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Conserved domains on  [gi|148687684|gb|EDL19631|]
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diablo homolog (Drosophila), isoform CRA_c [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smac_DIABLO super family cl09466
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
 10-143 5.49e-71

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


The actual alignment was detected with superfamily member pfam09057:

Pssm-ID: 462664  Cd Length: 231  Bit Score: 213.17  E-value: 5.49e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148687684   10 RSVCSLFRYR---QRFPVLANSKkrcfselikPWHKTVLTGFGMTLCAVPIAQKSEPhSLSNEALMRRAVSLVTDSTSTF 86
Cdd:pfam09057   2 RSASVLLRSRghlQSFPGLAANR---------PWSKAVSVGVGATLCAVPFTQKSEP-SLSHEALIRRAVSLVTDSANTF 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148687684   87 LSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEVSE 143
Cdd:pfam09057  72 LSQTTLALIDALTEYTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGARVEMTD 128
 
Name Accession Description Interval E-value
Smac_DIABLO pfam09057
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
 10-143 5.49e-71

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


Pssm-ID: 462664  Cd Length: 231  Bit Score: 213.17  E-value: 5.49e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148687684   10 RSVCSLFRYR---QRFPVLANSKkrcfselikPWHKTVLTGFGMTLCAVPIAQKSEPhSLSNEALMRRAVSLVTDSTSTF 86
Cdd:pfam09057   2 RSASVLLRSRghlQSFPGLAANR---------PWSKAVSVGVGATLCAVPFTQKSEP-SLSHEALIRRAVSLVTDSANTF 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148687684   87 LSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEVSE 143
Cdd:pfam09057  72 LSQTTLALIDALTEYTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGARVEMTD 128
 
Name Accession Description Interval E-value
Smac_DIABLO pfam09057
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
 10-143 5.49e-71

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


Pssm-ID: 462664  Cd Length: 231  Bit Score: 213.17  E-value: 5.49e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148687684   10 RSVCSLFRYR---QRFPVLANSKkrcfselikPWHKTVLTGFGMTLCAVPIAQKSEPhSLSNEALMRRAVSLVTDSTSTF 86
Cdd:pfam09057   2 RSASVLLRSRghlQSFPGLAANR---------PWSKAVSVGVGATLCAVPFTQKSEP-SLSHEALIRRAVSLVTDSANTF 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148687684   87 LSQTTYALIEAITEYTKAVYTLVSLYRQYTSLLGKMNSQEEDEVWQVIIGARVEVSE 143
Cdd:pfam09057  72 LSQTTLALIDALTEYTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGARVEMTD 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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