|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
185-584 |
1.53e-177 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 506.32 E-value: 1.53e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 185 VLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVL 264
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 265 TPLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYA 344
Cdd:cd17380 81 TPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 345 FGSLGSVWFALWQRKAhsspsedpelskaekryilggstlkepvtsipwklilskPPVWALIVSHFCHNWGTFILLTWMP 424
Cdd:cd17380 161 FGLLGLLWALVWLIYL---------------------------------------PPVWAIIVAHFCMNWGFYILLSWLP 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 425 TYYNQVLkFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITNVRKIMQSIGFLGPALFLTLLSKVRTPAMAVLC 504
Cdd:cd17380 202 TYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLC 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 505 MACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQK-GSWDSVFQVAVVLYIVGTVVWNVF 583
Cdd:cd17380 281 MSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEAtGSWSLVFVLAAVVNLVGAVVFLLF 360
|
.
gi 222642140 584 S 584
Cdd:cd17380 361 G 361
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
186-583 |
4.59e-127 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 378.50 E-value: 4.59e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 186 LLCFFSFLLCNMDRVNMSIAILPMSS----------------------EFGWSPATVGLIQSSFFWGYLLTQILGGIWAD 243
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAIVAMVNstathdnnntstdkdtlpveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 244 RFGGKVVLGFGVVWWSIATVLTPLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSV 323
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 324 TGLAFSPLLISRFGWPSVFYAFGSLGSVWFALWqrkahsspsedpelskaekrYILGgstlkepvtsipwklilskPPVW 403
Cdd:cd17318 162 IAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW--------------------FFLV-------------------LPVW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 404 ALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGV-SITNVRKIMQSIGF 482
Cdd:cd17318 203 AIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTTVRKLFTSIGF 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 483 LGPALFLTLLSKV-RTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQK-- 559
Cdd:cd17318 283 LGPGVFLIALGYLgSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVKNdq 362
|
410 420
....*....|....*....|....*.
gi 222642140 560 --GSWDSVFQVAVVLYIVGTVVWNVF 583
Cdd:cd17318 363 tiGQWRIVFFISAAIYILGAIFYLIF 388
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
187-583 |
6.18e-89 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 279.99 E-value: 6.18e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 187 LCFFSFLLCNMDRVNMSIAILPM---------------SSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVL 251
Cdd:cd17382 3 MAGLGFCISFGIRCNLGVAIVRMvnnftdayggkvivhKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 252 GFGVVWWSIATVLTPLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPL 331
Cdd:cd17382 83 GLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 332 LISRFGWPSVFYAFGSLGSVWFALWqrkahsspsedpelskaekryilggstlkepvtsipwklILSKPPVWALIVSHFC 411
Cdd:cd17382 163 LVQYVGWSSPFYVYGVFGIIWYMFW---------------------------------------MLVSMPVYAIIVANFC 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 412 HNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGV-SITNVRKIMQSIGFLGPALFLT 490
Cdd:cd17382 204 RSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGIlSTTAVRKIFNCGGFGMEATFLL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 491 LLSKVRTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQ---KGSWDSVFQ 567
Cdd:cd17382 284 VVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKhktREEWQYVFL 363
|
410
....*....|....*.
gi 222642140 568 VAVVLYIVGTVVWNVF 583
Cdd:cd17382 364 IASLVHFFGVIFYAIF 379
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
186-583 |
2.30e-77 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 250.47 E-value: 2.30e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 186 LLCFFSFLLCNMDRVNMSIAILPM------------------------------SSEFGWSPATVGLIQSSFFWGYLLTQ 235
Cdd:cd17381 3 LLAFFGFFVVYALRVNLSVALVDMvnsnstlpsnnssnacpehssspsvehnetGKKYDWDAETQGWILGSFFYGYIITQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 236 ILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVY 315
Cdd:cd17381 83 IPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 316 SGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVWFALWqrkahsspsedpelskaekryilggstlkepvtsipwkl 395
Cdd:cd17381 163 AGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLW--------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 396 ILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGV-SITNVR 474
Cdd:cd17381 204 IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNfSTVCVR 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 475 KIMQSIGFLGPALFLTLLSKVRTP-AMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAAT 553
Cdd:cd17381 284 KIFTLIGMIGPAVFLLAAGFTGCNySLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGPVIA 363
|
410 420 430
....*....|....*....|....*....|...
gi 222642140 554 GYILQK---GSWDSVFQVAVVLYIVGTVVWNVF 583
Cdd:cd17381 364 KSLTHNntvEEWQTVFYISAAINVFGAIFFTIF 396
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
181-580 |
5.40e-74 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 240.55 E-value: 5.40e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 181 RWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPS 340
Cdd:cd17319 81 FTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 341 VFYAFGSLGSVWFALWqrkahsspsedpelskaekryilggstlkepvtsipWKLIlskPPVWALIVSHFCHNWGTFILL 420
Cdd:cd17319 159 AFIIEGLLGLLLAVLW------------------------------------WFYL---RQVWGLALGYFGINYALYGLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 421 TWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLvgrgvsITNVRKIMQSIGFLGPALFLTLLSKVRTPAM 500
Cdd:cd17319 200 TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 501 AVLCMACSQGSDAFSQSGLYSNHQDIGPR-YAGVLLGLSNTAGVLAGVFGTAATGYILQK-GSWDSVFQVAVVLYIVGTV 578
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAAL 353
|
..
gi 222642140 579 VW 580
Cdd:cd17319 354 LV 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
179-580 |
3.14e-73 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 238.62 E-value: 3.14e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 179 PKRWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWW 258
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 259 SIATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:COG2271 86 GLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 339 PSVFYAFGSLGSVWFALwqrkahsspsedpelskaekryilggstlkepvtsipwklilskpPVWALIVSHFCHNWGTFI 418
Cdd:COG2271 164 RAAFLILGLPGLLLALL---------------------------------------------RFWLLALAYFLVYFALYG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 419 LLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRgvsitnvRKIMQSIGFLGPALFLTLLSKVRTP 498
Cdd:COG2271 199 FLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAALALLLLALLPSP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 499 AMAVLCMACSQGSDAFSQSGLYSNHQDI-GPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIVGT 577
Cdd:COG2271 272 ALAIALLFLAGFGLGGAFGLLWALAAELfPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA 351
|
...
gi 222642140 578 VVW 580
Cdd:COG2271 352 LLA 354
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
212-587 |
4.55e-72 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 238.87 E-value: 4.55e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 212 EFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLPFLLVMRAFMGIGEGVAM 291
Cdd:TIGR00894 70 NFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 292 PAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLI-SRFGWPSVFYAFGSLGSVWFALWQRKAHSSPSEDPEL 370
Cdd:TIGR00894 150 PATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCI 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 371 SKAEKRYIlgGSTLKEPVT----SIPWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPW 446
Cdd:TIGR00894 230 SKFEKKYI--NSSLQGQKGstrqSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPY 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 447 LTMAIFANIGGWIADTLVGRGV-SITNVRKIMQSIGFLGPALF---LTLLSKVRTPAMAVLCMACSQGSdaFSQSGLYSN 522
Cdd:TIGR00894 308 LFAWLCSIFAGYLADFLKSSKTlSLTAARKIFNGIGGLGPGIFayaLPYLSAAFYLTIIILTLANAVSS--GPLAGVLIN 385
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222642140 523 HQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQ---KGSWDSVFQVAVVLYIVGTVVWNVFSTGE 587
Cdd:TIGR00894 386 SLDLAPRFLGFIKGITGLPGFIGGLIASTLAGNILSqdsKNVWLIVFLIMAFVNILCVIFYLIFGSAE 453
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
187-550 |
2.67e-50 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 177.22 E-value: 2.67e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 187 LCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTP 266
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 267 LAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFG 346
Cdd:pfam07690 81 FAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 347 SLGSVWFALWQRKAHSSPSEDPELSKAEKRyilggstlkepVTSIPWKLILSKPPVWALIVShFCHNWGTFILLTWMPTy 426
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAEEARL-----------SLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPL- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 427 YNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRgvsitnVRKIMQSIGFLGPALFLTLLSKVRTPAMAVLCMA 506
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 222642140 507 CSQGSDAFSQSGLYSNHQD-IGPRYAGVLLGLSNTAGVLAGVFGT 550
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDlAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
192-579 |
4.26e-50 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 178.30 E-value: 4.26e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 192 FLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKI 271
Cdd:TIGR00893 3 TVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 272 GLpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSV 351
Cdd:TIGR00893 83 VS--LYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 352 WFALWQRKAHSSPsEDPELSKAEKRYILGGSTL-----KEPVTSIPWKL--ILSKPPVWALIVSHFCHNWGTFILLTWMP 424
Cdd:TIGR00893 161 WGVLWLKFIPDPP-QKAKWLTEEEKYIVVGGLLaeqqgKGPSTPKKYQIkeLLKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 425 TYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSItNVRKIMQSIGFLGPALFLTLLSKVRTPAMAVLC 504
Cdd:TIGR00893 240 TYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSL-VFARKTAIIAGLVLSLLMFATNYVNIPYAALAL 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222642140 505 MACSQGSDAFSqSGLYSNHQDIGPRY-AGVLLGLSNTAGVLAGVFGTAATGYIL-QKGSWDSVFQVAVVLYIVGTVV 579
Cdd:TIGR00893 319 VALGFFGLGAG-AIGWALISDNAPGNiAGLTGGLINSLGNLGGIVGPIVIGAIAaTTGSFAGALMVVAALALIGALS 394
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
179-580 |
7.69e-49 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 174.68 E-value: 7.69e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 179 PKRWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWW 258
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 259 SIATVLTPLAakIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:COG2223 81 GIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 339 PSVFYAFGSLGSVWFALWQRKAHSSPSEDPELSKAEKRyilggstlkepvtsiPWKLILSKPPVWALIVSHFCHNWGTFI 418
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR---------------DQLEALRDPRFWLLSLLYFGTFGSFIG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 419 LLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSItnvrkimqsIGFLGPALFLTLLSKVRTP 498
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL---------IVFALMALGLLLLALALGS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 499 -----AMAVLCMACSQGSDA--FSQSGLYsnhqdIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQK-GSWDSVFQVAV 570
Cdd:COG2223 295 lwlflVLFLLLGLALGGGNGavFALVPDI-----FPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYTAAFLVFA 369
|
410
....*....|
gi 222642140 571 VLYIVGTVVW 580
Cdd:COG2223 370 VLALVALVLT 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
179-546 |
7.62e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 157.06 E-value: 7.62e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 179 PKRWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWW 258
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 259 SIATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:COG2814 86 ALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 339 PSVFYAFGSLGSV-WFALWQRKAHSSPSEDPELSKAEKRyilggstlkepvtsipwklILSKPPVWALIVSHFCHNWGTF 417
Cdd:COG2814 164 RWVFLVNAVLALLaLLLLLRLLPESRPAARARLRGSLRE-------------------LLRRPRLLLLLLLAFLLGFGFF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 418 ILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSItnvrkimqsIGFLGPALFLTLLSKVRT 497
Cdd:COG2814 225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL---------IGLLLLALGLLLLALAGS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 222642140 498 PAMAVLCMACSQGSDAFSQSGLYSNHQDI-GPRYAGVLLGLSNTAGVLAG 546
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELaPPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
189-579 |
5.48e-40 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 149.88 E-value: 5.48e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 189 FFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLA 268
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 269 AkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISR--FGWPSVFYAFG 346
Cdd:cd06174 82 P--SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 347 SLGSVWFALWQRKAHSSPSEDPELSKAEkryilggstlKEPVTSIPWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTY 426
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEA----------SSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 427 YNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGrgvsitnvRKIMQSIGFLGPALFLTLLSKVRTPAMAVLCMA 506
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222642140 507 CSQGSDAFSQSGLYS-NHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYIL-QKGSWDSVFQVAVVLYIVGTVV 579
Cdd:cd06174 302 LLGFGLGGLLPLSFAlIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
188-584 |
7.61e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 132.70 E-value: 7.61e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 188 CFFSFLLCNMdRVNMSIAILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTP 266
Cdd:cd17325 1 LSLALFLDML-GYGIIIPILPlYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 267 LAAKIglPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFG 346
Cdd:cd17325 80 FATSY--WQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 347 SLG--SVWFALWQRKAHSSPSEDPELSKAEKRyilggstlkepvtsIPWKLILSKPPVWALIVSHFCHNWGTFILLTWMP 424
Cdd:cd17325 158 ALAllALVLALLLLPEPRPPPNKRAVSAARLR--------------SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 425 TYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLvgrgvsitnVRKIMQSIGFLGPALFLTLLSKVRTPAMAVLC 504
Cdd:cd17325 224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI---------GRKPLILIGLLLSAVALLLLPLATSFWLLLLL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 505 MACSQGSDAFSQSGLYSNHQDIGPRYA-GVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIVGTVVWNVF 583
Cdd:cd17325 295 LALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
.
gi 222642140 584 S 584
Cdd:cd17325 375 R 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
202-580 |
4.93e-28 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 115.72 E-value: 4.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 202 MSIAILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLpfLLVMR 280
Cdd:cd17324 17 VIQGLLPdIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL--LLLAR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 281 AFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLG-----SVWFAL 355
Cdd:cd17324 95 ALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAllaalLLWRLL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 356 WQRKAHSSPSEDPELSkaekryilggstlkepvtsipWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNL 435
Cdd:cd17324 175 PSLPPKKPGSLGLLSS---------------------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 436 TESGLLCVLPWLTMAIFANIGGWIADTLVGrgvsitnvRKIMQSIGFLGPALFLTLLSKVRTPAMAVLCMACSQGSDAFs 515
Cdd:cd17324 234 SAIIGLLLLFGVAGVVGSPLAGRLADRGGR--------RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAA- 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222642140 516 QSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIVGTVVW 580
Cdd:cd17324 305 HSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
189-566 |
2.07e-26 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 111.31 E-value: 2.07e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 189 FFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLtpLA 268
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 269 AKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSvtGLAFSPLLISR---FGWPSVFYAF 345
Cdd:TIGR00881 79 FSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGG--GLLPPLVLFGIaelYSWHWVFIVP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 346 GSLGSVWFALWQRKAHSSPsEDPELSKAEKRYI--LGGSTLKEPVTSIPWKL----ILSKPPVWALIVSHFCHNWGTFIL 419
Cdd:TIGR00881 157 GIIAIIVSLICFLLLRDSP-QSCGLPPAEEMPNeePDGDAEKKEEELTKKQIflqyVLLNKVLWYISLGYVFVYVVRTGI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 420 LTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLV-GRGVSITNVRKIMQSIGFLGPALFLTLlskvrTP 498
Cdd:TIGR00881 236 LDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFnGRRGPLAVFFMALIIVSLLVYWLNPAA-----NP 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222642140 499 AMAVLCMACSQGSDAFSQSGLYSNHQDIGP-RYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVF 566
Cdd:TIGR00881 311 LMDLICLFALGFLVYGPQMLIGVIASELAPkKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
185-580 |
1.34e-25 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 108.46 E-value: 1.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 185 VLLCFFSFLLCNMDRVNMSIAILPMSSEFGW--SPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIAT 262
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLglSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 263 VLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLG----SVTGLAFSPLLISRFGW 338
Cdd:cd17316 81 LLIGLLP--TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGallaALVASLLIPLLSGDWGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 339 PSVFyAFGSLGSVwFALWQRKAhsspsedpelskaekryilggstlkepvtsipwklilskppVWALIVSHFCHNWGTFI 418
Cdd:cd17316 159 RILF-LIGALPAL-LALLLRRR-----------------------------------------TLLLILLWFFISFGYYG 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 419 LLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTlVGrgvsitnvRKIMQSIGFLGPALFLTLLSKVR-- 496
Cdd:cd17316 196 LTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IG--------RKKTLVIGLILSGILALPLFYLLsg 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 497 TPAMAVLCMACSQGSDAFSQSGLYSNHQDIGP-RYAGVLLGLSNTAGVLAGVFGTAATGYIL-QKGSWDSVFQVAVVLYI 574
Cdd:cd17316 267 SPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVGLSYNLGRLGGGGAPPLIALLLaSTGGTGVPALILALLAI 346
|
....*.
gi 222642140 575 VGTVVW 580
Cdd:cd17316 347 VALIVA 352
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
179-557 |
6.89e-25 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 107.06 E-value: 6.89e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 179 PKRWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWW 258
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 259 SIATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:TIGR00895 93 SVFTLLCALAT--NVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 339 PSVFYaFGSLGS------VWFAL----------WQRKAHSSPSEDPELSKAEKRYILGGSTLKEPVTSIPWKLILSKPPV 402
Cdd:TIGR00895 171 RSLFY-VGGIAPllllllLMRFLpesidflvskRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 403 WA---LIVSHFCHNWGTFILLTWMPTYYNQvLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLvgrgvsitNVRKIMqs 479
Cdd:TIGR00895 250 RItvlLWLLYFMLLVGVYFLTNWLPKLMVE-LGFSLSLAATGGALFNFGGVIGSIIFGWLADRL--------GPRVTA-- 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 480 IGFLGPALFLTLL-SKVRTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGP---RYAGVLLGLSntAGVLAGVFGTAATGY 555
Cdd:TIGR00895 319 LLLLLGAVFAVLVgSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPtaiRATGVGWAIG--IGRLGAIIGPILAGY 396
|
..
gi 222642140 556 IL 557
Cdd:TIGR00895 397 LL 398
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
208-579 |
4.85e-24 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 104.57 E-value: 4.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 208 PMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAkiGLPFLLVMRAFMGIGE 287
Cdd:COG2807 43 EIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 288 GVAMPAMNNILSKWVPvseRSRSLAL-VYS-GMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVWFALWQRKAHSSPS 365
Cdd:COG2807 121 AVGNVLLPGLIKRWFP---DRVGLMTgLYTaAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 366 EDPELSKAEkryilggstlkepvtsiPWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQvLKFNLTESGLLcvlp 445
Cdd:COG2807 198 AAAAAPAAA-----------------SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLL---- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 446 wLTMAIFANI-GGWIADTLVGRgvsITNVRKIMQSIGFLGPALFLTLL-SKVRTPAMAVLCMACSQGSdAFSQSGLYSNH 523
Cdd:COG2807 256 -LSLFQLAGIpGSLLVPLLADR---LGDRRPLLLLLGLLGLAGLLGLLlAPGSLPWLWAVLLGLGQGG-LFPLALTLIGL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 222642140 524 QDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQK-GSWDSVFQVAVVLYIVGTVV 579
Cdd:COG2807 331 RARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDAtGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
185-578 |
1.03e-23 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 102.66 E-value: 1.03e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 185 VLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVL 264
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 265 TPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYA 344
Cdd:cd17365 81 TAFAQ--SVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 345 FGSLGSVWFalwqrkahsspsedpelskaekryILGGSTLkepvtsipwklilskppvwALIVSHFCHNWGTFILLTWMP 424
Cdd:cd17365 159 GGVPPLILL------------------------PLLRGTL-------------------LLWVTFFMGLLLVYLLNSWLP 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 425 TYYNQVlKFNLTESGLLCVLPWLTMAIFANIGGWIADTLvgrgvsitNVRKIMQSIGFLGPALFLTLLSKVRTPAMAVLC 504
Cdd:cd17365 196 KLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRF--------GPKRVLALFFALGAVSLALLGVSPASLVLLYVL 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222642140 505 MACSQGSDAFSQSGLYSNHQDIGP---RYAGVllGLSNTAGVLAGVFGTAATGYILQKGSwdSVFQVAVVLYIVGTV 578
Cdd:cd17365 267 VFLAGACVNGAQVGLYALAARFYPtevRATGV--GWALGVGRLGAILGPLLGGLLLAAGL--GPESVFLALAIPAAL 339
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
179-575 |
4.56e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 101.47 E-value: 4.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 179 PKRWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWW 258
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 259 SIATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRsLALVYSGMYLGSVTGLAFSPLLISR--- 335
Cdd:COG0738 84 ALGLLLFALAP--SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 336 FGWPSVFYAFGSLGSVWFALWqrkahsSPSEDPELSKAEKRYILGGSTLKEpvtsipwklILSKPPVWALIVSHFCHNWG 415
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLF------LRSKLPEIEEEEEEAAGSAASLKS---------LLKNPRLLLGGLAIFLYVGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 416 TFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLvgrgvsitNVRKIMQSIGFLGpALFLTLLSKV 495
Cdd:COG0738 226 EGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF--------GPVRLLRLSALLA-AVGLLLALLA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 496 RTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIV 575
Cdd:COG0738 297 PGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLL 376
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
176-355 |
2.75e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 97.57 E-value: 2.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 176 QQFPKRWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGV 255
Cdd:COG0477 7 APTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 256 VWWSIATVLTPLAakIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISR 335
Cdd:COG0477 87 LLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180
....*....|....*....|
gi 222642140 336 FGWPSVFYAFGSLGSVWFAL 355
Cdd:COG0477 165 LGWRWIFLINAPLGLLALVL 184
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
209-572 |
3.94e-22 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 98.46 E-value: 3.94e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 209 MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVvwWSIATVLTPLAAKIGLPFLLVMRAFMGIGEG 288
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGL--LLMGAAALLMALVGSYPVLLVLLFLVGAGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 289 VAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGS---LGSVWFALWQRkahssps 365
Cdd:cd17475 100 SVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLvsiLAAVLFWLFYR------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 366 eDPELSKAEKRyilggstlKEPVTSIPWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLP 445
Cdd:cd17475 173 -EPPAASAATE--------SASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 446 WLTmAIFANIG-GWIADTLVGRgvsitNVRKIMQSIGFLGPALFLTL-LSKVRTPAMAVLCMACSQGSDAFSQSGLYSNH 523
Cdd:cd17475 244 QLG-GALGRIGlGRVSDRVFGG-----RRRPVLVITAAIAAAALLVLsLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTL 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 222642140 524 --QDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQK-GSWDSVFQVAVVL 572
Cdd:cd17475 318 vaESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAtHSYAPAWLALALL 369
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
185-509 |
4.07e-22 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 98.85 E-value: 4.07e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 185 VLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVL 264
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 265 TPLAAKIGLpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRF-GWPSVFY 343
Cdd:cd17328 81 SSFAPNFWQ--LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 344 AFGSLGSV-----WFALwqrkahsspsEDPELSKAEkryilGGSTLKEPVTSIP--WKLILSKPPVWALIVSHFCHNWGT 416
Cdd:cd17328 159 VTGVLGVLlaillLLFV----------REPPRGAAE-----GGVMAKSTATSFLadLKALAKNPSFILSTLGFTAVSFVT 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 417 FILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITN-VRKIMQSIGFLG--PALFLTLLS 493
Cdd:cd17328 224 GALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPrADPLVCAVGLLAaaPFLFLALVL 303
|
330
....*....|....*.
gi 222642140 494 KVRTPAMAVLCMACSQ 509
Cdd:cd17328 304 ALSNLLLAWVLLFLGE 319
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
182-580 |
1.80e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 96.49 E-value: 1.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 182 WTVVLLCFFSFLlcnmdRVNMSIAILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17474 2 YAVFFATLLAVL-----GVSIVDPILPaIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLTPLAAKIglPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLgsvtGLAFSPLL---ISRFG 337
Cdd:cd17474 77 GGLLCGLSDSF--ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGL----GIAVGPLLgglLAAIS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 338 WPSVFYAFGSLGSVWFALWQRKAHSSPSEDPELSKAEKRYilggstlkepvtsipWKLILSKPPVWALIVSHFCHNWGTF 417
Cdd:cd17474 151 WRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD---------------LKKALRGRGLLTFLVSAFLYFFLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 418 ILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITnvrkimqsIGFLGPALFLTLLSKVRT 497
Cdd:cd17474 216 AFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILV--------IGLLLYALSLLLLGFVPS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 498 PAMAVLCMACS---QGSDAFSQSGLYSNHQDIGPRyaGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYI 574
Cdd:cd17474 288 LALLLIAIVLFglgLGLNLPLLTTLVTELAPEEER--GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIAL 365
|
....*.
gi 222642140 575 VGTVVW 580
Cdd:cd17474 366 AAAVLL 371
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
182-579 |
5.69e-21 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 95.03 E-value: 5.69e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 182 WTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIA 261
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 262 TVLTPLAAKIGLpFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSV 341
Cdd:cd17355 82 LVLLALATSLWQ-LYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 342 FYAFGSLGS-----VWFALWQRkahssPSEDPELSKAEKRYILGGSTLKEPVTSipwklilskPPVWALIVSHFCHNWGT 416
Cdd:cd17355 161 LLVLALLALlvlvpVLLLLRRR-----PADLALRAYDDASPASPGSTLKEALRS---------ASFWLLALAFFLCGFAV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 417 FILLTWMPTYynqvlkfnLTESGL---LCVLPWLTMAIFANIGGWIADTLVGRGvsitNVRKIMqSIGFLGPALFLTLLS 493
Cdd:cd17355 227 VGLIVHLVPY--------LADRGIspaAAAVALALIGLFNIVGRLLSGWLGDRY----SPRRLL-AASYALRALGLALLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 494 KVRTPAMAVLCMACSQGSDAFSQSGLYSN--HQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYIL-QKGSWDSVFQVAV 570
Cdd:cd17355 294 LLPFPPLALLLFAALFGLGWGATVPLTAAlaARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYdRTGSYTAAWALAV 373
|
....*....
gi 222642140 571 VLYIVGTVV 579
Cdd:cd17355 374 ALGLIAALL 382
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
203-557 |
8.58e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 94.55 E-value: 8.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 203 SIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAkiGLPFLLVMRAF 282
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP--SLAFLIAARAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 283 MGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGsvwfalwqrkahs 362
Cdd:cd17321 94 QGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG------------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 363 spsedpelskaekryILGgstlkepvtsipwkLILSKPPVWALIVShFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLc 442
Cdd:cd17321 161 ---------------LVA--------------LLLARTFSGAVLAA-FLLGAALGGLLFLLPLYLQGVLGYSPLQAGLA- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 443 VLPW-LTMAIFANIGGWIADTLVGRGVSITNVrkIMQSIGFLGPALFLTLLSKvrtPAMAVLCMACSQGSDAFSQSGLYS 521
Cdd:cd17321 210 LLPLaLAMLVAAPLAGRLADRFGPRLVLVAGL--LLTAVGLLLLALLGADSSV---WLLLPGLVLLGLGLGLFATPLTNA 284
|
330 340 350
....*....|....*....|....*....|....*.
gi 222642140 522 NHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYIL 557
Cdd:cd17321 285 ALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
153-356 |
4.48e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.25 E-value: 4.48e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 153 LSPSDVPAEAVLIGDTNEISPWWqqFPKRWTVVLLCFFSFLLCNMdRVNMSIAILP--MSSEFGWSPATVGLIQSSFFWG 230
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLR--LLLRDRRLLALFLAIFVLAF-AFGALEPFLPlyAAELGGLSPAQIGLLFGAQGLA 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 231 YLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRS 310
Cdd:cd17325 248 SALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 222642140 311 LALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGS---LGSVWFALW 356
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAlllLAAVLFLLL 374
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
216-580 |
6.80e-20 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 91.91 E-value: 6.80e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 216 SPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLgFGVVWWSIATVLT----PLAAKIGLPFLLVMRAFMGIGEGVAM 291
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL-ILADLLRALLAAVlallALLGSLSLWLLLVLAFLLGIASAFFG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 292 PAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFY--AFGSLGSVWFAL-WQRKAHSSPSEDP 368
Cdd:cd06173 111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAinALSFLLSALLLLfIRRPPPAAPGESS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 369 ELSKAEKRyilGGstlkepvtsipWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLcvlpwlt 448
Cdd:cd06173 191 SLLLRDLR---EG-----------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLL------- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 449 MAIFAnIGGWIADTLVGRGVSITNVRKIMqSIGFLGPALFLTLLSKVRTPAMAVLCMACSQGSDAFSQSGLYSN-HQDIG 527
Cdd:cd06173 250 LAAFG-VGALLGALLLGRLSKRRRRGRLL-LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLlQLRVP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 222642140 528 PRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIVGTVVW 580
Cdd:cd06173 328 DELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
184-579 |
6.90e-19 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 88.42 E-value: 6.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 184 VVLLCFFSFllcnmdrvNMSIAILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIAT 262
Cdd:cd17489 4 ANFFFFLSF--------YLLLPVLPlYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 263 VLTPLAAKIGLpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVF 342
Cdd:cd17489 76 LLYLLATSVAL--LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 343 YAFGSLGSV-WFALWQRKAHSSPSEDPelskaekryilggstlkEPVTSIPWKLILSK---PPVWALIVSHFCHnwgtFI 418
Cdd:cd17489 154 IVAAVLALLaLLLVFLVKDPPPVAAEE-----------------AEAGTRAFRRLVEKkvlPPALILFLASIAY----GA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 419 LLTWMPTYYNQVlkfNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSItnvrkimqsIGFLGPALFLTLLSKVRTP 498
Cdd:cd17489 213 ISTFLPLYAAER---GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVII---------PGLLLLALGLLLLSFAGSP 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 499 AMAVLC---MACSQGSdAFSQSGLYSnHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIV 575
Cdd:cd17489 281 WMLLLAavlYGLGFGL-LFPALQALA-VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLL 358
|
....
gi 222642140 576 GTVV 579
Cdd:cd17489 359 ALVL 362
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
187-578 |
4.37e-18 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 86.59 E-value: 4.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 187 LCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTP 266
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 267 LAAKIGLpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLIS----RFGWPSVF 342
Cdd:cd17371 83 FAQNYWQ--LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 343 YaFGSLGSVWFALWQRKAHSSPS-EDPELSKAEKRYILGGSTLKEPvtsipwklILSKPPVWALIVSHFCHnWGTFILLT 421
Cdd:cd17371 161 L-LGALPALLVLFIRRFVKEPPQwQAARAARRHFADRPSLRELFSP--------PLLRTTLLASLLATGAL-GGYYGITT 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 422 WMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADtLVGRGVSItnvrkimqSIGFLGPALF--LTLLSKVRTPA 499
Cdd:cd17371 231 WLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLAD-RIGRRNNF--------ALFALGSAISilLYFFLPLSPTL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 500 MAVLCMACsqgsdAFSQSGLYSNH-----QDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQV-AVVLY 573
Cdd:cd17371 302 ILILGFPL-----GFFASGPFSGMgayltELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVfAAVYY 376
|
....*
gi 222642140 574 IVGTV 578
Cdd:cd17371 377 IAGLV 381
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
181-578 |
1.44e-17 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 84.63 E-value: 1.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 181 RWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLtpLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPS 340
Cdd:cd17312 81 ANIF--MGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 341 VFYAFGSLGSVwfalwqrkahsspsedpelskaekryilggstlkepVTSIPWKLILSKPP-VWALIVSHFCHNWGTFIL 419
Cdd:cd17312 159 AFLVPGIVGLV------------------------------------VAIILFFFLRDSPPyVWVLSLAYAFVYIVRYAC 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 420 LTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITNVRKIMQSIGFLGpALFLTLLSKVRTPA 499
Cdd:cd17312 203 LDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLA-LFWFFPHNKLLSIV 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 500 MAVLCMACSQGSDAFSqSGLYSnhQDIGPRYA-GVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIVGTV 578
Cdd:cd17312 282 LLFLIGFFVGGPINLI-GGAAA--QDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVL 358
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
190-562 |
5.89e-16 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 79.93 E-value: 5.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 190 FSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSffwgYLLTQI----LGGIWADRFGGKVVLGFGVVWWSIATVLT 265
Cdd:cd17503 3 LGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITS----YLLALAimipLSGWLADRFGTRRLFLTALALFTLGSLLC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 266 PLAAKigLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAF 345
Cdd:cd17503 79 GLAPN--LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 346 GSLGSVWFALwqrkahsSPsedpelskaekryILGGSTLKEPVTSIpwklilskppvwaLIVSHFCHNWGTFILLTWMPT 425
Cdd:cd17503 157 LPIGILALLL-------AP-------------LLDLRLFKDRNFTL-------------GLLLSFLLGLGLFGAMFLLPL 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 426 YYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSItnvrkimqsIGFLGPALFLTLLSKVrTPAMAVLCM 505
Cdd:cd17503 204 YLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL---------AGLLLLALGTLLLAFL-TPDTSLWLI 273
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 222642140 506 ACSQGSDAFSQSGLYSN-----HQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSW 562
Cdd:cd17503 274 ILPLFIRGLGMGLVFMPlntlaLNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQ 335
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
182-471 |
2.82e-15 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 78.06 E-value: 2.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 182 WTVVLLCFFSFLLCNMDRVNMSIA-ILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAaVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLTplAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSV------TGLAFSPLLIS 334
Cdd:cd17327 84 LTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIfggllaYGVFKILGVGG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 335 RFGWPSVFYAFG---SLGSVWFALWQRKahsSPSEDPELSKAEKRYI---LGGSTLKEPVTSIPWKLI---LSKPPVWAL 405
Cdd:cd17327 162 LAGWRWLFIIEGlitIIIGLVIFFWLPD---NPSKAWFLTEEEKELAverLRANQTGKGDQKFKWKQIkeaFKDPRTWLL 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222642140 406 IVSHFCHNWGTFILLTWMPTYYNQvLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSIT 471
Cdd:cd17327 239 FLFFFCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAI 303
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
183-343 |
3.29e-15 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 77.70 E-value: 3.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 183 TVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIAT 262
Cdd:PRK11551 15 LTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 263 VLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVF 342
Cdd:PRK11551 95 LATAQAW--DFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF 172
|
.
gi 222642140 343 Y 343
Cdd:PRK11551 173 Y 173
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
205-578 |
6.47e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.44 E-value: 6.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 205 AILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLPFLLVMraFM 283
Cdd:cd17478 17 ALLPlLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA--LA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 284 GIGEGVAMP---AMNNILSKwvpvSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVWFALWQRKA 360
Cdd:cd17478 95 GIGSAAFHPegaRLASQAAG----GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 361 HSSPSEDPElskaekryilggsTLKEPVTSIPWKLILskPPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGL 440
Cdd:cd17478 171 PLKKPEAKK-------------AAAKSSARSTLKGVW--RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 441 LCVLpwLTMAIFAN-IGGWIADTLvGRgvsitnvRKIMQsIGFLGPALFLTLLSKVRTPAMAVLCMACSQG-SDAFSQSG 518
Cdd:cd17478 236 LSLF--LFAGAIGTlIGGPLSDRF-GR-------RRVII-ASLLLAAPFLLLFLLTPGIWSYILLVLAGFLlFASFPVTV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 519 LYSnhQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIVGTV 578
Cdd:cd17478 305 VLA--QELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
181-579 |
2.14e-14 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 75.14 E-value: 2.14e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 181 RWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLTPLAAKIgLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPvSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPS 340
Cdd:cd17314 81 GYTYLSYVFNS-FPLSYACFVFIGAGTGILYGSAVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLAL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 341 VFYAFGSLgsVWFALW---QRKAHSSPSEDPELSKAEKRYILGGSTLKEPVTsipwklilskppvWALIVSHFCHNWGTF 417
Cdd:cd17314 159 VYTILGIL--AAIVLSvvsLLGFKEPPDNQARLHVQKKKTQTMGEIFRDKVF-------------WILFIAIFLVLIGGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 418 ILLTWMPTYYNQVlkfNLTESGLLCVLpWLTMAIFANIG----GWIADTLVGRGVSITNVrkimqsIGFLGPALFLTLLS 493
Cdd:cd17314 224 LFIANMASLVRSL---QLDAPSFVTKL-MSIYGLFNAFGrllwGIVADFFGGRLSTLSIL------LTILGLGLCAFLFL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 494 KVRTPaMAVLCMACSQGsdaFSQSGLY-----SNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYI-LQKGSWDSVFQ 567
Cdd:cd17314 294 LKMTP-VGLVLTGSLLG---FSYGGLFtvypaTVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFyDRTPSYISAVY 369
|
410
....*....|..
gi 222642140 568 VAVVLYIVGTVV 579
Cdd:cd17314 370 IYAVIVFLASAI 381
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
203-579 |
4.21e-14 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 74.18 E-value: 4.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 203 SIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLpFLLVMRAF 282
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPL-LFLGYGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 283 MGIGEGVAMPAMNNILSKWVPvsERsRSLA--LVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFG-------SLGSVWF 353
Cdd:cd17353 102 GGIGAGIGYITPVSTAVKWFP--DK-RGLAtgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGiifliiiVIGAFLI 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 354 ----ALWQRKAHSSPSEDPELSKAEKRyilggstlkepvtsipWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQ 429
Cdd:cd17353 179 rdppKGWVPPGVDPLANNAENSPRDYT----------------PREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 430 VLKFNLTESGLLCVLpwltMAIFANIG----GWIADTLvGRgvsitnvRKIMqSIGFLGPALFLTLLSKVRTPAMAVLCM 505
Cdd:cd17353 243 FAGLDAGIAALAVSI----LSIFNGGGrpfwGWLSDKI-GR-------KNTL-SIAFLIQGVAMFLLPFIGSVAVLFVLG 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222642140 506 ACSQGsdaFSQSGLYS-----NHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLYIVGTVV 579
Cdd:cd17353 310 VALIG---FCYGGGFAlfpalTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
182-562 |
1.31e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 72.61 E-value: 1.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 182 WTVVLLCFFSFLLCNMdrvnMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIA 261
Cdd:cd17320 2 LLLALLVALGPLAIDM----YLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 262 TVLTPLAakIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSV 341
Cdd:cd17320 78 SLLCALA--SSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 342 F-----YAFGSLGSVWFALwqrkahsspsedPELSKAEKRYILGGSTLKEpvtsipWKLILSKPPVWALIVSHFCHNWGT 416
Cdd:cd17320 156 FvflalLGLLLLLLVLLFL------------PETLPEEKRKPLLSSLLRA------YKRVLKNRRFLGYALALGLSFAGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 417 FILLTWMPTYYNQVLKFNLTESGLLCVLpwltMAIFANIGGWIADTLVGRgvsITNVRKIMQSIGFLGPALFLTLLSKV- 495
Cdd:cd17320 218 FAYLAAAPFIYIEQLGLSPAQFGLLFAL----NAIALILGSLLNGRLVRR---FGPRRLLRLGLLLLLAAALVLLLAALl 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222642140 496 --RTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSW 562
Cdd:cd17320 291 ggLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTAL 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
206-509 |
3.58e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.45 E-value: 3.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 206 ILP-MSSEF-GWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAkiGLPFLLVMRAFM 283
Cdd:cd17473 21 ALPaIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLD--SLYALLASRALL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 284 GIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISrFGWPSVFYAFGS----LGSVWFALWQRK 359
Cdd:cd17473 99 GIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLalpvLILVLLFLPEPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 360 AHSSPSEDPElskaekryilggstlKEPVTSIPWKlilskpPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESG 439
Cdd:cd17473 178 RKSKSAASPG---------------AATAAALPWK------RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIG 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 440 LLcvlpwltMAIFaNIGGWIADTLVGRGVSITNVRKIMqSIGFLGPALFLTLLSKVRTPAMAVLCMACSQ 509
Cdd:cd17473 237 LA-------LAIA-SLAGAIGALLFGRLKRRLGKRRLL-AIGFALMALGFLLLALASGLWVVLLGAILAG 297
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
174-357 |
4.33e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.11 E-value: 4.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 174 WWQQFPKRWTVVLLCFFSFLLCNMdrvnMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGF 253
Cdd:cd06173 204 LRRSPLLRLLLLALALFALLGGAL----TVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLI 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 254 GVVWWSIATVLtpLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLI 333
Cdd:cd06173 280 GALLLGLALLV--LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA 357
|
170 180
....*....|....*....|....*.
gi 222642140 334 SRFGWPSVFYAFG--SLGSVWFALWQ 357
Cdd:cd06173 358 DALGLSAVFLLAGalLLLAALLLLLL 383
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
181-579 |
8.41e-11 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 64.19 E-value: 8.41e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 181 RWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVL--TPLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYS-----GMYLGSVTGLAFSPLLI 333
Cdd:cd17345 81 INILigFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNIshnvgGGLVGPLAGLGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 334 SRFGWPSVFYAFGSLGSVWFALWQrkAHSSPSE---DP-ELSKAEKRYILGGSTLKEPVTS--IPWKLILSKPPVWALIV 407
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFL--GKDTPESeglPPiEEYKGDYPEEADGEEEEQELSAweIFVKYVLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 408 ShfchnwGTFI------LLTWMPTYYNQVLKFNLTES-GLLCVLPWltMAIFANI-GGWIADtLVGRGvsitnvRKIMQS 479
Cdd:cd17345 239 A------NVFVylvrygILDWAPTYLSEVKGFSKAQAmWAFSLFEW--AAIPGTLlAGWLSD-KLFKG------RRAPTG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 480 IGFLGPALFLTLLSKVRTPAMAVLCMACSQGSDAFSQS---GLYSNhqDIGPRYA-GVLLGLSNTAGVLAG-VFGTAATG 554
Cdd:cd17345 304 IIFMILVIVALIVYWLAPNVLVDLIALIALGFLIYGPVmliGLQAL--ELVPKKAaGTAAGLTGLFGYLGGsVLATALIG 381
|
410 420
....*....|....*....|....*...
gi 222642140 555 YILQKGSWDSVFQV---AVVLYIVGTVV 579
Cdd:cd17345 382 IIVDHFGWNGGFIVllaSCILAIIFLAL 409
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
209-558 |
9.03e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.15 E-value: 9.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 209 MSSEFGWSPATVGLIQS-SFFWGyLLTQILGGIWADRFGGK-----VVLGFGVVWWSIATVLTPLAAKIGLPFLLVMRAF 282
Cdd:COG2211 37 YTDVLGLSAALVGLILLvARLWD-AITDPLIGALSDRTRTRwgrrrPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 283 MGIGEGVAMPAMNNILSKWVPV-----SERSRSLALVYSGMYLGSVTGLAFSPLLISRFG--------WPSVFYAFGSLG 349
Cdd:COG2211 116 TYLLLGLAYTLVNIPYSALGAEltpdyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgyrLTALIFAVLGLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 350 SVWFALWQRKAHSSPSEDPELSKAEkryilggstlkepvtsipWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQ 429
Cdd:COG2211 196 AFLLTFFGTKERPVPEEEKVSLKES------------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 430 VLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLvGRgvsitnvRKIMQ-SIGFLGPALFLTLLSKVRTPAMAVLCMACS 508
Cdd:COG2211 258 VLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF-GK-------KKAFIiGLLLAALGLLLLFFLGPGNLWLLLVLAALA 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 222642140 509 QGSDAFSQSGLYS--------NHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQ 558
Cdd:COG2211 330 GIGLGAILVLPWAmladvvdyDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
209-580 |
1.03e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 63.79 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 209 MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAkiGLPFLLVMRAFMGIGEG 288
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAH--SPWLFAIALVLTGFGGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 289 VAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTG-LAFSPLLISRFGWPSVFYAFGSLGSVWFALWQRKAHSSPSED 367
Cdd:cd17329 104 LFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGpLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 368 PElskaekryilggstlkEPVTSIPWKLILSKPPVWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWL 447
Cdd:cd17329 184 AE----------------KTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 448 TMAIFaniggwiaDTLVGRGVSITNVRKIMqSIGFLGPALFLTLLSKVRTPAMAVLCMA-CSQGSDafsqsgLYSNHQD- 525
Cdd:cd17329 248 LIVLL--------QFPVARLVERFRLRKIL-MIGILLFAIGFAVLAFANTLAVLILAMIvLTLGEM------LVFPAVQt 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 526 -----IGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFqvaVVLYIVGTVVW 580
Cdd:cd17329 313 lvaalAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW---LILAALGLIAA 369
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
230-580 |
3.54e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 61.81 E-value: 3.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 230 GYLLT----QILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAakIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVS 305
Cdd:cd17502 38 AYLLTstafQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA--PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 306 ERSRSLALVySGMY-LGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVWFALwqrkahsspsedpelskaekryilggstl 384
Cdd:cd17502 116 ERGKYQGYI-GAVFgIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALAL----------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 385 kepVTSIPWKLILSkppvwalivshFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLV 464
Cdd:cd17502 166 ---LRTILLSSIFG-----------FLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 465 GrgvsitnVRKIMQSIGFLGP--ALFLTLLSKVRTPAMAVLCMA-CSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTA 541
Cdd:cd17502 232 R-------YKPLIVIGTILMSvgAGLLTTLTLDTSKWLLIGYLIlLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFF 304
|
330 340 350
....*....|....*....|....*....|....*....
gi 222642140 542 GVLAGVFGTAATgyilqkgswdSVFQVAVVLYIVGTVVW 580
Cdd:cd17502 305 RSLGGTLGVAIT----------DVFLVALALAALAFLLS 333
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
206-429 |
8.40e-10 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 60.78 E-value: 8.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 206 ILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLPFLLvmRAFMG 284
Cdd:cd06180 21 LLPlMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLAL--RFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 285 IGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGS-VTGLAFSPLLISRFGWPSVFYAFGSLGSVWFALWQRKAHSS 363
Cdd:cd06180 99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIaLSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRG 178
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222642140 364 PSEDPELSKAEKRyilggstlkePVTSIPWklilskppvWALIVSHFCHNWGTFILLTWMPTYYNQ 429
Cdd:cd06180 179 PSAPTEASAAESA----------PGLNRPL---------WRLALAYGLFGFGYIITATFLPLIARE 225
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
185-580 |
8.88e-10 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 60.80 E-value: 8.88e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 185 VLLCFFSFLLCNMdrvnmSIAILPMSSE--FGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIAT 262
Cdd:cd17333 1 LYISFFSNGLTDA-----LLGILGPSLEeaFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLAL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 263 VLTPLAAKIglPFLLVMRAFMGIGEGVAMPAMNNILskwVPVSERSRSLALVYSGMYLGsvTGLAFSPLLISRF-----G 337
Cdd:cd17333 76 ALIFATPSI--YLFVVLMFLAGLGAGILDTGANTFV---GALFEESSATRLNVLHGFFG--LGALIGPLIATSLltselS 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 338 WPSVFYAFGSLGSVWFALWQRkahsspsedPELSKAEKRYILGGSTLKEPVTSIPWKLILSkppVWALIVSHFCHNWGTF 417
Cdd:cd17333 149 WSWAYLIIGLIYLLLAILILL---------TLFPELPSARNPQQSVGAFSASASRLLRNPS---IILGALALFLYVGAET 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 418 ILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLvgrgvsitNVRKIMQSIGFLGPALFLTLLSKVRT 497
Cdd:cd17333 217 AFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI--------KPHTLLVLSGSGALLGLLILLLAPTL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 498 PAMAVLCMACSqgsdaFSQSGLYSNHQDIG----PRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLY 573
Cdd:cd17333 289 VVGLVATALLG-----LFMAALFPTILSLGisnlPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILY 363
|
....*..
gi 222642140 574 IVGTVVW 580
Cdd:cd17333 364 AIIFVLA 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
182-348 |
1.07e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 60.28 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 182 WTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQIL-GGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17330 174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLTPLAAKigLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGwPS 340
Cdd:cd17330 254 GLLLLPFASS--VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG-PG 330
|
....*...
gi 222642140 341 VFYAFGSL 348
Cdd:cd17330 331 VPFLLAAG 338
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
202-561 |
2.35e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 59.51 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 202 MSIAILP-MSSEFGWSPATVGLIQSSFFW-GYLLTQILGGiWADRFGGKVVLGFGVVWWSIATVLTPLAAKIglPFLLVM 279
Cdd:cd17504 14 MLSPALPtIQREFGTSAAAVSWVLTAYLLvGAVSTPILGR-LGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL--PVLIAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 280 RAFMGIGEGVaMPAMNNILSKWVPvSERSRSLALVYSGMY-LGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVWFALwqr 358
Cdd:cd17504 91 RALQGIGGAV-FPLAFALVREEFP-PERVPVAQGILSATFgIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL--- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 359 kahsSPSEDPELskaekryilggstlkepvtsipwkliLSKPPVWALIVSHFCHNWGTFILLTWMPTYY--NQVLKFNL- 435
Cdd:cd17504 166 ----VPLIDLRL--------------------------LRRRNVLLANITALLAGFGMFMVFQLLPQLLqlPTPTGFGLg 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 436 -TESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITNVrkIMQSIGFLGPALFLTllskvrTPAMAVLCMACSQGSDAF 514
Cdd:cd17504 216 iTEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL--VISAVGLLLLALLHS------SLWALVVALLLIGIGLGL 287
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 222642140 515 SQSGL-----YSnhqdIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGS 561
Cdd:cd17504 288 AFASLpnivvES----VPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYT 335
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
202-355 |
2.37e-09 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 59.20 E-value: 2.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 202 MSIAILPM--------SSEFGWSPATVGLIQSSFFwgylltqILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAakIGL 273
Cdd:cd17476 16 SVIVILPIigdsfgtsPNQLSWLAASYSLTVGTFI-------LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFS--PNF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 274 PFLLVMRAFMGIGEGVAMPAMNNILSK-WVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVW 352
Cdd:cd17476 87 IFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIV 166
|
...
gi 222642140 353 FAL 355
Cdd:cd17476 167 AVA 169
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
185-579 |
3.94e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.80 E-value: 3.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 185 VLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVl 264
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 265 tpLAAKIGLPF--LLVMRAFMGIGEGVAMPAMNNIlSKWVPvSERSRSLALVYSGM-YLGSVTGLAFSPLLI-------S 334
Cdd:cd17341 80 --ALALAVSSYwgLLVLGFLLGFAGANFASGQPWA-SFWFP-KEKIGGAAGGIAGAgNMGVAVSQLLAPLIAgaivfdgG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 335 RFGWPSVFYAFG---SLGSVWFALWQRkahsspseDPELSKAEKRYILGgstlkepvtsiPWKLILSKPPVWALIVSHFC 411
Cdd:cd17341 156 FVGWRNAFFVPGillAIAAVLVLLFGD--------DLPTGKASALEFLK-----------VQLAVLKNYRTWILSLLYGV 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 412 hNWGTFILLT-WMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITNVrkIMQSIGFLgpALFLT 490
Cdd:cd17341 217 -TFGSFVGFSnVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLF--IVMTIGAA--LLSLS 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 491 LLSKVRTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQK-GSWDSVFQVA 569
Cdd:cd17341 292 LPTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMtGSGVGAFSLF 371
|
410
....*....|
gi 222642140 570 VVLYIVGTVV 579
Cdd:cd17341 372 GVLAVACTLL 381
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
213-584 |
1.72e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.84 E-value: 1.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 213 FGWSPATVGLIqssfFWGYLLTQIL----GGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLpfLLVMRAFMGIG-- 286
Cdd:cd17472 27 PGATPTLIGLA----LGIYGLTQAIfqipFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYG--LILGRALQGSGai 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 287 EGVAMpAMnniLSKWVPVSERSRSLALVysGMYLGS--VTGLAFSPLLISRFGWPSVFY--AFGSLGSVWFALWQRKAHS 362
Cdd:cd17472 101 SSVVM-AL---LADLTREENRTKAMALI--GASIGIafAISMVLGPLLAAHLGVSGLFLitAILSLVSLLILLFFVPDPP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 363 SPSEDPELSKAEKRYIlggstLKEPVTsipWKLILSkppvwalivshfchnwGTFILLTWMPTYYnqVLKFNLTESGLLC 442
Cdd:cd17472 175 KIVQISEKEKKKLKKL-----LKNKRL---LRLDFS----------------IFILHFVLMAFFY--ILPLLLTQLGGGK 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 443 VLPWLTMAIfANIGGWIADTLVGRGVSITNVRKIMQSIGFLGPAL-FLTLLSKVRTPAMAVLCMACsqgsdAFSQSGLYS 521
Cdd:cd17472 229 GQLWKVYLP-AILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVgFLLLLFAATSLWLLIIGLII-----FFIGFNLLE 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222642140 522 N------HQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWDSVFQVAVVLyivgTVVWNVFS 584
Cdd:cd17472 303 AllpslvSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILIL----ALLWLLVS 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
184-358 |
2.76e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 2.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 184 VVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQilggiwadRFGGKVVLGFGVVWWSIATV 263
Cdd:cd17474 209 LYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKK--------RFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 264 LTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFY 343
Cdd:cd17474 281 LLGFVP--SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFL 358
|
170
....*....|....*
gi 222642140 344 AFGSLGSVWFALWQR 358
Cdd:cd17474 359 VGAAIALAAAVLLAL 373
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
182-580 |
4.00e-08 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 55.64 E-value: 4.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 182 WTVVLLCFFSFLLCnmDRVNMSIAIL--PMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWS 259
Cdd:cd17352 2 WVVVFASFLVNFFT--DGILNSFGVLfvELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 260 IATVLTPLAAKIGLpFLLVMRAFMGIGEGVAMPAMNNILSKWVpvsERSRSLA--LVYSGMYLGSVTGLAFSPLLISRFG 337
Cdd:cd17352 80 LGLLLSSFATSLWQ-LYLTYGVLGGLGLGLIYSPAIVIVGQYF---EKKRGLAtgIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 338 WPSVFYAFGSLgsvwfalwqrKAHSspsedpelskaekryILGGSTLKepvtsipwklILSKPPVWALIVSHFCHNWGTF 417
Cdd:cd17352 156 WRGALLILGGL----------CLNL---------------CVCGLLLR----------LLKDPTFVLLALGVSFAMLGFF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 418 ILLTWMPTYYNQvLKFNLTESGLLCVLPWLTMAIFANIGGWIADTlvgRGVSITNVRKImqSIGFLGPALFLTLLSKvRT 497
Cdd:cd17352 201 VPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLADK---PRIGRLYLYIF--TLLILGLSLLAFPLAT-TY 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 498 PAMAVLCMACSqgsdaFSQSGLYSNH-----QDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYIL-QKGSWDSVFQVAVV 571
Cdd:cd17352 274 VGLIVFSVLFG-----FCSGSYSSLTpvilaDLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRdYTGDYDAAFYFCGA 348
|
....*....
gi 222642140 572 LYIVGTVVW 580
Cdd:cd17352 349 CLLLSGVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
405-580 |
5.62e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.12 E-value: 5.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 405 LIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADtLVGRgvsitnvRKIMqSIGFLG 484
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD-RFGR-------RRVL-LIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 485 PALFLTLLSKV-RTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQKGSWD 563
Cdd:pfam07690 72 FALGLLLLLFAsSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170
....*....|....*..
gi 222642140 564 SVFQVAVVLYIVGTVVW 580
Cdd:pfam07690 152 AAFLILAILSLLAAVLL 168
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
189-546 |
8.08e-08 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 54.62 E-value: 8.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 189 FFSFLLCNMDRVNMSIAILPM-SSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPL 267
Cdd:TIGR00886 7 WFGFFLSFLVWFAFSPLAVFLiKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 268 AakiGLPF--LLVMRAFMGIGEGVAMPAMNNIlSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISR---------- 335
Cdd:TIGR00886 87 A---VQSYsvLLLIRLFIGIAGGSFASCMPWI-SFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSlifgggqpah 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 336 --FGWPSVFYAFGSL---GSVWFALWQRkahsSPSEDPELSKAEKRyilggstlkepvtsiPWKLILSKPPVWALIVSHF 410
Cdd:TIGR00886 163 laWGWAFVIVPAGILllpALLIFFVGAD----TPPGKPATGKLSFK---------------EALKVFGNRHTWILALLYS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 411 ChNWGTFILLTWM-PTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITNVRKIMQSIGflgpALFL 489
Cdd:TIGR00886 224 V-TFGSFLGVSSIfAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAF----LVVL 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 490 TLLSKVRTPAMAVLCMACSqgsdAFSQSGLYSNHQ---DIGPRYAGVLLGLSNTAGVLAG 546
Cdd:TIGR00886 299 GLVSDGSLAAFIVLFVALF----FFAGAGNGSTFAlvpHIFRRATGAVSGLIGAIGNLGG 354
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
173-360 |
1.24e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 54.32 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 173 PWWQQF-PKRWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSP-ATVGLIQSSFFWGYLLTQILGGIwADRFGGKVV 250
Cdd:PRK03893 9 PWYRHLnRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTvQAASLISAAFISRWFGGLLLGAM-GDRYGRRLA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 251 LGFGVVWWSIATVLTPLAAkiGLPFLLVMRAFMGIG-EGVAMPAMNNILSKWvPVSERSRSLALVYSGMYLGSVTGLAFS 329
Cdd:PRK03893 88 MVISIVLFSVGTLACGFAP--GYWTLFIARLVIGMGmAGEYGSSATYVIESW-PKHLRNKASGFLISGFSIGAVVAAQVY 164
|
170 180 190
....*....|....*....|....*....|.
gi 222642140 330 PLLISRFGWPSVFYAfgSLGSVWFALWQRKA 360
Cdd:PRK03893 165 SLVVPVWGWRALFFI--GILPIIFALWLRKN 193
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
179-356 |
1.29e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.12 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 179 PKRWTVVLLCFFSFLLCNMdrVNMSIAI-LP--MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGV 255
Cdd:cd17473 193 ALPWKRVLPIYFLAFLAML--LFYVIPIqLPflLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 256 VWWSIATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLG-SVTGLAFSPLLIS 334
Cdd:cd17473 271 ALMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGqFLSPLVLGPLVNL 348
|
170 180
....*....|....*....|..
gi 222642140 335 RFGWPSVFYAFGSLGSVWFALW 356
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVL 370
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
202-337 |
1.68e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 202 MSIAILPMS-SEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAakIGLPFLLVMR 280
Cdd:cd17477 14 LLLPLLSLRlEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT--DSPWVWFLLR 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 222642140 281 AFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGlafsPLLISRFG 337
Cdd:cd17477 92 FVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG----PLLLALVG 144
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
216-368 |
2.83e-06 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 50.13 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 216 SPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGL--PFLLVMRAF-MGIGEGVAMP 292
Cdd:pfam05977 43 SPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLlsPWLLLGLTFlGGIGTALMDP 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222642140 293 AMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGwPSVFYAFGSLG--SVWFALWQRKAHSSPSEDP 368
Cdd:pfam05977 123 AWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFG-PAFTFALNALSyfAVIAALWRWKRAAPASPLP 199
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
213-336 |
5.74e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.71 E-value: 5.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 213 FGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATV-LTPLAAKIGLPFLLVMRAFMGIGEGVAM 291
Cdd:cd17321 199 LGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLlLALLGADSSVWLLLPGLVLLGLGLGLFA 278
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 222642140 292 PAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRF 336
Cdd:cd17321 279 TPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
239-348 |
7.14e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 48.41 E-value: 7.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 239 GIWADRFGG-KVVLGF----GVVWWSIATVLTPLAakiglpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLAL 313
Cdd:cd17391 261 GKLGDRIGHhRILLGAllasALLYIPQAFVQTPWQ-------LGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGY 333
|
90 100 110
....*....|....*....|....*....|....*
gi 222642140 314 VYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSL 348
Cdd:cd17391 334 NQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL 368
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
184-290 |
1.45e-05 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 47.57 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 184 VVLLCFFSFLlcnmdRVNMSIAILP--MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIA 261
Cdd:PRK05122 20 IVMFTFISYL-----TIGLPLAVLPgyVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALS 94
|
90 100 110
....*....|....*....|....*....|....*
gi 222642140 262 TVLTPLAA------KIGLPFLLVMRAFMGIGEGVA 290
Cdd:PRK05122 95 GLLYLLAGllaawpVLSLLLLLLGRLLLGIGESLA 129
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
213-356 |
1.46e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 47.57 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 213 FGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLtpLAAKIGLPFLLVMRAFMGIGeGVAMP 292
Cdd:cd17330 29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL--LGLSRNLWLLFLARFLDGLT-GGNVS 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222642140 293 AMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFG--WPSVFYAFGSLGSVWFALW 356
Cdd:cd17330 106 VAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGyaLPFLVAAALALLNLVLVLF 171
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
175-356 |
3.43e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.38 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 175 WQQFPKRWTVVLLCFFSFLLCNMDrvnMSIAILpMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFG 254
Cdd:cd17370 195 LKKLPKAFWLYLLAVALFALGNFS---FAFLIL-RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 255 VVWWSIATVLtpLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLIS 334
Cdd:cd17370 271 YLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD 348
|
170 180
....*....|....*....|..
gi 222642140 335 RFGWPSVFYaFGSLGSVWFALW 356
Cdd:cd17370 349 LISPSAAFL-FSAVLALIALLL 369
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
213-355 |
4.74e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 45.81 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 213 FGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAkiGLPFLLVMRAFMGIGEGVAMP 292
Cdd:cd17362 34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAP--SYPVLLVGRLIYGVGIGLAMH 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 222642140 293 AMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVWFAL 355
Cdd:cd17362 112 AAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGI 174
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
181-359 |
4.76e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 45.86 E-value: 4.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 181 RWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLTPLAAKIGLpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSvtglAFSPLLIS----RF 336
Cdd:cd17488 81 INILFGFSSSLWA--FAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGG----ALIPILTGfaalTY 154
|
170 180
....*....|....*....|....*
gi 222642140 337 GWPSVFYAFG--SLGSVWFALWQRK 359
Cdd:cd17488 155 GWRAGMYVPGiiAILMGIVLCWRLR 179
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
203-562 |
6.81e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 45.83 E-value: 6.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 203 SIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLpfLLVMRAF 282
Cdd:TIGR00711 22 NVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLEL--MIIFRVI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 283 MGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLG-----SVWFAL-W 356
Cdd:TIGR00711 100 QGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGiivvvVAFFILpR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 357 QRKAHSSP--------------------SEDPELSKAEKRYILGGS---------------TLKEPVTSIpwKLILSKPP 401
Cdd:TIGR00711 180 DKPAASENfdflgllllsvglgsllyglSEGPERGWFDSNEILILSitglvaiiafvvwelTDDNPLVDL--RLFKYRNF 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 402 VWALIVSH--FCHNWGTFILLtwmPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRgvsitnvrkIMQS 479
Cdd:TIGR00711 258 TIGCVYMSllGLGLYGSFYLL---PLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPR---------KLVT 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 480 IGFLGPALFLTLLSKVRTPAMAVLCMACSQGSDAFSQSGLY-----SNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATG 554
Cdd:TIGR00711 326 IGLILYAVGFYWRAFTFTPDTPFLAIALPQFIRGFGMGCFFmplttIALSGLPPHKIARGSSLSNFTRQLGGSIGTALIT 405
|
....*...
gi 222642140 555 YILQKGSW 562
Cdd:TIGR00711 406 TILTNRTQ 413
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
216-352 |
7.21e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 45.35 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 216 SPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLA----AKIGLPFLLVMRAFMGIGEGVAM 291
Cdd:cd17364 37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgstPLGVMGWLIFFRFLLGIGIGGDY 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222642140 292 PAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVW 352
Cdd:cd17364 117 PLSATIMSEYANKKRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYHHADLVW 177
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
209-357 |
1.00e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 44.85 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 209 MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAkiGLPFLLVMRAFMGIGEG 288
Cdd:cd17324 225 LTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGP--SPLLLLVGLVLWGLGFF 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222642140 289 VAMPAMNNILSKwvpVSERSRSLAL-VYSG-MYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSVWFALWQ 357
Cdd:cd17324 303 AAHSALQTRVLR---LAPEARGLASsLYLAaYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
211-349 |
1.16e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.52 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 211 SEFGWSPATVGLIQSSFFWGYLLTQILGG-IWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLpfLLVMRAFMGIGEGV 289
Cdd:cd17490 223 KQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTL--LYLLQALNGFGTGI 300
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222642140 290 AMPAMNNILSKWVPVSERSRSLAL---VYS-GMYLGSVtglaFSPLLISRFGWPSVFYAFGSLG 349
Cdd:cd17490 301 LFPLLMSLSIEGVPAEQRSTAMGFfqaIYAlGMFLGPV----LVGIISEAFGLQTGFFVIGVIA 360
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
197-338 |
1.23e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 44.45 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 197 MDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKigLPFL 276
Cdd:cd17372 13 MEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPN--YMWL 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 222642140 277 LVMRAFMGIGEGvAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:cd17372 91 IILRCLVGLGLG-GGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGW 151
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
185-338 |
1.70e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.10 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 185 VLLCFFSFLLcnmdrVNMSIAILP--MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIAT 262
Cdd:cd17503 184 LLLSFLLGLG-----LFGAMFLLPlyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGT 258
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222642140 263 VL-TPLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:cd17503 259 LLlAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQ 335
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
213-380 |
1.70e-04 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 44.42 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 213 FGWSPATVGLIQSSFF-WGYLLTqILGGIWADRFGG--KVVLGFGVVwwsIATVLTPLAAKIGLPFLLVMRAFMGIGEGV 289
Cdd:COG3104 50 LGLSEADAAAIYGAYTaLVYLTP-LLGGWLADRLLGqrRAILLGGIL---MALGHFLLALPGGVTLFYLGLALIAVGNGL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 290 AMPAMNNILSKWVPVSERSRSLA--LVYSGMYLGSVTGLAFSPLLISRFGWPsvfYAFGS------LGSVWFALWQRKAH 361
Cdd:COG3104 126 FKPNISSLVGQLYDPGDPRRDAGftIFYMGINIGAFLAPLLCGYLGEKYGWH---YGFGAaaigmlIGLIIFLLGRKYLG 202
|
170
....*....|....*....
gi 222642140 362 SSPSEDPELSKAEKRYILG 380
Cdd:COG3104 203 DIGLEPDNPLSKKERLIAV 221
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
184-379 |
2.59e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 184 VVLLCFFSFLlcnMDRVN-MSIAILPM-SSEFGWSPATVGLIQS-SFFWGYLLtQILGGIWADRFGGK---VVLGFGVvw 257
Cdd:cd17370 1 VWLLGLVSLF---ADISYeMARSILPLfLVVLGASAAAVGLIEGlAEALGSLL-RLFSGYLSDRTGKRkplVILGYGL-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 258 wSIATVLTpLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTG--LAFSPLLISR 335
Cdd:cd17370 75 -SALAKPL-LALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGplLAALLLYLLG 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 222642140 336 FGWPSVFY-----AFGSLGSVWFALWQRK------AHSSPSEDPELSKAEKRYIL 379
Cdd:cd17370 153 GNYRTIFLlaaipALLALLILLFVVKEYPrppklrKKSKKTSLKKLPKAFWLYLL 207
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
399-579 |
2.74e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.42 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 399 KPPVWALIVSHFCHNWGTFILLTWMPTYYNQvLKFNLTESGLLCVLPWLTMAIFANIGGWIADtLVGRgvsitnvRKIMQ 478
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLAD-RFGR-------RRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 479 sIGFLGPALFLTLLSKVRTPAMAVLCMACSQGSDAFSQSGLYSNHQDI-GPRYAGVLLGLSNTAGVLAGVFGTAATGYIL 557
Cdd:COG2814 80 -LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLvPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180
....*....|....*....|..
gi 222642140 558 QKGSWDSVFQVAVVLYIVGTVV 579
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLL 180
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
186-355 |
4.08e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 43.09 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 186 LLCFFSFLLCNMDRVNMSIAILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVL 264
Cdd:PRK10473 5 LLCSFALVLLYPAGIDMYLVGLPrIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 265 TPLAAKIGLpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYA 344
Cdd:PRK10473 85 CSLAETSSL--FLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYT 162
|
170
....*....|.
gi 222642140 345 FGSLGSVWFAL 355
Cdd:PRK10473 163 MAAMGILVLLL 173
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
197-338 |
4.56e-04 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 42.88 E-value: 4.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 197 MDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGlpFL 276
Cdd:cd17441 13 MEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYS--WI 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 222642140 277 LVMRAFMGIGEGvAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:cd17441 91 LVLRGLVGFGIG-GVPQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGW 151
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
200-354 |
6.03e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 42.62 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 200 VNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQ-ILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLPFLLV 278
Cdd:cd17388 224 VPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQaFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPIL 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 222642140 279 MRAFMGigeGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGlafsPLLISrfgwpSVFYAFGSL--GSVWFA 354
Cdd:cd17388 304 ILLALG---GIAGPALQGLLSRQVPENEQGELQGVLTSLTSLTSIIG----PLLFT-----GIFAASPATwpGLAWII 369
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
221-290 |
6.16e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.64 E-value: 6.16e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222642140 221 GLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLA-AKIGLPFLLVMRAFMGIGEGVA 290
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkGKWSVYQLIVGRVLVGIGVGGA 119
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
187-466 |
6.21e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 42.36 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 187 LCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFwgyllTQILGGI----WADRFGGKVVLGFGVVWWSIAT 262
Cdd:cd17368 10 LEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFF-----MRPIGAIvlgaYADRIGRKPAMTLTLAIMALGT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 263 VL---TPLAAKIGL--PFLLVM-RAFMGIGEGVAMPAMNNILSKWVPVSER----SRSLALVYSGMYLGSVTGLAFSPLL 332
Cdd:cd17368 85 LLialAPTYATIGIaaPLLVLLaRLLQGFAAGGEVGGVTAYLVEAAPPGRRgfytSWQSASQQVAIVAGALVGYLLSLTL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 333 ----ISRFGW-----------PSVFYAFGSLGSVwFALWQRKAHSSPSEDPELSKAEKRYILGGStlkepvtsipwkLIL 397
Cdd:cd17368 165 taeaLAEWGWripffiglliiPLGLWLRRSLEET-EAFLERKARPTRRELFALLANNRRIILLGM------------LLV 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 222642140 398 SKPPVwalivshfchnwGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTlVGR 466
Cdd:cd17368 232 AGSTV------------TFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDR-IGR 287
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
202-359 |
1.13e-03 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 41.41 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 202 MSIAILPMSSEF--GWSPATVGLIQSSF-FWGYLLTqILGGIWADRFGGK---VVLGFGVVwwsIATVLTPLAAKIGLPF 275
Cdd:cd17346 22 RAILILYLTAQLgdGFSEADAASIYGAYtALVYLTP-IIGGWLADKVLGArrtVFIGGILM---ALGYLLLALSPFSVSM 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 276 LLVMRAFMGIGEGVAMPAMNNILSKWVPV--SERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFG---SLGS 350
Cdd:cd17346 98 LYLGLALIIVGNGLFKPNISSLVGKLYDEndPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYGYHYGFGLAAvgmLLGL 177
|
....*....
gi 222642140 351 VWFALWQRK 359
Cdd:cd17346 178 LIFLLGRKK 186
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
202-350 |
1.24e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 202 MSIAILPMSSE------FGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTpLAAKIGLPF 275
Cdd:cd17504 195 MVFQLLPQLLQlptptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLL-ALLHSSLWA 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222642140 276 LLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGS 350
Cdd:cd17504 274 LVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGA 348
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
181-578 |
1.48e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 41.17 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 181 RWTVVLLCFFSFLLCNMDRVNMSIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSI 260
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 261 ATVLtpLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGWPS 340
Cdd:cd17343 81 TTVA--FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 341 VFYAFGSLGSVWFALWQRKAHSSPSED--PELSKAEKryilGGSTLKEPVTSIPWKLILSKPPVWAL--------IVSHF 410
Cdd:cd17343 159 TLSISGTVAVVMSVVCLLFIKNEPSDVglNNIEEEES----KGKKKKSPRGESTLKELLLSPFLWLLslgylvvfGVKTA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 411 CHNWGTFILLtwmptyyNQVLKFNLTESGLLCVLPwlTMAIFANI-GGWIADTLVGRGVSIT--NVRKIMQSIGFLGPAL 487
Cdd:cd17343 235 VTDWGQLFLI-------QDKGQSALTGSSFMSSLE--VGGFVGSIaAGYLSDWAVAKHGSSSrgNPRMPLALVFMAGLTV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 488 FLTLLSKVRTPA---MAVLCMACSQGSDA---FSQSGLYSNhQDIGPRYAG----VLLGLSNTAGVLAGVfgtaATGYIL 557
Cdd:cd17343 306 SLHLFRVHITSDsseLFILLLGFLIGFSLygpIAIFGVIAN-ESAPSHLCGtshaIVALAANVGGVLAGL----PFSYIA 380
|
410 420
....*....|....*....|.
gi 222642140 558 QKGSWDSVFQVAVVLYIVGTV 578
Cdd:cd17343 381 KHYDWRTAFLLLEILCAITVV 401
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
213-579 |
1.57e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.97 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 213 FGWSPATVGLIQS--SFFWGYLlTQILGGI----WADRFGGKVVLGFGVVWWSIATVLT---PLAAKIGL--PFLLV-MR 280
Cdd:cd17369 34 FPAVDPAAGTLAAfaTFGVGFL-ARPLGGVvfghFGDRIGRKKTLVLTLLLMGIATFLIgllPTYAQIGIlaPILLVlLR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 281 AFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTG-LAFspLLISRFGWPSVFYAFG-------SLGSVW 352
Cdd:cd17369 113 LLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLAtGVF--LLLSALLSDEAFLSWGwripfllSAVLVA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 353 FALWQRkahSSPSEDPELSKAEKRyilggstlKEPVTSIPWKLILSKP-PVWALIVSHFCHNWGTFILLTWMPTYYNQVL 431
Cdd:cd17369 191 VGLYIR---LRLEETPVFRRAKEA--------GQVVRAPLVEVLRRHWrALLLAIGLRLAENVLFYLFTTFALSYATQTL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 432 KFNLTESGLLCVLPWLTMAIFANIGGWIADTlVGrgvsitnvRKIMQSIGFLGPAL----FLTLLSKVRTPAM---AVLC 504
Cdd:cd17369 260 GVDRSTVLLAVLIASVVAAITIPLFGWLSDR-VG--------RRPVYLAGALLAALfafpFFWLLDTGSTWLIvlaAVVV 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 222642140 505 MACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGlSNTAGVLAGVFG-TAATGYILQKGSWdsvfqVAVVLYIVGTVV 579
Cdd:cd17369 331 LGVLHGMMYGPQAAFLAELFPTRVRYTGASLG-YQLGAILGGGFApLIATALVAATGSW-----WPVALYLAALAV 400
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
220-338 |
1.68e-03 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 40.95 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 220 VGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLA-AKIGLPFLLVMrafmgIGEGVAMPAMNNIL 298
Cdd:cd17442 38 VALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFApSYIWFVFLRCM-----VGCGVSGHSQGLII 112
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 222642140 299 -SKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:cd17442 113 kTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGW 153
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
177-356 |
2.03e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.67 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 177 QFPKRWTVVLLCFFSFLLCNMDRVNMSIAILpmsSEFGWSPATVGLIQSSFFWGYLLTQ-ILGGIWADRFGGKVVLGFGV 255
Cdd:cd17331 205 RLPGVAFLLLVKLLSGLPIGMFQSMFSLVAM---DFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLSV 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 256 VwwSIATVLTPLAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISR 335
Cdd:cd17331 282 A--LLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQA 359
|
170 180
....*....|....*....|..
gi 222642140 336 FGWPSVFY-AFGSLGSVWFALW 356
Cdd:cd17331 360 YGFPSFGLlGAAINGLLTVYLL 381
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
184-343 |
2.27e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 40.64 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 184 VVLLCFFSFLlcnmdrVNMSIAILP-----MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWW 258
Cdd:cd17323 1 VFIISFLTFV------VTFGSSIYSpalpqIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 259 SIATVLTPLAAKIGLpfLLVMRAFMGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:cd17323 75 VIFQIGCALAPNIAM--LIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152
|
....*
gi 222642140 339 PSVFY 343
Cdd:cd17323 153 RWIFW 157
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
205-356 |
2.35e-03 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 40.69 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 205 AILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKIGLpFLLvMRAFMG 284
Cdd:PRK15402 35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQ-FTL-LRFLQG 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 222642140 285 IGEG----VAMPAMNNILSKWVPVsersRSLALVYSGMYLGSVTGLAFSPLLISRFGWPSVFYAFGSLGSV-WFALW 356
Cdd:PRK15402 113 IGLCfigaVGYAAIQESFEEADAI----KITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALsFFGLW 185
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
220-323 |
2.61e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.77 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 220 VGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTplAAKIGLPFLLVMRAFMGIGEGVAMPAMNNILS 299
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLT--AFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNT 206
|
90 100
....*....|....*....|....
gi 222642140 300 KWVPVSERSRSLALVYSGMYLGSV 323
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLV 230
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
206-430 |
3.38e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 40.05 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 206 ILP-MSSEFGWSPATVGLIQSSFFWGYLLTQILGGIwaDRFGGKVVLGFGVVWWSIATVLTPLAAKIGLPFLLVM--RAF 282
Cdd:pfam06779 15 ILPvMIAEGQFSLSQAGLLAAANYAGYLAGALLASF--AWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLliRFL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 283 MGIGEGVAMPAMNNILSKWVPVSERSRSLALVYSGMYLG-SVTGLAFspLLISRFGWPSVF--YAFGSLGSVW----FAL 355
Cdd:pfam06779 93 AGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGiALSGLLV--PLGLQLGLGGSSlwYGAGVLSAVLtlavFPL 170
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 222642140 356 WQRKAHSSPSEDPELSKAEKRyilggstlkepvtSIPWklilskppvWALIVSHFCHNWGTFILLTWMPTYYNQV 430
Cdd:pfam06779 171 LPRRAPRHASAPAPAAKPLQR-------------SLPL---------WILTLAYGLAGFGYIITATFLPAMARDG 223
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
214-557 |
3.52e-03 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 39.89 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 214 GWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIATVLTPLAAKI--GLPFL---LVMRAFMGIGEG 288
Cdd:cd17385 30 GVSDTIIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDRVpdGTVFIalcFLVRIVEAVGFA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 289 VAMPAMNNILSKWVP--VSERSRSLAlVYSGmyLGSVTGLAFSPLLISRFGWPSVFYAFGS--LGSVWFALWqrkahSSP 364
Cdd:cd17385 110 AFITASFAIIAKEFPnnIATVLGTLE-TFSG--LGLMLGPPLGGFLYQAGGYELPFLVLGCllLLTVPLNMF-----ILP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 365 SEDPELSKAEkryilgGSTLKepvtsipwklILSKPPVWaliVSHFCHNWGTFILLTWMPTYYNQVLKFNLTES--GLLC 442
Cdd:cd17385 182 RYDDDPSPKS------GSMLK----------LLKIPSVL---LLCLSIVSGSVSLGFLDPTLSPHLRQFKLSPGqvGLMF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 443 VLPWLTMAIFANIGGWIADTlvgrgvsiTNVRKIMQSIG---------FLGPALFLTLLSK------------------- 494
Cdd:cd17385 243 LILAGSYAISAPLWGWLSDK--------KKIPKWLMVIGsiitgvgflLLGPAPLLPIKSElwmviiglvllglslgaal 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 222642140 495 VRTPAMAVLCMACSQGSDAFSQSGL--------YSNHQDIGPRYAGVL---LGLSNTAGVLAGVFGTAATGYIL 557
Cdd:cd17385 315 VPTFPELLNCAREYGFPDNLSTYGLvsglfnaaFSLGAFIGPTLGGFLlerLGFEWAATIQAGLAFVVGILMSI 388
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
200-287 |
3.99e-03 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 39.66 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 200 VNMSIAILPM--SSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGK--VVLGF------GVVWWSIATVLTPLAA 269
Cdd:PRK12382 31 VGLPLPVIPLfvHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKrsALQGMlacglaGLAYLLAAILPVSAPF 110
|
90
....*....|....*...
gi 222642140 270 KIGLpfLLVMRAFMGIGE 287
Cdd:PRK12382 111 KFAL--LVVGRLILGFGE 126
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
214-302 |
6.09e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 6.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 214 GWSPATVGLIQSSFFWGYLLTQILGGIWADRFG-GKVVLGFGVVWWSIATVLTPLAAKIGLPFLLVMrAFMGIGEGVAMP 292
Cdd:cd17335 28 GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLV-ILGAFFSAPVVP 106
|
90
....*....|
gi 222642140 293 AMNNILSKWV 302
Cdd:cd17335 107 LVDSITLQYL 116
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
184-503 |
9.53e-03 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 38.74 E-value: 9.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 184 VVLLCFF--SFLLCNMDrvnmsIAILPMSSEFGWSPATVGLIQSSFFWGYLLTQILGGIWADRFGGKVVLGFGVVWWSIA 261
Cdd:cd17394 3 LVTSLFFlwGFATNLND-----ILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 262 TVLTPLAAKIGL-PFLLVmrAFMGIGEGVAM--PAMNNILSKWVPVSERSRSLALVYSGMYLGSVTGLAFSPLLISRFGW 338
Cdd:cd17394 78 ALLFIPAASLRTyGLFLI--ALFVLASGLALlqTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYLILSGIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 339 PSVFYAFGSLGSVWFALWQRKAHS--SP-----------------SEDPELSKAEKRYILGGSTLKEpvtsipwklILSK 399
Cdd:cd17394 156 STATALAAMSAAELQAYKTAELASvqLPylgialvllllavlillSKLPEIEAAEAEALGSKGTLLR---------LLKN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 400 PPVWALIVSHFCHNWGTFILLTWMPTYYNQ-VLKFNLTESGLLCVLPWltmaIFANIGGWIAdTLVGRGVSITNVRKIMQ 478
Cdd:cd17394 227 PHLRLGVLAIFFYVGAEVAIWSFLINYLMEyIAGLTETSAATFVSYYW----GGFMVGRFLG-TALLKKISPKKLLAVFA 301
|
330 340
....*....|....*....|....*
gi 222642140 479 SIGFLgpALFLTLLSKVRTPAMAVL 503
Cdd:cd17394 302 LLGLL--LLLGAIFTGGMVALYALV 324
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
402-488 |
9.74e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 9.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222642140 402 VWALIVSHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAIFANIGGWIADTLVGRGVSITNVrkIMQSIG 481
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGL--LLRALG 78
|
....*..
gi 222642140 482 FLGPALF 488
Cdd:cd17329 79 FALLGFA 85
|
|
| |
