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Conserved domains on  [gi|119628122|gb|EAX07717|]
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XK, Kell blood group complex subunit-related family, member 8, isoform CRA_a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XK-related super family cl20385
XK-related protein; Members of this family comprise various XK-related proteins, that are ...
 17-162 1.85e-24

XK-related protein; Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome [MIM:314850], an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.


The actual alignment was detected with superfamily member pfam09815:

Pssm-ID: 462912  Cd Length: 332  Bit Score: 96.53  E-value: 1.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628122   17 VLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLASVALQLFSWLWLRADPAGLHGSQPPRRClaLLHLLQLGYL 96
Cdd:pfam09815   3 VLSLLLYLADLVTDIWLAVEYYSEGDYVWFGLTLGFILLPSLVVQIFSLRWYHDDLSKDRTKVEPLLL--LLHLLQLGPL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628122   97 YRCVQELRQGLLVWQQ----EEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAEYY 162
Cdd:pfam09815  81 LRYWDALYYGFKSRKAkerkEEEIEYYERLLVYEEADLSMLRLFEAFLESAPQLILQLYILLQTGQAEVL 150
 
Name Accession Description Interval E-value
XK-related pfam09815
XK-related protein; Members of this family comprise various XK-related proteins, that are ...
 17-162 1.85e-24

XK-related protein; Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome [MIM:314850], an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.


Pssm-ID: 462912  Cd Length: 332  Bit Score: 96.53  E-value: 1.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628122   17 VLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLASVALQLFSWLWLRADPAGLHGSQPPRRClaLLHLLQLGYL 96
Cdd:pfam09815   3 VLSLLLYLADLVTDIWLAVEYYSEGDYVWFGLTLGFILLPSLVVQIFSLRWYHDDLSKDRTKVEPLLL--LLHLLQLGPL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628122   97 YRCVQELRQGLLVWQQ----EEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAEYY 162
Cdd:pfam09815  81 LRYWDALYYGFKSRKAkerkEEEIEYYERLLVYEEADLSMLRLFEAFLESAPQLILQLYILLQTGQAEVL 150
 
Name Accession Description Interval E-value
XK-related pfam09815
XK-related protein; Members of this family comprise various XK-related proteins, that are ...
 17-162 1.85e-24

XK-related protein; Members of this family comprise various XK-related proteins, that are involved in sodium-dependent transport of neutral amino acids or oligopeptides. These proteins are responsible for the Kx blood group system - defects results in McLeod syndrome [MIM:314850], an X-linked multi-system disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.


Pssm-ID: 462912  Cd Length: 332  Bit Score: 96.53  E-value: 1.85e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628122   17 VLGTAAFLLDLGTDLWAAVQYALGGRYLWAALVLALLGLASVALQLFSWLWLRADPAGLHGSQPPRRClaLLHLLQLGYL 96
Cdd:pfam09815   3 VLSLLLYLADLVTDIWLAVEYYSEGDYVWFGLTLGFILLPSLVVQIFSLRWYHDDLSKDRTKVEPLLL--LLHLLQLGPL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119628122   97 YRCVQELRQGLLVWQQ----EEPSEFDLAYADFLALDISMLRLFETFLETAPQLTLVLAIMLQSGRAEYY 162
Cdd:pfam09815  81 LRYWDALYYGFKSRKAkerkEEEIEYYERLLVYEEADLSMLRLFEAFLESAPQLILQLYILLQTGQAEVL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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