HERV-H LTR-associating 3, isoform CRA_a [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| RME-8_N super family | cl44850 | DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in ... |
24-51 | 2.22e-03 | ||
DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in Arabidopsis) is involved in membrane trafficking through early endosomes and in the regulation of endosomal membrane tubulation. It regulates the dynamics of SNX1 (sorting nexin 1) on the endosomal membrane. It coordinates the function of the WASH complex and the retromer SNX dimer through its interaction with FAM21 subunit in WASH complex. This is the N-terminal domain of RME-8, which is required for membrane association and interaction with FAM21 tail domain. It contains critical residues mediating phosphatidylinositol 3-phosphate (PI(3)P) binding, required for its association with endosomes. The actual alignment was detected with superfamily member pfam19432: Pssm-ID: 466078 Cd Length: 819 Bit Score: 34.51 E-value: 2.22e-03
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| Name | Accession | Description | Interval | E-value | ||
| RME-8_N | pfam19432 | DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in ... |
24-51 | 2.22e-03 | ||
DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in Arabidopsis) is involved in membrane trafficking through early endosomes and in the regulation of endosomal membrane tubulation. It regulates the dynamics of SNX1 (sorting nexin 1) on the endosomal membrane. It coordinates the function of the WASH complex and the retromer SNX dimer through its interaction with FAM21 subunit in WASH complex. This is the N-terminal domain of RME-8, which is required for membrane association and interaction with FAM21 tail domain. It contains critical residues mediating phosphatidylinositol 3-phosphate (PI(3)P) binding, required for its association with endosomes. Pssm-ID: 466078 Cd Length: 819 Bit Score: 34.51 E-value: 2.22e-03
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| Name | Accession | Description | Interval | E-value | ||
| RME-8_N | pfam19432 | DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in ... |
24-51 | 2.22e-03 | ||
DNAJ protein RME-8 N-terminal; DNAJ protein RME-8 (receptor-mediated endocytosis-8; Gvr2 in Arabidopsis) is involved in membrane trafficking through early endosomes and in the regulation of endosomal membrane tubulation. It regulates the dynamics of SNX1 (sorting nexin 1) on the endosomal membrane. It coordinates the function of the WASH complex and the retromer SNX dimer through its interaction with FAM21 subunit in WASH complex. This is the N-terminal domain of RME-8, which is required for membrane association and interaction with FAM21 tail domain. It contains critical residues mediating phosphatidylinositol 3-phosphate (PI(3)P) binding, required for its association with endosomes. Pssm-ID: 466078 Cd Length: 819 Bit Score: 34.51 E-value: 2.22e-03
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