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Conserved domains on  [gi|119628439|gb|EAX08034|]
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ankylosis, progressive homolog (mouse), isoform CRA_a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ANKH super family cl09432
Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis ...
1-345 0e+00

Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralization and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterized by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters.


The actual alignment was detected with superfamily member pfam07260:

Pssm-ID: 429370  Cd Length: 344  Bit Score: 701.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439    1 MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80
Cdd:pfam07260   1 MVDFPSLTAYWPLIRFLVPLAITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439   81 RDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFL 160
Cdd:pfam07260  81 RDRSKAVLCMVVAGAIAAILHTLIAYTDLGYYIINKLHHVDDSVGSKTRKAFLYLAAFPLLDAMAWIHAGILLKHKYSFL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439  161 VGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSF 240
Cdd:pfam07260 161 VGSASISDVVAQIVFVAILLHSNLECFEPLLIPILSLYMGALVRFTIVGLGYYCNIHDIIPDSSGPDMGGDATIKKMLSF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439  241 WWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVSTSnTVT 320
Cdd:pfam07260 241 WWPLALILATQRISRPIVNLFVSRDLKGSSAATEAVAVLTATYPVGHMPYGWLTELRAVYPAFDKNNPSNKLNSGS-MVT 319
                         330       340
                  ....*....|....*....|....*
gi 119628439  321 AAHIKKFTFVCMALSLTLCFVMFWT 345
Cdd:pfam07260 320 KSHIKKFTFCCFALSLTLCFVVFWS 344
 
Name Accession Description Interval E-value
ANKH pfam07260
Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis ...
1-345 0e+00

Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralization and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterized by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters.


Pssm-ID: 429370  Cd Length: 344  Bit Score: 701.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439    1 MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80
Cdd:pfam07260   1 MVDFPSLTAYWPLIRFLVPLAITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439   81 RDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFL 160
Cdd:pfam07260  81 RDRSKAVLCMVVAGAIAAILHTLIAYTDLGYYIINKLHHVDDSVGSKTRKAFLYLAAFPLLDAMAWIHAGILLKHKYSFL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439  161 VGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSF 240
Cdd:pfam07260 161 VGSASISDVVAQIVFVAILLHSNLECFEPLLIPILSLYMGALVRFTIVGLGYYCNIHDIIPDSSGPDMGGDATIKKMLSF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439  241 WWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVSTSnTVT 320
Cdd:pfam07260 241 WWPLALILATQRISRPIVNLFVSRDLKGSSAATEAVAVLTATYPVGHMPYGWLTELRAVYPAFDKNNPSNKLNSGS-MVT 319
                         330       340
                  ....*....|....*....|....*
gi 119628439  321 AAHIKKFTFVCMALSLTLCFVMFWT 345
Cdd:pfam07260 320 KSHIKKFTFCCFALSLTLCFVVFWS 344
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
237-430 2.67e-03

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 39.93  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439 237 MLSFWWPLALILATQRISRPIVNLFVSRDLGgssaaTEAVAILTATYPVGHMPYGWLTEIRAV-YPAFdknnpSNKLVST 315
Cdd:COG2244  175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLG-----PAAVGIYSAAYRLASLLLLLITALSQVlFPRL-----SRLLAEG 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439 316 SNTVTAAHIKKFTFVCMALSLTLCFVMFWtpnVSEKILIDIIGVDFAFAelcVVPLRIFSFFPVPVTVRAHLTGWLMTLK 395
Cdd:COG2244  245 DREELRRLYRKALRLLLLLGLPLALGLAL---LAPPLLSLLFGPEYAEA---APVLPILALGALFLALSGVLSNLLLALG 318
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 119628439 396 KTFVLAPSSVLRIIVLIASLVVL-PYLGVHGATLGV 430
Cdd:COG2244  319 RTRLLLIISLIGAVLNLVLNLLLiPRYGLVGAAIAT 354
 
Name Accession Description Interval E-value
ANKH pfam07260
Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis ...
1-345 0e+00

Progressive ankylosis protein (ANKH); This family consists of several progressive ankylosis protein (ANK or ANKH) sequences. The ANK protein spans the outer cell membrane and shuttles inorganic pyrophosphate (PPi), a major inhibitor of physiologic and pathologic calcification, bone mineralization and bone resorption. Mutations in ANK are thought to give rise to Craniometaphyseal dysplasia (CMD) which is a rare skeletal disorder characterized by progressive thickening and increased mineral density of craniofacial bones and abnormally developed metaphyses in long bones. This family shows distant homology to the MOP (TCDB) superfamily of transporters.


Pssm-ID: 429370  Cd Length: 344  Bit Score: 701.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439    1 MVKFPALTHYWPLIRFLVPLGITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80
Cdd:pfam07260   1 MVDFPSLTAYWPLIRFLVPLAITNIAIDFGEQALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439   81 RDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHVDESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFL 160
Cdd:pfam07260  81 RDRSKAVLCMVVAGAIAAILHTLIAYTDLGYYIINKLHHVDDSVGSKTRKAFLYLAAFPLLDAMAWIHAGILLKHKYSFL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439  161 VGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCLGYYKNIHDIIPDRSGPELGGDATIRKMLSF 240
Cdd:pfam07260 161 VGSASISDVVAQIVFVAILLHSNLECFEPLLIPILSLYMGALVRFTIVGLGYYCNIHDIIPDSSGPDMGGDATIKKMLSF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439  241 WWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVYPAFDKNNPSNKLVSTSnTVT 320
Cdd:pfam07260 241 WWPLALILATQRISRPIVNLFVSRDLKGSSAATEAVAVLTATYPVGHMPYGWLTELRAVYPAFDKNNPSNKLNSGS-MVT 319
                         330       340
                  ....*....|....*....|....*
gi 119628439  321 AAHIKKFTFVCMALSLTLCFVMFWT 345
Cdd:pfam07260 320 KSHIKKFTFCCFALSLTLCFVVFWS 344
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
237-430 2.67e-03

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 39.93  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439 237 MLSFWWPLALILATQRISRPIVNLFVSRDLGgssaaTEAVAILTATYPVGHMPYGWLTEIRAV-YPAFdknnpSNKLVST 315
Cdd:COG2244  175 VLKYSLPLLLSGLLGLLLTNLDRLLLGALLG-----PAAVGIYSAAYRLASLLLLLITALSQVlFPRL-----SRLLAEG 244
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628439 316 SNTVTAAHIKKFTFVCMALSLTLCFVMFWtpnVSEKILIDIIGVDFAFAelcVVPLRIFSFFPVPVTVRAHLTGWLMTLK 395
Cdd:COG2244  245 DREELRRLYRKALRLLLLLGLPLALGLAL---LAPPLLSLLFGPEYAEA---APVLPILALGALFLALSGVLSNLLLALG 318
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 119628439 396 KTFVLAPSSVLRIIVLIASLVVL-PYLGVHGATLGV 430
Cdd:COG2244  319 RTRLLLIISLIGAVLNLVLNLLLiPRYGLVGAAIAT 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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