similar to mKIAA0843 protein (predicted), isoform CRA_a [Rattus norvegicus]
Protein Classification
LIM domain-containing protein( domain architecture ID 10912196)
LIM (LIN-11, Isl1 and MEC-3) domain-containing protein; LIM is a small protein-protein interaction domain, containing two zinc fingers
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| AbLIM_anchor | pfam16182 | Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ... |
32-362 | 4.25e-109 | ||||||
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types. : Pssm-ID: 465046 [Multi-domain] Cd Length: 319 Bit Score: 322.12 E-value: 4.25e-109
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| LIM super family | cl02475 | LIM is a small protein-protein interaction domain, containing two zinc fingers; LIM domains ... |
1-24 | 2.97e-12 | ||||||
LIM is a small protein-protein interaction domain, containing two zinc fingers; LIM domains are identified in a diverse group of proteins with wide variety of biological functions, including gene expression regulation, cell fate determination, cytoskeleton organization, tumor formation and development. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes. They perform their functions through interactions with other protein partners. LIM domains are 50-60 amino acids in size and share two characteristic highly conserved zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The consensus sequence of LIM domain has been defined as C-x(2)-C-x(16,23)-H-x(2)-[CH]-x(2)-C-x(2)-C-x(16,21)-C-x(2,3)-[CHD] (where X denotes any amino acid). The actual alignment was detected with superfamily member cd09330: Pssm-ID: 413332 Cd Length: 56 Bit Score: 60.84 E-value: 2.97e-12
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| Name | Accession | Description | Interval | E-value | ||||||
| AbLIM_anchor | pfam16182 | Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ... |
32-362 | 4.25e-109 | ||||||
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types. Pssm-ID: 465046 [Multi-domain] Cd Length: 319 Bit Score: 322.12 E-value: 4.25e-109
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| LIM4_abLIM | cd09330 | The fourth LIM domain of actin binding LIM (abLIM) proteins; The fourth LIM domain of actin ... |
1-24 | 2.97e-12 | ||||||
The fourth LIM domain of actin binding LIM (abLIM) proteins; The fourth LIM domain of actin binding LIM (abLIM) proteins: Three homologous members of the abLIM protein family have been identified; abLIM-1, abLIM-2 and abLIM-3. The N-terminal of abLIM consists of four tandem repeats of LIM domains and the C-terminal of acting binding LIM protein is a villin headpiece domain, which has strong actin binding activity. The abLIM-1, which is expressed in retina, brain, and muscle tissue, has been indicated to function as a tumor suppressor. AbLIM-2 and -3, mainly expressed in muscle and neuronal tissue, bind to F-actin strongly. They may serve as a scaffold for signaling modules of the actin cytoskeleton and thereby modulate transcription. It has shown that LIM domains of abLIMs interact with STARS (striated muscle activator of Rho signaling), which directly binds actin and stimulates serum-response factor (SRF)-dependent transcription. All LIM domains are 50-60 amino acids in size and share two characteristic highly conserved zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes. Pssm-ID: 188716 Cd Length: 56 Bit Score: 60.84 E-value: 2.97e-12
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| Name | Accession | Description | Interval | E-value | ||||||
| AbLIM_anchor | pfam16182 | Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between ... |
32-362 | 4.25e-109 | ||||||
Putative adherens-junction anchoring region of AbLIM; AbLIM_anchor is a domain lying between the LIM actin-binding and the vilin-head domain of actin-binding LIM proteins. It is likely that this domain is involved in anchoring abLIMs to circumferential actin bundles in specific cell types. Pssm-ID: 465046 [Multi-domain] Cd Length: 319 Bit Score: 322.12 E-value: 4.25e-109
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| LIM4_abLIM | cd09330 | The fourth LIM domain of actin binding LIM (abLIM) proteins; The fourth LIM domain of actin ... |
1-24 | 2.97e-12 | ||||||
The fourth LIM domain of actin binding LIM (abLIM) proteins; The fourth LIM domain of actin binding LIM (abLIM) proteins: Three homologous members of the abLIM protein family have been identified; abLIM-1, abLIM-2 and abLIM-3. The N-terminal of abLIM consists of four tandem repeats of LIM domains and the C-terminal of acting binding LIM protein is a villin headpiece domain, which has strong actin binding activity. The abLIM-1, which is expressed in retina, brain, and muscle tissue, has been indicated to function as a tumor suppressor. AbLIM-2 and -3, mainly expressed in muscle and neuronal tissue, bind to F-actin strongly. They may serve as a scaffold for signaling modules of the actin cytoskeleton and thereby modulate transcription. It has shown that LIM domains of abLIMs interact with STARS (striated muscle activator of Rho signaling), which directly binds actin and stimulates serum-response factor (SRF)-dependent transcription. All LIM domains are 50-60 amino acids in size and share two characteristic highly conserved zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes. Pssm-ID: 188716 Cd Length: 56 Bit Score: 60.84 E-value: 2.97e-12
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