain] Cd Length: 403 Bit Score: 38.72 E-value: 4.03e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 228783582 160 TLVQEIYDDFNDtLDWIVCPVGTAGLITGVAKGMKKLNPSVKVMAVDA 207
Cdd:PRK07334 160 TVALEMLEDAPD-LDTLVVPIGGGGLISGMATAAKALKPDIEIIGVQT 206
|
|
| |
