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Conserved domains on  [gi|148685969|gb|EDL17916|]
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polyamine oxidase (exo-N4-amino), isoform CRA_d [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02568 super family cl33517
polyamine oxidase
 53-260 3.65e-50

polyamine oxidase


The actual alignment was detected with superfamily member PLN02568:

Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 172.71  E-value: 3.65e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  53 GFLK---EHQDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFE-----EPFWEPDCQFIQVVWEDtsplQDTALSLQDT-- 122
Cdd:PLN02568 295 GVLKagiGEDSGLFSPPLPDFKTDAISRLGFGVVNKLFVELSprpdgSPEDVAKFPFLQMAFHR----SDSEARHDKIpw 370

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 123 WFKKLIGflVQPSFESSHVLCGFIAGLESEFMETLSDEEV-------LLSLTQ--------VLRRVTGNPQLPAAKS--- 184
Cdd:PLN02568 371 WMRRTAS--ICPIHKNSSVLLSWFAGKEALELEKLSDEEIirgvqttLSSFLKrrvaglgsQSHPLCNGGASSNDGSrwk 448

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 185 ---VRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLP-----EDGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREA 256
Cdd:PLN02568 449 fvkVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPrisdhDQAGGPPLQLLFAGEATHRTHYSTTHGAYFSGLREA 528


                 ....
gi 148685969 257 DRLV 260
Cdd:PLN02568 529 NRLL 532
HemY super family cl34197
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 6-50 3.40e-07

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


The actual alignment was detected with superfamily member COG1232:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 50.99  E-value: 3.40e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 148685969   6 PRVLVVGSGIAGLGAAQKLcsHRAAPHLRVLEATASAGGRIRSER 50
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRL--AKAGHEVTVLEASDRVGGLIRTVE 44
 
Name Accession Description Interval E-value
PLN02568 PLN02568
polyamine oxidase
 53-260 3.65e-50

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 172.71  E-value: 3.65e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  53 GFLK---EHQDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFE-----EPFWEPDCQFIQVVWEDtsplQDTALSLQDT-- 122
Cdd:PLN02568 295 GVLKagiGEDSGLFSPPLPDFKTDAISRLGFGVVNKLFVELSprpdgSPEDVAKFPFLQMAFHR----SDSEARHDKIpw 370

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 123 WFKKLIGflVQPSFESSHVLCGFIAGLESEFMETLSDEEV-------LLSLTQ--------VLRRVTGNPQLPAAKS--- 184
Cdd:PLN02568 371 WMRRTAS--ICPIHKNSSVLLSWFAGKEALELEKLSDEEIirgvqttLSSFLKrrvaglgsQSHPLCNGGASSNDGSrwk 448

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 185 ---VRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLP-----EDGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREA 256
Cdd:PLN02568 449 fvkVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPrisdhDQAGGPPLQLLFAGEATHRTHYSTTHGAYFSGLREA 528


                 ....
gi 148685969 257 DRLV 260
Cdd:PLN02568 529 NRLL 532
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
63-260 3.07e-32

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 122.72  E-value: 3.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDtsplqdtaLSLQDTWfkkligFLVQPSFESSHVL 142
Cdd:COG1231  261 FDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWEEDGLYGGISLTD--------LPIRQTW------YPSNGPDGGAGVL 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 143 CGFIAGLESEFMETLSDEEVLLSLTQVLRRVTGnpqlPAAKSVRRSQ---WHSAPYTRGSYSYVAVGSTGDDLDLMAQPl 219
Cdd:COG1231  327 LGYVGGDDARALAALSPEERVAAALEQLARIFG----VYAAEPVDYVstdWGRDPWSRGAYAAAPPGQLTAAGPALAEP- 401

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148685969 220 peDGTgtqlqVLFAGEATHRTFYSTTHGALLSGWREADRLV 260
Cdd:COG1231  402 --DGR-----IHFAGEHTSDEWPGWVEGALESGERAAAEIL 435
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 63-259 5.63e-32

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 122.21  E-value: 5.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969   63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVvwEDTSPLQDTALSLQDTWFKKLIGflvqpsfeSSHVL 142
Cdd:pfam01593 266 FTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDLGLLGLL--SELLTGLGTAFSWLTFPNRAPPG--------KGLLL 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  143 CGFI-AGLESEFMETLSDEEVLLSLTQVLRRVTGNPqLPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPlPE 221
Cdd:pfam01593 336 LVYVgPGDRARELEGLSDEELLQAVLRDLRKLFGEE-APEPLRVLVSDWHTDPWPRGSYSLPQYGPGHDDYRPLART-PD 413

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 148685969  222 DGtgtqlqVLFAGEATHRTFYSTTHGALLSGWREADRL 259
Cdd:pfam01593 414 PG------LFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 6-50 3.40e-07

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 50.99  E-value: 3.40e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 148685969   6 PRVLVVGSGIAGLGAAQKLcsHRAAPHLRVLEATASAGGRIRSER 50
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRL--AKAGHEVTVLEASDRVGGLIRTVE 44
PLN02568 PLN02568
polyamine oxidase
 6-46 1.47e-06

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 49.06  E-value: 1.47e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 148685969   6 PRVLVVGSGIAGLGAAQKLCSHRAAP---HLRVLEATASAGGRI 46
Cdd:PLN02568   6 PRIVIIGAGMAGLTAANKLYTSSAANdmfELTVVEGGDRIGGRI 49
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
10-50 1.03e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 42.52  E-value: 1.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148685969   10 VVGSGIAGLGAAQKLCSHRAapHLRVLEATASAGGRIRSER 50
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF--RVLVLEKRDRLGGNAYSYR 39
 
Name Accession Description Interval E-value
PLN02568 PLN02568
polyamine oxidase
 53-260 3.65e-50

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 172.71  E-value: 3.65e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  53 GFLK---EHQDTFFEPPLPAKKAEAIKKLGFGTNNKIFLEFE-----EPFWEPDCQFIQVVWEDtsplQDTALSLQDT-- 122
Cdd:PLN02568 295 GVLKagiGEDSGLFSPPLPDFKTDAISRLGFGVVNKLFVELSprpdgSPEDVAKFPFLQMAFHR----SDSEARHDKIpw 370

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 123 WFKKLIGflVQPSFESSHVLCGFIAGLESEFMETLSDEEV-------LLSLTQ--------VLRRVTGNPQLPAAKS--- 184
Cdd:PLN02568 371 WMRRTAS--ICPIHKNSSVLLSWFAGKEALELEKLSDEEIirgvqttLSSFLKrrvaglgsQSHPLCNGGASSNDGSrwk 448

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 185 ---VRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLP-----EDGTGTQLQVLFAGEATHRTFYSTTHGALLSGWREA 256
Cdd:PLN02568 449 fvkVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPrisdhDQAGGPPLQLLFAGEATHRTHYSTTHGAYFSGLREA 528


                 ....
gi 148685969 257 DRLV 260
Cdd:PLN02568 529 NRLL 532
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
63-260 3.07e-32

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 122.72  E-value: 3.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDtsplqdtaLSLQDTWfkkligFLVQPSFESSHVL 142
Cdd:COG1231  261 FDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWEEDGLYGGISLTD--------LPIRQTW------YPSNGPDGGAGVL 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 143 CGFIAGLESEFMETLSDEEVLLSLTQVLRRVTGnpqlPAAKSVRRSQ---WHSAPYTRGSYSYVAVGSTGDDLDLMAQPl 219
Cdd:COG1231  327 LGYVGGDDARALAALSPEERVAAALEQLARIFG----VYAAEPVDYVstdWGRDPWSRGAYAAAPPGQLTAAGPALAEP- 401

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 148685969 220 peDGTgtqlqVLFAGEATHRTFYSTTHGALLSGWREADRLV 260
Cdd:COG1231  402 --DGR-----IHFAGEHTSDEWPGWVEGALESGERAAAEIL 435
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 63-259 5.63e-32

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 122.21  E-value: 5.63e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969   63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVvwEDTSPLQDTALSLQDTWFKKLIGflvqpsfeSSHVL 142
Cdd:pfam01593 266 FTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDLGLLGLL--SELLTGLGTAFSWLTFPNRAPPG--------KGLLL 335

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  143 CGFI-AGLESEFMETLSDEEVLLSLTQVLRRVTGNPqLPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPlPE 221
Cdd:pfam01593 336 LVYVgPGDRARELEGLSDEELLQAVLRDLRKLFGEE-APEPLRVLVSDWHTDPWPRGSYSLPQYGPGHDDYRPLART-PD 413

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 148685969  222 DGtgtqlqVLFAGEATHRTFYSTTHGALLSGWREADRL 259
Cdd:pfam01593 414 PG------LFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 52-256 1.04e-29

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 117.79  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  52 FGFLKEHQDTFFePPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDTSPLQDTALslqdtwfkkligFL 131
Cdd:PLN02328 485 LGVLKKGSIEFY-PELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEIDTFGHLTEDPSMRGEFFL------------FY 551

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 132 VQPSFESSHVLCGFIAGLESEFMETLSDEEVLLSLTQVLRRVTgNPQ---LPAAKSVRRSQWHSAPYTRGSYSYVAVGST 208
Cdd:PLN02328 552 SYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIF-HPKgivVPDPVQAVCTRWGKDCFTYGSYSYVAVGSS 630

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 148685969 209 GDDLDLMAQPLpedGTGtqlQVLFAGEATHRTFYSTTHGALLSGWREA 256
Cdd:PLN02328 631 GDDYDILAESV---GDG---RVFFAGEATNKQYPATMHGAFLSGMREA 672
PLN02976 PLN02976
amine oxidase
 63-262 7.03e-26

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 106.88  E-value: 7.03e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969   63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDTSplqdtalsLQDTWF-----KKLIGflvqpsfe 137
Cdd:PLN02976 1005 FSPPLPDWKYSSIQRLGFGVLNKVVLEFPEVFWDDSVDYFGATAEETD--------LRGQCFmfwnvKKTVG-------- 1068

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  138 sSHVLCGFIAG---LESEFMEtlSDEEVLLSLTqVLRRVTGNPQLPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLDL 214
Cdd:PLN02976 1069 -APVLIALVVGkaaIDGQSMS--SSDHVNHALM-VLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYVAIGASGEDYDI 1144

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 148685969  215 MAQPLpedgtgtQLQVLFAGEATHRTFYSTTHGALLSGWREADRLVSL 262
Cdd:PLN02976 1145 LGRPV-------ENCLFFAGEATCKEHPDTVGGAMMSGLREAVRIIDI 1185
PLN03000 PLN03000
amine oxidase
 63-256 3.43e-25

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 104.72  E-value: 3.43e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCQFIQVVWEDTSPLQDTALslqdtwfkkligFLVQPSFESSHVL 142
Cdd:PLN03000 439 FVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDLDTFGHLTEDPNYRGEFFL------------FYSYAPVAGGPLL 506

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 143 CGFIAGLESEFMETLSDEEVLLSLTQVLRRVTgNPQ---LPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPL 219
Cdd:PLN03000 507 IALVAGEAAHKFETMPPTDAVTRVLHILRGIY-EPQginVPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYDILAESV 585

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 148685969 220 pedGTGtqlQVLFAGEATHRTFYSTTHGALLSGWREA 256
Cdd:PLN03000 586 ---GDG---RLFFAGEATTRRYPATMHGAFVTGLREA 616
PLN02529 PLN02529
lysine-specific histone demethylase 1
 63-273 1.02e-23

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 100.35  E-value: 1.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWEPDCqfiqvvwedtsplqDTALSLQDTWFKKLIGFLvqpsFESSH-- 140
Cdd:PLN02529 415 FEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL--------------DTFGCLNESSNKRGEFFL----FYGYHtv 476

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 141 ----VLCGFIAGLESEFMETLSDEEVLLSLTQVLRRVTgNPQ---LPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDDLD 213
Cdd:PLN02529 477 sggpALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIY-NPKginVPDPIQTICTRWGSDPLSYGSYSHVRVQSSGSDYD 555

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 214 LMAQPLPEdgtgtqlQVLFAGEATHRTFYSTTHGALLSGWREADRLVSLWDSQveQSRPR 273
Cdd:PLN02529 556 ILAESVSG-------RLFFAGEATTRQYPATMHGAFLSGLREASRILHVARSQ--QSNSR 606
PLN02268 PLN02268
probable polyamine oxidase
 63-252 2.33e-20

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 89.75  E-value: 2.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWePDCQFIQVVWEdTSPLQDTALSLQDTwfkkligflvqpsfeSSH-V 141
Cdd:PLN02268 260 FEPELPEWKEEAISDLGVGIENKIALHFDSVFW-PNVEFLGVVAP-TSYGCSYFLNLHKA---------------TGHpV 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 142 LCGFIAGLESEFMETLSDEE-VLLSLTQvLRRVTGNPQLPAAKSVrrSQWHSAPYTRGSYSYVAVGSTGDDLDLMAQPLP 220
Cdd:PLN02268 323 LVYMPAGRLARDIEKLSDEAaANFAMSQ-LKKMLPDATEPVQYLV--SRWGSDPNSLGCYSYDLVGKPHDLYERLRAPVD 399

                        170       180       190
                 ....*....|....*....|....*....|..
gi 148685969 221 EdgtgtqlqVLFAGEATHRTFYSTTHGALLSG 252
Cdd:PLN02268 400 N--------LFFAGEATSSDFPGSVHGAYSTG 423
PLN02676 PLN02676
polyamine oxidase
 63-261 1.79e-14

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 72.83  E-value: 1.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969  63 FEPPLPAKKAEAIKKLGFGTNNKIFLEFEEPFWE--PDCQFI---------QVVWEDtsplqdtalslqdtwfkkligfl 131
Cdd:PLN02676 294 FKPPLPDWKIEAIYQFDMAVYTKIFLKFPYKFWPsgPGTEFFlyaherrgyYPFWQH----------------------- 350

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148685969 132 VQPSFESSHVLCGFIAGLESEFMETLSDEEVLLSLTQVLRRVTGnPQLPAAKSVRRSQWHSAPYTRGSYSYVAVGSTGDD 211
Cdd:PLN02676 351 LENEYPGSNVLFVTVTDEESRRIEQQPDSETKAEIMEVLRKMFG-PNIPEATDILVPRWWSNRFFKGSYSNWPIGVSRYE 429

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 148685969 212 LDLMAQPLpedgtGTqlqVLFAGEATHRTFYSTTHGALLSGWREADRLVS 261
Cdd:PLN02676 430 FDQIRAPV-----GR---VYFTGEHTSEKYNGYVHGAYLAGIDTANDLLE 471
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 6-50 3.40e-07

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 50.99  E-value: 3.40e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 148685969   6 PRVLVVGSGIAGLGAAQKLcsHRAAPHLRVLEATASAGGRIRSER 50
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRL--AKAGHEVTVLEASDRVGGLIRTVE 44
PLN02568 PLN02568
polyamine oxidase
 6-46 1.47e-06

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 49.06  E-value: 1.47e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 148685969   6 PRVLVVGSGIAGLGAAQKLCSHRAAP---HLRVLEATASAGGRI 46
Cdd:PLN02568   6 PRIVIIGAGMAGLTAANKLYTSSAANdmfELTVVEGGDRIGGRI 49
PLN02268 PLN02268
probable polyamine oxidase
 6-54 2.00e-06

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 48.53  E-value: 2.00e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 148685969   6 PRVLVVGSGIAGLGAAQKLcsHRAAPHLRVLEATASAGGRIRSERCFGF 54
Cdd:PLN02268   1 PSVIVIGGGIAGIAAARAL--HDASFKVTLLESRDRIGGRVHTDYSFGF 47
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 4-48 5.78e-06

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 47.16  E-value: 5.78e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 148685969   4 PGPRVLVVGSGIAGLGAAQKLCshRAAPHLRVLEATASAGGRIRS 48
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELA--EAGFRVTLLEARPRLGGRARS 44
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 6-57 6.00e-06

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 47.15  E-value: 6.00e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 148685969   6 PRVLVVGSGIAGLGAAQKLcsHRAAPHLR--VLEATASAGGRIRSERCFGFLKE 57
Cdd:PRK11883   1 KKVAIIGGGITGLSAAYRL--HKKGPDADitLLEASDRLGGKIQTVRKDGFPIE 52
PLN02576 PLN02576
protoporphyrinogen oxidase
 2-57 9.51e-06

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 46.54  E-value: 9.51e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148685969   2 AFPGPRVLVVGSGIAGLGAAQKLCSHRaAPHLRVLEATASAGGRIRSERCFGFLKE 57
Cdd:PLN02576   9 AASSKDVAVVGAGVSGLAAAYALASKH-GVNVLVTEARDRVGGNITSVSEDGFIWE 63
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
10-50 1.03e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 42.52  E-value: 1.03e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148685969   10 VVGSGIAGLGAAQKLCSHRAapHLRVLEATASAGGRIRSER 50
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF--RVLVLEKRDRLGGNAYSYR 39
PLN02676 PLN02676
polyamine oxidase
 2-50 7.90e-05

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 43.55  E-value: 7.90e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 148685969   2 AFPGPRVLVVGSGIAGLGAAQKLcSHRAAPHLRVLEATASAGGRIRSER 50
Cdd:PLN02676  23 AKPSPSVIIVGAGMSGISAAKTL-SEAGIEDILILEATDRIGGRMRKAN 70
NadB COG0029
Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the ...
 7-36 5.51e-04

Aspartate oxidase [Coenzyme transport and metabolism]; Aspartate oxidase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 439800 [Multi-domain]  Cd Length: 521  Bit Score: 40.86  E-value: 5.51e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 148685969   7 RVLVVGSGIAGLGAAQKLcshraAPHLRVL 36
Cdd:COG0029    6 DVLVIGSGIAGLSAALKL-----AERGRVT 30
PRK07233 PRK07233
hypothetical protein; Provisional
 7-44 7.99e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 40.26  E-value: 7.99e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 148685969   7 RVLVVGSGIAGLGAAQKLCshRAAPHLRVLEATASAGG 44
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLA--KRGHEVTVFEADDQLGG 36
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 6-44 8.32e-04

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 40.23  E-value: 8.32e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 148685969   6 PRVLVVGSGIAGLGAAQKLcsHRAAPHLRVLEATASAGG 44
Cdd:COG2072    7 VDVVVIGAGQAGLAAAYHL--RRAGIDFVVLEKADDVGG 43
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 15-55 9.47e-03

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 37.09  E-value: 9.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 148685969   15 IAGLGAAQKLCshRAAPHLRVLEATASAGGRIRSERCFGFL 55
Cdd:pfam01593   1 LAGLAAARELL--RAGHDVTVLEARDRVGGRIRTVRDDGFL 39
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
6-32 9.52e-03

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 37.03  E-value: 9.52e-03
                         10        20
                 ....*....|....*....|....*..
gi 148685969   6 PRVLVVGSGIAGLGAAQKLCSHRAAPH 32
Cdd:COG1252    2 KRIVIVGGGFAGLEAARRLRKKLGGDA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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