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Conserved domains on  [gi|149056288|gb|EDM07719|]
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rCG54128, isoform CRA_b [Rattus norvegicus]

Protein Classification

transmembrane protein 147-like( domain architecture ID 10561078)

DUF2053 domain-containing protein similar to Homo sapiens transmembrane protein 147 (TMEM147) that forms a complex with NCLN and NOMO2, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2053 pfam09767
Predicted membrane protein (DUF2053); This entry is of the conserved N-terminal 150 residues ...
 2-155 1.67e-75

Predicted membrane protein (DUF2053); This entry is of the conserved N-terminal 150 residues of proteins conserved from plants to humans. The function is unknown although some annotation suggests it to be a transmembrane protein.


:

Pssm-ID: 462890  Cd Length: 157  Bit Score: 224.85  E-value: 1.67e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149056288    2 TLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADL 81
Cdd:pfam09767   1 TFFHFGNCLALAFGPYYIVYKASGLSEYGAFWKCVQAGGGYLLTQLCKMLILATFFPAFDTGNFDVIQEILKALVDLIDL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149056288   82 IGLNLVMSRNAGKG---EYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWM 155
Cdd:pfam09767  81 IGLYLVLSSVTGKGinaDSKVLGIGLGWAFAESLLTRLLPLWVGARGLEFDWKYIQMSLESNINLVQTIALAALVWL 157
 
Name Accession Description Interval E-value
DUF2053 pfam09767
Predicted membrane protein (DUF2053); This entry is of the conserved N-terminal 150 residues ...
 2-155 1.67e-75

Predicted membrane protein (DUF2053); This entry is of the conserved N-terminal 150 residues of proteins conserved from plants to humans. The function is unknown although some annotation suggests it to be a transmembrane protein.


Pssm-ID: 462890  Cd Length: 157  Bit Score: 224.85  E-value: 1.67e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149056288    2 TLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADL 81
Cdd:pfam09767   1 TFFHFGNCLALAFGPYYIVYKASGLSEYGAFWKCVQAGGGYLLTQLCKMLILATFFPAFDTGNFDVIQEILKALVDLIDL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149056288   82 IGLNLVMSRNAGKG---EYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWM 155
Cdd:pfam09767  81 IGLYLVLSSVTGKGinaDSKVLGIGLGWAFAESLLTRLLPLWVGARGLEFDWKYIQMSLESNINLVQTIALAALVWL 157
 
Name Accession Description Interval E-value
DUF2053 pfam09767
Predicted membrane protein (DUF2053); This entry is of the conserved N-terminal 150 residues ...
 2-155 1.67e-75

Predicted membrane protein (DUF2053); This entry is of the conserved N-terminal 150 residues of proteins conserved from plants to humans. The function is unknown although some annotation suggests it to be a transmembrane protein.


Pssm-ID: 462890  Cd Length: 157  Bit Score: 224.85  E-value: 1.67e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149056288    2 TLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADL 81
Cdd:pfam09767   1 TFFHFGNCLALAFGPYYIVYKASGLSEYGAFWKCVQAGGGYLLTQLCKMLILATFFPAFDTGNFDVIQEILKALVDLIDL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149056288   82 IGLNLVMSRNAGKG---EYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWM 155
Cdd:pfam09767  81 IGLYLVLSSVTGKGinaDSKVLGIGLGWAFAESLLTRLLPLWVGARGLEFDWKYIQMSLESNINLVQTIALAALVWL 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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