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Conserved domains on  [gi|148690250|gb|EDL22197|]
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mCG1048584, isoform CRA_a [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 142-246 2.10e-53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18275:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 104  Bit Score: 178.06  E-value: 2.10e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 142 VHGEPDLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQ 221
Cdd:cd18275    1 PLGEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQ 79

                         90       100
                 ....*....|....*....|....*
gi 148690250 222 LPGAAQRATEAMAPQLSLDNCYEVL 246
Cdd:cd18275   80 MPCAAQCAVDAVRAQLCLGNCYEVL 104
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 237-313 1.10e-26

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18484:

Pssm-ID: 475122  Cd Length: 77  Bit Score: 103.23  E-value: 1.10e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690250 237 LSLDNCYEVLSAGKRQRLTELRDAAYRFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLCTGRACLLAAALGTTGER 313
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
341-574 2.55e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 106.01  E-value: 2.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 341 GEWRELTRLPEgaPARGCGLCVLFNYLFVAGGVAPAgpdgraRPSDQVYCYNPVTDSWSTVRPL-RQARSQVQLLALDGH 419
Cdd:COG3055    1 ATWSSLPDLPT--PRSEAAAALLDGKVYVAGGLSGG------SASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 420 LYAVGG--------ECLLSVERYDPRADRWTAVAPLPRGafAVAHEAATCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 487
Cdd:COG3055   73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 488 EC-PCSSSRERSADMVALDGFLY----------------RFDLCGSRGEAQAAVGSG-----GGVS-----VFRYHCLAK 540
Cdd:COG3055  151 QLaPLPTPRDHLAAAVLPDGKILviggrngsgfsntwttLAPLPTARAGHAAAVLGGkilvfGGESgfsdeVEAYDPATN 230

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148690250 541 QWSQcAVHLrppgaPAGLQPFRCVALDGTIYCVS 574
Cdd:COG3055  231 TWTA-LGEL-----PTPRHGHAAVLTDGKVYVIG 258
PRK07003 super family cl35530
DNA polymerase III subunit gamma/tau;
5-113 3.53e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07003:

Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250   5 VAPFVLYSGTEPRTPGEDSLPLPAEEEGAASTAQTPCSLSASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQ 84
Cdd:PRK07003 428 AAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAV 507

                         90       100
                 ....*....|....*....|....*....
gi 148690250  85 WDVSSAASPESPEECARPEEPASPEDPPS 113
Cdd:PRK07003 508 PDARAPAAASREDAPAAAAPPAPEARPPT 536
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-246 2.10e-53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 178.06  E-value: 2.10e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 142 VHGEPDLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQ 221
Cdd:cd18275    1 PLGEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQ 79

                         90       100
                 ....*....|....*....|....*
gi 148690250 222 LPGAAQRATEAMAPQLSLDNCYEVL 246
Cdd:cd18275   80 MPCAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 237-313 1.10e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 103.23  E-value: 1.10e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690250 237 LSLDNCYEVLSAGKRQRLTELRDAAYRFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLCTGRACLLAAALGTTGER 313
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
341-574 2.55e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 106.01  E-value: 2.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 341 GEWRELTRLPEgaPARGCGLCVLFNYLFVAGGVAPAgpdgraRPSDQVYCYNPVTDSWSTVRPL-RQARSQVQLLALDGH 419
Cdd:COG3055    1 ATWSSLPDLPT--PRSEAAAALLDGKVYVAGGLSGG------SASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 420 LYAVGG--------ECLLSVERYDPRADRWTAVAPLPRGafAVAHEAATCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 487
Cdd:COG3055   73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 488 EC-PCSSSRERSADMVALDGFLY----------------RFDLCGSRGEAQAAVGSG-----GGVS-----VFRYHCLAK 540
Cdd:COG3055  151 QLaPLPTPRDHLAAAVLPDGKILviggrngsgfsntwttLAPLPTARAGHAAAVLGGkilvfGGESgfsdeVEAYDPATN 230

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148690250 541 QWSQcAVHLrppgaPAGLQPFRCVALDGTIYCVS 574
Cdd:COG3055  231 TWTA-LGEL-----PTPRHGHAAVLTDGKVYVIG 258
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 147-233 1.91e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 72.29  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250  147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRmaGVRPDNVAEVVAGARR 219
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKAlfsgqesESSVSEITLDDVSPEDFEALLEFMYTGK--LISEENVDDLLAAADK 89

                          90
                  ....*....|....
gi 148690250  220 LQLPGAAQRATEAM 233
Cdd:pfam00651  90 LQIPSLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 147-237 1.39e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.95  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250   147 DLVIEVAGRRLRAHKAVLAARSDYFRAR-------ASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALfssdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLD-LPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 148690250   220 LQLPGAAQRATEAMAPQL 237
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 354-491 3.03e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 72.49  E-value: 3.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 354 PARGCGLCVLFNYLFVAGGVAPAGPDGRarpsdqVYCYNPVTDSWSTVRPLRQARSQVQLLALDGHLYAVGG-----ECL 428
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGIYNSISLNT------VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskndELL 405

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 429 LSVERYDPRADRWTAVAPLPRGAFavAHEAATCNGEIYVSGG-------SLFYRLLKYDPRRDEWQECPC 491
Cdd:PHA03098 406 KTVECFSLNTNKWSKGSPLPISHY--GGCAIYHDGKIYVIGGisyidniKVYNIVESYNPVTNKWTELSS 473
Kelch smart00612
Kelch domain;
419-455 5.49e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.40  E-value: 5.49e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 148690250   419 HLYAVGG----ECLLSVERYDPRADRWTAVAPL--PRGAFAVA 455
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMptPRSGHGVA 43
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 407-448 1.57e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 45.30  E-value: 1.57e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 148690250  407 ARSQVQLLALDGHLYAVGG----ECLLSVERYDPRADRWTAVAPLP 448
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
5-113 3.53e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250   5 VAPFVLYSGTEPRTPGEDSLPLPAEEEGAASTAQTPCSLSASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQ 84
Cdd:PRK07003 428 AAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAV 507

                         90       100
                 ....*....|....*....|....*....
gi 148690250  85 WDVSSAASPESPEECARPEEPASPEDPPS 113
Cdd:PRK07003 508 PDARAPAAASREDAPAAAAPPAPEARPPT 536
 
Name Accession Description Interval E-value
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 142-246 2.10e-53

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 178.06  E-value: 2.10e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 142 VHGEPDLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQ 221
Cdd:cd18275    1 PLGEPDLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYATLRLLVDYVYSGRMA-VSKDNVVEVVAGARFLQ 79

                         90       100
                 ....*....|....*....|....*
gi 148690250 222 LPGAAQRATEAMAPQLSLDNCYEVL 246
Cdd:cd18275   80 MPCAAQCAVDAVRAQLCLGNCYEVL 104
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 237-313 1.10e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 103.23  E-value: 1.10e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690250 237 LSLDNCYEVLSAGKRQRLTELRDAAYRFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLCTGRACLLAAALGTTGER 313
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLEAGRACLVVAELNDVFER 77
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
341-574 2.55e-25

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 106.01  E-value: 2.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 341 GEWRELTRLPEgaPARGCGLCVLFNYLFVAGGVAPAgpdgraRPSDQVYCYNPVTDSWSTVRPL-RQARSQVQLLALDGH 419
Cdd:COG3055    1 ATWSSLPDLPT--PRSEAAAALLDGKVYVAGGLSGG------SASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 420 LYAVGG--------ECLLSVERYDPRADRWTAVAPLPRGafAVAHEAATCNGEIYVSGG----SLFYRLLKYDPRRDEWQ 487
Cdd:COG3055   73 LYVFGGftganpssTPLNDVYVYDPATNTWTKLAPMPTP--RGGATALLLDGKIYVVGGwddgGNVAWVEVYDPATGTWT 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 488 EC-PCSSSRERSADMVALDGFLY----------------RFDLCGSRGEAQAAVGSG-----GGVS-----VFRYHCLAK 540
Cdd:COG3055  151 QLaPLPTPRDHLAAAVLPDGKILviggrngsgfsntwttLAPLPTARAGHAAAVLGGkilvfGGESgfsdeVEAYDPATN 230

                        250       260       270
                 ....*....|....*....|....*....|....
gi 148690250 541 QWSQcAVHLrppgaPAGLQPFRCVALDGTIYCVS 574
Cdd:COG3055  231 TWTA-LGEL-----PTPRHGHAAVLTDGKVYVIG 258
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
333-509 6.61e-20

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 90.22  E-value: 6.61e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 333 VYCYQAEAGEWRELTRLPEGapaRGCGLCVLFN-YLFVAGGVAPAGPDGRarpsdqVYCYNPVTDSWSTVRPLRQARSQV 411
Cdd:COG3055   92 VYVYDPATNTWTKLAPMPTP---RGGATALLLDgKIYVVGGWDDGGNVAW------VEVYDPATGTWTQLAPLPTPRDHL 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 412 Q-LLALDGHLYAVGGecllsvERYDPRADRWTAVAPLPRGAFavAHEAATCNGEIYVSGGSLFYR--LLKYDPRRDEWQE 488
Cdd:COG3055  163 AaAVLPDGKILVIGG------RNGSGFSNTWTTLAPLPTARA--GHAAAVLGGKILVFGGESGFSdeVEAYDPATNTWTA 234

                        170       180
                 ....*....|....*....|.
gi 148690250 489 CPCSSSRERSADMVALDGFLY 509
Cdd:COG3055  235 LGELPTPRHGHAAVLTDGKVY 255
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-220 4.62e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 76.05  E-value: 4.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR-------ASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18186    3 DVTLVVGGREFPAHRAVLAARSPYFRAMfssgmkeSSSSEIELDDVSPEAFEALLDYIYTGELE-LSEENVEELLAAADK 81


                 .
gi 148690250 220 L 220
Cdd:cd18186   82 L 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 147-233 1.91e-15

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 72.29  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250  147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRmaGVRPDNVAEVVAGARR 219
Cdd:pfam00651  12 DVTLVVGDKEFRAHKAVLAACSPYFKAlfsgqesESSVSEITLDDVSPEDFEALLEFMYTGK--LISEENVDDLLAAADK 89

                          90
                  ....*....|....
gi 148690250  220 LQLPGAAQRATEAM 233
Cdd:pfam00651  90 LQIPSLVDKCEEFL 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 147-237 1.39e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.95  E-value: 1.39e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250   147 DLVIEVAGRRLRAHKAVLAARSDYFRAR-------ASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALfssdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLD-LPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 148690250   220 LQLPGAAQRATEAMAPQL 237
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
PHA03098 PHA03098
kelch-like protein; Provisional
 354-491 3.03e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 72.49  E-value: 3.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 354 PARGCGLCVLFNYLFVAGGVAPAGPDGRarpsdqVYCYNPVTDSWSTVRPLRQARSQVQLLALDGHLYAVGG-----ECL 428
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGIYNSISLNT------VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGiskndELL 405

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 429 LSVERYDPRADRWTAVAPLPRGAFavAHEAATCNGEIYVSGG-------SLFYRLLKYDPRRDEWQECPC 491
Cdd:PHA03098 406 KTVECFSLNTNKWSKGSPLPISHY--GGCAIYHDGKIYVIGGisyidniKVYNIVESYNPVTNKWTELSS 473
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 1.06e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 65.11  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18255   20 DVTLIADGQRFQAHKVVLASCSDYFRAmftggmrESSQDEIELKGVSAKGLKHILDFAYTSELT-LDLDCIQDVLGAAVH 98

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18255   99 LQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 4.12e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 63.50  E-value: 4.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSgRMAGVRPDNVAEVVAGARR 219
Cdd:cd18240   19 DVVIRVNGVEFPAHRNILCACSPYFRAlftngwnETEKKVYKIPGVSPEMMELIIEYAYT-RTVPITAENVEELLPAADQ 97

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18240   98 FNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 4.44e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 63.25  E-value: 4.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASR-DVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18250   23 DVTLCAGGREFPCHRTVLAAASSYFRAmfagelRESRaDRVVLHGVSAEILGLLLDFSYTGRVT-VTQDNVEALLRAADL 101

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18250  102 FQFPSVKEACCAYLQQRLDVSNC 124
PHA03098 PHA03098
kelch-like protein; Provisional
 356-509 9.19e-12

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 67.87  E-value: 9.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 356 RGCGLCVLFN-YLFVAGGVapagpDGRARPSDQVYCYNPVTDSWSTVRPLRQARSQVQLLALDGHLYAVGG----ECLLS 430
Cdd:PHA03098 285 VYCFGSVVLNnVIYFIGGM-----NKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNT 359

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 431 VERYDPRADRWTAVAPL--PRGAFAVaheaATCNGEIYVSGG-SLFYRLLK----YDPRRDEWQECPCSSSRERSADMVA 503
Cdd:PHA03098 360 VESWKPGESKWREEPPLifPRYNPCV----VNVNNLIYVIGGiSKNDELLKtvecFSLNTNKWSKGSPLPISHYGGCAIY 435


                 ....*.
gi 148690250 504 LDGFLY 509
Cdd:PHA03098 436 HDGKIY 441
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 2.04e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 60.84  E-value: 2.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18234    3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVreateeeIKLKDVDPDALWTLVQYCYTGRLE-LKEDNVESLLATACL 81

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18234   82 LQLSEVVEACCGFLMKQLHPSNC 104
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 3.05e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 60.88  E-value: 3.05e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18256   22 DVQLQVGMELFSVHRLVLAASSPYFAAlfaggmsESSKDVVQIHGVEPDIFHILLDFIYTGVVE-VTVSNVQELLVAADM 100

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18256  101 LQLTEVVEICCEFLKGQLHPSNC 123
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-245 3.07e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 61.12  E-value: 3.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARS----DYFRARASRDVLR---VQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18306   20 DVILQVGGHEIPAHRAVLACASpylfELFSSDSDGESILtvkLDGLDPDAVEVLVNYAYTSRLE-VPADLVKSVYSAAKK 98

                         90       100
                 ....*....|....*....|....*.
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNCYEV 245
Cdd:cd18306   99 LKMDRVKKACGDFLLEKLTPQNCIGI 124
PHA03098 PHA03098
kelch-like protein; Provisional
 343-486 9.65e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 61.32  E-value: 9.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 343 WRELTRLPEgaPARGCGLCVLFNYLFVAGGVAPAGPDgrarpSDQVYCYNPVTDSWSTVRPLRQARSQVQLLALDGHLYA 422
Cdd:PHA03098 370 WREEPPLIF--PRYNPCVVNVNNLIYVIGGISKNDEL-----LKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYV 442

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690250 423 VGG-------ECLLSVERYDPRADRWTAVAPL--PRGAFAVaheaATCNGEIYVSGGSLFYRLLK----YDPRRDEW 486
Cdd:PHA03098 443 IGGisyidniKVYNIVESYNPVTNKWTELSSLnfPRINASL----CIFNNKIYVVGGDKYEYYINeievYDDKTNTW 515
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-219 1.34e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 56.09  E-value: 1.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASR-DVLRVQGVSFTALRLLLADAYSGRM--AGVRPDNVAEVVAGA 217
Cdd:cd18287   24 DVTFVVEEKRFPAHRVILAARSEYFRAllyggmRESQqSEIELKDTNAEAFKALLKYIYTGRLtlTDLKEDVLLDVLGLA 103


                 ..
gi 148690250 218 RR 219
Cdd:cd18287  104 HQ 105
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 1.74e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 55.79  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR--ASRDVLRVQGVSFTALRLLLADAYSGRMAGVRPDN-VAEVVAGARRLQLP 223
Cdd:cd18303   20 DITIKLADKSIPAHKFVLAARSEKWSNEnlASTNELDLSDISYEVVLALLRWLYTDELDLTLDDEfLLELMKAAKRFQLT 99

                         90
                 ....*....|....*....
gi 148690250 224 GAAQRATEAMAPQLSLDNC 242
Cdd:cd18303  100 DLVERCERALMSSVNVDNC 118
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-233 3.67e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 55.25  E-value: 3.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR--------------ASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAE 212
Cdd:cd18228   21 DVTIRVQDKIFRAHKVVLAACSDFFRSKlvgqasprlvlvspAGKCVLDLHHVTVTGFAPLLEYAYTSTLS-INTENIID 99

                         90       100
                 ....*....|....*....|.
gi 148690250 213 VVAGARRLQLPGAAQRATEAM 233
Cdd:cd18228  100 VLAAASYMQMFNVANTCSEFM 120
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 147-242 4.69e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 54.43  E-value: 4.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASRD-VLRVQGVSFTALRLLLADAYSGRMAGVRPdNVAEVVAGARR 219
Cdd:cd18263   15 DVQLEADGSIFRVHRVILAAGSDYFRAmftsgmKESTQsVVQLPTIPAKDLRLLISFAYSGILHLSWE-NLFEATCTALQ 93

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18263   94 LQISGALALCLDFLQREISPARC 116
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 7.69e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 53.98  E-value: 7.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18242   23 DVTLRVEGKEFPAHRIVLAACSDYFCAmftsemsEKGKSEVELQGLTASTMEILLDFVYTETVH-VTVENVQELLPAACL 101

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18242  102 LQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-244 7.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 53.83  E-value: 7.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18238   17 DVTLKVGEKSIHCHRLVLACVSPYFRAmftsemaESKQDSITIKDIDEEAVELLVDFAYTGKLT-LTVDNVQSLLYAASL 95

                         90       100
                 ....*....|....*....|....*
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNCYE 244
Cdd:cd18238   96 LQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 9.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 54.01  E-value: 9.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18265   25 DVVLLVDGKDFPCHRATLSANSAYFRAmfgghlkESRQAVVEIQKVSAAAMEVLLDYMYGGGLR-IQEDNVESVLEASDL 103

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18265  104 LQVSKLREACVRFLEGQLHPCNC 126
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
336-426 1.16e-08

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 56.70  E-value: 1.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 336 YQAEAGEWRELTRLPEgaPARGCGLCVLFNYLFVAGGvapagpdgRARPSDQVYCYNPVTDSWSTVRPLRQARSQVQLLA 415
Cdd:COG3055  180 GSGFSNTWTTLAPLPT--ARAGHAAAVLGGKILVFGG--------ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVL 249

                         90
                 ....*....|.
gi 148690250 416 LDGHLYAVGGE 426
Cdd:COG3055  250 TDGKVYVIGGE 260
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-231 1.52e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 53.05  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18247   21 DVTLKVGDQKFSAHRIVLAATIPYFHAmfthdmvESKQDEITMQGIEPSALEALINFAYSGRIA-IDTSNVQSLLVGASF 99

                         90
                 ....*....|..
gi 148690250 220 LQLPGAAQRATE 231
Cdd:cd18247  100 LQLQSVKDACCE 111
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 2.69e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 52.49  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDVL-------RVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18237   23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTeskssevELKDAEPDIIELLVEFAYTARIS-VNSNNVQSLLDAANQ 101

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18237  102 YQIEPVKKMCVDFLKEQLDASNC 124
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 146-224 4.00e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 51.91  E-value: 4.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 146 PDLVIEVAGRRLRAHKAVLAARSDYFRA------------RASRDVLRVQGVSFTALRLLLADAYSGRmAGVRPDNVAEV 213
Cdd:cd18296   18 PDVCFQVEGHRFPCHKAFFCGRSDYFKAllrdhfaeseenNGSIPVVTLHDVSPEVFAIVLYYIYTDD-TDLPPENAYDV 96

                         90
                 ....*....|.
gi 148690250 214 VAGARRLQLPG 224
Cdd:cd18296   97 LYVADMYLLPG 107
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-227 5.04e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 51.74  E-value: 5.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR---ARASRDV----LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18251   25 DVVLVVEGKPIEAHRILLAASCDYFRgmfAGGLREMqqteVLIHGVSYNAMCKILDFIYTSELE-LSLDNVQETLTAACQ 103


                 ....*...
gi 148690250 220 LQLPGAAQ 227
Cdd:cd18251  104 LQIPEVIG 111
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 145-224 5.18e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 51.49  E-value: 5.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 145 EPDLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMagVRPDNV--AEVVA 215
Cdd:cd18286   17 DSDITIKVDGKTFKAHRCILCARSSYFAAmlsgswaESNSSEITLTGVSHAAVSFVLLFIYGGVL--DLPDDVnlGELLS 94


                 ....*....
gi 148690250 216 GARRLQLPG 224
Cdd:cd18286   95 LADMYGLDG 103
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-237 8.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 51.00  E-value: 8.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18257   20 DVVLRVGDVKIHAHKVVLASCSPYFKAmftgnlsEKENSEVEFQCIDETALQAIVEYAYTGTVF-ISQATVESLLPAANL 98

                         90
                 ....*....|....*...
gi 148690250 220 LQLPGAAQRATEAMAPQL 237
Cdd:cd18257   99 LQIKLVLKECCDFLESQL 116
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 147-223 1.21e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 50.32  E-value: 1.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAGVRPDNVAEVVAGARR 219
Cdd:cd18300   11 DVTFIVEDGTIPAHKALLVARCDVMAAmfggnfrESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGDCVGLIVLANR 90


                 ....
gi 148690250 220 LQLP 223
Cdd:cd18300   91 LCLP 94
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 149-242 1.30e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 50.81  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 149 VIEVAG-RRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRL 220
Cdd:cd18336   22 VLLIAGnLKIPAHRLVLSAVSDYFAAMFTNDVreakqeeIKMEGVDPDALKALVHYAYTGVLE-LKEDTIESLLAAACLL 100

                         90       100
                 ....*....|....*....|..
gi 148690250 221 QLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18336  101 QLSQVIDVCCNFLMKQLHPSNC 122
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-223 1.31e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 50.56  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRD--------VLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGAR 218
Cdd:cd18293   17 DVLLQAEGESVPAHCCVLSACSPYLTERLSSEpppagqkvVLELQGLKAHTLLKLVDFLYTSELE-VSSEEAQDVLAAAR 95


                 ....*
gi 148690250 219 RLQLP 223
Cdd:cd18293   96 RLQIS 100
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-241 1.60e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 50.42  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQLPGAA 226
Cdd:cd18243   34 DVTLTAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIGLRLVLEYLYTANVT-LSLDTVEEVLSVSKILHIPQVT 112

                         90
                 ....*....|....*
gi 148690250 227 QRATEAMAPQLSLDN 241
Cdd:cd18243  113 KLCVQFLNDQISVQN 127
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-241 1.67e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 49.96  E-value: 1.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRM--AGVRPDNVAEVVAGA 217
Cdd:cd18297   14 DVTFLVEGRPFYAHKIVLVTASDRFKSmlssgstEAQTPVIEIPDIRYDIFQLMMQYLYTGGVesLDVAQDDALELLRAA 93

                         90       100
                 ....*....|....*....|....*
gi 148690250 218 RRLQLPGaAQRATEAM-APQLSLDN 241
Cdd:cd18297   94 SFFQLDG-LKRHCEILlSQQIDLDN 117
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-233 2.09e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 50.02  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLrvQGVSFTALR------LLLADAYSGRMAgVRPDNVAEVVAGARRL 220
Cdd:cd18220   27 DIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTM--SGLSISVIKnpnvfeQLLSFCYTGRMS-LQLKDVVSFLTAASFL 103

                         90
                 ....*....|...
gi 148690250 221 QLPGAAQRATEAM 233
Cdd:cd18220  104 QMQCVIDKCTQIL 116
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 2.64e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 49.96  E-value: 2.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARAS-------RDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18261   30 DITLVAEEQKFHAHKAVLAACSDYFRAMFSlcmveseADEVNLHGVTSLGLKQALDFAYTGQIL-LEPGVIQDVLAAGSH 108


                 ...
gi 148690250 220 LQL 222
Cdd:cd18261  109 LQL 111
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 2.87e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 49.45  E-value: 2.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASRDVL-RVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18253   20 DVIICVEGREFPCHRAILSACSSYFRAmfcndhRESREMLvEINGILAEAMDCFLQYVYTGKVK-ITTENVQYLFETSSL 98

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18253   99 FQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 3.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 49.67  E-value: 3.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18337   25 DVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVreakqeeIKMEGVEPNALWALVQYAYTGRLE-LKEDNIECLLSTACL 103

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18337  104 LQLSQVVEACCKFLMKQLHPSNC 126
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 3.45e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 49.79  E-value: 3.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASR-DVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18264   30 DVVLEAEGNEFPAHRSLLACSSDYFRAlfkdytQESKaRVIHLPVVSAAGLQRVLDFIYTSWLS-LSLDTLEDTLEAASY 108

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18264  109 LQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-245 5.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 49.22  E-value: 5.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEV-AGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGAR 218
Cdd:cd18274   24 DIVVEVdHGKTFSCHRNVLAAISPYFRSmftsgltESTQKEVRIVGVEAESMHLVLDYAYTSRVT-LTEANVQALFTAAS 102

                         90       100
                 ....*....|....*....|....*..
gi 148690250 219 RLQLPGAAQRATEAMAPQLSLDNCYEV 245
Cdd:cd18274  103 IFQIPSLQDQCAQFMISRLDPQNSIGV 129
Kelch smart00612
Kelch domain;
419-455 5.49e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.40  E-value: 5.49e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 148690250   419 HLYAVGG----ECLLSVERYDPRADRWTAVAPL--PRGAFAVA 455
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMptPRSGHGVA 43
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-223 1.07e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 48.01  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR-------ARASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18326   27 DVVILVEGREFPTHRSVLAACSQYFKklftsgaVVDQQNVYEIDFVSAEALTALLDFAYTATLT-VSTSNVGDILSAARL 105


                 ....
gi 148690250 220 LQLP 223
Cdd:cd18326  106 LEIP 109
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 1.45e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 47.73  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18335   21 DVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVceakqeeIKMEGIDPNALWDLVQFAYTGCLE-LKEDTIENLLAAACL 99

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18335  100 LQLSQVVEVCCHFLMKLLHPSNC 122
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 407-448 1.57e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 45.30  E-value: 1.57e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 148690250  407 ARSQVQLLALDGHLYAVGG----ECLLSVERYDPRADRWTAVAPLP 448
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 1.65e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 47.54  E-value: 1.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18236   26 DVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLkekyeekIIIKGVDAETMQILLDYTYTSKVL-ITKQNVQRVLEAASL 104

                         90       100
                 ....*....|....*....|....*..
gi 148690250 220 LQLP----GAAQRATEAMAPqlslDNC 242
Cdd:cd18236  105 FQFLrmvdACASFLTEALHP----ENC 127
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-237 2.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 47.04  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA---------RASRDVLrvQGVSFTALRLLLADAYSGRMaGVRPDNVAEVVAGA 217
Cdd:cd18235   23 DVILVADGVEIPAHRVVLASCSPYFHAmftgdlsesRANRVTL--QDVDGKALLLLIDYVYTAEI-QVTEENVQVLLPAA 99

                         90       100
                 ....*....|....*....|
gi 148690250 218 RRLQLPGAAQRATEAMAPQL 237
Cdd:cd18235  100 NLLQLTDVRDACCDFLQSQL 119
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 2.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 47.12  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRD----VLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQL 222
Cdd:cd18260   20 DLTIATKTKSFDVHKVVMASCSEYFRNILKKDpslqRVELNDISPLGLATVITYAYTGKLT-LSLYTIGSTISAASYLQI 98

                         90       100
                 ....*....|....*....|
gi 148690250 223 PGAAQRATEAMAPQLSLDNC 242
Cdd:cd18260   99 HALVKMCCDFLMQEMNVENC 118
PHA03098 PHA03098
kelch-like protein; Provisional
 333-448 3.26e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 50.15  E-value: 3.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 333 VYCYQAEAGEWRELTRLPEgAPARGCGLcVLFNYLFVAGGVAPAGPDGRArpsDQVYCYNPVTDSWSTVRPLRQARSQVQ 412
Cdd:PHA03098 408 VECFSLNTNKWSKGSPLPI-SHYGGCAI-YHDGKIYVIGGISYIDNIKVY---NIVESYNPVTNKWTELSSLNFPRINAS 482

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 148690250 413 LLALDGHLYAVGGECLLS----VERYDPRADRWTAVAPLP 448
Cdd:PHA03098 483 LCIFNNKIYVVGGDKYEYyineIEVYDDKTNTWTLFCKFP 522
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-246 3.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 47.13  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVA--------GRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVA 211
Cdd:cd18273   28 DVTIEVNgpgsgpgsGRLFPCNRNVLAAASPYFKSmftgglyESKQETVTIHDVDSESMALIIDYCYTGRVT-LSEANVQ 106

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 148690250 212 EVVAGARRLQLPGAAQRATEAMAPQLSLDNCYEVL 246
Cdd:cd18273  107 RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 147-241 4.33e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 45.93  E-value: 4.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA--------RASRDVlRVQGVSFTALRLLLADAYSGRmAGVRPDNVAEVVAGAR 218
Cdd:cd18352   15 DVTFLVEGRRFYAHRIALLASSDAFRAmfdggyreKEARDI-EIPNIRWEVFELMMRFIYTGS-VDITNDIAKDLLRAAD 92

                         90       100
                 ....*....|....*....|...
gi 148690250 219 RLQLPGAAQRATEAMAPQLSLDN 241
Cdd:cd18352   93 QYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 147-202 5.61e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 44.85  E-value: 5.61e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-----RASRD-VLRVQGVSFTALRLLLADAYSGRM 202
Cdd:cd18315    3 DVTLACEGGSLKAHKLVLAAASPYFAAllketPPDEHpVIILPDVPYSELKALLDFIYTGEV 64
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-224 7.57e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 45.66  E-value: 7.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRD---VLRVQGVSFTALRLLLADAYSGRMAGVRP---DNVAEVVAGARRL 220
Cdd:cd18333   23 DVIIVVQNALFRAHKNILAASSVYLKSLVVHDnliNLDHEMVSPGIFRLILDYIYTGRLSEGDPgseQNLGAVLAAASYL 102


                 ....
gi 148690250 221 QLPG 224
Cdd:cd18333  103 QIPD 106
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-246 8.19e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 45.76  E-value: 8.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18270   28 DIVLIVEGTEFPCHKMVLATCSSYFRAmfmsglsESKQTHVHLRNVDAATLQIIITYAYTGNLA-INDSTVEQLYETACF 106

                         90       100
                 ....*....|....*....|....*..
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNCYEVL 246
Cdd:cd18270  107 LQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-233 8.20e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 45.42  E-value: 8.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSF----TALRLLLADAYSGRMAGVRPDNVAEVVAgARRLQL 222
Cdd:cd18222   27 DIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISViknpTVFEQLLSFCYTGRICLQLADIISYLTA-ASFLQM 105

                         90
                 ....*....|.
gi 148690250 223 PGAAQRATEAM 233
Cdd:cd18222  106 QHIIDKCTQIL 116
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-226 8.57e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 45.22  E-value: 8.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV---LRVQGVSFTALRLLLADAYSGRMAG--VRPDNVAEVVAGARRLQ 221
Cdd:cd18216   22 DVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNlihLDQDMVSPTVFQQILDFIYTGKLLDslFEEPNLSEVLAAANYLQ 101


                 ....*
gi 148690250 222 LPGAA 226
Cdd:cd18216  102 LPDLA 106
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-241 1.04e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 45.33  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAGVRPDNVA-EVVAGAR 218
Cdd:cd18344   25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMeerlknpIEIHDLDPQVFKEMMGFIYTGKAPHLHSHSMAcDVLAAAD 104

                         90       100
                 ....*....|....*....|...
gi 148690250 219 RLQLPGAAQRATEAMAPQLSLDN 241
Cdd:cd18344  105 KYGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 1.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 44.92  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA----------RASRDVLRVqgVSFTALRLLLADAYSGRMaGVRPDNVAEVVAG 216
Cdd:cd18330   20 DCSIIVEGRIFKAHRNILFANSGYFRAllihyiqdsgRHSTASLDI--VTSEAFSIILDFLYSGKL-DLCSENVIEVMSA 96


                 ....*.
gi 148690250 217 ARRLQL 222
Cdd:cd18330   97 ASYLQM 102
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-246 2.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 44.56  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18244   32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMrerdqdkIHLKGLTATGFSHVLQFMYYGTIE-LSMLTVHEILQAAMY 110

                         90       100
                 ....*....|....*....|....*..
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNCYEVL 246
Cdd:cd18244  111 VQLTEVVKFCCSFLLAKICLDNCAEIM 137
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-213 2.26e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 44.29  E-value: 2.26e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR------ASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEV 213
Cdd:cd18277   29 DVTILVEGQRFRAHRSVLAACSSYFHSRivgqadAELNITLPEEVTVKGFEPLIQFAYTAKLI-LSKDNVDEV 100
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-223 2.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 43.70  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR-------ARASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18198   27 DVVILVQGREYRTHRSVLAACSQYFKklftsgaVVDQQNVYEIDFVSPEALTALLEFAYTATLT-VSTANVGDILSAARL 105


                 ....
gi 148690250 220 LQLP 223
Cdd:cd18198  106 LEIP 109
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-223 3.48e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 43.32  E-value: 3.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYF------RARASRDVLRV-QGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18215   21 DVVLVVGREQFRAHKTVLMACSGLFysiftdQLKNNVSVINLdPEIEPEGFRILLDFMYTSRLN-LREGNIMAVMATAMY 99


                 ....
gi 148690250 220 LQLP 223
Cdd:cd18215  100 LQME 103
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-227 3.69e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 43.21  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR----ASRDVLRVQGVSfTALRLLLADAYSGRMAGVRpDNVAEVVAGARRLQL 222
Cdd:cd18232   20 DATLDVGGRVFKAHWSVLACCSHFFQSLygdgTSGSVVLPESFA-EVFGLLLDFFYTGELALTR-ENRDRVLLAAKELRV 97


                 ....*
gi 148690250 223 PGAAQ 227
Cdd:cd18232   98 PEAVE 102
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 354-405 4.24e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 4.24e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 148690250  354 PARGCGLCVLFNYLFVAGGVApagpdgRARPSDQVYCYNPVTDSWSTVRPLR 405
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD------GNQSLNSVEVYDPETNTWSKLPSMP 46
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 122-223 4.25e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 43.39  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 122 ELESLDELGEPvpvppgvgsvhgePDLVIEVAGRRLRAHKAVLAARSDYF------RARASRDV-LRVQGVSFTALRLLL 194
Cdd:cd18295    9 FLRRLLEQGSY-------------SDVTFNVHGESFPAHRCILSARSPYFaemfetKWKDKREInLKHPLVNPDAFRALL 75

                         90       100
                 ....*....|....*....|....*....
gi 148690250 195 ADAYSGRMAgVRPDNVAEVVAGARRLQLP 223
Cdd:cd18295   76 QYLYTGRLE-IHVDDVEDCKRLAKQCRLE 103
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 147-202 4.28e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 43.83  E-value: 4.28e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 148690250 147 DLVIEVA-GRRLRAHKAVLAARSDYFR------ARAS---------RDVLRVQGVSFTALRLLLADAYSGRM 202
Cdd:cd18310   20 DAEIIVEgGRPVPVHRCILAARSPFFRdifasaKAEGantkpklelRELIPGGIVGYDAFMLVLSYLYSGRL 91
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-233 4.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 43.07  E-value: 4.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSD----YFRARASRDVLRVQGVSFTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQL 222
Cdd:cd18221   20 DITLIVDGHQFKAHKAVLAACSQffykFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEEANDVWKAAEYLQM 99

                         90
                 ....*....|.
gi 148690250 223 pgaaQRATEAM 233
Cdd:cd18221  100 ----QEAIKAL 106
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-231 6.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 42.52  E-value: 6.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFrarasRDVLRVQGVSFT---------ALRLLLADAYSGRMAGVRPDNVAEVVAGA 217
Cdd:cd18210   23 DISIHVQGRVFRAHRAVLAASSPYF-----HDQVLLKNMSSIslpgvmdpgAFESVLASAYTGKLTMLADEIVNYLTVGS 97

                         90
                 ....*....|....
gi 148690250 218 rRLQLPGAAQRATE 231
Cdd:cd18210   98 -VLQMWHIVDKCTE 110
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 6.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 42.41  E-value: 6.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA---RASRDVLRVQGVSF-----TALRLLLADAYSGRMAgVRPDNVAEVVAGAR 218
Cdd:cd18199   20 DCSIIVEGRIFKAHRNVLFASSGYFRMllsHYIQDTGRPSTASFdvfssDAFSIILDFVYSGKLS-LTSQNVIEVMSAAS 98


                 ....
gi 148690250 219 RLQL 222
Cdd:cd18199   99 YLQM 102
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 8.40e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 42.89  E-value: 8.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDVL-----RVQ--GVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18259   34 DVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVesisaRVEikDVDPAVMESLIDFAYTGKLT-INQGNVEALIRTSNR 112

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18259  113 LQFPTVRKVCSRYLQQQIDATNC 135
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-241 9.99e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 42.14  E-value: 9.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAGVrpDNVA-EVVAGAR 218
Cdd:cd18345   20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMeerkqnrVEITDVDHEVMREMLRFIYTGKAPNL--DKMAdDLLAAAD 97

                         90       100
                 ....*....|....*....|...
gi 148690250 219 RLQLPGAAQRATEAMAPQLSLDN 241
Cdd:cd18345   98 KYALERLKVMCEEALCSNLSVEN 120
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 1.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 42.44  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASRDV-LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18249   25 DVVLVVGAKKIYAHRVILSACSPYFRAmftgelAESRQTeVTIRDIDERAMELLIDFAYTSQIT-VEEGNVQTLLPAACL 103

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18249  104 LQLAEIQEVCCEFLKRQLDPSNC 126
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-173 1.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 42.13  E-value: 1.11e-04
                         10        20
                 ....*....|....*....|....*..
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA 173
Cdd:cd18279   20 DCCLCVGGQEFQAHKAILAARSPVFSA 46
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 152-242 1.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 42.12  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 152 VAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQLPG 224
Cdd:cd18252   29 ASGQIFHCHKAALAACSSYFKVmftadmkEKSNNVIKLSGIDHDILEALVNYVYTSQIC-ITERNVQSLLEAADLLQFIS 107

                         90
                 ....*....|....*...
gi 148690250 225 AAQRATEAMAPQLSLDNC 242
Cdd:cd18252  108 VKKACEQFLVRHLDIDNC 125
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 1.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 41.84  E-value: 1.17e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR--ASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQL 222
Cdd:cd18206   24 DCTFVVDGVDFKAHKAVLAACSEYFRMLfvDQKDVVHLDISNAAGLGQVLEFMYTAKLS-LSPENVDDVLAVATFLQM 100
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-245 1.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 42.13  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRmAGVRPDNVAEVVAGARR 219
Cdd:cd18271   26 DFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMkerddgsVTISNLSPKAVKAFLDYAYTGK-AEITDDNVEMFFQMSSF 104

                         90       100
                 ....*....|....*....|....*.
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNCYEV 245
Cdd:cd18271  105 LQVSLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 147-223 1.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 41.56  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMaGVRPDNVAEVVAGARR 219
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSmltgsmiESNLKEVTLEDVEPEIFETVLKYMYTGQV-TLSEENVLDLLMLASK 86


                 ....
gi 148690250 220 LQLP 223
Cdd:cd18314   87 YQVP 90
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-233 1.56e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 41.85  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYF----RARASRDVLRVQGVSFTALRLLLADAYSGRMAGVRPDNVAEVVAgARRLQL 222
Cdd:cd18227   27 DISVVVQGHLFRAHKAVLAASSPYFcdqvLLKNSRRIVLPDVMNPRVFENILLSCYTGRLVLPAPEIVSYLTA-ASFLQM 105

                         90
                 ....*....|.
gi 148690250 223 PGAAQRATEAM 233
Cdd:cd18227  106 WHVVDKCTELL 116
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 147-172 1.63e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 41.12  E-value: 1.63e-04
                         10        20
                 ....*....|....*....|....*.
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR 172
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFR 45
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 238-283 1.65e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 39.57  E-value: 1.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 148690250 238 SLDNCYEVLSAGKRQRLTELRDAAYRFMSDHYLEVLREPAvFGRLS 283
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEE-FLELS 45
Kelch_6 pfam13964
Kelch motif;
407-450 1.68e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 39.63  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 148690250  407 ARSQVQLLALDGHLYAVGGEC-----LLSVERYDPRADRWTAVAPLPRG 450
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTnaspaLNKLEVYNPLTKSWEELPPLPTP 49
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-199 1.80e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 41.32  E-value: 1.80e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASR----DVLRVQGVSFTALRLLLADAYS 199
Cdd:cd18226   24 DLVITVEGKEFSAHKVVVAVGSSYFHACLSKnpntDAVTLDHVSYSVFQHLLEFLYT 80
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-245 1.88e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 41.74  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18340   29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLeeskkreIVLEDVDPDVMGKILHYIYTSEIE-ITEQNVQDIFAAANM 107

                         90       100
                 ....*....|....*....|....*.
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNCYEV 245
Cdd:cd18340  108 FQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-233 2.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 41.55  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR---ARASRDVLRVQG-VSFTALRLLLADAYSGRMAGVRPDNVAeVVAGARRLQL 222
Cdd:cd18289   31 DVSIVVKGQAFKAHRAVLAASSLYFRdlfSGNSKSAFELPAtVPPACFQQILSFCYTGKLTMAASEQLV-VMYTAGFLQI 109

                         90
                 ....*....|.
gi 148690250 223 PGAAQRATEAM 233
Cdd:cd18289  110 QHIVERGTDLM 120
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-227 2.23e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 41.37  E-value: 2.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR--------------ARASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAE 212
Cdd:cd18327   27 DLTIKTRGLEYRTHRAVLAACSLYFRklftgggggsgdlgAGGGQDVCELDFVGPEALGALLEFAYTATLT-ISSSNMRE 105

                         90
                 ....*....|....*
gi 148690250 213 VVAGARRLQLPGAAQ 227
Cdd:cd18327  106 VLRAARLLEIPCVAD 120
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 149-220 2.92e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 39.96  E-value: 2.92e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148690250 149 VIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRmAGVRPDNVAEVVAGARRL 220
Cdd:cd01165    2 VLVVEGEKFHVNKELLAQSSEYFRAlfrggfrESGQAEINLRDISPEDFRALLEFLYGGK-RDLDASNLLELLEAANFL 79
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 2.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 40.79  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR---------ASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGA 217
Cdd:cd18245   16 DATLVVGGEEIPVQKNVLAAASPYFRAKlnynppkddGSTYKIELEGISVEVMEEILDYIYTGQIK-LSEDNIQDIVQAA 94


                 ....*
gi 148690250 218 RRLQL 222
Cdd:cd18245   95 DLLLM 99
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-237 3.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 41.17  E-value: 3.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSFT-------ALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18246   41 DIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTlhdidpqALEQLVQYAYTAEIV-VGEGNVQTLLPAASL 119

                         90
                 ....*....|....*...
gi 148690250 220 LQLPGAAQRATEAMAPQL 237
Cdd:cd18246  120 LQLNGVRDACCKFLLSQL 137
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-233 4.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 40.12  E-value: 4.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRD-----VLRVQGVSFTALRLLLADAYSGRMaGVRPDNVAEVVAGARRLQ 221
Cdd:cd18217   20 DCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTednivFLDQSQVSADGFQKLLEFIYTGNL-NLDSWNVAEIHQAASYLG 98

                         90
                 ....*....|..
gi 148690250 222 LPGAAQRATEAM 233
Cdd:cd18217   99 MEEVVAKCKIKM 110
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-176 5.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 39.37  E-value: 5.40e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARAS 176
Cdd:cd18955    3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVV 32
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 237-276 5.45e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 39.75  E-value: 5.45e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 148690250 237 LSLDNCYEVLSAGKRQRLTELRDAAYRFMSDHYLEVLREP 276
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRP 40
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 456-490 6.10e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.98  E-value: 6.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148690250  456 HEAATCNGEIYVSGGSLFYRLLK----YDPRRDEWQECP 490
Cdd:pfam01344   5 AGVVVVGGKIYVIGGFDGNQSLNsvevYDPETNTWSKLP 43
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-237 6.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 40.06  E-value: 6.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLR----AHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVA 215
Cdd:cd18248   23 DVTLKVKYQDPKeefmAHKVVLASSSPYFKAmftsglrECGMEVVPIEGVHPCVMSRLIEFAYTASIS-VGEKCVLHVLP 101

                         90       100
                 ....*....|....*....|..
gi 148690250 216 GARRLQLPGAAQRATEAMAPQL 237
Cdd:cd18248  102 GAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 8.65e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 39.61  E-value: 8.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASRDvlrvQGVSF------TALRLLLADAYSGRMAgVRPDNVAEVV 214
Cdd:cd18254   24 DVTLWAGNRSFPCHRAVLAACSRYFEAmfsnglRESLD----STVNFhdslhpEVLELLLDFAYSSRII-INEENAESLL 98

                         90       100
                 ....*....|....*....|....*...
gi 148690250 215 AGARRLQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18254   99 EAGDMLQFHDVRDAAAEFLEKNLYPSNC 126
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-173 9.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 39.62  E-value: 9.22e-04
                         10        20
                 ....*....|....*....|....*..
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA 173
Cdd:cd18280   16 DVTFNVDGEKFRAHKLVLAARSPVFRS 42
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-203 1.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 39.25  E-value: 1.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA--RASRDVL-----RVQGVSFtalRLLLADAYSGRMA 203
Cdd:cd18290   29 DVSVVVKGHAFKAHRAVLAASSSYFRDlfNSSRSAVvelpaAVQPQSF---QQILSFCYTGRLS 89
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 1.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 39.31  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18269   29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLeeskkkeVVLEDVDPDVMGMILKYLYTSEID-LNDQNVQDIFALASR 107

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18269  108 FQIPSIFTVCVSYLQKRLSLSNC 130
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 1.39e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 39.06  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR-------ARASRD-VLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGAR 218
Cdd:cd18202   21 DVTLLIEGEEYKAHKSVLAANSEYFRelfiekgAVSSHEaVVDLSGFCKSSFLPLLEFAYTSELT-FDFCSMAEVAMLAR 99


                 ....
gi 148690250 219 RLQL 222
Cdd:cd18202  100 HLFM 103
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 1.44e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 39.03  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYF----RARA-SRDVLRVQG--VSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18194   25 DCTVLVGSAQFPAHRAVLASCSMYFhlfyRDRLdKRDLVRLNSdiVTAPAFGLLLDFMYEGRLA-LRDLPVEDVLAAASY 103


                 ...
gi 148690250 220 LQL 222
Cdd:cd18194  104 LHM 106
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 1.47e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 39.19  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR---ARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAG 216
Cdd:cd18258   19 DLKIIVEGKEFEVHQNVLASCSLYFKdliKRSSRDSgggekleLTMSNINADVLELLLEFVYTGSLI-IDSANAKTLLEA 97

                         90       100
                 ....*....|....*....|....*.
gi 148690250 217 ARRLQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18258   98 ANKFQFHTFCKVCVSFLEKQLTASNC 123
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 1.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 38.65  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFR---ARASRDVLRVQGVSFTALR-----LLLADAYSGRMAgVRPDNVAEVVAGAR 218
Cdd:cd18329   23 DCSILVEGQVFKAHRNVLFASSGYFKmllSQNAKETGQPTVATFDVFSpdtftIILDFVYSGKLS-LTSQNVIEVMSAAS 101


                 ....
gi 148690250 219 RLQL 222
Cdd:cd18329  102 YLQM 105
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 160-242 1.54e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 39.02  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 160 HKAVLAARSDYFRARASRDV-------LRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARRLQLPGAAQRATEA 232
Cdd:cd18239   40 HRAMMASASDYFKAMFTGGMkeqelmcIKLHGVSKIGLKNIIDFIYTAKLS-LNMDNLQDTLEAASFLQILPVLDFCKVL 118

                         90
                 ....*....|
gi 148690250 233 MAPQLSLDNC 242
Cdd:cd18239  119 LISGVTLENC 128
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-202 1.54e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 38.68  E-value: 1.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRAR-----ASRDVLR--VQGVSFTALRLLLadaYSGRM 202
Cdd:cd18200   20 DLSVHVQGRVFRAHKAVLAASSPYFHDKlllndTNCLVLPsvIEAAAFENLLQLI---YSGRL 79
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-223 1.72e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 38.27  E-value: 1.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARAS--RDVLRVQGVSFTALRLLLADAYSGRMAGVRPDNVAEVVAGARRLQLP 223
Cdd:cd18219   23 DVTVIVEDRKFRAHKNILSASSTYFHQLFSvaGQVVELNFIRADIFAEILNYIYSSKIVRVRSDLLEELIKSGQLLGVK 101
PRK14131 PRK14131
N-acetylneuraminate epimerase;
337-425 1.78e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.15  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 337 QAEAGEWRELTRLPeGAPARGCGLCVLFNYLFVAGGVAPAGPDGRARPSDQVYCYNPVTDSWSTVrplrQARSQVQLL-- 414
Cdd:PRK14131  58 NAPSKGWTKIAAFP-GGPREQAVAAFIDGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKL----DTRSPVGLAgh 132

                         90
                 ....*....|....*
gi 148690250 415 ---ALDG-HLYAVGG 425
Cdd:PRK14131 133 vavSLHNgKAYITGG 147
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 147-219 1.78e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 37.88  E-value: 1.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQ--GVSFTALRLLLADAYSGRMAGVRPDNVAEVVAGA 217
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAmlygnfrESTSDCIDFEenGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                 ..
gi 148690250 218 RR 219
Cdd:cd18190   81 SK 82
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-227 2.18e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 38.30  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYF------RARASRDVLRV-QGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18332   21 DVTLLVGGTPLRAHKAVLIACSGFFysifsgRVGEGVSVLTLpSGLEARGFQLLLDFMYTSRLP-LTPRTVPAVLAAATY 99


                 ....*...
gi 148690250 220 LQLPGAAQ 227
Cdd:cd18332  100 LQMEHVVE 107
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-223 2.47e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 38.23  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFrarasRDVLRVQGVSFTALRLLLAD------------AYSGRMAGVRPDNVAEVV 214
Cdd:cd18223   20 DVTIVVEDTKFKAHKNVLAASSLYF-----KNAFSSQEIWISSHVLELPDlkaevfaeilnfIYSSKVVVKRQETVTDLV 94


                 ....*....
gi 148690250 215 AGARRLQLP 223
Cdd:cd18223   95 AAGKKLGIT 103
Kelch_3 pfam13415
Galactose oxidase, central domain;
365-409 2.75e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 2.75e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 148690250  365 NYLFVAGGvapAGPDGRARPSDqVYCYNPVTDSWSTVRPLRQARS 409
Cdd:pfam13415   2 DKLYIFGG---LGFDGQTRLND-LYVYDLDTNTWTQIGDLPPPRS 42
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-242 2.90e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 38.23  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18268   25 DVILCTGDKEIPCHRNVLASSSPYFRAmfcnnfrESSQAKVDLKGIDSDVLDQIVDYVYTGEIL-ITRDNVLPLMEAASM 103

                         90       100
                 ....*....|....*....|...
gi 148690250 220 LQLPGAAQRATEAMAPQLSLDNC 242
Cdd:cd18268  104 LQYPKLFEACSLYLQDQLTPENC 126
PRK14131 PRK14131
N-acetylneuraminate epimerase;
406-471 3.35e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.00  E-value: 3.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148690250 406 QARSQVQLLALDGHLYAVGG----------ECLLSVERYDPRADRWTAVAPL-PRGaFAVAHEAATCNGEIYVSGGS 471
Cdd:PRK14131  73 GPREQAVAAFIDGKLYVFGGigktnsegspQVFDDVYKYDPKTNSWQKLDTRsPVG-LAGHVAVSLHNGKAYITGGV 148
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
5-113 3.53e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 40.60  E-value: 3.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250   5 VAPFVLYSGTEPRTPGEDSLPLPAEEEGAASTAQTPCSLSASLCFSSGDDSPPQSRASAAEGSEASPPSLRSDLRVVETQ 84
Cdd:PRK07003 428 AAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAV 507

                         90       100
                 ....*....|....*....|....*....
gi 148690250  85 WDVSSAASPESPEECARPEEPASPEDPPS 113
Cdd:PRK07003 508 PDARAPAAASREDAPAAAAPPAPEARPPT 536
Kelch_6 pfam13964
Kelch motif;
365-408 3.67e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 35.77  E-value: 3.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148690250  365 NYLFVAGGVapagpDGRARPSDQVYCYNPVTDSWSTVRPLRQAR 408
Cdd:pfam13964  12 GYIYVFGGY-----TNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-226 4.53e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 37.64  E-value: 4.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRD---VLRVQGVSFTALRLLLADAYSGR-MAGVRP--DNVAEVVAGARRL 220
Cdd:cd18334   23 DVIIVVENALFRAHKNILAASSMYFKSLVLHDnliNLDTDMVNPTVFRQILDFIYTGKlLTSDQPgeQNFNALLTAASYL 102


                 ....*.
gi 148690250 221 QLPGAA 226
Cdd:cd18334  103 QLHDLA 108
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-223 4.96e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 37.55  E-value: 4.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRDVLRVQG-------VSFTALRLLLADAYSGRMAgVRPDNVAEVVAGARR 219
Cdd:cd18328   27 DVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPyvyeidfVTPEALSAILEFAYTSTLT-ITTSNVKHILNAAQM 105


                 ....
gi 148690250 220 LQLP 223
Cdd:cd18328  106 LEIQ 109
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-227 5.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 37.24  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA------RASR--------DVLRVQGVSftalrLLLADAYSGRMAgVRPDNVAE 212
Cdd:cd18201   23 DVNIVVSGKVFRAHKNILVAGSRFFKTlycftnKESCdqttvthlDVVAVQGFS-----VILDFMYSGNLV-LTSQNAIE 96

                         90
                 ....*....|....*
gi 148690250 213 VVAGARRLQLPGAAQ 227
Cdd:cd18201   97 VMSVASYLQMTEVVQ 111
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 147-173 6.64e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 36.98  E-value: 6.64e-03
                         10        20
                 ....*....|....*....|....*..
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA 173
Cdd:cd18309   22 DITLLLDGHPIPAHKAILAARCSYFEA 48
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-241 7.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 37.00  E-value: 7.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRA-------RASRDVLRVQGVSFTALRLLLADAYSGRMAGVrpDNVA-EVVAGAR 218
Cdd:cd18342   24 DCCLCVAGQEFQAHKAILAARSPVFSAmfehemeESKKNRVEINDVEPEVFKEMMCFIYTGKAPNL--DKMAdDLLAAAD 101

                         90       100
                 ....*....|....*....|...
gi 148690250 219 RLQLPGAAQRATEAMAPQLSLDN 241
Cdd:cd18342  102 KYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 7.65e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 37.10  E-value: 7.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYF------RARASRDVLRVQG--VSFTALRLLLADAYSGRMaGVRPDNVAEVVAGAR 218
Cdd:cd18956   25 DCTVLVGDARFPAHRAVLAACSVYFhlfyrdRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEGRL-DLRSLPVEDVLAAAS 103


                 ....
gi 148690250 219 RLQL 222
Cdd:cd18956  104 YLHM 107
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 147-223 7.70e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 36.42  E-value: 7.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYFRARASRdvlRVQG-------VSFTALRLLLADAYSGRMaGVRPDNVAEVVAGARR 219
Cdd:cd18262   20 DETVSVGGRSYGVHSVILAAVSSLFRERLLG---SNGPlpplsleVTPVGWEAVLTFAYTGVL-GRNPATVGDILVAAEA 95


                 ....
gi 148690250 220 LQLP 223
Cdd:cd18262   96 LGAP 99
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 147-222 8.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 36.85  E-value: 8.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148690250 147 DLVIEVAGRRLRAHKAVLAARSDYF------RARASRDVLRVQGVSFTALRLLLADAYSGRMAGVRpDNVAEVVAGARRL 220
Cdd:cd18278   33 DVTLIVEGKEFRAHRAVLAACSEYFlqalvgQTENDLVVSLPEEVTARGFGPLLQFAYTAKLLLSR-ENIQEVIRCAEFL 111


                 ..
gi 148690250 221 QL 222
Cdd:cd18278  112 RM 113
Kelch smart00612
Kelch domain;
367-409 9.19e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.46  E-value: 9.19e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 148690250   367 LFVAGGVapagpDGrARPSDQVYCYNPVTDSWSTVRPLRQARS 409
Cdd:smart00612   2 IYVVGGF-----DG-GQRLKSVEVYDPETNKWTPLPSMPTPRS 38
Kelch_6 pfam13964
Kelch motif;
452-490 9.46e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 9.46e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 148690250  452 FAVAHEAATCNGEIYVSGGS-----LFYRLLKYDPRRDEWQECP 490
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtnaspALNKLEVYNPLTKSWEELP 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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