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Conserved domains on  [gi|149060500|gb|EDM11214|]
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similar to hypothetical protein MGC7537 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 77-197 1.72e-22

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


:

Pssm-ID: 460567  Cd Length: 109  Bit Score: 89.54  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149060500   77 ICRAALSAGIIGWAYGGIPAFIYAKRRYIEQSQAeiyHNRFdavqsahRAATRGFIRYGWRWSWRTAVFVTIFNTVNTGL 156
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNRPPPLTA---KLRL-------RGALNAVGKRGPSLGNNFAVFGGLYSGIECGL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 149060500  157 TVYRNKDALSHFAIAGAVTGGLFRinLGLRGLVAGGIIGAL 197
Cdd:pfam02466  71 EKYRGKEDPWNSIAAGALTGALLR--GGPRAAAVGGAVGAA 109
Pinin_SDK_memA super family cl47897
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 195-267 9.91e-04

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


The actual alignment was detected with superfamily member pfam04696:

Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 38.43  E-value: 9.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149060500  195 GALLGTpmgsllmaLEKHCGETVQERRQKDREAQQEQRLEEwRRNLQVTELLPMEIESgLEKIQPEKDAQRIE 267
Cdd:pfam04696  12 GGLLGT--------LQKFKKEESKQKEKEERRAEIEKRLEE-KAKQEKEELEERKREE-REELFEERRAEQIE 74
 
Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 77-197 1.72e-22

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 89.54  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149060500   77 ICRAALSAGIIGWAYGGIPAFIYAKRRYIEQSQAeiyHNRFdavqsahRAATRGFIRYGWRWSWRTAVFVTIFNTVNTGL 156
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNRPPPLTA---KLRL-------RGALNAVGKRGPSLGNNFAVFGGLYSGIECGL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 149060500  157 TVYRNKDALSHFAIAGAVTGGLFRinLGLRGLVAGGIIGAL 197
Cdd:pfam02466  71 EKYRGKEDPWNSIAAGALTGALLR--GGPRAAAVGGAVGAA 109
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 133-198 5.70e-04

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 39.44  E-value: 5.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149060500  133 RYGWRWSWRTAVFVTIFNTVNTGLTVYRNKDALSHFAIAGAVTGGLFRINLGLRGLVAGGIIGALL 198
Cdd:TIGR00983  80 RRGPFWGNTLGILALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKSTRGLRGMARSGALGATA 145
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 195-267 9.91e-04

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 38.43  E-value: 9.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149060500  195 GALLGTpmgsllmaLEKHCGETVQERRQKDREAQQEQRLEEwRRNLQVTELLPMEIESgLEKIQPEKDAQRIE 267
Cdd:pfam04696  12 GGLLGT--------LQKFKKEESKQKEKEERRAEIEKRLEE-KAKQEKEELEERKREE-REELFEERRAEQIE 74
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 143-242 1.51e-03

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 38.49  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149060500 143 AVFVTIFNTVNTGLTVYRNKDALSHFAIAGAVTGGLFRINLGLRGLVAGGIIGALLGTPMGSLLMALEKHCGETvqERRQ 222
Cdd:PTZ00236  67 AIWGGLFSTFDCTLQYLRGKEDHWNAIASGFFTGGVLAIRGGWRSAVRNAIFGGILLGIIELVSIGMNRRQMRT--PRQQ 144

                         90       100
                 ....*....|....*....|
gi 149060500 223 KDREAQQEQRLEEWRRNLQV 242
Cdd:PTZ00236 145 FQQQQEMEKQLEEEDKKEQA 164
 
Name Accession Description Interval E-value
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 77-197 1.72e-22

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 89.54  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149060500   77 ICRAALSAGIIGWAYGGIPAFIYAKRRYIEQSQAeiyHNRFdavqsahRAATRGFIRYGWRWSWRTAVFVTIFNTVNTGL 156
Cdd:pfam02466   1 CLYKTGGAFLMGAVLGGVFGLVYGARNRPPPLTA---KLRL-------RGALNAVGKRGPSLGNNFAVFGGLYSGIECGL 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 149060500  157 TVYRNKDALSHFAIAGAVTGGLFRinLGLRGLVAGGIIGAL 197
Cdd:pfam02466  71 EKYRGKEDPWNSIAAGALTGALLR--GGPRAAAVGGAVGAA 109
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 133-198 5.70e-04

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 39.44  E-value: 5.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149060500  133 RYGWRWSWRTAVFVTIFNTVNTGLTVYRNKDALSHFAIAGAVTGGLFRINLGLRGLVAGGIIGALL 198
Cdd:TIGR00983  80 RRGPFWGNTLGILALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKSTRGLRGMARSGALGATA 145
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 195-267 9.91e-04

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 38.43  E-value: 9.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149060500  195 GALLGTpmgsllmaLEKHCGETVQERRQKDREAQQEQRLEEwRRNLQVTELLPMEIESgLEKIQPEKDAQRIE 267
Cdd:pfam04696  12 GGLLGT--------LQKFKKEESKQKEKEERRAEIEKRLEE-KAKQEKEELEERKREE-REELFEERRAEQIE 74
PTZ00236 PTZ00236
mitochondrial import inner membrane translocase subunit tim17; Provisional
 143-242 1.51e-03

mitochondrial import inner membrane translocase subunit tim17; Provisional


Pssm-ID: 173487  Cd Length: 164  Bit Score: 38.49  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149060500 143 AVFVTIFNTVNTGLTVYRNKDALSHFAIAGAVTGGLFRINLGLRGLVAGGIIGALLGTPMGSLLMALEKHCGETvqERRQ 222
Cdd:PTZ00236  67 AIWGGLFSTFDCTLQYLRGKEDHWNAIASGFFTGGVLAIRGGWRSAVRNAIFGGILLGIIELVSIGMNRRQMRT--PRQQ 144

                         90       100
                 ....*....|....*....|
gi 149060500 223 KDREAQQEQRLEEWRRNLQV 242
Cdd:PTZ00236 145 FQQQQEMEKQLEEEDKKEQA 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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