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Conserved domains on  [gi|149031931|gb|EDL86843|]
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achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A) (predicted), isoform CRA_a [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-417 1.66e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 1.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 158 AWHPHTNKFAVALLDDSIRVYNANS-TIVPSLKHRlQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 237 QVLshPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 316 ARMWTCEGWPT-LSGRCQTGCWSPDGKRLLFTVL-GEALIYSLSFPEPCGTEKGHVGGAKSATIvadlsettiqTPDGeE 393
Cdd:COG2319  275 LATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDG-K 343

                        250       260
                 ....*....|....*....|....*..
gi 149031931 394 RL---GGEAHAMVWDPSGERLAVLMKG 417
Cdd:COG2319  344 TLasgSDDGTVRLWDLATGELLRTLTG 370
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-417 1.66e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 1.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 158 AWHPHTNKFAVALLDDSIRVYNANS-TIVPSLKHRlQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 237 QVLshPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 316 ARMWTCEGWPT-LSGRCQTGCWSPDGKRLLFTVL-GEALIYSLSFPEPCGTEKGHVGGAKSATIvadlsettiqTPDGeE 393
Cdd:COG2319  275 LATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDG-K 343

                        250       260
                 ....*....|....*....|....*..
gi 149031931 394 RL---GGEAHAMVWDPSGERLAVLMKG 417
Cdd:COG2319  344 TLasgSDDGTVRLWDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-368 7.84e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 7.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 155 RVFAWHPHTNKFAVALLDDSIRVYNANSTivpSLKHRLQ---RNVAALAWKPLSASVLAVACQSCILIWTLDptslstrp 231
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKghtGPVRDVAASADGTYLASGSSDKTIRLWDLE-------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 232 SSGCAQVLShpGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKVLATTPS 308
Cdd:cd00200   82 TGECVRTLT--GHTsYVSSVAFSPDGRILSSSS-RDKTIKVWDVETGKCLTT--LRGhtDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 149031931 309 AVFRVWEARMWTCEGwpTLSG---RCQTGCWSPDGKRLLFTVL-GEALIYSLSFPEPCGTEKGH 368
Cdd:cd00200  157 GTIKLWDLRTGKCVA--TLTGhtgEVNSVAFSPDGEKLLSSSSdGTIKLWDLSTGKCLGTLRGH 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-273 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 149031931   237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-273 1.28e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.28e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 149031931  237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 231-336 2.60e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.65  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 231 PSSGCAQVLSHP-----GHTP-VTSLAWAPNGGWLLSASPVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLA 304
Cdd:PTZ00421 106 PEEGLTQNISDPivhlqGHTKkVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCT 185

                         90       100       110
                 ....*....|....*....|....*....|....
gi 149031931 305 TTPSAVFRVWEARMWT--CEGWPTLSGRCQTGCW 336
Cdd:PTZ00421 186 TSKDKKLNIIDPRDGTivSSVEAHASAKSQRCLW 219
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
158-417 1.66e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.58  E-value: 1.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 158 AWHPHTNKFAVALLDDSIRVYNANS-TIVPSLKHRlQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSSGCA 236
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGH-SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--------TGKLL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 237 QVLshPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  198 RTL--TGHTgAVRSVAFSPDGKLLASGS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 316 ARMWTCEGWPT-LSGRCQTGCWSPDGKRLLFTVL-GEALIYSLSFPEPCGTEKGHVGGAKSATIvadlsettiqTPDGeE 393
Cdd:COG2319  275 LATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDG-K 343

                        250       260
                 ....*....|....*....|....*..
gi 149031931 394 RL---GGEAHAMVWDPSGERLAVLMKG 417
Cdd:COG2319  344 TLasgSDDGTVRLWDLATGELLRTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 155-368 7.84e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 7.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 155 RVFAWHPHTNKFAVALLDDSIRVYNANSTivpSLKHRLQ---RNVAALAWKPLSASVLAVACQSCILIWTLDptslstrp 231
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKghtGPVRDVAASADGTYLASGSSDKTIRLWDLE-------- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 232 SSGCAQVLShpGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKVLATTPS 308
Cdd:cd00200   82 TGECVRTLT--GHTsYVSSVAFSPDGRILSSSS-RDKTIKVWDVETGKCLTT--LRGhtDWVNSVAFSPDGTFVASSSQD 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 149031931 309 AVFRVWEARMWTCEGwpTLSG---RCQTGCWSPDGKRLLFTVL-GEALIYSLSFPEPCGTEKGH 368
Cdd:cd00200  157 GTIKLWDLRTGKCVA--TLTGhtgEVNSVAFSPDGEKLLSSSSdGTIKLWDLSTGKCLGTLRGH 218
WD40 COG2319
WD40 repeat [General function prediction only];
158-344 7.06e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 7.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 158 AWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPlSASVLAVACQSC-ILIWTLDPTSlstrpssgCA 236
Cdd:COG2319  211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE--------LL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 237 QVLSHPGHtPVTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEA 316
Cdd:COG2319  282 RTLTGHSG-GVNSVAFSPDGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359

                        170       180       190
                 ....*....|....*....|....*....|.
gi 149031931 317 RmwTCEGWPTLSG---RCQTGCWSPDGKRLL 344
Cdd:COG2319  360 A--TGELLRTLTGhtgAVTSVAFSPDGRTLA 388
WD40 COG2319
WD40 repeat [General function prediction only];
154-414 7.19e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 7.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 154 LRVFAWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCILIWTLDptslstrpSS 233
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--------TG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 234 GCAQVLShpGHT-PVTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFR 312
Cdd:COG2319  153 KLLRTLT--GHSgAVTSVAFSPDGKLLASGSD-DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 313 VWEARmwTCEGWPTLSGrcQTGC-----WSPDGKRLLFTVL-GEALIYSLSFPEPCGTEKGHVGGAKSATIvadlsetti 386
Cdd:COG2319  230 LWDLA--TGKLLRTLTG--HSGSvrsvaFSPDGRLLASGSAdGTVRLWDLATGELLRTLTGHSGGVNSVAF--------- 296

                        250       260       270
                 ....*....|....*....|....*....|..
gi 149031931 387 qTPDGeERL---GGEAHAMVWDP-SGERLAVL 414
Cdd:COG2319  297 -SPDG-KLLasgSDDGTVRLWDLaTGKLLRTL 326
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 153-380 9.16e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 9.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 153 CLRVFAWHPHTNKFAVALLDDSIRVYNANStivPSLKHRL---QRNVAALAWKPLSASVLAVACQSCILIWTLdptslst 229
Cdd:cd00200   53 PVRDVAASADGTYLASGSSDKTIRLWDLET---GECVRTLtghTSYVSSVAFSPDGRILSSSSRDKTIKVWDV------- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 230 rPSSGCAQVLshPGHT-PVTSLAWAPNGgWLLSASPVDAVILVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKVLATT 306
Cdd:cd00200  123 -ETGKCLTTL--RGHTdWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVAT--LTGhtGEVNSVAFSPDGEKLLSSS 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 149031931 307 PSAVFRVWEARMWTCEGwpTLSG---RCQTGCWSPDGkRLLFTVLGEALIY--SLSFPEPCGTEKGHVGGAKSATIVAD 380
Cdd:cd00200  197 SDGTIKLWDLSTGKCLG--TLRGhenGVNSVAFSPDG-YLLASGSEDGTIRvwDLRTGECVQTLSGHTNSVTSLAWSPD 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-315 1.19e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931  79 RCINVWhDVGLFGVLNEIANSEEEVFEWVKTASSWALALCGRASSLHgsLFphlSLRSEDLIAEFAQVTNWSSCClrvfA 158
Cdd:cd00200   73 KTIRLW-DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIK--VW---DVETGKCLTTLRGHTDWVNSV----A 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 159 WHPhTNKF-AVALLDDSIRVYNANStivPSLKHRL---QRNVAALAWKPLSASVLAVACQSCILIWTLDPTSlstrpssg 234
Cdd:cd00200  143 FSP-DGTFvASSSQDGTIKLWDLRT---GKCVATLtghTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 235 CAQVLShpGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLpwFRG--GGVTNLLWSPDGSKVLATTPSAVF 311
Cdd:cd00200  211 CLGTLR--GHEnGVNSVAFSPDGYLLASGS-EDGTIRVWDLRTGECVQT--LSGhtNSVTSLAWSPDGKRLASGSADGTI 285


                 ....
gi 149031931 312 RVWE 315
Cdd:cd00200  286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
158-317 3.69e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 3.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 158 AWHPHTNKFAVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPlSASVLAVACQSC-ILIWTLDPTSLstrpssgca 236
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGtVRLWDLATGKL--------- 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 237 qVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWE 315
Cdd:COG2319  323 -LRTLTGHTgAVRSVAFSPDGKTLASGS-DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                 ..
gi 149031931 316 AR 317
Cdd:COG2319  401 LA 402
WD40 COG2319
WD40 repeat [General function prediction only];
167-413 1.17e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 1.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 167 AVALLDDSIRVYNANSTIVPSLKHRLQRNVAALAWKPLSASVLAVACQSCILIWTLDPTSLSTRPssgcaqvlsHPGHTP 246
Cdd:COG2319   10 AAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL---------LGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 247 VTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEARMWTCEGwpT 326
Cdd:COG2319   81 VLSVAFSPDGRLLASASA-DGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR--T 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 327 LSG---RCQTGCWSPDGKRLLFTVL-GEALIYSLSFPEPCGTEKGHVGGAKSA-------TIVADLSETTIQ---TPDGE 392
Cdd:COG2319  158 LTGhsgAVTSVAFSPDGKLLASGSDdGTVRLWDLATGKLLRTLTGHTGAVRSVafspdgkLLASGSADGTVRlwdLATGK 237

                        250       260
                 ....*....|....*....|....*.
gi 149031931 393 ERL-----GGEAHAMVWDPSGERLAV 413
Cdd:COG2319  238 LLRtltghSGSVRSVAFSPDGRLLAS 263
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 243-413 5.00e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 5.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 243 GHT-PVTSLAWAPNGGWLLSASPvDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLATTPSAVFRVWEARMWTC 321
Cdd:cd00200    7 GHTgGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 322 EGwpTLSGRCQ---TGCWSPDGkRLLFT--VLGEALIYSLSFPEPCGTEKGHVGGAKSATI-----------------VA 379
Cdd:cd00200   86 VR--TLTGHTSyvsSVAFSPDG-RILSSssRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasssqdgtikLW 162

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 149031931 380 DL-SETTIQTPDGEErlgGEAHAMVWDPSGERLAV 413
Cdd:cd00200  163 DLrTGKCVATLTGHT---GEVNSVAFSPDGEKLLS 194
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 219-359 7.29e-08

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 51.98  E-value: 7.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 219 IWTLDPTSLSTRpssgcaQVLSHPGHtpVTSLAWAPNGGWLL--SASPVDAVILVWDVSTETCVPLpWFRGGGVTNLLWS 296
Cdd:COG0823   13 IYVVDLDGGEPR------RLTNSPGI--DTSPAWSPDGRRIAftSDRGGGPQIYVVDADGGEPRRL-TFGGGYNASPSWS 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 149031931 297 PDGSKVL-ATTPSAVFRVWEARMWTceGWPT-LSGRCQTGCWSPDGKRLLFT--VLGEALIYSLSFP 359
Cdd:COG0823   84 PDGKRLAfVSRSDGRFDIYVLDLDG--GAPRrLTDGPGSPSWSPDGRRIVFSsdRGGRPDLYVVDLD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 237-273 1.18e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 149031931   237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:smart00320   4 LLKTLKGHTgPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
237-273 1.28e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.28e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 149031931  237 QVLSHPGHT-PVTSLAWAPNGGWLLSASpVDAVILVWD 273
Cdd:pfam00400   3 LLKTLEGHTgSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 231-336 2.60e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.65  E-value: 2.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031931 231 PSSGCAQVLSHP-----GHTP-VTSLAWAPNGGWLLSASPVDAVILVWDVSTETCVPLPWFRGGGVTNLLWSPDGSKVLA 304
Cdd:PTZ00421 106 PEEGLTQNISDPivhlqGHTKkVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCT 185

                         90       100       110
                 ....*....|....*....|....*....|....
gi 149031931 305 TTPSAVFRVWEARMWT--CEGWPTLSGRCQTGCW 336
Cdd:PTZ00421 186 TSKDKKLNIIDPRDGTivSSVEAHASAKSQRCLW 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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