|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
181-1091 |
6.74e-171 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 524.36 E-value: 6.74e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 181 TYPQSQAPPLSQAQGHPGVQPPLRSAPPLAS--SFTSPASGGPrmpsmPGPLPPGQgfgslpvSQANRvsSPPAHALPpg 258
Cdd:COG5028 2 SQHKKGVYPQAQSQVHTGAASSKKSARPHRAyaNFSAGQMGMP-----PYTTPPLQ-------QQSRR--QIDQAATA-- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 259 tqmtgppappppMHspqQPGYQLQQNGSFGPARGPQPNYESPYPGAPTFGTqpgppqplppkrLDPDAIPS-PIQVIEDd 337
Cdd:COG5028 66 ------------MH---NTGANNPAPSVMSPAFQSQQKFSSPYGGSMADGT------------APKPTNPLvPVDLFED- 117
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 338 rnnrgSEPFVTGVRG----QVPPLvTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASP 413
Cdd:COG5028 118 -----QPPPISDLFLppppIVPPL-TTNFVGSEQSNCSPKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPV 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 414 YVVDHGEsgPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCINDVPPQYFQHLDHTGKRVDAYDRPELSLGSYEFLATVDY 493
Cdd:COG5028 192 PLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEY 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 494 ckNNKFPSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREGGAeesaIRVGFVTYNKVLHFYNVKSSLaQPQMMV 573
Cdd:COG5028 270 --SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILENLDQIPNFDPR----TKIAIICFDSSLHFFKLSPDL-DEQMLI 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 574 VSDVADMFVPLLDG-FLVNVSESRAVITSLLDQIPEMFADTRETETVFAPviqagmeALKAA-----ECAGKLFLFHTSL 647
Cdd:COG5028 343 VSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIFQDNKSPKNALGP-------ALKAAksligGTGGKIIVFLSTL 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 648 PIAeAPGKLKNRDDrklintdKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACF 727
Cdd:COG5028 416 PNM-GIGKLQLRED-------KESSLLSCKDSFYKEFAIECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNF 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 728 QVE--NDQERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNTTDVELAGLDGDKTVTVEFKHDDRLNEeSG 805
Cdd:COG5028 488 SATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLMT-SD 566
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 806 ALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYMAKFAYRAVVSSPVKTVRDTLITQCAQILACYRK 885
Cdd:COG5028 567 VYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYKK 646
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 886 NCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAeVTTDDRAYVRQLVSSMDVAETNVFFYPRLLPLTKSPLDS--- 962
Cdd:COG5028 647 ELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSGS-TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAglp 725
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 963 ----TTEPPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQGVVQSLFNVSSFSQITSGLSVLPVLDNPLSKKVRGLID 1038
Cdd:COG5028 726 deglLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIG 805
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 149031233 1039 TLRAQ-RTRYMKLIVVKQ--EDKLEMLFKHFLVEDKSLsGGASYVDFLCHMHKEIR 1091
Cdd:COG5028 806 ELRSVnDDSTLPLVLVRGggDPSLRLWFFSTLVEDKTL-NIPSYLDYLQILHEKIK 860
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
500-759 |
8.40e-124 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 378.54 E-value: 8.40e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 500 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREggaeESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 579
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGD----DPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 580 MFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKaaECAGKLFLFHTSLPIAEApGKLKNR 659
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 660 DDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYAcfqvendqeRFLSD 739
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYP---------SFNFS 224
|
250 260
....*....|....*....|
gi 149031233 740 LRRDVQKVVGFDAVMRVRTS 759
Cdd:cd01479 225 APNDVEKLVNELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
500-744 |
1.11e-115 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 357.33 E-value: 1.11e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 500 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREggaeeSAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 579
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGD-----PRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 580 MFVPLLDGFLVNVSESRAVITSLLDQIPEMFADTRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLPIAEAPGKLKNR 659
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 660 DDRKLINTDKEKTLFQPQT-GTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFLS 738
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 149031233 739 DLRRDV 744
Cdd:pfam04811 236 DLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
500-742 |
2.44e-103 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 324.20 E-value: 2.44e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 500 PSPPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYLPREGGAeesaiRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 579
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRA-----RVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 580 MFVPLLDGFLVNVSESRAVITSLLDQIPEMFAD--TRETETVFAPVIQAGMEALKAAECAGKLFLFHTSLPIAEaPGKLK 657
Cdd:cd01468 76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 658 NRDDRKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQERFL 737
Cdd:cd01468 155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234
|
....*
gi 149031233 738 SDLRR 742
Cdd:cd01468 235 QDLQR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
19-1092 |
5.66e-49 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 190.67 E-value: 5.66e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 19 IYPGYHqsnyGGQPGPAAPATPYGAYNGPVPG--YQQAPP--QGVPRAPPCSGAPPASAAQVPCGQTTYGQfgqgdiqng 94
Cdd:PTZ00395 338 IYGGFH----DGSPNAASAGAPFNGLGNQADGghINQVHPdaRGAWAGGPHSNASYNCAAYSNAAQSNAAQ--------- 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 95 psSTAQMPRVPGSQQfGPPLAPVVSQPAVLQPYGPPPTSTQVTAQlaamqisgavaqaPPPSGlgygPPTSlasasgNFP 174
Cdd:PTZ00395 405 --SNAGFSNAGYSNP-GNSNPGYNNAPNSNTPYNNPPNSNTPYSN-------------PPNSN----PPYS------NLP 458
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 175 NSG-PYSTYPQSQAPPlSQAQGHPGVqpplrsappLASSFTSPASGGPRMPSMPGPLPPGQGF-GSLPVSQANRVSSPPA 252
Cdd:PTZ00395 459 YSNtPYSNAPLSNAPP-SSAKDHHSA---------YHAAYQHRAANQPAANLPTANQPAANNFhGAAGNSVGNPFASRPF 528
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 253 HALPPGTQMTGPPAPPPPMHSPQQPG-----YQLQQNGSFGPARGPQPNYESPYPGAPTFGTQPGPPQPLPPKRLDPDAI 327
Cdd:PTZ00395 529 GSAPYGGNAATTADPNGIAKREDHPEggtnrQKYEQSDEESVESSSSENSSENENEVTDKGEEIYSLLKKTINRIDMNKI 608
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 328 PSPIQVIEDDRNNRGSEPFVTgVRGQVPPLVTTNFLVKDQGNASPRYIRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLP 407
Cdd:PTZ00395 609 PRPIINTQEKKKKKNLKVFET-CKYISPPSYYQPYISIDTGKADPRFLKSTLYQIPLFSETLKLSQIPFGIIVNPFACLN 687
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 408 PEEASPYV-----VDHGESGP--LRCNRCKAYMcpLMTFIEG-GRRFQCSFCSC---IND-------------------- 456
Cdd:PTZ00395 688 EGEGIDKIdmkdiINDKEENIeiLRCPKCLGYL--HATILEDiSSSVQCVFCDTdflINEnvlfdifqynekighkesdh 765
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 457 ------------------VPPQYFQHLD-------HTGKRV--------------------------------------- 472
Cdd:PTZ00395 766 nehgnslspllkgsvdiiIPPIYYHNVNkfkltytYLNKNInqtafmitnkimsftkhisnslvandskggnkatsasaf 845
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 473 -DAYDRPELSLGSY--------------------------------------------EFLATVD------------YCK 495
Cdd:PTZ00395 846 gDSGDANFLAGGGYtnyggaggyntydnqsgynnhdvvnnrggsgagnhlygkdhdvqNFDNVMDnanftihdmknlICE 925
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 496 NN---------------KFPS-----PPAFIFMIDVSYNAIRTGLVRLLCEELKSLLDYL--PReggaeesaIRVGFVTY 553
Cdd:PTZ00395 926 KNgepdsakirrnsflaKYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIRYAVQNVkcPQ--------TKIAIITF 997
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 554 NKVLHFYNVKSSLAQP-------------QMMVVSDVADMFVPL-LDGFLVNVSESRAVITSLLDQIPEMFADTRETETV 619
Cdd:PTZ00395 998 NSSIYFYHCKGGKGVSgeegdggggsgnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSC 1077
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 620 FAPVIQAGMEALKAAECAGKLFLFHTSLPIAeAPGKLKnrddrKLINTDKEKTLFQPQTGTYQTLAKECVAQGCCVDLFL 699
Cdd:PTZ00395 1078 GNSALKIAMDMLKERNGLGSICMFYTTTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFI 1151
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 700 FP--NQYVDVATLSVVPQLTGGSVYKYACFQVEND-QERFLSDLRRDVQKVVGFDAVMRVRTSTGIRAVDFFGAFYMSNT 776
Cdd:PTZ00395 1152 ISsnNVRVCVPSLQYVAQNTGGKILFVENFLWQKDyKEIYMNIMDTLTSEDIAYCCELKLRYSHHMSVKKLFCCNNNFNS 1231
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 777 T----DVELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHNLALNCCTQLADLYRNCETDTLINYM 852
Cdd:PTZ00395 1232 IisvdTIKIPKIRHDQTFAFLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNIL 1311
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 853 AKFAYRAVVSSpvKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQpgAEVTTDDRAYV 932
Cdd:PTZ00395 1312 IKQLCTNILHN--DNYSKIIIDNLAAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNVTK--KEILHDLKVYS 1387
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 933 RQLVSSMDVAETNVFFYPRLLPL----TKSPLDSTTE------PPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQGV 1002
Cdd:PTZ00395 1388 LIKLLSMPIISSLLYVYPVMYVIhikgKTNEIDSMDVdddlfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANF 1467
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 1003 VQSLFNVSSFSQITSGLSvlpVLDNPLSKKVRGLIDTLRA--QRTRYMKLIVVKQEDKLEMLFKHFLVEDKSlSGGASYV 1080
Cdd:PTZ00395 1468 AKEIVGDIPTEKNAHELN---LTDTPNAQKVQRIIKNLSRihHFNKYVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYV 1543
|
1290
....*....|..
gi 149031233 1081 DFLCHMHKEIRQ 1092
Cdd:PTZ00395 1544 NFLCFIHKLVHK 1555
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
846-944 |
6.73e-35 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 128.39 E-value: 6.73e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 846 DTLINYMAKFAYRAVVSSPVKTVRDTLITQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGAEVT 925
Cdd:pfam04815 3 EAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNSSP 82
|
90
....*....|....*....
gi 149031233 926 TDDRAYVRQLVSSMDVAET 944
Cdd:pfam04815 83 SDERAYARHLLLSLPVEEL 101
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
749-832 |
3.62e-28 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 108.78 E-value: 3.62e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 749 GFDAVMRVRTSTGIRAVDFFGAFYMSNTTD-VELAGLDGDKTVTVEFKHDDRLNEESGALLQCALLYTSCAGQRRLRIHN 827
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*
gi 149031233 828 LALNC 832
Cdd:pfam08033 81 VALPV 85
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
379-721 |
3.54e-17 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 86.92 E-value: 3.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 379 SYNI-PCTSDMAKQAQVPLAAVIKPLARLPPEEASPYvvdhgesGPLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCINDV 457
Cdd:PLN00162 15 SWNVwPSSKIEASKCVIPLAALYTPLKPLPELPVLPY-------DPLRCRTCRAVLNPYCRVDFQAKIWICPFCFQRNHF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 458 PPQYF----QHLDhtgkrvdaydrPELslgsYEFLATVDY---CKNNKFPSPPAFIFMIDVSynAIRTGLvRLLCEELKS 530
Cdd:PLN00162 88 PPHYSsiseTNLP-----------AEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDTC--MIEEEL-GALKSALLQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 531 LLDYLPreggaeESAiRVGFVTY----------------------------NKVLHFYNVKSSLAQPQMMVVSDVADMFV 582
Cdd:PLN00162 150 AIALLP------ENA-LVGLITFgthvhvhelgfsecsksyvfrgnkevskDQILEQLGLGGKKRRPAGGGIAGARDGLS 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 583 PL-LDGFLVNVSESRAVITSLLDQI-PEMF---ADTRETE-TVFAPVIQAGMEALKAAECAGKLFLFhTSLPIAEAPGKL 656
Cdd:PLN00162 223 SSgVNRFLLPASECEFTLNSALEELqKDPWpvpPGHRPARcTGAALSVAAGLLGACVPGTGARIMAF-VGGPCTEGPGAI 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 657 KNRDDRKLINTDKE-----KTLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSV 721
Cdd:PLN00162 302 VSKDLSEPIRSHKDldkdaAPYYKKAVKFYEGLAKQLVAQGHVLDVFACSLDQVGVAEMKVAVERTGGLV 371
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
423-460 |
5.11e-15 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 69.78 E-value: 5.11e-15
10 20 30
....*....|....*....|....*....|....*...
gi 149031233 423 PLRCNRCKAYMCPLMTFIEGGRRFQCSFCSCINDVPPQ 460
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
375-1000 |
6.34e-15 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 79.54 E-value: 6.34e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 375 IRCTSYNIPCTSDMAKQAQVPLAAVIKPLARLPPEEASPYvvdhgesGPLRCNR-CKAYMCPLMTFIEGGRRFQCSFCSC 453
Cdd:COG5047 12 IRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYY-------EPVKCTApCKAVLNPYCHIDERNQSWICPFCNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 454 INDVPPQYfqhldhtgkrvDAYDRPELSLGSYEFLATVDYCKNNKFPSPPAFIFMIDVSYNAIRtglVRLLCEELKSLLD 533
Cdd:COG5047 85 RNTLPPQY-----------RDISNANLPLELLPQSSTIEYTLSKPVILPPVFFFVVDACCDEEE---LTALKDSLIVSLS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 534 YLPREggaeesAIrVGFVTYNKVLHFYNVkSSLAQPQMMVVSDVADMFVPLLD--------------------------- 586
Cdd:COG5047 151 LLPPE------AL-VGLITYGTSIQVHEL-NAENHRRSYVFSGNKEYTKENLQellalskptksggfeskisgigqfass 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 587 GFLVNVSESRAVITSLLDQI-PEMF---ADTRETE-TVFAPVIQAGMEALKAAECAGKLFLFhTSLPIAEAPGKLKNRDD 661
Cdd:COG5047 223 RFLLPTQQCEFKLLNILEQLqPDPWpvpAGKRPLRcTGSALNIASSLLEQCFPNAGCHIVLF-AGGPCTVGPGTVVSTEL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 662 RK------LINTDKEKtLFQPQTGTYQTLAKECVAQGCCVDLFLFPNQYVDVATLSVVPQLTGGSVYKYACFQVENDQER 735
Cdd:COG5047 302 KEpmrshhDIESDSAQ-HSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSIFKQS 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 736 FLSDLRRDVQK--VVGFDAVMRVRTSTGIRAVDFFG---------------AFYMSNTTDVELAGLDGDKTVTVEFKHDD 798
Cdd:COG5047 381 FQRIFNRDSEGylKMGFNANMEVKTSKNLKIKGLIGhavsvkkkannisdsEIGIGATNSWKMASLSPKSNYALYFEIAL 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 799 RLNEESG-----ALLQCALLYTSCAGQRRLRIHNLALNCCTQLADL-YRNCETDTLINYMAKFA-YRAVVSSPVKTVR-- 869
Cdd:COG5047 461 GAASGSAqrpaeAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIAaFKAETEDIIDVFRwi 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 870 -DTLITQCaQILACYRKNcaSPSSAGqliLPECMKLLPVYLNCVLKSDVLQPGAEvTTDDRAYVRQLVSSMDVAETNVFF 948
Cdd:COG5047 541 dRNLIRLC-QKFADYRKD--DPSSFR---LDPNFTLYPQFMYHLRRSPFLSVFNN-SPDETAFYRHMLNNADVNDSLIMI 613
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 149031233 949 YPRLLPLT--KSP----LDSTTEPPAVraseerlssgdIYLLENGLNLFVWVGASVQQ 1000
Cdd:COG5047 614 QPTLQSYSfeKGGvpvlLDSVSVKPDV-----------ILLLDTFFHILIFHGSYIAQ 660
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
7-305 |
1.73e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 75.75 E-value: 1.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 7 APPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQAP--PQGVPRAPPCSGAPPASAAQVPCGqttyg 84
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPAPAPPAAPAA----- 2777
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 85 qfgqgdiqnGPSSTAQMPRVpGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPT 164
Cdd:PHA03247 2778 ---------GPPRRLTRPAV-ASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPP 2847
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 165 SLASASGNFPNSGPYSTYPQSQAPPLS-QAQGHPGVQPPLRSAPPLAS-SFTSPASGGPRMPSMPGPLPPGQGFGSLPVS 242
Cdd:PHA03247 2848 PSLPLGGSVAPGGDVRRRPPSRSPAAKpAAPARPPVRRLARPAVSRSTeSFALPPDQPERPPQPQAPPPPQPQPQPPPPP 2927
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149031233 243 QANRVSSPPAHALPPGTQMTGPPAPpppmhSPQQPGYQLQQNGSFGPARGPQPNYESPYPGAP 305
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTTDPAGA-----GEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPS 2985
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
7-308 |
3.96e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 74.59 E-value: 3.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 7 APPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTygqf 86
Cdd:PHA03247 2709 EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT---- 2784
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 87 gqgdIQNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYG------PPPTSTQVTAqlaamqisgavaqAPPPSGLgy 160
Cdd:PHA03247 2785 ----RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAspagplPPPTSAQPTA-------------PPPPPGP-- 2845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 161 gPPTSLASASGNFPnSGPYSTYPQSQAPPlsqaqghpgVQPPLRSAPPlASSFTSPAsggPRMPSMPGPLPPgqgfgslP 240
Cdd:PHA03247 2846 -PPPSLPLGGSVAP-GGDVRRRPPSRSPA---------AKPAAPARPP-VRRLARPA---VSRSTESFALPP-------D 2903
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149031233 241 VSQANRVSSPPAHALPPgTQMTGPPAPPPPMHSPQQPGYQLQQNGSFGPARGPQPNYESPYPGAPTFG 308
Cdd:PHA03247 2904 QPERPPQPQAPPPPQPQ-PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPG 2970
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
5-305 |
1.32e-12 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 72.49 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 5 QSAPPVPPfgqnQPIYPGYHQSNYGGqPGPAAPATPygayNGPVPGYQQAPPQGVPRAPPCS---GAPPASAAQVPCGQT 81
Cdd:pfam03154 177 QSGAASPP----SPPPPGTTQAATAG-PTPSAPSVP----PQGSPATSQPPNQTQSTAAPHTliqQTPTLHPQRLPSPHP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 82 TYGQFGQG--DIQNGPSST------AQMPRVPGSQQFGPPLAPvvsQPAVLQPYGPPPTSTQvtaqlaamqisgavAQAP 153
Cdd:pfam03154 248 PLQPMTQPppPSQVSPQPLpqpslhGQMPPMPHSLQTGPSHMQ---HPVPPQPFPLTPQSSQ--------------SQVP 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 154 PPsglgygPPTSLASASGNFPNSGPYSTYPQSQAPPLSQA-----QGHPGVQPPLRSA-PPLASSFT---SPASGGPRMP 224
Cdd:pfam03154 311 PG------PSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlppapLSMPHIKPPPTTPiPQLPNPQShkhPPHLSGPSPF 384
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 225 SMPGPLPPG---QGFGSLPVSQANRVSSPPAHALPPGTQMTGPpappppmhsPQQPGYqLQQNGSFGPARGPQPNYESPY 301
Cdd:pfam03154 385 QMNSNLPPPpalKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPP---------PAQPPV-LTQSQSLPPPAASHPPTSGLH 454
|
....
gi 149031233 302 PGAP 305
Cdd:pfam03154 455 QVPS 458
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
962-1037 |
5.82e-12 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 62.33 E-value: 5.82e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149031233 962 STTEPPAVRASEERLSSGDIYLLENGLNLFVWVGASVQQgvVQSLFNVSSFSQI-TSGLSVLPVLDN-PLSKKVRGLI 1037
Cdd:pfam00626 1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKGSSL--LEKLFAALLAAQLdDDERFPLPEVIRvPQGKEPARFL 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
7-356 |
3.56e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.49 E-value: 3.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 7 APPVPPFGqnqpiypGYHQSNYGGQPGPAAPATPYGAYNGPVPG---------------YQQAPPQG-VPRAPPCSGAPP 70
Cdd:PHA03247 2623 APDPPPPS-------PSPAANEPDPHPPPTVPPPERPRDDPAPGrvsrprrarrlgraaQASSPPQRpRRRAARPTVGSL 2695
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 71 ASAAQVPCGQTTygqfgqgdiqNGPSSTAQMPRVPGSQqfGPPLAPVVSQPAVLQPYGPPPTSTQVT-----AQLAAMQI 145
Cdd:PHA03247 2696 TSLADPPPPPPT----------PEPAPHALVSATPLPP--GPAAARQASPALPAAPAPPAVPAGPATpggpaRPARPPTT 2763
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 146 SGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRS-----APPLASSFTSPA-SG 219
Cdd:PHA03247 2764 AGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPpPP 2843
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 220 GPRMPSMP--GPLPPGQGFGSLPVSQANrVSSPPAHALPPGTQMTGPPAPPPPMHSPQQPGYQLQQNGSFGPARgPQPNY 297
Cdd:PHA03247 2844 GPPPPSLPlgGSVAPGGDVRRRPPSRSP-AAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP-PQPQP 2921
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149031233 298 ESPYPGAPTfgtqpgPPQPLPPK-------RLDPDAIPSPIQVIEDDRNNRGSEPFVTGVRGQVPP 356
Cdd:PHA03247 2922 QPPPPPQPQ------PPPPPPPRpqpplapTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQ 2981
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
119-305 |
4.88e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 60.55 E-value: 4.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 119 SQPAVLQPYGPPPtstqVTAQLAAMQISGAVAQAPPPSGLGYGPPTSlasasgnfPNSGPYSTYPQSQAPPLSQAQG--- 195
Cdd:pfam03154 169 TQPPVLQAQSGAA----SPPSPPPPGTTQAATAGPTPSAPSVPPQGS--------PATSQPPNQTQSTAAPHTLIQQtpt 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 196 ---------HPGVQPPLRSAPPL---ASSFTSPASGGPrMPSMPGPLPPG----------QGFGSLPVSQANRVSSPPAH 253
Cdd:pfam03154 237 lhpqrlpspHPPLQPMTQPPPPSqvsPQPLPQPSLHGQ-MPPMPHSLQTGpshmqhpvppQPFPLTPQSSQSQVPPGPSP 315
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 149031233 254 ALPPGTQMTgppappppmhsPQQPGYQLQqngsfgpARGPQPNYESPYPGAP 305
Cdd:pfam03154 316 AAPGQSQQR-----------IHTPPSQSQ-------LQSQQPPREQPLPPAP 349
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
29-240 |
1.14e-08 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 59.12 E-value: 1.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPATpygAYNGPVPgyQQAPPQGVPR-APPCSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTA-QMPRVPG 106
Cdd:PRK12323 366 GQSGGGAGPAT---AAAAPVA--QPAPAAAAPAaAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAlAAARQAS 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 107 SQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPtSLASASGNFPNSGPYSTYPqSQ 186
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP-PWEELPPEFASPAPAQPDA-AP 518
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 149031233 187 APPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMP--GPLPPGQGFGSLP 240
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPvvAPRPPRASASGLP 574
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
8-330 |
1.26e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 59.57 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 8 PPVPPfGQNQPIYPGyhqSNYGGQPGPAAPATPYGAYNGPVPgyqqAPPQGVPRA--PPCSGAPPASAAQVPCGQTTYGQ 85
Cdd:PHA03247 2589 PDAPP-QSARPRAPV---DDRGDPRGPAPPSPLPPDTHAPDP----PPPSPSPAAnePDPHPPPTVPPPERPRDDPAPGR 2660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 86 FG------QGDIQNGPSSTAQMPRVPGSQqfgPPLAPVVS----QPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPP 155
Cdd:PHA03247 2661 VSrprrarRLGRAAQASSPPQRPRRRAAR---PTVGSLTSladpPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPA 2737
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 156 SGLGYGPPTSLASASGNFPNSGPystyPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFtspASGGPRMPSMPGPLPPGQG 235
Cdd:PHA03247 2738 APAPPAVPAGPATPGGPARPARP----PTTAGPPAPAPPAAPAAGPPRRLTRPAVASL---SESRESLPSPWDPADPPAA 2810
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 236 fgSLPVSQANRVSSPPAHALPPGTQMTGPPAPP-----PpmhSPQQPGYQLQQNGSFgpARGPQPNYESPYPGAPTFGTQ 310
Cdd:PHA03247 2811 --VLAPAAALPPAASPAGPLPPPTSAQPTAPPPppgppP---PSLPLGGSVAPGGDV--RRRPPSRSPAAKPAAPARPPV 2883
|
330 340
....*....|....*....|
gi 149031233 311 PGPPQPLPPKRLDPDAIPSP 330
Cdd:PHA03247 2884 RRLARPAVSRSTESFALPPD 2903
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
4-296 |
2.47e-08 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 58.10 E-value: 2.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 4 NQSAPPVPPFGQNQPIYPGYHQSNYGGQPGP---AAPATPYGAYNGPVPGYQQAPPQGVPRAPPCSGAP-------PASA 73
Cdd:pfam09606 112 QQMGGPGTASNLLASLGRPQMPMGGAGFPSQmsrVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPgqgqaggMNGG 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 74 AQVPCGQTTYGQFGQGdIQNGPSST-AQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPP-PTSTQVTAQLAA---MQISGA 148
Cdd:pfam09606 192 QQGPMGGQMPPQMGVP-GMPGPADAgAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPqQQGQQSQLGMGInqmQQMPQG 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 149 VAQAPPPSGLG--YGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQG--HPGVQP-----------PLRSAPPLASSF 213
Cdd:pfam09606 271 VGGGAGQGGPGqpMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGgnHPAAHQqqmnqsvgqggQVVALGGLNHLE 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 214 TSPAS--GGPRMPSMpGPLPPGQGFGSLPVSQANRVSSPPAHALPPGTQmtgppappPPMHSPQQPGYQLQQNGSFG--- 288
Cdd:pfam09606 351 TWNPGnfGGLGANPM-QRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQ--------PSVPSPQGPGSQPPQSHPGGmip 421
|
....*....
gi 149031233 289 -PARGPQPN 296
Cdd:pfam09606 422 sPALIPSPS 430
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
29-257 |
2.94e-08 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 57.94 E-value: 2.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPATPYGAYNGPVP------GYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMP 102
Cdd:PRK07003 365 GGAPGGGVPARVAGAVPAPGAraaaavGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAAD 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 103 RVPGSQQFGPPLAPVVSQPAvlqPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTY 182
Cdd:PRK07003 445 GDAPVPAKANARASADSRCD---ERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDA 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 183 PQSQAPPLSQA-QGHPGV-QPPLRS----------------------------APPLASSFTSPASGGPRmPSMPGPLP- 231
Cdd:PRK07003 522 PAAAAPPAPEArPPTPAAaAPAARAggaaaaldvlrnagmrvssdrgaraaaaAKPAAAPAAAPKPAAPR-VAVQVPTPr 600
|
250 260 270
....*....|....*....|....*....|....
gi 149031233 232 --------PGQGFGSLPVSQANRVSSPPAHALPP 257
Cdd:PRK07003 601 araatgdaPPNGAARAEQAAESRGAPPPWEDIPP 634
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
5-306 |
4.95e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.47 E-value: 4.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 5 QSAPPVPPFGQN--QPIYPGYHQsnyggqpGPAAPAtPYGAYNGPVPGYQQAPPQGVPRAPPCSGA--PPASAAQVPcgq 80
Cdd:pfam03154 250 QPMTQPPPPSQVspQPLPQPSLH-------GQMPPM-PHSLQTGPSHMQHPVPPQPFPLTPQSSQSqvPPGPSPAAP--- 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 81 ttyGQFGQGDIQNGPSSTAQMPRVPGSQqfgpPLAPVvsqPAVLQPYGPPPTSTqvTAQLAAMQISGAVAQAPPPSGLGY 160
Cdd:pfam03154 319 ---GQSQQRIHTPPSQSQLQSQQPPREQ----PLPPA---PLSMPHIKPPPTTP--IPQLPNPQSHKHPPHLSGPSPFQM 386
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 161 G----PPTSLASASgNFPNSGPYSTYPqsqaPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGprmpSMPGPLPPGQGF 236
Cdd:pfam03154 387 NsnlpPPPALKPLS-SLSTHHPPSAHP----PPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAA----SHPPTSGLHQVP 457
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 237 GSLPVSQANRVSSPPAHALPPGTqmtgppapPPPMHSPQQPGYQlqqngsfgPARGPQPNYESPYPGAPT 306
Cdd:pfam03154 458 SQSPFPQHPFVPGGPPPITPPSG--------PPTSTSSAMPGIQ--------PPSSASVSSSGPVPAAVS 511
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
21-224 |
9.16e-08 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 56.60 E-value: 9.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 21 PGYHQSNYGGQPGPAAPATPYGAYNGPVP------GYQQAPPQGVPRAP-PCSGAPPASAAQVPCGQTTYgqfgqgdiqn 93
Cdd:PHA03377 741 PPSHQAPYSGHEEPQAQQAPYPGYWEPRPpqapylGYQEPQAQGVQVSSyPGYAGPWGLRAQHPRYRHSW---------- 810
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 94 gpsstAQMPRVPGsqqFGPPLAPVVSQPAVLQPYGPPptstqvTAQLAAMQISGAVAQAPPPsglgyGPPTSLASASGNF 173
Cdd:PHA03377 811 -----AYWSQYPG---HGHPQGPWAPRPPHLPPQWDG------SAGHGQDQVSQFPHLQSET-----GPPRLQLSQVPQL 871
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 149031233 174 PNSGPYSTypqSQAPPLSQAQGHPGVQP-PLRSAPP-------LASSFTSPASGGPRMP 224
Cdd:PHA03377 872 PYSQTLVS---SSAPSWSSPQPRAPIRPiPTRFPPPpmplqdsMAVGCDSSGTACPSMP 927
|
|
| Retinal |
pfam15449 |
Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. ... |
15-251 |
1.81e-07 |
|
Retinal protein; This family of proteins is found in the photoreceptor cells of the retina. Mutations of the gene encoding this protein have been associated with retinal disorders such as retinitis pigmentosa and late-onset progressive retinal atrophy. The function of this family of proteins is unknown, but it is likely to be important in the development and function of the retina.
Pssm-ID: 464722 [Multi-domain] Cd Length: 1293 Bit Score: 55.55 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 15 QNQPIYPGYHQSNYGGQPGPAAPAT--PYGAYNGPvpgyqQAPPQGVPRAPPCS-GAPPASAAQVPcgQTTYGQFGQgdi 91
Cdd:pfam15449 967 QPRKAIPWHHSSHTSGQSRTSEPSLarPTRGPHSP-----EAPRQSQERSPPLVrKASPTRAHWAP--RADKRHPSL--- 1036
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 92 qngPSS--TAQmPRVPGSQ-QFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLAS 168
Cdd:pfam15449 1037 ---PSShrPAQ-PSLPTVQrSPSPPLSPRAPSPPRSPRVLSPPTSKKRTSPPPQHKLPSPPPESPPAQHKLSSPPTQRTE 1112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 169 ASGnfPNSGPystypqSQAPPLSQAQGHPGV------QPPLRSAPPLASSFTSPASG------GPRMPSMPGPLP-PGQG 235
Cdd:pfam15449 1113 ASS--PSSGP------SPSPPTSPSQGHKETrdsedsQAATAKASGNTCSIFCPATSslfeakSPFSTAHPLLPPeAGGP 1184
|
250
....*....|....*.
gi 149031233 236 FGSLPVSQanRVSSPP 251
Cdd:pfam15449 1185 LETPAGCW--RSSSGP 1198
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
71-308 |
5.55e-07 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 53.86 E-value: 5.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 71 ASAAQVPCGQTTYGQFGQGD---------IQNGPSstaQMPRVPGSQQFGP-PLAPVVSQpavlqpYGPPPTSTQVTAQL 140
Cdd:pfam09606 57 AAQQQQPQGGQGNGGMGGGQqgmpdpinaLQNLAG---QGTRPQMMGPMGPgPGGPMGQQ------MGGPGTASNLLASL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 141 --AAMQISGA--------VAQAPPPSGLGYGPPTSLASASGNFPNS-GPYSTYPQSQAP-PLSQAQGHPGVQPPLRSAPP 208
Cdd:pfam09606 128 grPQMPMGGAgfpsqmsrVGRMQPGGQAGGMMQPSSGQPGSGTPNQmGPNGGPGQGQAGgMNGGQQGPMGGQMPPQMGVP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 209 LASSFTSPASGGPRMPSMPGPLPPGQGFGslpvSQANRvsspPAHALPPGTQMTgPPAPPPPMHSPQQ-PGYQLQQNGSF 287
Cdd:pfam09606 208 GMPGPADAGAQMGQQAQANGGMNPQQMGG----APNQV----AMQQQQPQQQGQ-QSQLGMGINQMQQmPQGVGGGAGQG 278
|
250 260
....*....|....*....|.
gi 149031233 288 GPARGPQPNYESPYPGAPTFG 308
Cdd:pfam09606 279 GPGQPMGPPGQQPGAMPNVMS 299
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
8-295 |
6.99e-07 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 53.53 E-value: 6.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 8 PPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQAPPQgvPRAPPCSGAPPASAAQvpCGQTTYGQFG 87
Cdd:PHA03378 526 PPSPPQPRAGRRAPCVYTEDLDIESDEPASTEPVHDQLLPAPGLGPLQIQ--PLTSPTTSQLASSAPS--YAQTPWPVPH 601
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 88 QGDIQNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLA 167
Cdd:PHA03378 602 PSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGA 681
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 168 SASgNFPNSGPYSTYPQSQAP-PLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGfgslPVSQANR 246
Cdd:PHA03378 682 NTM-LPIQWAPGTMQPPPRAPtPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAA----APGRARP 756
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 149031233 247 VSSPPAHALPPGTQmTGPPAPPPPMHSPQQPgyqlQQNGSFGPARGPQP 295
Cdd:PHA03378 757 PAAAPGRARPPAAA-PGAPTPQPPPQAPPAP----QQRPRGAPTPQPPP 800
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
29-224 |
7.83e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 53.45 E-value: 7.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMPRVPGSQ 108
Cdd:PRK07764 595 AGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAG 674
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 109 QFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSglgyGPPTSLASASGNFPNSGPYSTYPQSQAP 188
Cdd:PRK07764 675 GAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPP----QAAQGASAPSPAADDPVPLPPEPDDPPD 750
|
170 180 190
....*....|....*....|....*....|....*.
gi 149031233 189 PLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMP 224
Cdd:PRK07764 751 PAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMA 786
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
6-306 |
9.03e-07 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 53.25 E-value: 9.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 6 SAPPVPPFGQNQPIYPGyhQSNYGGQPGPAAPATPYGAYNGPVPGY---QQAPPQGVPRAPPCSGAPPASAAQVPCGQTT 82
Cdd:PHA03307 91 SLSTLAPASPAREGSPT--PPGPSSPDPPPPTPPPASPPPSPAPDLsemLRPVGSPGPPPAASPPAAGASPAAVASDAAS 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 83 YGQfgQGDIQNGPSSTAQMPRVPgsqqfgPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAmQISGAVAQAPPPSGLGYGP 162
Cdd:PHA03307 169 SRQ--AALPLSSPEETARAPSSP------PAEPPPSTPPAAASPRPPRRSSPISASASSP-APAPGRSAADDAGASSSDS 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 163 PTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRsAPPLASSFTSPASGGPRMPSMPG-PLPPGQGFGSL-- 239
Cdd:PHA03307 240 SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSR-PGPASSSSSPRERSPSPSPSSPGsGPAPSSPRASSss 318
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 149031233 240 -PVSQANRVSSPPAHAlPPGTQMTGPPAPPPPMHSPQQPgyqlqqNGSFGPARGPQPNYESPYPGAPT 306
Cdd:PHA03307 319 sSSRESSSSSTSSSSE-SSRGAAVSPGPSPSRSPSPSRP------PPPADPSSPRKRPRPSRAPSSPA 379
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
65-257 |
9.60e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 53.07 E-value: 9.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 65 CSGAPPASAAQvPCGQTTYGQFGQGDIQNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQ 144
Cdd:PRK07764 586 AVVGPAPGAAG-GEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 145 -ISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQghpgvQPPLRSAPPLASSFTSPASGGPRM 223
Cdd:PRK07764 665 gGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD-----DPAAQPPQAAQGASAPSPAADDPV 739
|
170 180 190
....*....|....*....|....*....|....
gi 149031233 224 PSMPGPLPPGQGFGSLPVSQANRVSSPPAHALPP 257
Cdd:PRK07764 740 PLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
29-329 |
1.22e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPatpygayngPVPGYQQapPQGVPRAPPCSGAPPASAAQVpcgqTTYGQFGQGDIQNGPSSTAQMPRVPGSQ 108
Cdd:PHA03247 2501 GGPPDPDAP---------PAPSRLA--PAILPDEPVGEPVHPRMLTWI----RGLEELASDDAGDPPPPLPPAAPPAAPD 2565
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 109 QFGPP--LAPVVSQPAV----LQPYGPPPTSTQVTAQLAAMQISGAVAQAP-PPSGLGYGPPTSLASASGNFPNSGPYST 181
Cdd:PHA03247 2566 RSVPPprPAPRPSEPAVtsraRRPDAPPQSARPRAPVDDRGDPRGPAPPSPlPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 182 YPQSQAPPLSQAQGHpgVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSSP----PAHALPP 257
Cdd:PHA03247 2646 VPPPERPRDDPAPGR--VSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPhalvSATPLPP 2723
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 149031233 258 GTQMTGPPAPPPpmhsPQQPGYQLQQNGSFGPArGPQPNYESPYPGAPTFGTQPGPPQPLPPKRLDPDAIPS 329
Cdd:PHA03247 2724 GPAAARQASPAL----PAAPAPPAVPAGPATPG-GPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVAS 2790
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
6-229 |
1.38e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 6 SAPPVPPFGQNQPIYPGYHQSNYG----GQPGPAAPATPYGAYNGPV--------PGYQQAPPQGVPRAPPCSGAPPASA 73
Cdd:PHA03247 2769 PAPPAAPAAGPPRRLTRPAVASLSesreSLPSPWDPADPPAAVLAPAaalppaasPAGPLPPPTSAQPTAPPPPPGPPPP 2848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 74 AQVPCGQTTYGqfgqGDIQNGPSSTA--------------QMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQ 139
Cdd:PHA03247 2849 SLPLGGSVAPG----GDVRRRPPSRSpaakpaaparppvrRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 140 LAAMQisgavAQAPPPSGLgygPPTSLASASGNFPNSGPYSTYPQSQAPPLSqaqghPG-VQPPLRSAPPLASSFTSPAS 218
Cdd:PHA03247 2925 PPPQP-----QPPPPPPPR---PQPPLAPTTDPAGAGEPSGAVPQPWLGALV-----PGrVAVPRFRVPQPAPSREAPAS 2991
|
250
....*....|.
gi 149031233 219 GGPRMPSMPGP 229
Cdd:PHA03247 2992 STPPLTGHSLS 3002
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
47-305 |
4.32e-06 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 50.80 E-value: 4.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 47 PVPGYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTYGQFGQ-GDIQngpsSTAQMPRVPGSQQFGPPLAPVVS-QPAVL 124
Cdd:pfam09770 111 AAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKEPEPiPDLQ----VDASLWGVAPKKAAAPAPAPQPAaQPASL 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 125 QPYGPPPTSTQ-VTAQLAAmQISGAVAQAPPPSglgYGPPTSLASASGNFPNSGPYSTYPQSQApplsQAQGHPGVQPPL 203
Cdd:pfam09770 187 PAPSRKMMSLEeVEAAMRA-QAKKPAQQPAPAP---AQPPAAPPAQQAQQQQQFPPQIQQQQQP----QQQPQQPQQHPG 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 204 RSAPPlaSSFTSPASGGPRmPSMPGPLPPGQGFGSLPvsqanrvssPPAhalppgtqmtgppappppmhsPQQPGYQLQQ 283
Cdd:pfam09770 259 QGHPV--TILQRPQSPQPD-PAQPSIQPQAQQFHQQP---------PPV---------------------PVQPTQILQN 305
|
250 260
....*....|....*....|..
gi 149031233 284 NGSFGPARGPQPNYESPYPGAP 305
Cdd:pfam09770 306 PNRLSAARVGYPQNPQPGVQPA 327
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
67-257 |
6.67e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 50.26 E-value: 6.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 67 GAPPASAAQVPCGQTTygqfgqgdiqngPSSTAQMPRV--PGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQ 144
Cdd:PRK12323 371 GAGPATAAAAPVAQPA------------PAAAAPAAAApaPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQ 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 145 IS---GAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGV-----QPPLRSAPPLASSFTSP 216
Cdd:PRK12323 439 ASargPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPppweeLPPEFASPAPAQPDAAP 518
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 149031233 217 ASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSSPPAHALPP 257
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEP 559
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
184-308 |
8.61e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.15 E-value: 8.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 184 QSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMPGP---LPPGQGFGSL---------PVSQANRVSSP- 250
Cdd:pfam03154 167 LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPatsQPPNQTQSTAaphtliqqtPTLHPQRLPSPh 246
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149031233 251 ----PAHALPPGTQMTGPPAPPPPMHSPQQP-GYQLQQngsfGPARGPQPNYESPYPGAPTFG 308
Cdd:pfam03154 247 pplqPMTQPPPPSQVSPQPLPQPSLHGQMPPmPHSLQT----GPSHMQHPVPPQPFPLTPQSS 305
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
6-139 |
1.21e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.60 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 6 SAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPyGAYNGPVPGYQQAPPQGVPRAPPcsgAPPASAAQVPCGQTTYGQ 85
Cdd:PRK07764 650 PEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA-PAPAAPAAPAGAAPAQPAPAPAA---TPPAGQADDPAAQPPQAA 725
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 149031233 86 FGQGDIQNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQ 139
Cdd:PRK07764 726 QGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPP 779
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
8-197 |
1.21e-05 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 49.67 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 8 PPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAP--PCSGAPPASAAQVPC-GQTTYG 84
Cdd:PHA03377 770 PQAPYLGYQEPQAQGVQVSSYPGYAGPWGLRAQHPRYRHSWAYWSQYPGHGHPQGPwaPRPPHLPPQWDGSAGhGQDQVS 849
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 85 QFGQGDIQNGPSS--TAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTstqvtaqlaamqisgavaQAPPPSGLGYGP 162
Cdd:PHA03377 850 QFPHLQSETGPPRlqLSQVPQLPYSQTLVSSSAPSWSSPQPRAPIRPIPT------------------RFPPPPMPLQDS 911
|
170 180 190
....*....|....*....|....*....|....*.
gi 149031233 163 PTSLASASGNFPNSGPY-STYPQSQAPPLSQAQGHP 197
Cdd:PHA03377 912 MAVGCDSSGTACPSMPFaSDYSQGAFTPLDINAQTP 947
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
27-305 |
1.37e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.21 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 27 NYGGQPGPAAPATPYGAYNGPVPgyqQAPPQGVPRAPPCSGAPPASAAQVPcgqttygqfgqgdiqnGPSSTAQMPRVPG 106
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAAAAPAA---APAPAAAAPAAAAAPAPAAAPQPAP----------------APAPAPAPPSPAG 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 107 SQQFGPPLAPVVSQPAVLQPyGPPPTSTQVTAQLAAMQISGAVAQAPPPsglgyGPPTSLASASGNFPNSGPYSTYPQ-- 184
Cdd:PRK07764 447 NAPAGGAPSPPPAAAPSAQP-APAPAAAPEPTAAPAPAPPAAPAPAAAP-----AAPAAPAAPAGADDAATLRERWPEil 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 185 ---------------SQA----------------PPLSQAQGHPGVQPPLRSA-----------------PPLASSFTSP 216
Cdd:PRK07764 521 aavpkrsrktwaillPEAtvlgvrgdtlvlgfstGGLARRFASPGNAEVLVTAlaeelggdwqveavvgpAPGAAGGEGP 600
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 217 ASGGPRMPSMPGPLPPGQGFGSLPVSQAnRVSSPPAHALPPGTQMTGPPAPPPPMHSPQQPGYQLQQNGSFGPARGPQPN 296
Cdd:PRK07764 601 PAPASSGPPEEAARPAAPAAPAAPAAPA-PAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPA 679
|
....*....
gi 149031233 297 YESPYPGAP 305
Cdd:PRK07764 680 APPPAPAPA 688
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
24-294 |
1.61e-05 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 49.18 E-value: 1.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 24 HQSNYGGQPGPAAPatpygaynGPVPGYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTYgQFGQGdiqngpsstaQMPR 103
Cdd:pfam03157 339 QQPAQGQQPGQGQP--------GYYPTSPQQPGQGQPGYYPTSQQQPQQGQQPEQGQQGQ-QQGQG----------QQGQ 399
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 104 VPGSQQfgpplapvvsQPAVLQPyGPPPTSTQVTAQ------LAAMQISGAVAQAPPPSGLGYGPPtslasASGNFPNSG 177
Cdd:pfam03157 400 QPGQGQ----------QPGQGQP-GYYPTSPQQSGQgqpgyyPTSPQQSGQGQQPGQGQQPGQEQP-----GQGQQPGQG 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 178 PYSTYPQSQAPPLSQAQGHPGVQPplrsapplassfTSPASGGPrmpsmpgplppGQGFGSLPVSQANRVSSPPAHALPP 257
Cdd:pfam03157 464 QQGQQPGQPEQGQQPGQGQPGYYP------------TSPQQSGQ-----------GQQLGQWQQQGQGQPGYYPTSPLQP 520
|
250 260 270
....*....|....*....|....*....|....*..
gi 149031233 258 GTQMTGPPAPpppmhSPQQPGYQLQQNGSFGPARGPQ 294
Cdd:pfam03157 521 GQGQPGYYPT-----SPQQPGQGQQLGQLQQPTQGQQ 552
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
29-345 |
2.54e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.44 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAPPCSGAP----PASAAQVPCGQTTYGQFGQGDIQNGPSSTAQmPRV 104
Cdd:PRK07764 390 GAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQpapaPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ-PAP 468
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 105 PGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAM----------QISGAV--------------AQAPPP----- 155
Cdd:PRK07764 469 APAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADdaatlrerwpEILAAVpkrsrktwaillpeATVLGVrgdtl 548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 156 ------SGLGY-----------------------------GPPTSLASASGNfPNSGPYSTYPQSQAPPLSQAQGHPgvQ 200
Cdd:PRK07764 549 vlgfstGGLARrfaspgnaevlvtalaeelggdwqveavvGPAPGAAGGEGP-PAPASSGPPEEAARPAAPAAPAAP--A 625
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 201 PPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSSPPAHALPPGTQMTGPPAPPppmhSPQQPGYQ 280
Cdd:PRK07764 626 APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAP----AGAAPAQP 701
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149031233 281 LQQNGSFGPARGPQPNYESPYPGAPTFGTQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNRGSEP 345
Cdd:PRK07764 702 APAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAP 766
|
|
| Gag_spuma |
pfam03276 |
Spumavirus gag protein; |
92-251 |
2.72e-05 |
|
Spumavirus gag protein;
Pssm-ID: 460872 [Multi-domain] Cd Length: 614 Bit Score: 48.20 E-value: 2.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 92 QNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTqvtaqlaAMQISGAVAQAPPPSGLGYGPPTSLASasg 171
Cdd:pfam03276 175 LAEISPGAQGGIPPGASFSGLPSLPAIGGIHLPAIPGIHARAP-------PGNIARSLGDDIMPSLGDAGMPQPRFA--- 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 172 nFPNSGPYSTYPQSqaPPLSQAQGHPGVQP--PLRSApPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSS 249
Cdd:pfam03276 245 -FHPGNPFAEAEGH--PFAEAEGERPRDIPraPRIDA-PSAPAIPAIQPIAPPMIPPIGAPIPIPHGASIPGEHIRNPRE 320
|
..
gi 149031233 250 PP 251
Cdd:pfam03276 321 EP 322
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
5-305 |
2.78e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.44 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 5 QSAPPVPPFGQNQPIYPGYhqsnyGGQPGPAAPATPygayngpVPGYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTYG 84
Cdd:PRK07764 436 APAPAPPSPAGNAPAGGAP-----SPPPAAAPSAQP-------APAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 85 QFGQGDIQ---------------NGPSSTAQMPRVPGSQQFG---------PPLAPVVSQP--------AVLQPYG---- 128
Cdd:PRK07764 504 AGADDAATlrerwpeilaavpkrSRKTWAILLPEATVLGVRGdtlvlgfstGGLARRFASPgnaevlvtALAEELGgdwq 583
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 129 ------PPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLASASGNfPNSGPYSTYPQSQAPPLSQAQGHPGVQPP 202
Cdd:PRK07764 584 veavvgPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAA-AAPAEASAAPAPGVAAPEHHPKHVAVPDA 662
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 203 LRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSSPPAHALPPGTQMTG--------PPAPPPPMHSP 274
Cdd:PRK07764 663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQaaqgasapSPAADDPVPLP 742
|
330 340 350
....*....|....*....|....*....|.
gi 149031233 275 QQPGYQLQQNGSFGPARGPQPNYESPYPGAP 305
Cdd:PRK07764 743 PEPDDPPDPAGAPAQPPPPPAPAPAAAPAAA 773
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
31-194 |
4.25e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 47.72 E-value: 4.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 31 QPGPAAPATPYGAYNGPVPGYQQAPPQgvprappcsgappASAAQVPCGQTTYGQFGQGdiQNGPSSTAQMPRvpgSQQF 110
Cdd:pfam09770 213 QPAPAPAQPPAAPPAQQAQQQQQFPPQ-------------IQQQQQPQQQPQQPQQHPG--QGHPVTILQRPQ---SPQP 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 111 GPPlAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQ-ISGAVAQAP--PPSGLGYGPPTSLASASGNFPNSGPYSTYPQsQA 187
Cdd:pfam09770 275 DPA-QPSIQPQAQQFHQQPPPVPVQPTQILQNPNrLSAARVGYPqnPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQ-QL 352
|
....*..
gi 149031233 188 PPLSQAQ 194
Cdd:pfam09770 353 AQLSEEE 359
|
|
| SP6_N |
cd22544 |
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins ... |
89-278 |
5.05e-05 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 6; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP6, also known as epiprofin, shows specific expression pattern in hair follicles and the apical ectodermal ridge (AER) of the developing limbs. SP6 null mice are nude and show defects in skin, teeth, limbs (syndactyly and oligodactyly), and lung alveoli. SP6 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. This model represents the N-terminal domain of SP6.
Pssm-ID: 411693 [Multi-domain] Cd Length: 245 Bit Score: 46.07 E-value: 5.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 89 GDIQNGPSSTaqmPRVPGSQQFGPPLapvvsqpavlQPYGPPPTSTQVTAQLAAmqiSGAVAQAPPP------SGLGYGP 162
Cdd:cd22544 7 GSLGNQHSET---PRASPPTLDLQPL----------QPYQIHSSPEAGDYPSPL---QPTELQSLPLgpgvdfSARESYE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 163 PTSLASASGNFPNSGPYSTYPQSQAPPLSQAQ--------GHPGVQPPLRSAPPL-----ASSFT--SPASGGPRMPSMP 227
Cdd:cd22544 71 PHSSRRTCLDLESDLPLGPFPKLLHPPPDMAHpyeswfrpPHPGGSGEEGGVPSWwdlhaGSSWMdlQHGQGGLQSPGPP 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 149031233 228 GPL-PPGQGFGSlpvsqANRVSSPPAHALPPGTQMTGPPAPPPPMHSPQQPG 278
Cdd:cd22544 151 GGLqPPLGGYGS-----EHQLCGPPHHLLPPAQHLMGQEGPKLLEHPAEDPS 197
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
80-305 |
5.09e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 47.77 E-value: 5.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 80 QTTYGQFGQGD-IQNGPSSTAQMPRVP----GSQQFGPPLAPVVSQPAVLQPyGPPPTSTQVTAQLAAMQISGAVAQAPP 154
Cdd:PRK10263 298 RATQPEYDEYDpLLNGAPITEPVAVAAaattATQSWAAPVEPVTQTPPVASV-DVPPAQPTVAWQPVPGPQTGEPVIAPA 376
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 155 PSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPlrSAPPLASSFTSPASGGPRMPSMPGPLPPGQ 234
Cdd:PRK10263 377 PEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPA--PEQPAQQPYYAPAPEQPVAGNAWQAEEQQS 454
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149031233 235 GFGSLPVSQANRVSSPPAhalppgtqmtgppappppmhsPQQPGYQLQQNGSFGPARGPQPNYESPYPGAP 305
Cdd:PRK10263 455 TFAPQSTYQTEQTYQQPA---------------------AQEPLYQQPQPVEQQPVVEPEPVVEETKPARP 504
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
3-234 |
5.85e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 47.37 E-value: 5.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 3 VNQSAPPVPPFGQNQ-PIYPGYHQSNYGGQPGPAAPATPYGA-YNGPVPGYQQAPPQGVPRAPPCSGAPPAsaaQVPCGQ 80
Cdd:PHA03378 600 PHPSQTPEPPTTQSHiPETSAPRQWPMPLRPIPMRPLRMQPItFNVLVFPTPHQPPQVEITPYKPTWTQIG---HIPYQP 676
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 81 TTYGQFGQGDIQNGPSSTAQMPRVPGSQQfgPPLAPVVS--QPAVLQPYGPPPTSTQVTAQlaamqisgavaqaPPPSGL 158
Cdd:PHA03378 677 SPTGANTMLPIQWAPGTMQPPPRAPTPMR--PPAAPPGRaqRPAAATGRARPPAAAPGRAR-------------PPAAAP 741
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149031233 159 GYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQ 234
Cdd:PHA03378 742 GRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQ 817
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
6-314 |
7.09e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.90 E-value: 7.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 6 SAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPygayngpVPGYQQAPPQGVPRAPPCSGAPPASAAQVPcGQTTYGQ 85
Cdd:PRK07764 409 APAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPS-------PAGNAPAGGAPSPPPAAAPSAQPAPAPAAA-PEPTAAP 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 86 FGQGDIQNGPSSTAQMPRVPGSQQFGPPLAPV----------------------VSQPAVLQPYGPPPTSTQVTAQLAAM 143
Cdd:PRK07764 481 APAPPAAPAPAAAPAAPAAPAAPAGADDAATLrerwpeilaavpkrsrktwailLPEATVLGVRGDTLVLGFSTGGLARR 560
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 144 ----------------------QI--------SGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQA 193
Cdd:PRK07764 561 faspgnaevlvtalaeelggdwQVeavvgpapGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEAS 640
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 194 QGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSSPPAHALPPGTQMTGPPAPPPPMHS 273
Cdd:PRK07764 641 AAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQ 720
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 149031233 274 PQQPGYQLQQNGSFGPARGPQPNYESPYPGAPTFGTQPGPP 314
Cdd:PRK07764 721 PPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPP 761
|
|
| MISS |
pfam15822 |
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic ... |
4-258 |
7.18e-05 |
|
MAPK-interacting and spindle-stabilising protein-like; MISS is a family of eukaryotic MAPK-interacting and spindle-stabilising protein-like proteins. MISS is rich in prolines and has four potential MAPK-phosphorylation sites, a MAPK-docking site, a PEST sequence (PEST motif) and a bipartite nuclear localization signal. The endogenous protein accumulates during mouse meiotic maturation and is found as discrete dots on the MII spindle. MISS is the first example of a physiological MAPK-substrate that is stabilized in MII that specifically regulates MII spindle integrity during the CSF arrest.
Pssm-ID: 318115 [Multi-domain] Cd Length: 238 Bit Score: 45.75 E-value: 7.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 4 NQSAPPVPPFGQNqpiypgyhqsnyggqPGPAAPATPYGAynGPVPGYQQAPPQGVPRAPPcsgaPPASAAQVPCGQtty 83
Cdd:pfam15822 38 NPSAPPAVPSGLP---------------PSTAPSTVPFGP--APTGMYPSIPLTGPSPGPP----APFPPSGPSCPP--- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 84 gqfgqgdiqngPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTStqvtAQLAAMQISGAVAQAPPPSGLGYGPP 163
Cdd:pfam15822 94 -----------PGGPYPAPTVPGPGPIGPYPTPNMPFPELPRPYGAPTDP----AAAAPSGPWGSMSSGPWAPGMGGQYP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 164 TslasASGNFPNSGPYSTYPQSQAPPlsqaqghpgvqpplrSAPPLASSFTSPASGGPrmpsmPGPLPPGQGFGSLP--- 240
Cdd:pfam15822 159 A----PNMPYPSPGPYPAVPPPQSPG---------------AAPPVPWGTVPPGPWGP-----PAPYPDPTGSYPMPgly 214
|
250 260
....*....|....*....|.
gi 149031233 241 --VSQANRVSSPPAHALP-PG 258
Cdd:pfam15822 215 ptPNNPFQVPSGPSGAPPmPG 235
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
14-305 |
7.83e-05 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 46.86 E-value: 7.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 14 GQNQP-IYPGYHQSNYGGQPGpAAPATPYGAYNGPVPGYQQAPPQGVP--RAPPCSGAPPASAAQVPCGQTTyGQFGQGD 90
Cdd:pfam03157 408 GQGQPgYYPTSPQQSGQGQPG-YYPTSPQQSGQGQQPGQGQQPGQEQPgqGQQPGQGQQGQQPGQPEQGQQP-GQGQPGY 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 91 IQNGPSSTAQMPRVPGSQQFG---------PPLAPVVSQP-----AVLQP-YGPPPTSTQVTAQLAAMQISGAVAQAPPP 155
Cdd:pfam03157 486 YPTSPQQSGQGQQLGQWQQQGqgqpgyyptSPLQPGQGQPgyyptSPQQPgQGQQLGQLQQPTQGQQGQQSGQGQQGQQP 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 156 SGLGYG-----PPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGG----PRMPSM 226
Cdd:pfam03157 566 GQGQQGqqpgqGQQGQQPGQGQQPGQGQPGYYPTSPQQSGQGQQPGQWQQPGQGQPGYYPTSSLQLGQGQqgyyPTSPQQ 645
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 227 PGPLP-PGQGFGSLPVSQANRVSSP--------------PAHALPPGTQMTGPPAPpppmhSPQQPGyQLQQNGSFGPAR 291
Cdd:pfam03157 646 PGQGQqPGQWQQSGQGQQGYYPTSPqqsgqaqqpgqgqqPGQWLQPGQGQQGYYPT-----SPQQPG-QGQQLGQGQQSG 719
|
330
....*....|....
gi 149031233 292 GPQPNYESPYPGAP 305
Cdd:pfam03157 720 QGQQGYYPTSPGQG 733
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
34-330 |
7.84e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.24 E-value: 7.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 34 PAAPATPYGAYNGPVPGyQQAPPQgvPRAPPCSGAP-PASAAQVPCGQTTY----------GQFGQGDIQNGPSSTAQMP 102
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPG-GGGPPD--PDAPPAPSRLaPAILPDEPVGEPVHprmltwirglEELASDDAGDPPPPLPPAA 2559
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 103 RVPGSQQFGPP--LAPVVSQPAV----LQPYGPPPTSTQVTAQLAAMQISGAVAQAP-PPSGLGYGPPTSLASASGNFPN 175
Cdd:PHA03247 2560 PPAAPDRSVPPprPAPRPSEPAVtsraRRPDAPPQSARPRAPVDDRGDPRGPAPPSPlPPDTHAPDPPPPSPSPAANEPD 2639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 176 SGPYSTYPQSQAPPLSQAQGHpgVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGFgslpvsqanrvSSPPAHAL 255
Cdd:PHA03247 2640 PHPPPTVPPPERPRDDPAPGR--VSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL-----------ADPPPPPP 2706
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149031233 256 PPgtqmtgppappPPMHSPQQPGYQLQQNGSFGPARGPQPNYeSPYPGAPTFGTQPGPPQPLPPKRLDPDAIPSP 330
Cdd:PHA03247 2707 TP-----------EPAPHALVSATPLPPGPAAARQASPALPA-APAPPAVPAGPATPGGPARPARPPTTAGPPAP 2769
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
99-239 |
7.85e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.90 E-value: 7.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 99 AQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLgyGPPTSLASASGNFPNSGP 178
Cdd:PRK07764 376 ARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAP--APAPAPPSPAGNAPAGGA 453
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149031233 179 YSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASggPRMPSMPGPLPPGQGFGSL 239
Cdd:PRK07764 454 PSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA--PAAPAAPAAPAGADDAATL 512
|
|
| DUF4813 |
pfam16072 |
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ... |
23-258 |
1.60e-04 |
|
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.
Pssm-ID: 435117 [Multi-domain] Cd Length: 288 Bit Score: 44.75 E-value: 1.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 23 YHQSNYGGQPGPAAPATPYGAYNGPVP-GYQQAPPQGVPRAppCSGAPPASAAQVPCGqTTYGQFGQGdIQNGPSSTAQM 101
Cdd:pfam16072 4 YHPAGATYHPGGYAPAGATYHPAGQVPaGATYYPSGGVPHG--ATYYPQAPVAAVPAG-ATYLPAGAA-IPAGATYYPQA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 102 PRVPGSQQFGPPLAPVVSQPAVLQpYGPPPTSTQVTAQLAAMQISGAVAQAPPPSG------LGYGPPTSLASASGNFPN 175
Cdd:pfam16072 80 PKSSSGLGLGTGLIAGALGGAILG-HALTPTQTRVVEHAPSSGGGGGGGGYSNGNNedkiiiINNGPPGSVTTTSAGSGT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 176 SGPYSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLAssftsPASGGPRMPSmpGPLPPGQGFGSLPVSQANR----VSSPP 251
Cdd:pfam16072 159 TVINAGGQQPAAPAAPAYPVAPAAYPAQAPAAAPA-----PAPGAPQTPL--APLNPVAAAPAAAAGAAAApvvaAAAPA 231
|
....*..
gi 149031233 252 AHALPPG 258
Cdd:pfam16072 232 AAAPPPP 238
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
128-305 |
1.95e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 45.64 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 128 GPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAppLSQAQGHPGVQPPLRSAP 207
Cdd:PRK12323 373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEA--LAAARQASARGPGGAPAP 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 208 PLASSfTSPASGGPrmPSMPGPLPPGQGFGSLPVSQANRVSSPPA-HALPPGTQMTGPPAPPPPMHSPQQPGYQLQQNGS 286
Cdd:PRK12323 451 APAPA-AAPAAAAR--PAAAGPRPVAAAAAAAPARAAPAAAPAPAdDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIP 527
|
170
....*....|....*....
gi 149031233 287 FGPARGPQPNYESPYPGAP 305
Cdd:PRK12323 528 DPATADPDDAFETLAPAPA 546
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
85-259 |
2.98e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.87 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 85 QFGQGDIQNGPSSTAQMPRvpgSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQlAAMQISGAVAQAPPPSGLgygPPT 164
Cdd:PRK12323 364 RPGQSGGGAGPATAAAAPV---AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAA-ARAVAAAPARRSPAPEAL---AAA 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 165 SLASASGNFPNSGPYSTYPQS----QAPPLSQAQGHP--GVQPPLRSAPPLASS----FTSPASGGPRMPSMPGPLPPGQ 234
Cdd:PRK12323 437 RQASARGPGGAPAPAPAPAAApaaaARPAAAGPRPVAaaAAAAPARAAPAAAPApaddDPPPWEELPPEFASPAPAQPDA 516
|
170 180
....*....|....*....|....*
gi 149031233 235 GFGSLPVSQANRvsspPAHALPPGT 259
Cdd:PRK12323 517 APAGWVAESIPD----PATADPDDA 537
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
5-309 |
3.28e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 45.05 E-value: 3.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 5 QSAPPVP-PFGQNQPIYPGYHQSnygGQPGPAAPATPYGAYNGP-------VPGYQQAP--PQGVPRAP----------P 64
Cdd:PHA03379 468 AQLPPGPlQDLEPGDQLPGVVQD---GRPACAPVPAPAGPIVRPweaslsqVPGVAFAPvmPQPMPVEPvpvptvalerP 544
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 65 CSGAPPASAAQvpcgqttygqfgqgdiqnGPSSTAQMPRVPGSQQfGPPLAPVVSQPavlqpygppPTSTQVTAQLAAMQ 144
Cdd:PHA03379 545 VCPAPPLIAMQ------------------GPGETSGIVRVRERWR-PAPWTPNPPRS---------PSQMSVRDRLARLR 596
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 145 ISGAVAQAPPPSglgygPPTSLASASGNFPNSGP-------YSTYPQSQAPPLSQAQGHPGVQPPLRSAPpLASSFTSPA 217
Cdd:PHA03379 597 AEAQPYQASVEV-----QPPQLTQVSPQQPMEYPlepeqqmFPGSPFSQVADVMRAGGVPAMQPQYFDLP-LQQPISQGA 670
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 218 SGGPRMPSMpGPLPP----GQGFGSLPVSQANRVSSPPAHALPPgTQMTGPPAPPPPMHspqqPGYQLQQNGSFGPARGP 293
Cdd:PHA03379 671 PLAPLRASM-GPVPPvpatQPQYFDIPLTEPINQGASAAHFLPQ-QPMEGPLVPERWMF----QGATLSQSVRPGVAQSQ 744
|
330
....*....|....*....
gi 149031233 294 Q---PNYESPYPGAPTFGT 309
Cdd:PHA03379 745 YfdlPLTQPINHGAPAAHF 763
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
43-251 |
3.37e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 44.66 E-value: 3.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 43 AYNGPVPGYQQAPPQgVPRAppCSGAPPASAAQVPCGQTTYgQFGQGDIQN----GPSSTAQMPRVP------GSQQFGP 112
Cdd:PHA03379 412 TYGTPRPPVEKPRPE-VPQS--LETATSHGSAQVPEPPPVH-DLEPGPLHDqhsmAPCPVAQLPPGPlqdlepGDQLPGV 487
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 113 PLAPVVSQPAVLQPYGP-----PPTSTQVTAQLAAMQISGAVAQAPPP-----SGLGYGPPTSLASASGNFPNSGPYSTY 182
Cdd:PHA03379 488 VQDGRPACAPVPAPAGPivrpwEASLSQVPGVAFAPVMPQPMPVEPVPvptvaLERPVCPAPPLIAMQGPGETSGIVRVR 567
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 183 PQSQAPPLSQAQGHPGVQPPLRSAP----PLASSFTSP-ASGGPRMPSMP------GPL-PPGQGFGSLPVSQANRVSSP 250
Cdd:PHA03379 568 ERWRPAPWTPNPPRSPSQMSVRDRLarlrAEAQPYQASvEVQPPQLTQVSpqqpmeYPLePEQQMFPGSPFSQVADVMRA 647
|
.
gi 149031233 251 P 251
Cdd:PHA03379 648 G 648
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
35-209 |
5.34e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 44.31 E-value: 5.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 35 AAPATPYGAYNGPVPGYQQAPPqgVPRAPPCSGAPPASAAQVPCGQTtygqfGQGDIQNGPSSTAQMPRV--PGSQQFGP 112
Cdd:PRK10263 324 AAATTATQSWAAPVEPVTQTPP--VASVDVPPAQPTVAWQPVPGPQT-----GEPVIAPAPEGYPQQSQYaqPAVQYNEP 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 113 PLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQ-------------ISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPY 179
Cdd:PRK10263 397 LQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPaqqpyyapapeqpVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEP 476
|
170 180 190
....*....|....*....|....*....|
gi 149031233 180 STYPQSQAPPLSQAQGHPGVQPPLRSAPPL 209
Cdd:PRK10263 477 LYQQPQPVEQQPVVEPEPVVEETKPARPPL 506
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
32-173 |
5.85e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.93 E-value: 5.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 32 PGPAAPATPYGAYNGPVPGYQQAP---PQGVPRAPPCSGAPPASAAQVPCGQTTYGQfgqgdiqngPSSTAQMPRVPgsq 108
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPaaaPVAQAAAAPAPAAAPAAAASAPAAPPAAAP---------PAPVAAPAAAA--- 433
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 149031233 109 qfGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLASASGNF 173
Cdd:PRK14951 434 --PAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGDV 496
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
47-258 |
5.93e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.07 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 47 PVPGYQQAPPQGVPRAPPcsGAPPASAAQVPcgqttygqfgqgdiqNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQP 126
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVA--GAVPAPGARAA---------------AAVGASAVPAVTAVTGAAGAALAPKAAAAAAATR 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 127 YGPPPTSTQVTAqlaamqiSGAVAQAPPPSGlgygPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQghpgvqpPLRSA 206
Cdd:PRK07003 423 AEAPPAAPAPPA-------TADRGDDAADGD----APVPAKANARASADSRCDERDAQPPADSGSASA-------PASDA 484
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 149031233 207 PPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQANRVSSPPAHALPPG 258
Cdd:PRK07003 485 PPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPT 536
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
56-231 |
5.93e-04 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 42.93 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 56 PQGVPRAP--PCsgapPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMPRVPGSQQFGPplAPVVSQPAVLQPYGPPPTs 133
Cdd:PHA02682 30 PQATIPAPaaPC----PPDADVDPLDKYSVKEAGRYYQSRLKANSACMQRPSGQSPLAP--SPACAAPAPACPACAPAA- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 134 tqvtaqLAAMQISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPL--RSAPPLas 211
Cdd:PHA02682 103 ------PAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLPTPKPAPAAKPIFlhNQLPPP-- 174
|
170 180
....*....|....*....|
gi 149031233 212 sfTSPASGGPRMPSMPGPLP 231
Cdd:PHA02682 175 --DYPAASCPTIETAPAASP 192
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
32-243 |
6.80e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 43.89 E-value: 6.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 32 PGPAAPATPYGAYNGPVPGYQQAPPQGVPRA---PPCSGAPPASAAQVPCGQTTygQFGQGDIQNGPSSTAQMPRVPG-- 106
Cdd:PHA03379 577 PNPPRSPSQMSVRDRLARLRAEAQPYQASVEvqpPQLTQVSPQQPMEYPLEPEQ--QMFPGSPFSQVADVMRAGGVPAmq 654
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 107 SQQFGPPLAPVVSQPAVLQPY----GPPPTSTQVTAQLAAMQISGAVAQ-APPPSGLGYGPPTS-LASASGNFPNSgpys 180
Cdd:PHA03379 655 PQYFDLPLQQPISQGAPLAPLrasmGPVPPVPATQPQYFDIPLTEPINQgASAAHFLPQQPMEGpLVPERWMFQGA---- 730
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149031233 181 TYPQSQAPPLSQAQ--GHPGVQPPLRSAPplassftspASGGPRMPSMPGPLPPGQG-FGSLPVSQ 243
Cdd:PHA03379 731 TLSQSVRPGVAQSQyfDLPLTQPINHGAP---------AAHFLHQPPMEGPWVPEQWmFQGAPPSQ 787
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
6-214 |
7.41e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.71 E-value: 7.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 6 SAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPAtpygayngpVPGYQQAPPQGVPRAPpcsgAPPASAAQVPCGQTtygq 85
Cdd:PRK12323 400 AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEA---------LAAARQASARGPGGAP----APAPAPAAAPAAAA---- 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 86 fgqgdiqngPSSTAQMPRVPGSQQFGPPLAPVVSQPAVlQPYGPPPTStQVTAQLAAMQISGAVAqAPPPSGLGYGPPTS 165
Cdd:PRK12323 463 ---------RPAAAGPRPVAAAAAAAPARAAPAAAPAP-ADDDPPPWE-ELPPEFASPAPAQPDA-APAGWVAESIPDPA 530
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 149031233 166 LASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVqPPLRSAPPLASSFT 214
Cdd:PRK12323 531 TADPDDAFETLAPAPAAAPAPRAAAATEPVVAPR-PPRASASGLPDMFD 578
|
|
| COG3416 |
COG3416 |
Uncharacterized conserved protein, DUF2076 domain [Function unknown]; |
13-62 |
8.36e-04 |
|
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
Pssm-ID: 442642 [Multi-domain] Cd Length: 237 Bit Score: 42.32 E-value: 8.36e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 149031233 13 FGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQ----APPQGVPRA 62
Cdd:COG3416 90 FGGGQRPPPAPQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQpqygQPAAGPSGG 143
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
146-259 |
9.59e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 43.13 E-value: 9.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 146 SGAVAQAPPPSGLGygpPTSLASASGNFPNSGPYSTYPQSQAPPlsqaqghPGVqpPLRSAPPLASSFTSPASGGPRMP- 224
Cdd:PRK14959 391 SGGAATIPTPGTQG---PQGTAPAAGMTPSSAAPATPAPSAAPS-------PRV--PWDDAPPAPPRSGIPPRPAPRMPe 458
|
90 100 110
....*....|....*....|....*....|....*..
gi 149031233 225 --SMPGPlppgqgfgslPVSQANRVSSPPAHALPPGT 259
Cdd:PRK14959 459 asPVPGA----------PDSVASASDAPPTLGDPSDT 485
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
6-306 |
9.62e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 9.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 6 SAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNGPVPGYQQAPPQGVPRAP-PCSGAPPASAA-QVPCGQTTY 83
Cdd:PHA03307 125 SPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETaRAPSSPPAEPPpSTPPAAASP 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 84 GQFGQGDIQNGPSSTAQmPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPP 163
Cdd:PHA03307 205 RPPRRSSPISASASSPA-PAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPG 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 164 TSlaSASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQGFGSLPVSQ 243
Cdd:PHA03307 284 PA--SSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPAD 361
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149031233 244 ANRVSSPPAHALPPGTQMTGPPAPPPPMHSPQQPGYQLQQNGSF---GPARGPQPNYESPYPGAPT 306
Cdd:PHA03307 362 PSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGrfpAGRPRPSPLDAGAASGAFY 427
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
3-249 |
1.39e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.00 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 3 VNQSAPPVPPFGQNQPiypgyhqsnyggQPGPAAPATPygayNGPVPGYQQAPPQGVPRAPPCSGAPPASAAQVPCGQTT 82
Cdd:PHA03247 2886 LARPAVSRSTESFALP------------PDQPERPPQP----QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDP 2949
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 83 YGQFGQGDIQNGPSSTAQMP-RVPGSQQFGPPLAPVVSQPAvlqPYGPPPTSTQVTAQLA-AMQISGAVAQAPPPSGL-- 158
Cdd:PHA03247 2950 AGAGEPSGAVPQPWLGALVPgRVAVPRFRVPQPAPSREAPA---SSTPPLTGHSLSRVSSwASSLALHEETDPPPVSLkq 3026
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 159 GYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPlRSAPPLASSFTSPASggprmpsmpgplppgqGFGS 238
Cdd:PHA03247 3027 TLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEP-DPATPEAGARESPSS----------------QFGP 3089
|
250
....*....|.
gi 149031233 239 LPVSqANRVSS 249
Cdd:PHA03247 3090 PPLS-ANAALS 3099
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
5-174 |
1.60e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 42.56 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 5 QSAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPygaynGPVPGYQQAPPQGVPRAPPcSGAPPASAAQVPCGQTTYG 84
Cdd:PRK12323 419 VAAAPARRSPAPEALAAARQASARGPGGAPAPAPAP-----AAAPAAAARPAAAGPRPVA-AAAAAAPARAAPAAAPAPA 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 85 QFGQGDIQNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPT 164
Cdd:PRK12323 493 DDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASG 572
|
170
....*....|
gi 149031233 165 SLASASGNFP 174
Cdd:PRK12323 573 LPDMFDGDWP 582
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
127-341 |
1.66e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.76 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 127 YGPPPTSTQVTAQLAAMQISGAVAQApppsglgYGPPTSLASASGNFPNSGPYSTYPQSQAPPLSQAQ-GHPGVQPPLRS 205
Cdd:PRK10263 307 YDPLLNGAPITEPVAVAAAATTATQS-------WAAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQtGEPVIAPAPEG 379
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 206 APPlASSFTSPASGGPRMPSMP-GPLPPGQGFGSLPVSQANRVSSPPAHALP---PGTQMTGPPAPPPPMHSPQQPGYQL 281
Cdd:PRK10263 380 YPQ-QSQYAQPAVQYNEPLQQPvQPQQPYYAPAAEQPAQQPYYAPAPEQPAQqpyYAPAPEQPVAGNAWQAEEQQSTFAP 458
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 282 QqngsfgPARGPQPNYESPYPGAPTFgtqpgppqpLPPKRLDPDAIPSPIQVIEDDRNNR 341
Cdd:PRK10263 459 Q------STYQTEQTYQQPAAQEPLY---------QQPQPVEQQPVVEPEPVVEETKPAR 503
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
29-278 |
2.44e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.08 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPATPYGAYNGPVPGyqqAPPQGVPRAPPCSGAPPASAAqvpcgqttygqfgqgdiqnGPSSTAQMPRVPGSq 108
Cdd:PHA03307 17 GGEFFPRPPATPGDAADDLLSG---SQGQLVSDSAELAAVTVVAGA-------------------AACDRFEPPTGPPP- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 109 qfGPPLAPVVSQPAVLQPYGPPPtstqvtaqLAAMQISGAVAQAPPPSGLGYGPPTSLASASGnfpnsgpystyPQSQAP 188
Cdd:PHA03307 74 --GPGTEAPANESRSTPTWSLST--------LAPASPAREGSPTPPGPSSPDPPPPTPPPASP-----------PPSPAP 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 189 PLSQAQ--GHPGVQPPLRSAPPLASSFTSPASG--GPRMPSMPGPLPPgqgfgslpvsQANRVSSPPAHALPPGTQMTGP 264
Cdd:PHA03307 133 DLSEMLrpVGSPGPPPAASPPAAGASPAAVASDaaSSRQAALPLSSPE----------ETARAPSSPPAEPPPSTPPAAA 202
|
250
....*....|....
gi 149031233 265 PAPPPPMHSPQQPG 278
Cdd:PHA03307 203 SPRPPRRSSPISAS 216
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
29-245 |
2.67e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.84 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPATPygayNGPVPGYQQAPPQG---VPR-----------APPCSGAP--PASAAQVPCGQTTYGQFGQGDIQ 92
Cdd:PLN03209 338 GPKPVPTKPVTP----EAPSPPIEEEPPQPkavVPRplspytayedlKPPTSPIPtpPSSSPASSKSVDAVAKPAEPDVV 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 93 NGPSSTAQMPRV---PGSQQFGPPLAPVVSQPAVLQPYGPPPTstqvtaqlaamqisgavaqapPPSGLGygPPTSLASA 169
Cdd:PLN03209 414 PSPGSASNVPEVepaQVEAKKTRPLSPYARYEDLKPPTSPSPT---------------------APTGVS--PSVSSTSS 470
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 149031233 170 SGNFPNSGPYSTYPQSQAPPLSQAQGHPGVQPPLRSAPPLASsftSPASGGPRMPSMPGPLPPGQGFGSLPVSQAN 245
Cdd:PLN03209 471 VPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSP---SPAAPVGKVAPSSTNEVVKVGNSAPPTALAD 543
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
6-155 |
3.19e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.51 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 6 SAPPVPPFGQNQPIYPGYHQSNYGGQPGPAAPATPYGAYNG-PVPGYQQAPPQGVPRAPPcSGAPPASAAQVPCGQTTYG 84
Cdd:PRK07764 634 AAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGgAAPAAPPPAPAPAAPAAP-AGAAPAQPAPAPAATPPAG 712
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 149031233 85 QfGQGDIQNGPSSTAQMPRVPGSQQFGPPLAPVVSQPAVLQPYGPPPTSTQVTAQLAAMQISGAVAQAPPP 155
Cdd:PRK07764 713 Q-ADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
|
|
| SOBP |
pfam15279 |
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
106-302 |
3.94e-03 |
|
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 40.57 E-value: 3.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 106 GSQQFGPPLAPVVSQ-PAVLQPYGPPPTSTQVTAQLAA-MQISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYP 183
Cdd:pfam15279 91 ESVSPGPSSSASPSSsPTSSNSSKPLISVASSSKLLAPkPHEPPSLPPPPLPPKKGRRHRPGLHPPLGRPPGSPPMSMTP 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 184 QS---------QAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASggPRMPSMPGPLPPGQGFGSLPVSQANRVSSPPAHA 254
Cdd:pfam15279 171 RGllgkpqqhpPPSPLPAFMEPSSMPPPFLRPPPSIPQPNSPLS--NPMLPGIGPPPKPPRNLGPPSNPMHRPPFSPHHP 248
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 149031233 255 LPPGTqMTGPPAPPPPMH-----------SPQQPGYQLQQ--NGSFGPARG--PQPNYESPYP 302
Cdd:pfam15279 249 PPPPT-PPGPPPGLPPPPprgftppfgppFPPVNMMPNPPemNFGLPSLAPlvPPVTVLVPYP 310
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
156-306 |
5.07e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 41.06 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 156 SGLGYGPPTSLASASGNFPNSGP----YSTYPQSQ--APPLSQAQ-GHPGVQPPLRSAPPLASSFTSPASGGPRMPS--M 226
Cdd:pfam05109 394 SGLGTAPKTLIITRTATNATTTThkviFSKAPESTttSPTLNTTGfAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTadV 473
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 227 PGPLPPGQGFGSLPV------------SQANRVSSPPAHALPPGTQMTGPPAPPPPmHSPQQPGYQLQQNGSFGPARGPQ 294
Cdd:pfam05109 474 TSPTPAGTTSGASPVtpspsprdngteSKAPDMTSPTSAVTTPTPNATSPTPAVTT-PTPNATSPTLGKTSPTSAVTTPT 552
|
170
....*....|..
gi 149031233 295 PNYESPYPGAPT 306
Cdd:pfam05109 553 PNATSPTPAVTT 564
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
29-262 |
5.62e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.08 E-value: 5.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 29 GGQPGPAAPATPygayngPVPGYQQAPPQGVPRAPP------CSGAPPA-SAAQVPCGQTTYGQFGQGDIQNGP---SST 98
Cdd:PHA03247 266 DRAPETARGATG------PPPPPEAAAPNGAAAPPDgvwgaaLAGAPLAlPAPPDPPPPAPAGDAEEEDDEDGAmevVSP 339
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 99 AQMPRVPGSQQFGPPLAPVVSQPAVLQ---------PYGPPPTSTQVTAQLAAmqisgavaqAPPPSGLGYGPPTSLASA 169
Cdd:PHA03247 340 LPRPRQHYPLGFPKRRRPTWTPPSSLEdlsagrhhpKRASLPTRKRRSARHAA---------TPFARGPGGDDQTRPAAP 410
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 170 SgnfpnsgPYSTyPQSQAPPLSQAQGHPGVQPPLRSAPPLASSFTSPASGGPRMPSMPgPLPPGQGFGSLPVSQANRVSS 249
Cdd:PHA03247 411 V-------PASV-PTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATE-PAPDDPDDATRKALDALRERR 481
|
250
....*....|...
gi 149031233 250 PPAhalPPGTQMT 262
Cdd:PHA03247 482 PPE---PPGADLA 491
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
112-234 |
5.86e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 40.47 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 112 PPLAPVVSQPAVlqpyGPPPTSTQVTAQLAAMQISGAVAQAPPPSGLGYGPPTSLASASGNFPNSGPYSTYPQSQAPPLS 191
Cdd:PRK14951 380 TPARPEAAAPAA----APVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQA 455
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 149031233 192 QAQghpGVQPPLRSAPPLASSFTSPASGGPRMPSMPGPLPPGQ 234
Cdd:PRK14951 456 APE---TVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGD 495
|
|
| DAZAP2 |
pfam11029 |
DAZ associated protein 2 (DAZAP2); DAZ associated protein 2 has a highly conserved sequence ... |
51-144 |
6.63e-03 |
|
DAZ associated protein 2 (DAZAP2); DAZ associated protein 2 has a highly conserved sequence throughout evolution including a conserved polyproline region and several SH2/SH3 binding sites. It occurs as a single copy gene with a four-exon organization and is located on chromosome 12. It encodes a ubiquitously expressed protein and binds to DAZ and DAZL1 through DAZ repeats.
Pssm-ID: 402565 [Multi-domain] Cd Length: 129 Bit Score: 37.79 E-value: 6.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 51 YQQAPPQGVPRAPPCSGAPPASAAQVPCGQTTYGQFGQGDIQNGPSSTAQMPRVPGSQQFGPPLAPVV------------ 118
Cdd:pfam11029 1 YPDAPPAYSQLYQPRYAHPPYAASVAPSMSAAYPPAQAYPPMAQMASPPPMAYQPPGPAQPPGQTVVVpggfdagarfga 80
|
90 100
....*....|....*....|....*.
gi 149031233 119 SQPAVLQPygPPPTSTQVTAQLAAMQ 144
Cdd:pfam11029 81 GSQPSIPP--PPPGCAPNAAQLAAMQ 104
|
|
| GEL |
smart00262 |
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ... |
964-1000 |
6.92e-03 |
|
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.
Pssm-ID: 214590 [Multi-domain] Cd Length: 90 Bit Score: 36.89 E-value: 6.92e-03
10 20 30
....*....|....*....|....*....|....*....
gi 149031233 964 TEPPAVRASEERLSSGDIYLLENGLNLFVWVG--ASVQQ 1000
Cdd:smart00262 11 VRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGkkSSQDE 49
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
34-411 |
8.44e-03 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 40.06 E-value: 8.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 34 PAAPATPYGAYNGPVPGYQQA-------PPQGVPRAPPCSGAPPASAAQV------------------------------ 76
Cdd:pfam03546 39 PAAKTPLQAKPSGKTPQVRAAsapakesPRKGAPPVPPGKTGPAAAQAQAgkpeedsessseesdsdgetpaaatlttsp 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 77 ----PCGQTTYGQFGQGdIQNGPSSTAQMPRVPGSqqfgppLAPVVSQPAVLQPYGPPPTSTQ-------VTAQLAAMQI 145
Cdd:pfam03546 119 aqvkPLGKNSQVRPAST-VGKGPSGKGANPAPPGK------AGSAAPLVQVGKKEEDSESSSEesdsegeAPPAATQAKP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 146 SGAVAQAPPPSGLGYG----PPTSL--------ASASGNFPNSGPYSTYPQSQAPP-LSQAQGHPGVQPPLRSAPPLASS 212
Cdd:pfam03546 192 SGKILQVRPASGPAKGaapaPPQKAgpvatqvkAERSKEDSESSEESSDSEEEAPAaATPAQAKPALKTPQTKASPRKGT 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 213 FTSPAS--GGPRMPSMPGPLPPGQgfgslpVSQANRVSSPpahALPPGTQMTGPPAPPPPMHSPQQ---PGYQLQQNGSF 287
Cdd:pfam03546 272 PITPTSakVPPVRVGTPAPWKAGT------VTSPACASSP---AVARGAQRPEEDSSSSEESESEEetaPAAAVGQAKSV 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 288 GpaRGPQPNYESpypgAPTFGTQPGPPQPLPPKRLDPDAIPSPIQVIEDDRNNR---GSEPfVTGVRGQVPPLVTTNflv 364
Cdd:pfam03546 343 G--KGLQGKAAS----APTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEeesDSEE-AAATPAQVKASGKTP--- 412
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 149031233 365 kdQGNASPRYIRCTSYNIPCTS-----DMAKQAQVPLAAVIKPLARLPPEEA 411
Cdd:pfam03546 413 --QAKANPAPTKASSAKGAASApgkvvAAAAQAKQGSPAKVKPPARTPQNSA 462
|
|
| DUF4645 |
pfam15488 |
Domain of unknown function (DUF4645); This family of proteins is found in eukaryotes. Proteins ... |
116-258 |
9.63e-03 |
|
Domain of unknown function (DUF4645); This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 298 amino acids in length.
Pssm-ID: 406050 [Multi-domain] Cd Length: 294 Bit Score: 39.46 E-value: 9.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 116 PVVSQPAVLQPYGPPPTSTQ---VTAQ------LAAMQISGA----VAQ---APPPSGLGYGPPTSLASASGNFPNSGPY 179
Cdd:pfam15488 82 PVDSSRALRHPYGPPPAVAEeslATAEvnssegLAGWRQKGQdsinVSQefsGSPPALMVGGTRVSNGGTERGGNNAKLY 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149031233 180 STYPQSQA---PPLSQAQGHPGVqPPLRSA-----PPLASSFTSPAS--------GGPRMP--SMPGPLPpgqgfgsLPV 241
Cdd:pfam15488 162 SALPRGQGffpPRGPQVRGPPHI-PTLRSGimmevPPGNTRMAGKERlahvsfplGGPRHPmdNWPRPIP-------LSS 233
|
170
....*....|....*...
gi 149031233 242 SQANRVSSPPAHA-LPPG 258
Cdd:pfam15488 234 STPGLPSCSTAHCfIPPR 251
|
|
| |
