NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|149047849|gb|EDM00465|]
View 

rCG37744 [Rattus norvegicus]

Protein Classification

PPE family protein( domain architecture ID 10565047)

proline-proline-glutamate (PPE) family protein similar to various Mycobacterium tuberculosis PPE virulence/immunogenicity factors; also contains a region similar to the enhancer of polycomb C-terminus

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
E_Pc_C pfam06752
Enhancer of Polycomb C-terminus; This family represents the C-terminus of eukaryotic enhancer ...
578-808 2.18e-56

Enhancer of Polycomb C-terminus; This family represents the C-terminus of eukaryotic enhancer of polycomb proteins, which have roles in heterochromatin formation. This family contains several conserved motifs.


:

Pssm-ID: 462002  Cd Length: 229  Bit Score: 193.13  E-value: 2.18e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  578 GITEEQFQTHQQQLAQMQRQQLAQLQQKQqsqhssqqTHPKAQGSSTS-DCMSKTLDSASAHFAASAVVSAPVPSRSEGS 656
Cdd:pfam06752   1 AFTAEQYQQHQEQLVLMQKQQLEQLQQQQ--------QSQSSDTSNTTqSLVSKTLDSASAQFAASALVTTDQLLALKTK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  657 KEQNTGhNNMNGVVQPSGPSKTLYSTNMAL------SSSPGISAVQLV-------RTVGHTTTNHLIPALCTSSPQTLPM 723
Cdd:pfam06752  73 EDLVLG-GGVNGVLSASGVYKGLHLTSTTSaspvtsSNSTTTSPPTLLqpssnstSTSSHSPTSHHTTALSTSTTQVLIG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  724 NNSCLTNAVHLNNVSVvspvnvHINTRT-SAPSPTALKLAtvAASMDRVPKVTPSSAISSIARENHEPERLGLNGIAETT 802
Cdd:pfam06752 152 NNIRLSVPSASNPLNA------RHLPRTlSSVPPSALKLA--ATANCQVPKVTGSSSLDSVPRENHEQEKPALNSIAENT 223

                  ....*.
gi 149047849  803 VAMEVT 808
Cdd:pfam06752 224 VAMEVT 229
EPL1 pfam10513
Enhancer of polycomb-like; This is a family of EPL1 (Enhancer of polycomb-like) proteins. The ...
7-148 1.82e-13

Enhancer of polycomb-like; This is a family of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes.


:

Pssm-ID: 463128  Cd Length: 168  Bit Score: 69.05  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849    7 RARALDAAKPLPIYRGKDMPDLNDCVSI----------NRAVPQMPTGMEKEEESEHHLQRAISAQQ------------- 63
Cdd:pfam10513   1 RHRRISIKQPLPIISEDEVDGLDTSPDEdepsecnsnkENSLHAVETGVDKEEEDEVHLKVINAAKKalssskksqntse 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849   64 --VFREKKESMVIPVPEAES---NVNYYNRLYKgefkqpkqFIHIQPFNLDNEqPDYDMDSEDETLLNRLN--RKME--- 133
Cdd:pfam10513  81 ssVPAPNKERLYLPTPDAGKfreFERPPASYIR--------FSETVEEELDEG-VEYDMDEEDEAWLEELNekRKSEgve 151
                         170
                  ....*....|....*.
gi 149047849  134 -IKPLQFEIMIDRLEK 148
Cdd:pfam10513 152 kISEDEFEILMDRFEK 167
 
Name Accession Description Interval E-value
E_Pc_C pfam06752
Enhancer of Polycomb C-terminus; This family represents the C-terminus of eukaryotic enhancer ...
578-808 2.18e-56

Enhancer of Polycomb C-terminus; This family represents the C-terminus of eukaryotic enhancer of polycomb proteins, which have roles in heterochromatin formation. This family contains several conserved motifs.


Pssm-ID: 462002  Cd Length: 229  Bit Score: 193.13  E-value: 2.18e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  578 GITEEQFQTHQQQLAQMQRQQLAQLQQKQqsqhssqqTHPKAQGSSTS-DCMSKTLDSASAHFAASAVVSAPVPSRSEGS 656
Cdd:pfam06752   1 AFTAEQYQQHQEQLVLMQKQQLEQLQQQQ--------QSQSSDTSNTTqSLVSKTLDSASAQFAASALVTTDQLLALKTK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  657 KEQNTGhNNMNGVVQPSGPSKTLYSTNMAL------SSSPGISAVQLV-------RTVGHTTTNHLIPALCTSSPQTLPM 723
Cdd:pfam06752  73 EDLVLG-GGVNGVLSASGVYKGLHLTSTTSaspvtsSNSTTTSPPTLLqpssnstSTSSHSPTSHHTTALSTSTTQVLIG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  724 NNSCLTNAVHLNNVSVvspvnvHINTRT-SAPSPTALKLAtvAASMDRVPKVTPSSAISSIARENHEPERLGLNGIAETT 802
Cdd:pfam06752 152 NNIRLSVPSASNPLNA------RHLPRTlSSVPPSALKLA--ATANCQVPKVTGSSSLDSVPRENHEQEKPALNSIAENT 223

                  ....*.
gi 149047849  803 VAMEVT 808
Cdd:pfam06752 224 VAMEVT 229
EPL1 pfam10513
Enhancer of polycomb-like; This is a family of EPL1 (Enhancer of polycomb-like) proteins. The ...
7-148 1.82e-13

Enhancer of polycomb-like; This is a family of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes.


Pssm-ID: 463128  Cd Length: 168  Bit Score: 69.05  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849    7 RARALDAAKPLPIYRGKDMPDLNDCVSI----------NRAVPQMPTGMEKEEESEHHLQRAISAQQ------------- 63
Cdd:pfam10513   1 RHRRISIKQPLPIISEDEVDGLDTSPDEdepsecnsnkENSLHAVETGVDKEEEDEVHLKVINAAKKalssskksqntse 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849   64 --VFREKKESMVIPVPEAES---NVNYYNRLYKgefkqpkqFIHIQPFNLDNEqPDYDMDSEDETLLNRLN--RKME--- 133
Cdd:pfam10513  81 ssVPAPNKERLYLPTPDAGKfreFERPPASYIR--------FSETVEEELDEG-VEYDMDEEDEAWLEELNekRKSEgve 151
                         170
                  ....*....|....*.
gi 149047849  134 -IKPLQFEIMIDRLEK 148
Cdd:pfam10513 152 kISEDEFEILMDRFEK 167
COG5141 COG5141
PHD zinc finger-containing protein [General function prediction only];
95-148 6.29e-04

PHD zinc finger-containing protein [General function prediction only];


Pssm-ID: 227470 [Multi-domain]  Cd Length: 669  Bit Score: 43.43  E-value: 6.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 149047849  95 KQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLNR---KMEIKPLQFEIMIDRLEK 148
Cdd:COG5141  113 DEGKKFIDIEPPRGLFFSVIYDLDEYDTMWLRYLNEsaiDENVSEEAFEIIVTRLEK 169
 
Name Accession Description Interval E-value
E_Pc_C pfam06752
Enhancer of Polycomb C-terminus; This family represents the C-terminus of eukaryotic enhancer ...
578-808 2.18e-56

Enhancer of Polycomb C-terminus; This family represents the C-terminus of eukaryotic enhancer of polycomb proteins, which have roles in heterochromatin formation. This family contains several conserved motifs.


Pssm-ID: 462002  Cd Length: 229  Bit Score: 193.13  E-value: 2.18e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  578 GITEEQFQTHQQQLAQMQRQQLAQLQQKQqsqhssqqTHPKAQGSSTS-DCMSKTLDSASAHFAASAVVSAPVPSRSEGS 656
Cdd:pfam06752   1 AFTAEQYQQHQEQLVLMQKQQLEQLQQQQ--------QSQSSDTSNTTqSLVSKTLDSASAQFAASALVTTDQLLALKTK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  657 KEQNTGhNNMNGVVQPSGPSKTLYSTNMAL------SSSPGISAVQLV-------RTVGHTTTNHLIPALCTSSPQTLPM 723
Cdd:pfam06752  73 EDLVLG-GGVNGVLSASGVYKGLHLTSTTSaspvtsSNSTTTSPPTLLqpssnstSTSSHSPTSHHTTALSTSTTQVLIG 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849  724 NNSCLTNAVHLNNVSVvspvnvHINTRT-SAPSPTALKLAtvAASMDRVPKVTPSSAISSIARENHEPERLGLNGIAETT 802
Cdd:pfam06752 152 NNIRLSVPSASNPLNA------RHLPRTlSSVPPSALKLA--ATANCQVPKVTGSSSLDSVPRENHEQEKPALNSIAENT 223

                  ....*.
gi 149047849  803 VAMEVT 808
Cdd:pfam06752 224 VAMEVT 229
EPL1 pfam10513
Enhancer of polycomb-like; This is a family of EPL1 (Enhancer of polycomb-like) proteins. The ...
7-148 1.82e-13

Enhancer of polycomb-like; This is a family of EPL1 (Enhancer of polycomb-like) proteins. The EPL1 protein is a member of a histone acetyltransferase complex which is involved in transcriptional activation of selected genes.


Pssm-ID: 463128  Cd Length: 168  Bit Score: 69.05  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849    7 RARALDAAKPLPIYRGKDMPDLNDCVSI----------NRAVPQMPTGMEKEEESEHHLQRAISAQQ------------- 63
Cdd:pfam10513   1 RHRRISIKQPLPIISEDEVDGLDTSPDEdepsecnsnkENSLHAVETGVDKEEEDEVHLKVINAAKKalssskksqntse 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149047849   64 --VFREKKESMVIPVPEAES---NVNYYNRLYKgefkqpkqFIHIQPFNLDNEqPDYDMDSEDETLLNRLN--RKME--- 133
Cdd:pfam10513  81 ssVPAPNKERLYLPTPDAGKfreFERPPASYIR--------FSETVEEELDEG-VEYDMDEEDEAWLEELNekRKSEgve 151
                         170
                  ....*....|....*.
gi 149047849  134 -IKPLQFEIMIDRLEK 148
Cdd:pfam10513 152 kISEDEFEILMDRFEK 167
COG5141 COG5141
PHD zinc finger-containing protein [General function prediction only];
95-148 6.29e-04

PHD zinc finger-containing protein [General function prediction only];


Pssm-ID: 227470 [Multi-domain]  Cd Length: 669  Bit Score: 43.43  E-value: 6.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 149047849  95 KQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRLNR---KMEIKPLQFEIMIDRLEK 148
Cdd:COG5141  113 DEGKKFIDIEPPRGLFFSVIYDLDEYDTMWLRYLNEsaiDENVSEEAFEIIVTRLEK 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH