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Conserved domains on  [gi|148676794|gb|EDL08741|]
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mCG6232 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cupredoxin super family cl19115
Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in ...
 1290-1393 1.01e-31

Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins, having an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. The majority of family members contain multiple cupredoxin domain repeats: ceruloplasmin and the coagulation factors V/VIII have six repeats; laccase, ascorbate oxidase, spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase, and the periplasmic domain of cytochrome c oxidase subunit II.


The actual alignment was detected with superfamily member cd04217:

Pssm-ID: 473140 [Multi-domain]  Cd Length: 86  Bit Score: 119.58  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1290 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPflrgiGYRIFSVSSPGSVTYDdkgftngrQKSASGSFSYQFTSP 1369
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 148676794 1370 GIYYYSSGYVDEahsisLQGVINV 1393
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 166-259 8.72e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 8.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  166 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILkaiyPGGRGLKVEVWNN 245
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG----EGPVEVTVDGANV 76

                          90
                  ....*....|....
gi 148676794  246 SRPAHLEDILEYNE 259
Cdd:cd00603    77 SARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1554-1640 8.80e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.11  E-value: 8.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1554 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ---QLVLVDILIHGVPAQC 1630
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 148676794 1631 QSNCSFSYLE 1640
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1726-1805 2.69e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 75.56  E-value: 2.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1726 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVN--AIIYPPL 1801
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGggGISSSPL 80


                   ....
gi 148676794  1802 SFTY 1805
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1136-1210 4.29e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.10  E-value: 4.29e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148676794 1136 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGL 1210
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1053-1130 1.82e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 67.48  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1053 ISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQVTA 1124
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 148676794 1125 KDSFSY 1130
Cdd:cd00603    83 NTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1644-1724 2.47e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 2.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1644 PYVTGIFPNS--IQGYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNL 1721
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 148676794  1722 TIS 1724
Cdd:pfam01833   81 TFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1461-1543 2.78e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.23  E-value: 2.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1461 PSIINITPSTGTAN--ELITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNSMNVGIreIVTLIVYNLGTA 1538
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV--SVTVGGGGISSS 78


                   ....*
gi 148676794  1539 INTLT 1543
Cdd:pfam01833   79 PLTFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1231-1301 4.19e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 4.19e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148676794  1231 FPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL--HSTGTV-FRITNNGSHLVHGLG 1301
Cdd:pfam01833    7 SPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 963-1039 3.70e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 3.70e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148676794   963 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAQN 1039
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
PA14 super family cl08459
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 259-363 4.20e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


The actual alignment was detected with superfamily member pfam07691:

Pssm-ID: 471833 [Multi-domain]  Cd Length: 141  Bit Score: 51.21  E-value: 4.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   259 EHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtgrteDKVRIAYysgNANTYF 337
Cdd:pfam07691   22 IDTDPDNTFYWdTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPP 90

                           90       100
                   ....*....|....*....|....*.
gi 148676794   338 SNSTQRSDEIHLQKGKEYYIEILLQE 363
Cdd:pfam07691   91 DASPEESNTLYLVAGKLYPIRIEYFH 116
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 42-151 4.89e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.59  E-value: 4.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794    42 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELlIPHSDDlyglkldhangdtgSV 119
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 148676794   120 TCKTTGTYIGHHNVSFILDSDYGRSFPEKMTY 151
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
 
Name Accession Description Interval E-value
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1290-1393 1.01e-31

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 119.58  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1290 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPflrgiGYRIFSVSSPGSVTYDdkgftngrQKSASGSFSYQFTSP 1369
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 148676794 1370 GIYYYSSGYVDEahsisLQGVINV 1393
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 166-259 8.72e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 8.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  166 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILkaiyPGGRGLKVEVWNN 245
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG----EGPVEVTVDGANV 76

                          90
                  ....*....|....
gi 148676794  246 SRPAHLEDILEYNE 259
Cdd:cd00603    77 SARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1554-1640 8.80e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.11  E-value: 8.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1554 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ---QLVLVDILIHGVPAQC 1630
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 148676794 1631 QSNCSFSYLE 1640
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1726-1805 2.69e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 75.56  E-value: 2.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1726 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVN--AIIYPPL 1801
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGggGISSSPL 80


                   ....
gi 148676794  1802 SFTY 1805
Cdd:pfam01833   81 TFTY 84
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1726-1805 1.19e-15

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 73.80  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1726 PAVASVSPTSGSIAGGTTLMITGNGFSPGNTT-VTVGDQPCQITFISSSEVYCSTPAGRA-GTANLKISV-NAIIYPPLS 1802
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIdGARRLAPLV 80


                  ...
gi 148676794 1803 FTY 1805
Cdd:cd01179    81 FTY 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1136-1210 4.29e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.10  E-value: 4.29e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148676794 1136 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGL 1210
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1053-1130 1.82e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 67.48  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1053 ISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQVTA 1124
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 148676794 1125 KDSFSY 1130
Cdd:cd00603    83 NTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1554-1638 1.18e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.46  E-value: 1.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1554 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVpAQCQSN 1633
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 148676794  1634 CSFSY 1638
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1644-1724 2.47e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 2.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1644 PYVTGIFPNS--IQGYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNL 1721
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 148676794  1722 TIS 1724
Cdd:pfam01833   81 TFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 166-242 9.40e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 9.40e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148676794   166 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPhilkaiyPGGRGLKVEV 242
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-------SGLVNVSVTV 70
IPT smart00429
ig-like, plexins, transcription factors;
166-223 1.13e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 59.74  E-value: 1.13e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 148676794    166 PEVVMVSPSKGSTEGGTLLTIHGHFFDQ-TDLPVRVLVGGQACAILNVTENTIYCKTPP 223
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPP 60
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1461-1543 2.78e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.23  E-value: 2.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1461 PSIINITPSTGTAN--ELITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNSMNVGIreIVTLIVYNLGTA 1538
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV--SVTVGGGGISSS 78


                   ....*
gi 148676794  1539 INTLT 1543
Cdd:pfam01833   79 PLTFT 83
IPT smart00429
ig-like, plexins, transcription factors;
1726-1805 5.12e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.82  E-value: 5.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   1726 PAVASVSPTSGSIAGGTTLMITGNGFSPGNT---TVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAII----- 1797
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggvp 81


                    ....*...
gi 148676794   1798 YPPLSFTY 1805
Cdd:smart00429   82 SSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1052-1130 3.88e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 3.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1052 QISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ-VTAKDS 1127
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiSSSPLT 81


                   ...
gi 148676794  1128 FSY 1130
Cdd:pfam01833   82 FTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1231-1301 4.19e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 4.19e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148676794  1231 FPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL--HSTGTV-FRITNNGSHLVHGLG 1301
Cdd:pfam01833    7 SPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 963-1039 3.70e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 3.70e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148676794   963 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAQN 1039
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 963-1050 8.64e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 8.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  963 PLILTTTPSEGSYAESTILTIAGSGFSPTSA-VSVSVGSTRCSLLSVEENEIKCQIL-NGSAGHVPVAVSIaDVGLAQNL 1040
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVTV-DGANVSAR 79

                          90
                  ....*....|
gi 148676794 1041 EGEGSHFIYR 1050
Cdd:cd00603    80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1136-1213 8.66e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 51.29  E-value: 8.66e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148676794  1136 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLPPGKHDIYVKVRNWGLAST 1213
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1227-1280 8.90e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.30  E-value: 8.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148676794 1227 VIHMF-PQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL 1280
Cdd:cd00603     2 VITSIsPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRT 56
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 259-363 4.20e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 51.21  E-value: 4.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   259 EHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtgrteDKVRIAYysgNANTYF 337
Cdd:pfam07691   22 IDTDPDNTFYWdTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPP 90

                           90       100
                   ....*....|....*....|....*.
gi 148676794   338 SNSTQRSDEIHLQKGKEYYIEILLQE 363
Cdd:pfam07691   91 DASPEESNTLYLVAGKLYPIRIEYFH 116
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 237-363 4.55e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 4.55e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794    237 GLKVEVWNNSRPAHLEDIleynEHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFS 315
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYWdSDKFGE--GEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 148676794    316 qtgrteDKVRIayysgNANTYFSNSTQRSDEIHLQKGKEYYIEILLQE 363
Cdd:smart00758   76 ------GKLVI-----DNWGKHEARPSTSSTLYLLAGGTYPIRIEYFE 112
PetE COG3794
Plastocyanin [Energy production and conversion];
1302-1374 1.23e-05

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 44.99  E-value: 1.23e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148676794 1302 YAWSPSVLNVTVGDTVVWSWQAhpflrGIGYRIFSVSSPgsvtydDKGFTNGRQKsASGSFSYQFTSPGIYYY 1374
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
IPT smart00429
ig-like, plexins, transcription factors;
1553-1639 2.27e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.72  E-value: 2.27e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   1553 LPNIDMVMPKAGSTTGMTRVTIQGSGFMS-SPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVL-----VDILIHGV 1626
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 148676794   1627 PAQCQsncSFSYL 1639
Cdd:smart00429   81 PSSPQ---PFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
963-1050 2.38e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.72  E-value: 2.38e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794    963 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV--GSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAqNL 1040
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80

                            90
                    ....*....|
gi 148676794   1041 EGEGSHFIYR 1050
Cdd:smart00429   81 PSSPQPFTYV 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1461-1519 4.06e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 43.98  E-value: 4.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148676794 1461 PSIINITPSTGTANE--LITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNS 1519
Cdd:cd00603     1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 42-151 4.89e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.59  E-value: 4.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794    42 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELlIPHSDDlyglkldhangdtgSV 119
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 148676794   120 TCKTTGTYIGHHNVSFILDSDYGRSFPEKMTY 151
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1053-1130 1.10e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.79  E-value: 1.10e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   1053 ISHVWPDSGSLAGGTLLTISGFGF----SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQV----TA 1124
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNggvpSS 83


                    ....*.
gi 148676794   1125 KDSFSY 1130
Cdd:smart00429   84 PQPFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
1227-1280 7.49e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 7.49e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 148676794   1227 VIH-MFPQRGSLYGGTEITIMGFGFSTIPTEN-SVLLGSFPCDITSSSENVIKCTL 1280
Cdd:smart00429    3 VITrISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKT 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 42-140 1.10e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 39.75  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   42 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELLiphsddlyglkldhaNGDTGSV 119
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNL-------------GSGSPRVRVTVGGVPCKVL---------------NVSSTEI 52

                          90       100
                  ....*....|....*....|..
gi 148676794  120 TCKT-TGTYIGHHNVSFILDSD 140
Cdd:cd00603    53 VCRTpAAATPGEGPVEVTVDGA 74
 
Name Accession Description Interval E-value
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1290-1393 1.01e-31

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 119.58  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1290 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPflrgiGYRIFSVSSPGSVTYDdkgftngrQKSASGSFSYQFTSP 1369
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 148676794 1370 GIYYYSSGYVDEahsisLQGVINV 1393
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 166-259 8.72e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 8.72e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  166 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILkaiyPGGRGLKVEVWNN 245
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPG----EGPVEVTVDGANV 76

                          90
                  ....*....|....
gi 148676794  246 SRPAHLEDILEYNE 259
Cdd:cd00603    77 SARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1554-1640 8.80e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 77.11  E-value: 8.80e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1554 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ---QLVLVDILIHGVPAQC 1630
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 148676794 1631 QSNCSFSYLE 1640
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1726-1805 2.69e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 75.56  E-value: 2.69e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1726 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVN--AIIYPPL 1801
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGggGISSSPL 80


                   ....
gi 148676794  1802 SFTY 1805
Cdd:pfam01833   81 TFTY 84
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1726-1805 1.19e-15

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 73.80  E-value: 1.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1726 PAVASVSPTSGSIAGGTTLMITGNGFSPGNTT-VTVGDQPCQITFISSSEVYCSTPAGRA-GTANLKISV-NAIIYPPLS 1802
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIdGARRLAPLV 80


                  ...
gi 148676794 1803 FTY 1805
Cdd:cd01179    81 FTY 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1136-1210 4.29e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.10  E-value: 4.29e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148676794 1136 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGL 1210
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1726-1805 6.58e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 71.72  E-value: 6.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1726 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPA-GRAGTANLKISVN-----AII 1797
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAaATPGEGPVEVTVDganvsARV 80


                  ....*...
gi 148676794 1798 YPPLSFTY 1805
Cdd:cd00603    81 LSNTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1053-1130 1.82e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 67.48  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1053 ISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQVTA 1124
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 148676794 1125 KDSFSY 1130
Cdd:cd00603    83 NTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1726-1805 5.26e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 66.33  E-value: 5.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1726 PAVASVSPTSGSIAGGTTLMITGNGFSPG-NTTVTV-GDQPCQITFISSSEVYCSTPAGR-AGTANLKISV----NAIIY 1798
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnPGPGPVEVTVdrgnGGITS 80


                  ....*..
gi 148676794 1799 PPLSFTY 1805
Cdd:cd00102    81 SPLTFTY 87
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 166-242 3.32e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 64.02  E-value: 3.32e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148676794  166 PEVVMVSPSKGSTEGGTLLTIHGHFFDqTDLPVRVLVGG-QACAILNVTENTIYCKTPPkphilkaiYPGGRGLKVEV 242
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFG-SGSNLRVTFGGgVPCSVLSVSSTAIVCTTPP--------YANPGPGPVEV 69
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1554-1640 4.19e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 63.63  E-value: 4.19e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1554 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQL-VLVDILIHGVPAQCQS 1632
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGpGPVEVTVDRGNGGITS 80


                  ....*....
gi 148676794 1633 NC-SFSYLE 1640
Cdd:cd00102    81 SPlTFTYVP 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1554-1638 1.18e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.46  E-value: 1.18e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1554 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVpAQCQSN 1633
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 148676794  1634 CSFSY 1638
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1644-1724 2.47e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 61.31  E-value: 2.47e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1644 PYVTGIFPNS--IQGYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNL 1721
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 148676794  1722 TIS 1724
Cdd:pfam01833   81 TFT 83
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1052-1130 5.19e-11

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 60.55  E-value: 5.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1052 QISHVWPDSGSLAGGTLLTISG--FGFSENSTVLV-GNETCNVIEGDLNRITCRTSK---RIEGTVDISVIT-NGIQVTA 1124
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGsnFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPyanPGPGPVEVTVDRgNGGITSS 81


                  ....*.
gi 148676794 1125 KDSFSY 1130
Cdd:cd00102    82 PLTFTY 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 166-242 9.40e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 9.40e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 148676794   166 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPhilkaiyPGGRGLKVEV 242
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-------SGLVNVSVTV 70
IPT smart00429
ig-like, plexins, transcription factors;
166-223 1.13e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 59.74  E-value: 1.13e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 148676794    166 PEVVMVSPSKGSTEGGTLLTIHGHFFDQ-TDLPVRVLVGGQACAILNVTENTIYCKTPP 223
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPP 60
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 166-259 1.93e-10

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 58.77  E-value: 1.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  166 PEVVMVSPSKGSTEGGTLLTIHGHFFDqTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILKAiypggrglKVEVWNN 245
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLN-AGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEA--------PVKVLID 71

                          90
                  ....*....|....
gi 148676794  246 SRPAHLEDILEYNE 259
Cdd:cd01179    72 GARRLAPLVFTYTE 85
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1461-1543 2.78e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 58.23  E-value: 2.78e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1461 PSIINITPSTGTAN--ELITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNSMNVGIreIVTLIVYNLGTA 1538
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV--SVTVGGGGISSS 78


                   ....*
gi 148676794  1539 INTLT 1543
Cdd:pfam01833   79 PLTFT 83
IPT smart00429
ig-like, plexins, transcription factors;
1726-1805 5.12e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 57.82  E-value: 5.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   1726 PAVASVSPTSGSIAGGTTLMITGNGFSPGNT---TVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAII----- 1797
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggvp 81


                    ....*...
gi 148676794   1798 YPPLSFTY 1805
Cdd:smart00429   82 SSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1052-1130 3.88e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 3.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  1052 QISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ-VTAKDS 1127
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiSSSPLT 81


                   ...
gi 148676794  1128 FSY 1130
Cdd:pfam01833   82 FTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1231-1301 4.19e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 55.15  E-value: 4.19e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148676794  1231 FPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL--HSTGTV-FRITNNGSHLVHGLG 1301
Cdd:pfam01833    7 SPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1136-1213 3.45e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 52.46  E-value: 3.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1136 PVVTDFSPKERTVLGKVNLTIKGYNFGNElAQNTVYV-GRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGLAST 1213
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSG-SNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnPGPGPVEVTVDRGNGGIT 79
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 963-1039 3.70e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 3.70e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148676794   963 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAQN 1039
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 963-1050 8.64e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.69  E-value: 8.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  963 PLILTTTPSEGSYAESTILTIAGSGFSPTSA-VSVSVGSTRCSLLSVEENEIKCQIL-NGSAGHVPVAVSIaDVGLAQNL 1040
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVTV-DGANVSAR 79

                          90
                  ....*....|
gi 148676794 1041 EGEGSHFIYR 1050
Cdd:cd00603    80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1136-1213 8.66e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 51.29  E-value: 8.66e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 148676794  1136 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLPPGKHDIYVKVRNWGLAST 1213
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1227-1280 8.90e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 51.30  E-value: 8.90e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148676794 1227 VIHMF-PQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL 1280
Cdd:cd00603     2 VITSIsPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRT 56
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1554-1640 1.03e-07

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 51.07  E-value: 1.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1554 PNIDMVMPKAGSTTGMTRVTIQGSgFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ-QLVLVDILIHGvpAQCQS 1632
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGK-HLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDG--ARRLA 77


                  ....*...
gi 148676794 1633 NCSFSYLE 1640
Cdd:cd01179    78 PLVFTYTE 85
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 259-363 4.20e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 51.21  E-value: 4.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   259 EHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtgrteDKVRIAYysgNANTYF 337
Cdd:pfam07691   22 IDTDPDNTFYWdTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPP 90

                           90       100
                   ....*....|....*....|....*.
gi 148676794   338 SNSTQRSDEIHLQKGKEYYIEILLQE 363
Cdd:pfam07691   91 DASPEESNTLYLVAGKLYPIRIEYFH 116
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 237-363 4.55e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 4.55e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794    237 GLKVEVWNNSRPAHLEDIleynEHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFS 315
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYWdSDKFGE--GEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 148676794    316 qtgrteDKVRIayysgNANTYFSNSTQRSDEIHLQKGKEYYIEILLQE 363
Cdd:smart00758   76 ------GKLVI-----DNWGKHEARPSTSSTLYLLAGGTYPIRIEYFE 112
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1726-1794 6.42e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.24  E-value: 6.42e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 148676794 1726 PAVASVSPTSGSIAGGTTLMITGN--GFSPG--NTTVTVGDQPCQIT---FISSSEVYCSTPAGRAGTANLKISVN 1794
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNdvRHGVRVGGVPCNPEppeYSSSEKIVCTTGPAGNPVFNGPVEVT 76
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1554-1640 2.11e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 47.70  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1554 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVE--VFMGDFPCKVLSVTY---TAIECETSPAPQQL--VLVDILIHGV 1626
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhgVRVGGVPCNPEPPEYsssEKIVCTTGPAGNPVfnGPVEVTVGHG 80

                          90
                  ....*....|....
gi 148676794 1627 PAQCQSNCSFSYLE 1640
Cdd:cd01180    81 SFRTESSEGFSFVD 94
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 963-1051 3.97e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 46.69  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  963 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV-GSTRCSLLSVEENEIKCQI---LNGSAGHVPVAVSIADVGLAQ 1038
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTppyANPGPGPVEVTVDRGNGGITS 80

                          90
                  ....*....|...
gi 148676794 1039 NlegeGSHFIYRS 1051
Cdd:cd00102    81 S----PLTFTYVP 89
Halocyanin cd04220
Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) ...
 1301-1374 8.50e-06

Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) copper redox proteins found in halophilic archaea such as Natronomonas pharaonis (Natronobacterium pharaonis). Halocyanin may serve as a mobile electron carrier at a peripheral membrane protein. The copper-binding domain is present only once in some halocyanins and is duplicated in others.


Pssm-ID: 259882 [Multi-domain]  Cd Length: 92  Bit Score: 45.84  E-value: 8.50e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 148676794 1301 GYAWSPSVLNVTVGDTVVWSWQAHpflrGIGYRIfsVSSPGSVTYDDKGFTNgrqKSASGSFSYQFTSPGIYYY 1374
Cdd:cd04220    11 GFAFDPAAIRVSPGTTVTWEWTGE----GGGHNV--VAYEDPITAFDSGSTD---SSEGETYEHTFEETGEYRY 75
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1053-1130 1.15e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 45.38  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1053 ISHVWPDSGSLAGGTLLTISG--FGFSEN---STVLVGNETCNVIEG---DLNRITCRT----SKRIEGTVDISVITNGI 1120
Cdd:cd01180     3 ITEFFPLSGPLEGGTRLTICGsnLGLRKNdvrHGVRVGGVPCNPEPPeysSSEKIVCTTgpagNPVFNGPVEVTVGHGSF 82

                          90
                  ....*....|
gi 148676794 1121 QVTAKDSFSY 1130
Cdd:cd01180    83 RTESSEGFSF 92
PetE COG3794
Plastocyanin [Energy production and conversion];
1302-1374 1.23e-05

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 44.99  E-value: 1.23e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 148676794 1302 YAWSPSVLNVTVGDTVVWSWQAhpflrGIGYRIFSVSSPgsvtydDKGFTNGRQKsASGSFSYQFTSPGIYYY 1374
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
IPT smart00429
ig-like, plexins, transcription factors;
1553-1639 2.27e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.72  E-value: 2.27e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   1553 LPNIDMVMPKAGSTTGMTRVTIQGSGFMS-SPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVL-----VDILIHGV 1626
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 148676794   1627 PAQCQsncSFSYL 1639
Cdd:smart00429   81 PSSPQ---PFTYV 90
IPT smart00429
ig-like, plexins, transcription factors;
963-1050 2.38e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 44.72  E-value: 2.38e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794    963 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV--GSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAqNL 1040
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80

                            90
                    ....*....|
gi 148676794   1041 EGEGSHFIYR 1050
Cdd:smart00429   81 PSSPQPFTYV 90
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1053-1130 2.81e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.14  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1053 ISHVWPDSGSLAGGTLLTISGFGFSENST--VLVGNETCNVIEGDLNRITCRTSKRIE-GTVDISVITNGIQVTAKDSFS 1129
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLNAGSSvrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDGARRLAPLVFT 82


                  .
gi 148676794 1130 Y 1130
Cdd:cd01179    83 Y 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1461-1519 4.06e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 43.98  E-value: 4.06e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148676794 1461 PSIINITPSTGTANE--LITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNS 1519
Cdd:cd00603     1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 42-151 4.89e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 43.59  E-value: 4.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794    42 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELlIPHSDDlyglkldhangdtgSV 119
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 148676794   120 TCKTTGTYIGHHNVSFILDSDYGRSFPEKMTY 151
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 166-225 5.23e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 43.84  E-value: 5.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148676794  166 PEVVMVSPSKGSTEGGTLLTIHGHFF--DQTDLPVRVLVGGQACAILN---VTENTIYCKTPPKP 225
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLglRKNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAG 65
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1225-1279 5.77e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 43.60  E-value: 5.77e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 148676794 1225 LEVIHMFPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCT 1279
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCT 55
IPT smart00429
ig-like, plexins, transcription factors;
1053-1130 1.10e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.79  E-value: 1.10e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   1053 ISHVWPDSGSLAGGTLLTISGFGF----SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQV----TA 1124
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNggvpSS 83


                    ....*.
gi 148676794   1125 KDSFSY 1130
Cdd:smart00429   84 PQPFTY 89
Amicyanin cd13921
Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; ...
 1294-1374 1.33e-04

Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.


Pssm-ID: 259988 [Multi-domain]  Cd Length: 81  Bit Score: 42.32  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1294 SHLVHGLGYAWSPSVLNVTVGDTVVWswqahpflrgigyrIFSVSSPGSVTYDDKGFTnGRQKSASGSFSYQFTSPGIYY 1373
Cdd:cd13921     1 THVVTIEDFKFNPAEVTVKVGDTVTW--------------TNKDSVPHTVTAEDGAFD-SGMLATGKSFSYTFTAAGTYD 65


                  .
gi 148676794 1374 Y 1374
Cdd:cd13921    66 Y 66
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 963-1050 5.39e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 40.67  E-value: 5.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794  963 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSVGSTRCSLLSVEENEIKCQILNGSAGH-VPVAVSIadvGLAQNLe 1041
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGeAPVKVLI---DGARRL- 76


                  ....*....
gi 148676794 1042 gEGSHFIYR 1050
Cdd:cd01179    77 -APLVFTYT 84
IPT smart00429
ig-like, plexins, transcription factors;
1227-1280 7.49e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 7.49e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 148676794   1227 VIH-MFPQRGSLYGGTEITIMGFGFSTIPTEN-SVLLGSFPCDITSSSENVIKCTL 1280
Cdd:smart00429    3 VITrISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKT 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 42-140 1.10e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 39.75  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   42 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELLiphsddlyglkldhaNGDTGSV 119
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNL-------------GSGSPRVRVTVGGVPCKVL---------------NVSSTEI 52

                          90       100
                  ....*....|....*....|..
gi 148676794  120 TCKT-TGTYIGHHNVSFILDSD 140
Cdd:cd00603    53 VCRTpAAATPGEGPVEVTVDGA 74
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1461-1543 2.34e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 38.98  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794 1461 PSIINITPSTGTAN--ELITIIGHGFSSLPCAnKVTI-GSYPCVVEESSENSIICHIDPQ-NSMNVGIReiVTLIVYNLG 1536
Cdd:cd00102     1 PVITSISPSSGPVSggTEVTITGSNFGSGSNL-RVTFgGGVPCSVLSVSSTAIVCTTPPYaNPGPGPVE--VTVDRGNGG 77


                  ....*..
gi 148676794 1537 TAINTLT 1543
Cdd:cd00102    78 ITSSPLT 84
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1136-1205 4.15e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.45  E-value: 4.15e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 148676794 1136 PVVTDFSPKERTVLGKVNLTIKGYNFGN--ELAQNTVYVGRKHCQVLHSNFTD---ITCLLPTLPPGKHDIYVKV 1205
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSsekIVCTTGPAGNPVFNGPVEV 75
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 42-99 6.43e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 37.68  E-value: 6.43e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 148676794   42 PTIRSITPLSGTP--GTLITIkgrlftdvYGSNTALSSNGRNVRIlriYIGGMPCELLIP 99
Cdd:cd01180     1 PVITEFFPLSGPLegGTRLTI--------CGSNLGLRKNDVRHGV---RVGGVPCNPEPP 49
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 963-1033 7.23e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 37.68  E-value: 7.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 148676794  963 PLILTTTPSEGSYAESTILTIAGS--GFSPT-SAVSVSVGSTRCSLLSVEE---NEIKCQI--LNGSAGHVPVAVSIAD 1033
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNdVRHGVRVGGVPCNPEPPEYsssEKIVCTTgpAGNPVFNGPVEVTVGH 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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