Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 149023177    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 149023177  2004 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2047
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 149023177  1368 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1403
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 149023177  2293 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2326
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 149023177  1327 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1362
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 149023177   1744 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1776
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 149023177    531 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 572
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 149023177   1866 DVDECATGNgnLCRNG-QCVNTVGSFQCRCNEGYEvapDGRTCV 1908
Cdd:smart00179    1 DIDECASGN--PCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 149023177   2063 DMDECKEPDVCKHG-QCINTDGSYRCECPFGYIlEGNECV 2101
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT-DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 149023177   2543 DENECLSAHVCG-GASCHNTLGSYKCMCPAGFQ 2574
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 149023177    573 DMDECSIRNMCLNG-MCINEDGSFKCICKPGFQlasDGRYCK 613
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 149023177 2378 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2418
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 149023177  1949 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 1979
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 149023177    288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFYtspDGTRCV 329
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 149023177 1909 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 1944
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 149023177   1585 VNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1623
Cdd:smart00179    2 IDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 149023177    766 DINECVLNSLLCDNGQCRNTPGSFVCTCPKGF 797
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 149023177   1071 DIDECRiSPDLCGRG-QCVNTPGDFECKCDEGYESG 1105
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 149023177    491 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 522
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 149023177    48 GGHDALKGPNVCGSRYNAYCCPGWKTLPGGNQCIV 82
Cdd:pfam18193    3 GGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 149023177  2004 GKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQIC 2047
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 149023177  1368 CSNGTHMCSQHADCKNTMGSYRCLCKDGYTGDGFTC 1403
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 149023177  2293 PVTKSECCCD-GGRGWGPHCEICPFEGTVAYKKLC 2326
Cdd:pfam00683   10 NVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 149023177  1327 CEIGAHNCGRHAVCTNTAGSFKCSCSPGWIGDGIKC 1362
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 149023177   1744 DIDECQNGPVCQRNAECINTAGSYRCDCKPGYR 1776
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 149023177  1202 CSIMNGGCETFCTNSDGSYECSCQPGFALMPDQRSC 1237
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 149023177    531 DIDECLQNGRICNNGRCINTDGSFHCVCNAGFHvtrDGKNCE 572
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 149023177    614 DINECETPGICMNG-RCVNTDGSYRCECFPGLAVG 647
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 149023177  2421 DLDECATKQHNCQ--FLCVNTIGGFTCKCPPG 2450
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 149023177   2102 DTDECSVGNPCGNG-TCKNVIGGFECTCEEGFEPGpmMTCE 2141
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|..
gi 149023177   2503 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2532
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 149023177   1364 DLDECSNGtHMCSQHADCKNTMGSYRCLCKDGYTgDGFTCT 1404
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 149023177 2063 DMDECKEPDVCK-HGQCINTDGSYRCECPFGYIL 2095
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 149023177  1744 DIDECQNGP-VCQRNAECINTAGSYRCDCKPG 1774
Cdd:pfam07645    1 DVDECATGThNCPANTVCVNTIGSFECRCPDG 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|..
gi 149023177   861 GRCEININGATLKSECC-SSLGAAWGSPCTIC 891
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 149023177 2378 CVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQEDGRS 2418
Cdd:cd01475   184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 149023177 1861 NNDCIDVDECATGNGNlCRNGqCVNTVGSFQCRCNEGYEVAPDGRT 1906
Cdd:cd01475   181 GKICVVPDLCATLSHV-CQQV-CISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 149023177 2543 DENECLSAHVCG-GASCHNTLGSYKCMCPAGFQ 2574
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 149023177  1949 DIDECVEEPEICALGT-CSNTEGSFKCLCPEG 1979
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 149023177 2503 DVDECEGNHRCQHG--CQNIIGGYRCSCPQGY 2532
Cdd:cd00054     1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 149023177 2102 DTDECSVGNPCGN-GTCKNVIGGFECTCEEGFE 2133
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 149023177 1114 DIDECQRDPLLCRGGICHNTEGSYRCECPSGHQL 1147
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....
gi 149023177 1488 DVNECLDPTTC-ISGNCVNTPGSYTCDCPPDFEL 1520
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 149023177 1909 DINECVLDPGKCAPGTCQNLDGSYRCICPPGYSLQN 1944
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 149023177   1585 VNECETPGICGPG-TCYNTVGNYTCICPPDYMQvngGNNC 1623
Cdd:smart00179    2 IDECASGNPCQNGgTCVNTVGSYRCECPPGYTD---GRNC 38

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 149023177   1702 DIDECrEIPGVCENG-VCINMVGSFRCECPVGF 1733
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY 32

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 149023177   194 MCQGQLSGIVCTKTLCCATVGRAWGHPCEMCPAQ 227
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 149023177 1447 DINECSLPNICVF-GTCHNLPGLFRCECEIGYELDR 1481
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 149023177   1909 DINECvLDPGKCAPG-TCQNLDGSYRCICPPGYS 1941
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 149023177 1702 DIDECREIPGVCENGVCINMVGSFRCECPVGF 1733
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....
gi 149023177    491 DVDECE-KNPC-TGGECINNQGSYTCHCRAGYQS 522
Cdd:smart00179    1 DIDECAsGNPCqNGGTCVNTVGSYRCECPPGYTD 34

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 149023177 2460 DNNECTSEiNLCGSKGVCQNTPGSFTCECQRGFSLD 2495
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 149023177  288 DIDECSTIPGVCDGGECTNTVSSYFCKCPPGFY 320
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33