BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  155 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET-PCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGES 233
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 946581059  234 LQVRG 238
Cdd:cd18315    81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  155 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET-PCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGES 233
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 946581059  234 LQVRG 238
Cdd:cd18315    81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059    157 DVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESL 234
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                    ....*...
gi 946581059    235 QVRGLVES 242
Cdd:smart00225   81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  155 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET-PCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGES 233
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                  ....*
gi 946581059  234 LQVRG 238
Cdd:cd18315    81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059    157 DVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESL 234
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                    ....*...
gi 946581059    235 QVRGLVES 242
Cdd:smart00225   81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  155 LVDVTLVCAETSIRAHKMVLSACSPFFQRVF--AETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGE 232
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFssGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80

                  ..
gi 946581059  233 SL 234
Cdd:cd18186    81 KL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  138 HQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA--ETPCKHPVIVLKDFRGWVVQAIVDFMYRG 215
Cdd:cd18338     4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTgeMSESRAKRVRIKEVDGWTLKMLIDYVYTA 83

                          90       100
                  ....*....|....*....|..
gi 946581059  216 EISVPQQRLQTLIQAGESLQVR 237
Cdd:cd18338    84 EIQVTEENVQVLLPAAGLLQLQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  141 HILRAFDAL--LQTK-TLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRG 215
Cdd:cd18339     4 HMKKAFKVMneLRSKqLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSesKAKKIEIKDVDGQTLSKLIDYIYTA 83

                          90       100
                  ....*....|....*....|.
gi 946581059  216 EISVPQQRLQTLIQAGESLQV 236
Cdd:cd18339    84 EIEVTEENVQVLLPAASLLQL 104

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 946581059   834 TNTELTEALQHVWNKKMTTSQASRIFGIPYNSLLMYVRGKYGKS 877
Cdd:pfam05225    1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLWRRKRGKYSLK 44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  134 RWNNHQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA----ETPCKHPVIVLKDFRGwvVQAIV 209
Cdd:cd18266     4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmrEAHQKEVELVGASYIG--LKAVI 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 946581059  210 DFMYRGEISVPQQRLQTLIQAGESLQVRGLVE 241
Cdd:cd18266    82 DFLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  136 NNHQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF----AETpcKHPVIVLKDFRGWVVQAIVDF 211
Cdd:cd18242     2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtsemSEK--GKSEVELQGLTASTMEILLDF 79

                          90       100
                  ....*....|....*....|....*..
gi 946581059  212 MYRGEISVPQQRLQTLIQAGESLQVRG 238
Cdd:cd18242    80 VYTETVHVTVENVQELLPAACLLQLKG 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  151 QTKTLVDVTLVCAETSIRAHKMVLSACSPFF-QRVFAETP--CKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTL 227
Cdd:cd18293    11 NSGVFCDVLLQAEGESVPAHCCVLSACSPYLtERLSSEPPpaGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDV 90

                          90
                  ....*....|...
gi 946581059  228 IQAGESLQVRGLV 240
Cdd:cd18293    91 LAAARRLQISELE 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  136 NNHQNHILRAF---DALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAE--TPCKHPVIVLKDFRGWVVQAIVD 210
Cdd:cd18246    17 HNSKRHYHDAFvsmNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNemSESRQTHVTLHDIDPQALEQLVQ 96

                          90       100
                  ....*....|....*....|....*....
gi 946581059  211 FMYRGEISVPQQRLQTLIQAGESLQVRGL 239
Cdd:cd18246    97 YAYTAEIVVGEGNVQTLLPAASLLQLNGV 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  133 LRWNNHQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA-ETPCKHPVIVLKDFRGWVVQAIVDF 211
Cdd:cd18212     1 IHSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFAdEGEVGQSIYMLEGMVAETFGALLEF 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 946581059  212 MYRGEISVPQQRLQTLIQAGESLQVRGLVES 242
Cdd:cd18212    81 IYTGCLQVGEKSLEQILATAQFLKVNDLVKA 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  138 HQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA--ETPCKHPVIVLKDFRGWVVQAIVDFMYRG 215
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSsdSDGESILTVKLDGLDPDAVEVLVNYAYTS 80

                          90       100
                  ....*....|....*....|..
gi 946581059  216 EISVPQQRLQTLIQAGESLQVR 237
Cdd:cd18306    81 RLEVPADLVKSVYSAAKKLKMD 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  138 HQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETpCKHPVIVLK-----DFRGwvVQAIVDFM 212
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR-VGEGVSVLTlpsglEARG--FQLLLDFM 78

                          90       100       110
                  ....*....|....*....|....*....|
gi 946581059  213 YRGEISVPQQRLQTLIQAGESLQVRGLVES 242
Cdd:cd18332    79 YTSRLPLTPRTVPAVLAAATYLQMEHVVET 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  138 HQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETpCKHPVIVLKDFRGwVVQAIVDFMYRGEI 217
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDG-TSGSVVLPESFAE-VFGLLLDFFYTGEL 78

                          90       100
                  ....*....|....*....|....
gi 946581059  218 SVPQQRLQTLIQAGESLQVRGLVE 241
Cdd:cd18232    79 ALTRENRDRVLLAAKELRVPEAVE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  155 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFA--ETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVP-QQRLQTLIQAG 231
Cdd:cd18223    18 LCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSsqEIWISSHVLELPDLKAEVFAEILNFIYSSKVVVKrQETVTDLVAAG 97

                  ...
gi 946581059  232 ESL 234
Cdd:cd18223    98 KKL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  137 NHQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF-AETPCKHPVIVLKDF-RGWVVQAIVDFMYR 214
Cdd:cd18328     7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFtAGTLADQPYVYEIDFvTPEALSAILEFAYT 86

                          90       100
                  ....*....|....*....|....*.
gi 946581059  215 GEISVPQQRLQTLIQAGESLQVRGLV 240
Cdd:cd18328    87 STLTITTSNVKHILNAAQMLEIQCII 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  138 HQNHILRAFDALLQTKTLVDVTLVCAETSI-RAHKMVLSACSPFFQRVF-AETPCK-HPVIVLKDFRGWVVQAIVDFMYR 214
Cdd:cd18252     4 HPADFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFtADMKEKsNNVIKLSGIDHDILEALVNYVYT 83

                          90       100
                  ....*....|....*....|.
gi 946581059  215 GEISVPQQRLQTLIQAGESLQ 235
Cdd:cd18252    84 SQICITERNVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  131 YSLRWNNHQNHILRA-FDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET--PCKHPVIVLKDFRGWVVQA 207
Cdd:cd18272     7 YTFTDRSHSSRVAQSiMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNlkEARNRVIELKDVSESVFQL 86

                          90       100       110
                  ....*....|....*....|....*....|....
gi 946581059  208 IVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVE 241
Cdd:cd18272    87 LVDYIYHGTVKLRVEELQETYEVADMYQLTALFE 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  149 LLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF--AETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQT 226
Cdd:cd18269    21 LLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFlsDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQD 100

                          90
                  ....*....|
gi 946581059  227 LIQAGESLQV 236
Cdd:cd18269   101 IFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  157 DVTLVCAETSIRAHKMVLSACSPFFQRVFA-ETPCKHP--------------VIVLKDFRGWVVQAIVDFMYRGEISVPQ 221
Cdd:cd18195    20 DVTLIAGDTKFRAHRSVLAASSPYFRELLSsPLPLGAAavaaapgatqsperVLELPGVKAGVFSDVLNFIYSSRVALPG 99

                          90
                  ....*....|....*....
gi 946581059  222 QRL-QTLIQAGESLQVRGL 239
Cdd:cd18195   100 SAAaKELGAAGKRLGIPFL 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  149 LLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET--PCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQT 226
Cdd:cd18340    21 LLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDleESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQD 100

                          90
                  ....*....|
gi 946581059  227 LIQAGESLQV 236
Cdd:cd18340   101 IFAAANMFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  157 DVTLVCAETSIRAHKMVLSACSPFFQR--VFAETPCKHPVIVLKDfrgwVVQAIVDFMYRGEISVPQQRLQTLIQAGESL 234
Cdd:cd18229    20 DVTVRIHDASLRAHRCVLAAGSPFFHDklLLGHSEIEVPPVVPAQ----TVRQLVEFMYSGSLVVAQSEALQILTAASIL 95

                  ....*..
gi 946581059  235 QVRGLVE 241
Cdd:cd18229    96 QIKTVID 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  142 ILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET--PCKHPVIVLKDFRGWVVQAIVDFMYRGEISV 219
Cdd:cd18268    10 LLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNfrESSQAKVDLKGIDSDVLDQIVDYVYTGEILI 89

                          90       100
                  ....*....|....*....|...
gi 946581059  220 PQQRLQTLIQAGESLQVRGLVES 242
Cdd:cd18268    90 TRDNVLPLMEAASMLQYPKLFEA 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  157 DVTLVCAETSIRAHKMVLSACSPFFQRVFAetpCKHPVIVLKDFRGWVVQAIVDFMYRGEI-SVPQQRLQTLIQAGESLQ 235
Cdd:cd18219    23 DVTVIVEDRKFRAHKNILSASSTYFHQLFS---VAGQVVELNFIRADIFAEILNYIYSSKIvRVRSDLLEELIKSGQLLG 99

                  ....*.
gi 946581059  236 VRGLVE 241
Cdd:cd18219   100 VKFIAE 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  149 LLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF--AETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQT 226
Cdd:cd18341    21 LLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFlsEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQD 100

                          90
                  ....*....|
gi 946581059  227 LIQAGESLQV 236
Cdd:cd18341   101 IFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  138 HQNHILRAFDALLQTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIV---LKDFRGwvVQAIVDFMYR 214
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFhldIKNVGG--IGQILDFMYT 78

                          90       100
                  ....*....|....*....|....*.
gi 946581059  215 GEISVPQQRLQTLIQAGESLQVRGLV 240
Cdd:cd18233    79 SHLDLNQDNVQVMLDIAQCLQVQNVL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  139 QNHILRAFDALLQTK---TLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA--ETPCKHPVIVLKDFRGWVVQAIVDFMY 213
Cdd:cd18276     2 QKHSLTLLDQLNRMKelaELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTcgLMECSQREVVLHDITAESVSIILNYMY 81

                          90       100
                  ....*....|....*....|...
gi 946581059  214 RGEISVPQQRLQTLIQAGESLQV 236
Cdd:cd18276    82 SSDLHLTNSNVQGVATAAFFLQM 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946581059  155 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGE 232
Cdd:cd18234     1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVReaTEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                          90
                  ....*....|
gi 946581059  233 SLQVRGLVES 242
Cdd:cd18234    81 LLQLSEVVEA 90