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Conserved domains on  [gi|148677248|gb|EDL09195|]
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tetratricopeptide repeat domain 21A, isoform CRA_a, partial [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 15-136 9.26e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 9.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  15 QIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNY 94
Cdd:COG2956  115 LLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDY 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148677248  95 ETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFE 136
Cdd:COG2956  195 EEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLR 236
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 15-136 9.26e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 9.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  15 QIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNY 94
Cdd:COG2956  115 LLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDY 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148677248  95 ETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFE 136
Cdd:COG2956  195 EEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLR 236
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 5-149 5.03e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 59.71  E-value: 5.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248    5 QNQLAASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLcEQRCAPLLEMEQTHERAAVML 84
Cdd:TIGR02917 698 QHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEA-VKTLEAWLKTHPNDAVLRTAL 776

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148677248   85 ADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSgkleEAPAFFELAKKVSSRVPLEP 149
Cdd:TIGR02917 777 AELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLEL----KDPRALEYAERALKLAPNIP 837
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 3-134 1.67e-06

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 46.34  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   3 PFQNQLAASICiQIGEHHLAEKDYDSALKSYKDALAYSPtdskvvlelahlylllgqldlceqRCApllemeqtheRAAV 82
Cdd:PRK11788 174 SLRVEIAHFYC-ELAQQALARGDLDAARALLKKALAADP------------------------QCV----------RASI 218

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148677248  83 MLADLMFRRQNYETAINLYHQVLEKAPDNF-LVLNKLVDLLRRSGKLEEAPAF 134
Cdd:PRK11788 219 LLGDLALAQGDYAAAIEALERVEEQDPEYLsEVLPKLMECYQALGDEAEGLEF 271
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 83-146 8.56e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.16  E-value: 8.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148677248   83 MLADLMFRRQNYETAINLYHQVLEK---APDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVSSRVP 146
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARfpeSPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGDP 68
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 15-136 9.26e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.28  E-value: 9.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  15 QIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNY 94
Cdd:COG2956  115 LLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDY 194

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 148677248  95 ETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFE 136
Cdd:COG2956  195 EEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLR 236
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 5-149 5.03e-11

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 59.71  E-value: 5.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248    5 QNQLAASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLcEQRCAPLLEMEQTHERAAVML 84
Cdd:TIGR02917 698 QHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRALLASGNTAEA-VKTLEAWLKTHPNDAVLRTAL 776

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148677248   85 ADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSgkleEAPAFFELAKKVSSRVPLEP 149
Cdd:TIGR02917 777 AELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAWLYLEL----KDPRALEYAERALKLAPNIP 837
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 2-138 1.78e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 1.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   2 IPFQNQLAASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAA 81
Cdd:COG3914   70 AAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAY 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 148677248  82 VMLADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELA 138
Cdd:COG3914  150 LNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRA 206
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 9-140 9.72e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.66  E-value: 9.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   9 AASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLM 88
Cdd:COG4783    3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 148677248  89 FRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKK 140
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 10-138 2.56e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  10 ASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMF 89
Cdd:COG2956   76 AEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYL 155

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148677248  90 RRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELA 138
Cdd:COG2956  156 EQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERA 204
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 14-111 2.97e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 46.92  E-value: 2.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  14 IQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQN 93
Cdd:COG4235   21 LLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGD 100

                         90
                 ....*....|....*...
gi 148677248  94 YETAINLYHQVLEKAPDN 111
Cdd:COG4235  101 YAEAIAAWQKLLALLPAD 118
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
10-138 3.31e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 3.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  10 ASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMF 89
Cdd:COG0457    8 AEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQ 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148677248  90 RRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELA 138
Cdd:COG0457   88 ALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERA 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
15-140 6.23e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 47.31  E-value: 6.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  15 QIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNY 94
Cdd:COG0457   47 NLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRY 126

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 148677248  95 ETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKK 140
Cdd:COG0457  127 DEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEA 172
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 14-142 8.64e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 8.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  14 IQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQN 93
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 148677248  94 YETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVS 142
Cdd:COG2956   92 LDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG 140
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 16-151 1.12e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.91  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  16 IGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNYE 95
Cdd:COG3914  118 LGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLE 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 148677248  96 TAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVSSRVPLEPGF 151
Cdd:COG3914  198 EAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPF 253
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 3-134 1.67e-06

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 46.34  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   3 PFQNQLAASICiQIGEHHLAEKDYDSALKSYKDALAYSPtdskvvlelahlylllgqldlceqRCApllemeqtheRAAV 82
Cdd:PRK11788 174 SLRVEIAHFYC-ELAQQALARGDLDAARALLKKALAADP------------------------QCV----------RASI 218

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 148677248  83 MLADLMFRRQNYETAINLYHQVLEKAPDNF-LVLNKLVDLLRRSGKLEEAPAF 134
Cdd:PRK11788 219 LLGDLALAQGDYAAAIEALERVEEQDPEYLsEVLPKLMECYQALGDEAEGLEF 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 14-138 4.55e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.11  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  14 IQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQN 93
Cdd:COG2956   46 LALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGD 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 148677248  94 YETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELA 138
Cdd:COG2956  126 WEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 20-156 7.83e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 44.69  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   20 HLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNYETAIN 99
Cdd:TIGR02917 135 YLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALA 214

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 148677248  100 LYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKvssRVPLEPGFNYCQG 156
Cdd:TIGR02917 215 AYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLK---KAPNSPLAHYLKA 268
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 71-138 1.05e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 40.33  E-value: 1.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148677248  71 LEMEQTHERAAVMLADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELA 138
Cdd:COG5010   81 LQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRA 148
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 79-140 6.17e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 6.17e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148677248  79 RAAVMLADLMFRRQNYETAINLYHQVLEKAPDNFLV---LNKLVDLLRRSGKLEEAPAFFELAKK 140
Cdd:COG1729   31 DALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKApdaLLKLGLSYLELGDYDKARATLEELIK 95
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
87-131 7.40e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 7.40e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 148677248  87 LMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEA 131
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA 45
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 83-146 8.56e-04

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.16  E-value: 8.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148677248   83 MLADLMFRRQNYETAINLYHQVLEK---APDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVSSRVP 146
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALARfpeSPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAPGDP 68
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 20-131 8.74e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 8.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   20 HLAEKDYDSALKSYKDALAYSP--TDSKVVLELAHLYLLLGQLDLCEQRcapllEMEQTHERAAV---MLADLMFRRQNY 94
Cdd:TIGR02917 645 YAVMKNYAKAITSLKRALELKPdnTEAQIGLAQLLLAAKRTESAKKIAK-----SLQKQHPKAALgfeLEGDLYLRQKDY 719

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 148677248   95 ETAINLYHQVLEKAPDNFLVLnKLVDLLRRSGKLEEA 131
Cdd:TIGR02917 720 PAAIQAYRKALKRAPSSQNAI-KLHRALLASGNTAEA 755
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 5-110 1.23e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.51  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   5 QNQLAASICIQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVvlelahlylllgqldlceqrcapllemeqthERAAVML 84
Cdd:COG1729   25 NSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKA-------------------------------PDALLKL 73

                         90       100
                 ....*....|....*....|....*.
gi 148677248  85 ADLMFRRQNYETAINLYHQVLEKAPD 110
Cdd:COG1729   74 GLSYLELGDYDKARATLEELIKKYPD 99
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 78-138 2.83e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.48  E-value: 2.83e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148677248  78 ERAAVMLADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELA 138
Cdd:COG5010   54 FAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKA 114
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
20-144 2.93e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.15  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  20 HLAEKDYDSALKSYKDALAYSPTDSkvvlelahlylllgqldlceqrcapllemeqtheRAAVMLADLMFRRQNYETAIN 99
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNA----------------------------------DALNNLGLLLLEQGRYDEAIA 47

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 148677248 100 lYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVSSR 144
Cdd:COG3063   48 -LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
TPR_19 pfam14559
Tetratricopeptide repeat;
93-131 3.04e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 34.48  E-value: 3.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 148677248   93 NYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEA 131
Cdd:pfam14559   3 DYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEA 41
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 29-142 3.82e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 35.37  E-value: 3.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  29 ALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNYETAINLYHQVLEKA 108
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALD 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 148677248 109 PDNFLVLNKLVDLLRRSGKLEEAPAFFELAKKVS 142
Cdd:COG4235   82 PDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALL 115
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 16-138 4.36e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 36.60  E-value: 4.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   16 IGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHERAAVMLADLMFRRQNYE 95
Cdd:TIGR02917 437 LILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPD 516

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 148677248   96 TAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFELA 138
Cdd:TIGR02917 517 DAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKA 559
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 14-158 6.24e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 36.21  E-value: 6.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   14 IQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVlelahlylllgqldlceqRCAPLLEMEQTHERAAVML--------- 84
Cdd:PRK11447  389 LGLGDVAMARKDYAAAERYYQQALRMDPGNTNAV------------------RGLANLYRQQSPEKALAFIaslsasqrr 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248   85 -----------------ADLMFRRQNYETAINLYHQVLEKAPDNFLVLNKLVDLLRRSGKLEEAPAFFelaKKVSSRVPL 147
Cdd:PRK11447  451 siddierslqndrlaqqAEALENQGKWAQAAELQRQRLALDPGSVWLTYRLAQDLRQAGQRSQADALM---RRLAQQKPN 527

                         170
                  ....*....|.
gi 148677248  148 EPGFNYCQGIY 158
Cdd:PRK11447  528 DPEQVYAYGLY 538
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 14-107 7.41e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 35.48  E-value: 7.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148677248  14 IQIGEHHLAEKDYDSALKSYKDALAYSPTDSKVVLELAHLYLLLGQLDLCEQRCAPLLEMEQTHErAAVMLADLMFRRQN 93
Cdd:COG2956  182 LLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDD-LLLALADLLERKEG 260

                         90
                 ....*....|....
gi 148677248  94 YETAINLYHQVLEK 107
Cdd:COG2956  261 LEAALALLERQLRR 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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