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Conserved domains on  [gi|149068815|gb|EDM18367|]
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chordin-like 2 (predicted), isoform CRA_a [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 166-228 9.41e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


:

Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 9.41e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149068815  166 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCMDGYQDCHRVTCPTQyPCSQPKKV--AGKCCKTC 228
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICPPL-DCPNPRLEipPGECCPVC 57
CHRDL_1_2_C super family cl44960
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 252-343 1.40e-07

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


The actual alignment was detected with superfamily member pfam19548:

Pssm-ID: 437380  Cd Length: 120  Bit Score: 49.42  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068815  252 FHVY-TLVSPSPDSLHRFVLEHEASDQVEMYIWRLVKGIYHLIQIKRVRKQDFQKEAqNFRLLTGTHEGYWTVFLAQTPE 330
Cdd:pfam19548  11 MPVYeSVFMEEGETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELG-HFKLLTRTTLSQWKIFSEGEAQ 89

                          90
                  ....*....|...
gi 149068815  331 LKVTASpDKVTRT 343
Cdd:pfam19548  90 ISQMCS-SRVCRT 101
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 26-89 6.60e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 34.71  E-value: 6.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149068815   26 CQLNETTYQHGEIFSaqelfparlSNQCVLCSCIEGHTYCGLMTCPEPSCPSTL--PLPDSCCQTC 89
Cdd:pfam00093   1 CVQNGVVYENGETWK---------PDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 166-228 9.41e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 9.41e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149068815  166 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCMDGYQDCHRVTCPTQyPCSQPKKV--AGKCCKTC 228
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICPPL-DCPNPRLEipPGECCPVC 57
CHRDL_1_2_C pfam19548
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 252-343 1.40e-07

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


Pssm-ID: 437380  Cd Length: 120  Bit Score: 49.42  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068815  252 FHVY-TLVSPSPDSLHRFVLEHEASDQVEMYIWRLVKGIYHLIQIKRVRKQDFQKEAqNFRLLTGTHEGYWTVFLAQTPE 330
Cdd:pfam19548  11 MPVYeSVFMEEGETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELG-HFKLLTRTTLSQWKIFSEGEAQ 89

                          90
                  ....*....|...
gi 149068815  331 LKVTASpDKVTRT 343
Cdd:pfam19548  90 ISQMCS-SRVCRT 101
VWC smart00214
von Willebrand factor (vWF) type C domain;
166-228 1.43e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.81  E-value: 1.43e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149068815   166 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCMDGYQ-DCHRVTCPTQYPCSQP--KKVAGKCCKTC 228
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTvLCDPVECPPPPDCPNPerVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 26-89 6.60e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 34.71  E-value: 6.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149068815   26 CQLNETTYQHGEIFSaqelfparlSNQCVLCSCIEGHTYCGLMTCPEPSCPSTL--PLPDSCCQTC 89
Cdd:pfam00093   1 CVQNGVVYENGETWK---------PDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 166-228 9.41e-08

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 48.19  E-value: 9.41e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149068815  166 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCMDGYQDCHRVTCPTQyPCSQPKKV--AGKCCKTC 228
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIICPPL-DCPNPRLEipPGECCPVC 57
CHRDL_1_2_C pfam19548
Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 ...
 252-343 1.40e-07

Chordin-like protein 1/2 C-terminal; This is the C-terminal domain of Chordin-like proteins 1 and 2. These proteins can bind BMPs family ligands and inhibit its activity by blocking their interaction with their receptors. They are involved in myoblast and osteoblast differentiation and maturation.


Pssm-ID: 437380  Cd Length: 120  Bit Score: 49.42  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149068815  252 FHVY-TLVSPSPDSLHRFVLEHEASDQVEMYIWRLVKGIYHLIQIKRVRKQDFQKEAqNFRLLTGTHEGYWTVFLAQTPE 330
Cdd:pfam19548  11 MPVYeSVFMEEGETTRKIALETERPPQVEVHVWTIRKGILHHFHIEKISKREFEELG-HFKLLTRTTLSQWKIFSEGEAQ 89

                          90
                  ....*....|...
gi 149068815  331 LKVTASpDKVTRT 343
Cdd:pfam19548  90 ISQMCS-SRVCRT 101
VWC smart00214
von Willebrand factor (vWF) type C domain;
166-228 1.43e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.81  E-value: 1.43e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149068815   166 CTHNGKTYSHGEVWHPTvlsfgpmPCILCTCMDGYQ-DCHRVTCPTQYPCSQP--KKVAGKCCKTC 228
Cdd:smart00214   1 CVHNGRVYNDGETWKPD-------PCQICTCLDGTTvLCDPVECPPPPDCPNPerVKPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 26-89 6.60e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 34.71  E-value: 6.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149068815   26 CQLNETTYQHGEIFSaqelfparlSNQCVLCSCIEGHTYCGLMTCPEPSCPSTL--PLPDSCCQTC 89
Cdd:pfam00093   1 CVQNGVVYENGETWK---------PDLCTICTCDDGKVLCDKIICPPLDCPNPRleIPPGECCPVC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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