BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  26 HCEVVLASrDGVRVRAHLFVLSTCSELMRNLLVDVPRGQEATIMLPDIRGDLLECMLSFIYMGETSLPSTSLPEFLEAIN 105
Cdd:cd18315    1 LVDVTLAC-EGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*
gi 194128237 106 LLGIK 110
Cdd:cd18315   80 LLQIK 84

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 194128237  347 INDALDLAADAVIIEGLSLQKAADRFDISKTVLWRRVRTNPAYMR 391
Cdd:pfam05225   1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLWRRKRGKYSLKR 45

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  26 HCEVVLASrDGVRVRAHLFVLSTCSELMRNLLVDVPRGQEATIMLPDIRGDLLECMLSFIYMGETSLPSTSLPEFLEAIN 105
Cdd:cd18315    1 LVDVTLAC-EGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*
gi 194128237 106 LLGIK 110
Cdd:cd18315   80 LLQIK 84

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   20 LRNDNQHCEVVLASrDGVRVRAHLFVLSTCSELMRNLLVDVPRGQE-ATIMLPDIRGDLLECMLSFIYMGETsLPSTSLP 98
Cdd:pfam00651   4 LREQGELCDVTLVV-GDKEFRAHKAVLAACSPYFKALFSGQESESSvSEITLDDVSPEDFEALLEFMYTGKL-ISEENVD 81

                          90
                  ....*....|....*
gi 194128237   99 EFLEAINLLGIKSAI 113
Cdd:pfam00651  82 DLLAAADKLQIPSLV 96

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237    35 DGVRVRAHLFVLSTCSELMRNLLVDVPR-GQEATIMLPDIRGDLLECMLSFIYMGETSLPSTSLPEFLEAINLLGIKSAI 113
Cdd:smart00225   7 GGKKFHAHKAVLAAHSPYFKALFSSDFKeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYLQIPGLV 86

                   ....*
gi 194128237   114 SFECN 118
Cdd:smart00225  87 ELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  26 HCEVVLASrDGVRVRAHLFVLSTCSELMRNLLVDVPRGQEATIMLPDIRGDLLECMLSFIYMGETSLPSTSLPEFLEAIN 105
Cdd:cd18315    1 LVDVTLAC-EGGSLKAHKLVLAAASPYFAALLKETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                 ....*
gi 194128237 106 LLGIK 110
Cdd:cd18315   80 LLQIK 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  26 HCEVVLASrDGVRVRAHLFVLSTCSELMRNLLV-DVPRGQEATIMLPDIRGDLLECMLSFIYMGETSLPSTSLPEFLEAI 104
Cdd:cd18186    1 LCDVTLVV-GGREFPAHRAVLAARSPYFRAMFSsGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                 ...
gi 194128237 105 NLL 107
Cdd:cd18186   80 DKL 82

helix-turn-helix, Psq domain; This DNA-binding motif is found in four copies in the pipsqueak protein of Drosophila melanogaster. In pipsqueak this domain binds to GAGA sequence.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 194128237  347 INDALDLAADAVIIEGLSLQKAADRFDISKTVLWRRVRTNPAYMR 391
Cdd:pfam05225   1 TPEALAEALEAVRNGQMSIRKAARIYGIPYSTLWRRKRGKYSLKR 45

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLASrDGVRVRAHLFVLSTCSELMRNLLVDvprGQEATIMLPDIRGDLLECMLSFIYMG 88
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDV-GGRVFKAHWSVLACCSHFFQSLYGD---GTSGSVVLPESFAEVFGLLLDFFYTG 76

                         90       100
                 ....*....|....*....|....*
gi 194128237  89 ETSLPSTSLPEFLEAINLLGIKSAI 113
Cdd:cd18232   77 ELALTRENRDRVLLAAKELRVPEAV 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLaSRDGVRVRAHLFVLSTCSELMRNLLV-DVPRGQEATIMLPDIRGDLLECMLSFIYM 87
Cdd:cd18253    1 HSESILQVFNEFRDSRLFTDVII-CVEGREFPCHRAILSACSSYFRAMFCnDHRESREMLVEINGILAEAMDCFLQYVYT 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 194128237  88 GETSLPSTSLPEFLEAINLLGIkSAISFEC 117
Cdd:cd18253   80 GKVKITTENVQYLFETSSLFQI-SPLRDAC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLASRDgVRVRAHLFVLSTCSELMRNLLVDVPRGQEATIMLPDIRGDLLECMLSFIYMG 88
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVED-VKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTA 79

                         90       100
                 ....*....|....*....|..
gi 194128237  89 ETSLPSTSLPEFLEAINLLGIK 110
Cdd:cd18204   80 KISVKKEDVNLMMSSGQILGIR 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194128237  36 GVRVRAHLFVLSTCSELMRNLLVDVPR-GQEATIMLPDIRGDLLECMLSFIYMGETSLPSTSLPEFLE 102
Cdd:cd18297   21 GRPFYAHKIVLVTASDRFKSMLSSGSTeAQTPVIEIPDIRYDIFQLMMQYLYTGGVESLDVAQDDALE 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLASRDGV-RVRAHLFVLSTCSELMRNLLVDVPRGQE-ATIMLPDIRGDLLECMLSFIY 86
Cdd:cd18239    6 HSSVVLQGFDQLRGEGLLCDVTLVPGDGDeTFPVHRAMMASASDYFKAMFTGGMKEQElMCIKLHGVSKIGLKNIIDFIY 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 194128237  87 MGETSLPSTSLPEFLEAINLLGIKSAISFeCN 118
Cdd:cd18239   86 TAKLSLNMDNLQDTLEAASFLQILPVLDF-CK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  21 RNDNQHCEVVLASrDGVRVRAHLFVLSTCSELMRNLL--VDVPRGQEATIMLPDIRGDLLECMLSFIYMGETSLPSTSLP 98
Cdd:cd18293   10 QNSGVFCDVLLQA-EGESVPAHCCVLSACSPYLTERLssEPPPAGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQ 88

                         90
                 ....*....|.
gi 194128237  99 EFLEAINLLGI 109
Cdd:cd18293   89 DVLAAARRLQI 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   5 KWMGHSSTIMDIQRSLRNDNQHCEVVLASrDGVRVRAHLFVLSTCSELMRNLL-VDVPRGQEATIMLPDIRGDLLECMLS 83
Cdd:cd18266    4 RWADHSNLVLQGLNEQRQRGLFCDVVLVA-DEQRVPAHRNLLAVCSDYFNSMFtIGMREAHQKEVELVGASYIGLKAVID 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194128237  84 FIYMGETSLPSTSLPEFLEAINLLGIKSAISFEC 117
Cdd:cd18266   83 FLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLASrDGVRVRAHLFVLSTCSELMRNLLV-DVPRGQEATIMLPDIRGDLLECMLSFIYM 87
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRV-GDVKIHAHKVVLASCSPYFKAMFTgNLSEKENSEVEFQCIDETALQAIVEYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 194128237  88 GETSLPSTSLPEFLEAINLLGIKSAISFEC 117
Cdd:cd18257   80 GTVFISQATVESLLPAANLLQIKLVLKECC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLASRdGVRVRAHLFVLSTCSELMRNLLVDVPRGQ------------EATIMLPDIRGD 76
Cdd:cd18327    8 HSSELLSCLNEQRRAGLLCDLTIKTR-GLEYRTHRAVLAACSLYFRKLFTGGGGGSgdlgagggqdvcELDFVGPEALGA 86

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 194128237  77 LLEcmlsFIYMGETSLPSTSLPEFLEAINLLGIKSAI 113
Cdd:cd18327   87 LLE----FAYTATLTISSSNMREVLRAARLLEIPCVA 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLASRDGVrVRAHLFVLSTCSELMRNLLVD--------VPRGQEATIMLPDIRGDLLEC 80
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKI-FRAHKVVLAACSDFFRSKLVGqasprlvlVSPAGKCVLDLHHVTVTGFAP 80

                         90       100
                 ....*....|....*....|...
gi 194128237  81 MLSFIYMGETSLPSTSLPEFLEA 103
Cdd:cd18228   81 LLEYAYTSTLSINTENIIDVLAA 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237   9 HSSTIMDIQRSLRNDNQHCEVVLASRDGvRVRAHLFVLSTCSELMRNL-----LVDVPRGQEATIMLPDIrgdlLECMLS 83
Cdd:cd18328    8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQ-EYRTHRSVLAACSKYFKKLftagtLADQPYVYEIDFVTPEA----LSAILE 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 194128237  84 FIYMGETSLPSTSLPEFLEAINLLGIKSAIS 114
Cdd:cd18328   83 FAYTSTLTITTSNVKHILNAAQMLEIQCIIN 113

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194128237  35 DGVRVRAHLFVLSTCSELMR-NLLVDVPRGQEA----TIMLPDIRGDLLECMLSFIYMGETSLPST 95
Cdd:cd18301   26 GGKTFPAHKFILASRSDYFRkLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYTDTCDLLTD 91

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  18 RSLRNDNQHCEVVLASRDGVRVRAHLFVLSTCSELMRNLLVDvprgQEATIMLPDI-RGDLLECmLSFIYMGETSLPSTS 96
Cdd:cd18299    4 RNLLHSPSCADVVFILQGGVRIFAHRIVLAAASSVFADLFLM----MTVVTLDSDItPEAFRRV-LEFLYTGVLDENEDD 78

                         90
                 ....*....|....
gi 194128237  97 LPEFLEAINLLGIK 110
Cdd:cd18299   79 LKELKDAAELLELF 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  18 RSLRNDNQHCEVV-LASRDGVRVRAHLFVLSTCSELMRNLLVDVPRGQEATIMLP--DIRGDLLECMLSFIYMGETSLPS 94
Cdd:cd18294    6 KSLINNPEFSDVKfLVGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlsDIEPEVFRAVLEFIYTNCVTLSN 85

                         90
                 ....*....|....*
gi 194128237  95 TSLPEFLEAINLLGI 109
Cdd:cd18294   86 HTVIEVLAAAVEYGL 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194128237  20 LRNDNQHCEVVLaSRDGVRVRAHLFVLSTCSE-LMRNLLVDVPRGQEATIMLPDIRGDLLECMLSFIYMG 88
Cdd:cd18306   12 LRKNRQFCDVIL-QVGGHEIPAHRAVLACASPyLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTS 80