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Conserved domains on  [gi|149041215|gb|EDL95148|]
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solute carrier family 24 (sodium/potassium/calcium exchanger), member 3, isoform CRA_a [Rattus norvegicus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 39-578 3.37e-109

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 352.38  E-value: 3.37e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215    39 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 115
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   116 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 195
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   196 MYLIYIIIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 242
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   243 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 305
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   306 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPY 384
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   385 T--------------------------------------------------------------PFDPPSGKLETVKWAFT 402
Cdd:TIGR00927  832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   403 WPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 482
Cdd:TIGR00927  912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   483 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 562
Cdd:TIGR00927  992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070

                          650
                   ....*....|....*.
gi 149041215   563 CLFLYGVFLCFSIMTE 578
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 39-578 3.37e-109

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 352.38  E-value: 3.37e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215    39 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 115
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   116 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 195
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   196 MYLIYIIIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 242
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   243 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 305
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   306 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPY 384
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   385 T--------------------------------------------------------------PFDPPSGKLETVKWAFT 402
Cdd:TIGR00927  832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   403 WPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 482
Cdd:TIGR00927  912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   483 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 562
Cdd:TIGR00927  992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070

                          650
                   ....*....|....*.
gi 149041215   563 CLFLYGVFLCFSIMTE 578
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-573 2.93e-33

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 128.71  E-value: 2.93e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  79 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 158
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 159 SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIimkynacihqcferrtkgagnmvnglannaeiddss 238
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------------------------------------ 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 239 ncdatvvllkkanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasRMLINERQRlinsraytnges 318
Cdd:COG0530  124 -----------------------------------------------------------YLIRRARKE------------ 132

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 319 evaikipikhtvengtgpssapdrgvngtRRDDIVAEadnetenenedennendeeededddegpytpfDPPSGKLETVK 398
Cdd:COG0530  133 -----------------------------PAWEEVEE--------------------------------ELEEKPKMSLW 151

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 399 WAFTWplsfvlyftvpncnkphwekwfmvtFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 478
Cdd:COG0530  152 KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATS 206

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 479 LIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLnsrgliySVGLLLASVFVTVFGvhLNKWQLDKK 558
Cdd:COG0530  207 IVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDPAVLSFD-------LPVMLAATLLLLGLL--RTGGRIGRW 277

                        490
                 ....*....|....*
gi 149041215 559 LGCGCLFLYGVFLCF 573
Cdd:COG0530  278 EGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 62-204 1.05e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 105.76  E-value: 1.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   62 HVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 141
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149041215  142 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIM 204
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 57-587 4.44e-16

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 81.73  E-value: 4.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  57 GAVVLHVlCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFITK--GDVGVGTIVG 134
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKdaGEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 135 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKYNAcIHQC 213
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 214 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 292
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 293 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVNgtrrdDIVAEADNETENENEDENNEND 372
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWT-----DEGAEVESSLFSCSKLFSLLEM 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 373 EEEDEDDDEGPYT-------PFDPPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPncNKPHW 421
Cdd:PLN03151 401 PLTIPRRLTIPIVeedrwskTYAVASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEP--DRPPR 478

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 422 E---KWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSI 495
Cdd:PLN03151 479 RfliPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCY 557

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 496 GSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSI 575
Cdd:PLN03151 558 AGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637

                        570
                 ....*....|..
gi 149041215 576 MTEFNVFTFVNL 587
Cdd:PLN03151 638 STAMGFIPWAGL 649
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 39-578 3.37e-109

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 352.38  E-value: 3.37e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215    39 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 115
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   116 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 195
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   196 MYLIYIIIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 242
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   243 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 305
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   306 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPY 384
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   385 T--------------------------------------------------------------PFDPPSGKLETVKWAFT 402
Cdd:TIGR00927  832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   403 WPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 482
Cdd:TIGR00927  912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   483 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 562
Cdd:TIGR00927  992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070

                          650
                   ....*....|....*.
gi 149041215   563 CLFLYGVFLCFSIMTE 578
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 61-554 7.51e-42

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 153.25  E-value: 7.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   61 LHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNI 140
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  141 LCIIGVCGLFAGQVVAlsSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYiiimkynacihqcferrtkg 220
Cdd:TIGR00367  81 LLILGLSAIFSPIIVD--KDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY-------------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  221 agnmvnglannaeiddssncdaTVVLLKKanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasrml 300
Cdd:TIGR00367 139 ----------------------LLFLVKN--------------------------------------------------- 145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  301 inerQRLINSRAYTNgesevaikipiKHTVENGTGPSSapdrgvngtrrddivaeadnetenenedennendeeededdd 380
Cdd:TIGR00367 146 ----ERWVKYDTYTE-----------ENLDENNRRPQI------------------------------------------ 168

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  381 egpytpfdppsgkletvkwaftwPLSFVlyftvpncnkphwekWFMVTFAsstlWIAAFSYMMVWMVTIIGYTLGIPDVI 460
Cdd:TIGR00367 169 -----------------------FFSLV---------------LLIIGLI----GLVVGSRLLVDGAVKIAEILGISEKI 206

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  461 MGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLas 540
Cdd:TIGR00367 207 IGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLML-- 284

                         490
                  ....*....|....
gi 149041215  541 vfVTVFGVHLNKWQ 554
Cdd:TIGR00367 285 --FFKTSMKLGRWE 296
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
79-573 2.93e-33

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 128.71  E-value: 2.93e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  79 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 158
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 159 SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIimkynacihqcferrtkgagnmvnglannaeiddss 238
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------------------------------------ 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 239 ncdatvvllkkanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasRMLINERQRlinsraytnges 318
Cdd:COG0530  124 -----------------------------------------------------------YLIRRARKE------------ 132

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 319 evaikipikhtvengtgpssapdrgvngtRRDDIVAEadnetenenedennendeeededddegpytpfDPPSGKLETVK 398
Cdd:COG0530  133 -----------------------------PAWEEVEE--------------------------------ELEEKPKMSLW 151

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 399 WAFTWplsfvlyftvpncnkphwekwfmvtFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 478
Cdd:COG0530  152 KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATS 206

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 479 LIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLnsrgliySVGLLLASVFVTVFGvhLNKWQLDKK 558
Cdd:COG0530  207 IVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDPAVLSFD-------LPVMLAATLLLLGLL--RTGGRIGRW 277

                        490
                 ....*....|....*
gi 149041215 559 LGCGCLFLYGVFLCF 573
Cdd:COG0530  278 EGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 62-204 1.05e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 105.76  E-value: 1.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   62 HVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 141
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149041215  142 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIM 204
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 424-576 6.03e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 103.84  E-value: 6.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  424 WFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDIL 503
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149041215  504 IGLGLPWALQTLAVDyGSYIRLNSRGLIYSVGLLLASVFVTVFgvhLNKWQLDKKLGCGCLFLYGVFLCFSIM 576
Cdd:pfam01699  81 LVLGLSALIGPVKVD-SLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
38-204 4.17e-23

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 99.82  E-value: 4.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  38 EPALHEFPRDIFSNEDRRQGAVVLHVLCAMymfyALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSV 117
Cdd:COG0530  132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 118 IGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALSSWCLLRDSIYYTLSVVALIVFIY-DEKVSWWESLVLVLM 196
Cdd:COG0530  208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                 ....*...
gi 149041215 197 YLIYIIIM 204
Cdd:COG0530  286 YLAYLALL 293
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 57-587 4.44e-16

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 81.73  E-value: 4.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  57 GAVVLHVlCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFITK--GDVGVGTIVG 134
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKdaGEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 135 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKYNAcIHQC 213
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 214 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 292
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 293 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVNgtrrdDIVAEADNETENENEDENNEND 372
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWT-----DEGAEVESSLFSCSKLFSLLEM 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 373 EEEDEDDDEGPYT-------PFDPPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPncNKPHW 421
Cdd:PLN03151 401 PLTIPRRLTIPIVeedrwskTYAVASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEP--DRPPR 478

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 422 E---KWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSI 495
Cdd:PLN03151 479 RfliPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCY 557

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 496 GSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSI 575
Cdd:PLN03151 558 AGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637

                        570
                 ....*....|..
gi 149041215 576 MTEFNVFTFVNL 587
Cdd:PLN03151 638 STAMGFIPWAGL 649
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 45-264 5.45e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.21  E-value: 5.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   45 PRDIfSNEDRRQGAVVLHVLcAMYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGATFMAAG 107
Cdd:TIGR00845  63 PQNP-SVGDKIARATVYFVA-MVYMFLGVSIIADRFMAsievitsqekeitikkPNGETTVTTVRIwNETVSNLTLMALG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  108 SSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLF--AGQVVAL---------SSWcllrdSIY-YTLS 172
Cdd:TIGR00845 141 SSAPEILLSVIEVCghnFEAGDLGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtAAW-----SVFaYVWL 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  173 VVALIVFIYDEkVSWWESLvLVLMYLIYIIIMKYNACIHQCFE-------RRTKGAGNMVNGLANNAEIDDSSNCDATVV 245
Cdd:TIGR00845 216 YLILAVFSPGV-VEVWEGL-LTFFFFPLCVVFAWVADRRLLFYkyvykryRAGKQRGMIIETEGDRPKSKTEIEMDGKMV 293

                         250
                  ....*....|....*....
gi 149041215  246 LLKKANFHRKASVIMVDEL 264
Cdd:TIGR00845 294 NSHVDNFLDGALVLEVKEF 312
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
454-578 5.56e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 69.78  E-value: 5.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 454 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDygsyirlnSRGLIYS 533
Cdd:COG0530   15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVD--------RRVLRRD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 149041215 534 VGLLLASVFVTVFGVHLNkwQLDKKLGCGCLFLYGVFLCFSIMTE 578
Cdd:COG0530   87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 52-200 9.85e-13

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 69.27  E-value: 9.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   52 EDRRQGAVVLHVLCAMYMFYALAIVCDdFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGT 131
Cdd:TIGR00367 161 ENNRRPQIFFSLVLLIIGLIGLVVGSR-LLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGN 239

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149041215  132 IVGSAVFNILCIIGVCGLFA-GQVVALSswcLLRD-SIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIY 200
Cdd:TIGR00367 240 VIGSNIFNILVGLGVPSLFMpIPVEPLA---YNLDaPVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 442-584 1.15e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 69.29  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215 442 MMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGS 521
Cdd:PRK10734 192 MVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLA 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149041215 522 YIRlnsrglIYSVgLLLASVFVTVFGvhlnkWQLDKKLG--CGCLFLYGVFLCFSIMTEFNVFTF 584
Cdd:PRK10734 272 FSR------DYWV-MLLVSVIFALLC-----WRRKRRIGrgAGALLLGGFIVWLAMLYWLSPILV 324
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 448-575 5.12e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 66.96  E-value: 5.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  448 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYgSYIRLNS 527
Cdd:TIGR00367  26 VRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPIIVDK-DWLRRDI 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 149041215  528 RGLIYSVGLLLasvFVTVFGvhlnkwQLDKKLGCGCLFLYGVFLCFSI 575
Cdd:TIGR00367 105 LFYLLVSILLL---FFGLDG------QISRIDGVVLLILYIVYLLFLV 143
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 408-545 5.94e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 65.58  E-value: 5.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  408 VLYFTVPNCNkpHWEKWfmVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMG 487
Cdd:TIGR00845 742 VLFAFVPPTE--YWGGW--ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQY 817

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149041215  488 -DMAVSNSIGSNVFDILIGLGLPWalqTLAVDY----GSYIRLNSRGLIYSVGLLLASVFVTV 545
Cdd:TIGR00845 818 aDASIGNVTGSNAVNVFLGIGVAW---SIAAIYhaanGTQFKVSPGTLAFSVTLFTIFAFICI 877
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 443-517 2.96e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.97  E-value: 2.96e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149041215 443 MVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAV 517
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTV 96
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 60-204 5.01e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 51.96  E-value: 5.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  60 VLHVLCAMYMFYALAIVCDDFFVPSLekicerlhlsedVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 139
Cdd:PRK10734  13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149041215 140 ILCIIGVCGLFAGQVVALSswcLLRDSIYYTLSVVALI-VFIYDEKVSWWESLVLVLMYLIYIIIM 204
Cdd:PRK10734  81 ILLILGLAALIRPFTVHSD---VLRRELPLMLLVSVLAgSVLYDGQLSRSDGIFLLLLAVLWLLFI 143
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 94-171 5.38e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 51.96  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215  94 LSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGL-----FAGQVVALSSWCLLRDSIY 168
Cdd:PRK10734 206 ISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALispgeINPLAFSRDYWVMLLVSVI 285


                 ...
gi 149041215 169 YTL 171
Cdd:PRK10734 286 FAL 288
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 75-200 1.92e-03

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 40.90  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149041215   75 IVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIgvcglfagQV 154
Cdd:TIGR00846 232 ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIILFVV--------PL 303

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 149041215  155 VALSSWCLLRD---------SIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIY 200
Cdd:TIGR00846 304 VVLVAWMLGIPmdlnfgtfeTIVLALSLFLTTITLQDGRSNYLEGAVLLALYIII 358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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