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Conserved domains on  [gi|156215766|gb|EDO36718|]
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predicted protein [Nematostella vectensis]

Protein Classification

WVD2 family protein( domain architecture ID 10536413)

WVD2 (WAVE-DAMPENED 2) family protein similar to Arabidopsis thaliana WVD2 that is a novel microtubule-associated protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPX2 pfam06886
Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region ...
 136-207 9.42e-13

Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.


:

Pssm-ID: 462029 [Multi-domain]  Cd Length: 77  Bit Score: 61.44  E-value: 9.42e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156215766  136 VLNSDKRAQERAIYEMQKHEKEMEEEAILRQREEEREEEERRNIAMLRQQMVHKANPIARFKGVQILPSEKP 207
Cdd:pfam06886   2 KLHTDERAEERKEFDKKLEEKEQAKEAEKEERERKRKEEEEEEIKQLRKELVFKAQPMPHFYRVFIPPSKKP 73
 
Name Accession Description Interval E-value
TPX2 pfam06886
Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region ...
 136-207 9.42e-13

Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.


Pssm-ID: 462029 [Multi-domain]  Cd Length: 77  Bit Score: 61.44  E-value: 9.42e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156215766  136 VLNSDKRAQERAIYEMQKHEKEMEEEAILRQREEEREEEERRNIAMLRQQMVHKANPIARFKGVQILPSEKP 207
Cdd:pfam06886   2 KLHTDERAEERKEFDKKLEEKEQAKEAEKEERERKRKEEEEEEIKQLRKELVFKAQPMPHFYRVFIPPSKKP 73
 
Name Accession Description Interval E-value
TPX2 pfam06886
Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region ...
 136-207 9.42e-13

Targeting protein for Xklp2 (TPX2) domain; This family represents a conserved region approximately 60 residues long within the eukaryotic targeting protein for Xklp2 (TPX2). Xklp2 is a kinesin-like protein localized on centrosomes throughout the cell cycle and on spindle pole microtubules during metaphase. In Xenopus, it has been shown that Xklp2 protein is required for centrosome separation and maintenance of spindle bi-polarity. TPX2 is a microtubule-associated protein that mediates the binding of the C-terminal domain of Xklp2 to microtubules. It is phosphorylated during mitosis in a microtubule-dependent way. The TPX domain appears to be truncated in fungal species.


Pssm-ID: 462029 [Multi-domain]  Cd Length: 77  Bit Score: 61.44  E-value: 9.42e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 156215766  136 VLNSDKRAQERAIYEMQKHEKEMEEEAILRQREEEREEEERRNIAMLRQQMVHKANPIARFKGVQILPSEKP 207
Cdd:pfam06886   2 KLHTDERAEERKEFDKKLEEKEQAKEAEKEERERKRKEEEEEEIKQLRKELVFKAQPMPHFYRVFIPPSKKP 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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