type I K homology (KH) RNA-binding domain found in protein quaking (Hqk) family; The Hqk family includes Hqk and protein held out wings (how) found in Drosophila. Hqk, also called HqkI, is an RNA-binding protein that plays a central role in myelinization. It binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence and regulates target mRNA stability. It acts by regulating pre-mRNA splicing, mRNA export and protein translation. Hqk is a regulator of oligodendrocyte differentiation and maturation in the brain that may play a role in myelin and oligodendrocyte dysfunction in schizophrenia. How, also called KH domain protein KH93F, or protein muscle-specific, or protein Struthio, or protein wings held out (who), or Quaking-related 93F (qkr93F), is an RNA-binding protein involved in the control of muscular and cardiac activity. It is required for integrin-mediated cell-adhesion in wing blade. It plays essential roles during embryogenesis, in late stages of somatic muscle development, for myotube migration and during metamorphosis for muscle reorganization.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148802147 2370 KYTAKYEVQIDPFNGFDIAKRIIGLKGTNMKKICIDTDCKLRLRGRGS---GYLEGEEKKEAN-----ESLHLCVSCQKY 2441
Cdd:cd22383     1 KLSEKVYVPVDEYPDYNFVGRILGPRGMTAKQLEQDTGCKIMIRGKGSmrdKKKEEANRGKPNwehlnDDLHVLITVEDT 80

                          90       100
                  ....*....|....*....|
gi 148802147 2442 D---HYVLAKKL--IEQLLV 2456
Cdd:cd22383    81 EnraHIKLAKAVeeVKKLLI 100

type I K homology (KH) RNA-binding domain found in yeast branchpoint-bridging protein (BBP) and similar proteins; Yeast BBP, also called mud synthetic-lethal 5 protein, or splicing factor 1, or zinc finger protein BBP, is a mammalian splicing factor SF1 ortholog. It is involved in protein-protein interactions that bridge the 3' and 5' splice-site ends of the intron during the early steps of yeast pre-mRNA splicing. BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148802147 2370 KYTAKYEVQIDPFNGFDIAKRIIGLKGTNMKKICIDTDCKLRLRGRGS-----GYLEGEEKKEANESLHLCVSCQKYDHY 2444
Cdd:cd02395     1 KKQRKIYIPVDEYPDYNFIGLIIGPRGNTQKRMEKESGAKIAIRGKGSvkegkGRSDPQPDPDEEEDLHVLITADTEEKV 80

                          90
                  ....*....|..
gi 148802147 2445 VLAKKLIEQLLV 2456
Cdd:cd02395    81 DKAAKLIEKLLI 92

type I K homology (KH) RNA-binding domain found in the KH domain-containing, RNA-binding, signal transduction-associated protein (KHDRBS) family; The KHDRBS family includes three members, KHDRBS1-3. KHDRBS1, also called GAP-associated tyrosine phosphoprotein p62, or Src-associated in mitosis 68 kDa protein, or Sam68, or p21 Ras GTPase-activating protein-associated p62, or p68, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS1 acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. It is recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. KHDRBS2, also called Sam68-like mammalian protein 1, or SLM-1, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds both poly(A) and poly(U) homopolymers. KHDRBS2 may function as an adapter protein for Src kinases during mitosis. KHDRBS3, also called RNA-binding protein T-Star, or Sam68-like mammalian protein 2, or SLM-2, or Sam68-like phosphotyrosine protein, is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. It binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. It also binds poly(A). KHDRBS3 may play a role as a negative regulator of cell growth.

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                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148802147 2369 KKYTAKYEVQIDPFNGFDIAKRIIGLKGTNMKKICIDTDCKLRLRGRGSgyLEGEEKKEA------------NESLHLCV 2436
Cdd:cd22384     3 IKLSEKVLIPVKEFPKFNFVGKLLGPRGNTLKRLQEETGTKMSILGKGS--MRDKAKEEElrksgdpkyahlNEDLHVLI 80

                  ..
gi 148802147 2437 SC 2438
Cdd:cd22384    81 EA 82