NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|194193493|gb|EDX07069|]
View 

GD11040 [Drosophila simulans]

Protein Classification

shroom family protein( domain architecture ID 10554662)

shroom family protein is a PDZ (PSD-95, Dlg, and ZO-1/2) domain-containing protein that functions in cell morphology by coordinating the assembly of both microtubule and actin cytoskeletons

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 152-405 1.44e-78

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


:

Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 244.48  E-value: 1.44e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  152 ELVKLLPPGDK-IADILTPK-ICKPTSQYVSNLYnPDVPLRLAKRDVGTS---------------------------TLM 202
Cdd:pfam08687   1 ELVKELVPKDKsLADILDPKpSRKTTMDLMEGLF-PEDTLRAMKPDLGEAykkapseegseeeasgtsslsscsayyTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  203 RMKS---ITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEK 279
Cdd:pfam08687  80 APKAellTKMKDLTTLPSPDQPEEQGEEELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  280 VRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETRQQEKGALESKRDLLYEQLEEAQRLKSDIERRGVSI 354
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALssldsDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 194193493  355 AGLLGKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 405
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 152-405 1.44e-78

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 244.48  E-value: 1.44e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  152 ELVKLLPPGDK-IADILTPK-ICKPTSQYVSNLYnPDVPLRLAKRDVGTS---------------------------TLM 202
Cdd:pfam08687   1 ELVKELVPKDKsLADILDPKpSRKTTMDLMEGLF-PEDTLRAMKPDLGEAykkapseegseeeasgtsslsscsayyTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  203 RMKS---ITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEK 279
Cdd:pfam08687  80 APKAellTKMKDLTTLPSPDQPEEQGEEELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  280 VRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETRQQEKGALESKRDLLYEQLEEAQRLKSDIERRGVSI 354
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALssldsDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 194193493  355 AGLLGKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 405
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
 152-405 1.44e-78

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 462561 [Multi-domain]  Cd Length: 290  Bit Score: 244.48  E-value: 1.44e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  152 ELVKLLPPGDK-IADILTPK-ICKPTSQYVSNLYnPDVPLRLAKRDVGTS---------------------------TLM 202
Cdd:pfam08687   1 ELVKELVPKDKsLADILDPKpSRKTTMDLMEGLF-PEDTLRAMKPDLGEAykkapseegseeeasgtsslsscsayyTTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  203 RMKS---ITSSAEIRVVSVELQLAEPSEEPTNLIKQKMDELIKHLNQKIVSLKREQQTISEECSANDRLGQDLFAKLAEK 279
Cdd:pfam08687  80 APKAellTKMKDLTTLPSPDQPEEQGEEELDNDLQQKKVELIESLQRKLQVLREEQEALQEEIQANAALGAEVEALVQEV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194193493  280 VRPSEASKFRTHVDAVGNITSLLLSLSERLAQTESSL-----ETRQQEKGALESKRDLLYEQLEEAQRLKSDIERRGVSI 354
Cdd:pfam08687 160 CKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALssldsDADAEERQSLLEKRRLLLRQLEDAKELKENLDRRERVV 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 194193493  355 AGLLGKNLSADMCADYDYFINMKAKLIADARDLAVRIKGSEEQLSSLSDAL 405
Cdd:pfam08687 240 SGILARYLTAEQLQDYRHFVKMKAALLIEQRELDEKIKLGEEQLKALKESL 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH