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Conserved domains on  [gi|119614808|gb|EAW94402|]
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DEAH (Asp-Glu-Ala-His) box polypeptide 40, isoform CRA_a, partial [Homo sapiens]

Protein Classification

DEAD/DEAH box helicase family protein( domain architecture ID 1000205)

DEAD/DEAH box helicase family protein such as a DEAD/DEAH box-containing ATP-dependent helicase, which catalyzes the unwinding of DNA or RNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 3-91 2.29e-58

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd17984:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 178  Bit Score: 177.74  E-value: 2.29e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAF 82
Cdd:cd17984   90 KETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAF 169


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17984  170 FGNCPVFDI 178
 
Name Accession Description Interval E-value
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 3-91 2.29e-58

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 177.74  E-value: 2.29e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAF 82
Cdd:cd17984   90 KETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAF 169


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17984  170 FGNCPVFDI 178
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
5-98 2.26e-29

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 110.56  E-value: 2.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   5 TAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAFFG 84
Cdd:COG1643  101 TRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARLLG 176

                         90
                 ....*....|....
gi 119614808  85 NCPIFDIPGRLYPV 98
Cdd:COG1643  177 DAPVIESSGRTYPV 190
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 5-98 2.05e-23

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 93.59  E-value: 2.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808    5 TAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFG 84
Cdd:PRK11131  164 TMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELL----PRRPD-LKVIITSATIDPERFSRHFN 238

                          90
                  ....*....|....
gi 119614808   85 NCPIFDIPGRLYPV 98
Cdd:PRK11131  239 NAPIIEVSGRTYPV 252
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 2-98 2.45e-23

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 93.29  E-value: 2.45e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808     2 KQETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSA 81
Cdd:TIGR01967  154 SSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLP-----RRPDLKIIITSATIDPERFSR 228

                           90
                   ....*....|....*..
gi 119614808    82 FFGNCPIFDIPGRLYPV 98
Cdd:TIGR01967  229 HFNNAPIIEVSGRTYPV 245
DEXDc smart00487
DEAD-like helicases superfamily;
2-97 8.15e-11

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 56.35  E-value: 8.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808     2 KQETAIKYMTDGCLLKHILGDP-NLTKFSVIILDEAHERT--LTTDILFGLLKKLfqekspnrKEHLKVVVMSATM--EL 76
Cdd:smart00487 103 SGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL--------PKNVQLLLLSATPpeEI 174

                           90       100
                   ....*....|....*....|.
gi 119614808    77 AKLSAFFGNCPIFDIPGRLYP 97
Cdd:smart00487 175 ENLLELFLNDPVFIDVGFTPL 195
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 7-74 5.76e-04

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 37.22  E-value: 5.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119614808    7 IKYMTDGCLLKHILGDPNLTKFSVIILDEAHErtlTTDILFG-LLKKLFQEKSPNRkehlKVVVMSATM 74
Cdd:pfam00270  97 ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpDLEEILRRLPKKR----QILLLSATL 158
 
Name Accession Description Interval E-value
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 3-91 2.29e-58

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 177.74  E-value: 2.29e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAF 82
Cdd:cd17984   90 KETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAF 169


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17984  170 FGNCPVFDI 178
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 4-91 8.45e-42

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 135.28  E-value: 8.45e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   4 ETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFF 83
Cdd:cd17917   77 KTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLR-----KRPDLKVILMSATLDAEKFSSYF 151


                 ....*...
gi 119614808  84 GNCPIFDI 91
Cdd:cd17917  152 GGAPVIHI 159
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 3-92 1.64e-36

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 122.21  E-value: 1.64e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAF 82
Cdd:cd17971   95 PETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQ-----KRPDLKLIVTSATLDAVKFSQY 169

                         90
                 ....*....|
gi 119614808  83 FGNCPIFDIP 92
Cdd:cd17971  170 FYEAPIFTIP 179
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 3-91 2.32e-36

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 121.80  E-value: 2.32e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAF 82
Cdd:cd17983   90 ENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVA-----RRRDLKLIVTSATMDADKFADF 164


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17983  165 FGNVPIFTI 173
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 4-91 1.71e-35

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 119.77  E-value: 1.71e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   4 ETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFF 83
Cdd:cd17978   91 ETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEQKLSPLKVIIMSATLDADLFSEYF 170


                 ....*...
gi 119614808  84 GNCPIFDI 91
Cdd:cd17978  171 NGAPVLYI 178
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 5-91 8.59e-32

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 110.58  E-value: 8.59e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   5 TAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFG 84
Cdd:cd17973  106 TILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVR-----RRPDLKLIVMSATLDAGKFQKYFD 180


                 ....*..
gi 119614808  85 NCPIFDI 91
Cdd:cd17973  181 NAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 3-91 5.23e-30

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 105.66  E-value: 5.23e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfqekSPNRKEhLKVVVMSATMELAKLSAF 82
Cdd:cd17974   91 EKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDI----ARFRPD-LKLLISSATMDAEKFSAF 165


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17974  166 FDDAPIFRI 174
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
5-98 2.26e-29

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 110.56  E-value: 2.26e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   5 TAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAFFG 84
Cdd:COG1643  101 TRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARLLG 176

                         90
                 ....*....|....
gi 119614808  85 NCPIFDIPGRLYPV 98
Cdd:COG1643  177 DAPVIESSGRTYPV 190
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 2-83 1.09e-27

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 99.85  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   2 KQETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSA 81
Cdd:cd17980   91 PQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQK-----KRGDLRLIVASATLDAEKFRD 165


                 ..
gi 119614808  82 FF 83
Cdd:cd17980  166 FF 167
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 4-92 1.37e-24

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 92.03  E-value: 1.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   4 ETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLL-------KKLFqeKSPNRKEHLKVVVMSATMel 76
Cdd:cd17982   95 NTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLsrivplrAKLY--LQDQTVKPLKLVIMSATL-- 170

                         90
                 ....*....|....*.
gi 119614808  77 aKLSAFFGNCPIFDIP 92
Cdd:cd17982  171 -RVEDFTENKLLFPRP 185
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 5-98 2.05e-23

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 93.59  E-value: 2.05e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808    5 TAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFG 84
Cdd:PRK11131  164 TMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELL----PRRPD-LKVIITSATIDPERFSRHFN 238

                          90
                  ....*....|....
gi 119614808   85 NCPIFDIPGRLYPV 98
Cdd:PRK11131  239 NAPIIEVSGRTYPV 252
DEAH_box_HrpA TIGR01967
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ...
 2-98 2.45e-23

RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273900 [Multi-domain]  Cd Length: 1283  Bit Score: 93.29  E-value: 2.45e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808     2 KQETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSA 81
Cdd:TIGR01967  154 SSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLP-----RRPDLKIIITSATIDPERFSR 228

                           90
                   ....*....|....*..
gi 119614808    82 FFGNCPIFDIPGRLYPV 98
Cdd:TIGR01967  229 HFNNAPIIEVSGRTYPV 245
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 5-89 1.31e-21

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 83.92  E-value: 1.31e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   5 TAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEkspnRKEHLKVVVMSATMELAKLSAFFG 84
Cdd:cd17990   92 TRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQL----LRDDLRLLAMSATLDGDGLAALLP 167


                 ....*
gi 119614808  85 NCPIF 89
Cdd:cd17990  168 EAPVV 172
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 2-91 5.94e-21

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 82.58  E-value: 5.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   2 KQETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFqekspNRKEHLKVVVMSATMELAKLSA 81
Cdd:cd17981   96 RKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLL-----PFRSDLKVILMSATLNAEKFSD 170

                         90
                 ....*....|
gi 119614808  82 FFGNCPIFDI 91
Cdd:cd17981  171 YFNNCPMIHI 180
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 2-91 2.21e-20

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 80.96  E-value: 2.21e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   2 KQETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSA 81
Cdd:cd17989   89 SDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLL----PRRPD-LKVIITSATIDAERFSR 163

                         90
                 ....*....|
gi 119614808  82 FFGNCPIFDI 91
Cdd:cd17989  164 HFNNAPIIEV 173
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 3-91 6.92e-19

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 77.10  E-value: 6.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAF 82
Cdd:cd17979   87 LATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLR-----LRPDLKLILMSATINIELFSGY 161


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17979  162 FEGAPVVQV 170
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 3-91 2.79e-18

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 75.63  E-value: 2.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEkspnRKEhLKVVVMSATMELAKLSAF 82
Cdd:cd17977   93 NETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLS----RPE-LKLVIITCPHLSSKLLSY 167


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17977  168 YGNVPLIEV 176
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 6-88 1.09e-16

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 71.36  E-value: 1.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   6 AIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGN 85
Cdd:cd17976   98 ALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNP-----ELRVVLMSATGDNQRLSRYFGG 172


                 ...
gi 119614808  86 CPI 88
Cdd:cd17976  173 CPV 175
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 3-91 1.16e-16

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 71.41  E-value: 1.16e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAF 82
Cdd:cd17985   94 SATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRP-----DLKVILMSATLNAELFSDY 168


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17985  169 FNSCPVIHI 177
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 3-91 8.55e-16

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 69.17  E-value: 8.55e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAF 82
Cdd:cd17975  100 EATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRS-----DLHLILMSATVDCEKFSSY 174


                 ....*....
gi 119614808  83 FGNCPIFDI 91
Cdd:cd17975  175 FTHCPILRI 183
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 3-84 3.42e-15

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 67.53  E-value: 3.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSpnrkEHLKVVVMSATMELAKLSAF 82
Cdd:cd17988   92 EETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNS----RHVKIILMSATISCKEFADY 167


                 ..
gi 119614808  83 FG 84
Cdd:cd17988  168 FT 169
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 4-91 1.08e-14

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 66.46  E-value: 1.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   4 ETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEkspnRKEHLKVVVMSATMElAKLSAFF 83
Cdd:cd17986   95 NTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQ----RPELRVVVVTSPALE-PKLRAFW 169


                 ....*...
gi 119614808  84 GNCPIFDI 91
Cdd:cd17986  170 GNPPVVHV 177
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 11-98 1.49e-12

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 62.63  E-value: 1.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808  11 TDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLLKKLfQEkspNRKEHLKVVVMSATMELAKLSAFFGNCPIFD 90
Cdd:PRK11664 100 TEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDV-QQ---GLRDDLKLLIMSATLDNDRLQQLLPDAPVIV 175


                 ....*...
gi 119614808  91 IPGRLYPV 98
Cdd:PRK11664 176 SEGRSFPV 183
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 3-91 3.32e-12

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 59.84  E-value: 3.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   3 QETAIKYMTDGCLLKHIL-GDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSA 81
Cdd:cd17987   92 PKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHP-----NLKLILSSAALDVNLFIR 166

                         90
                 ....*....|
gi 119614808  82 FFGNCPIFDI 91
Cdd:cd17987  167 YFGSCPVIYI 176
DEXDc smart00487
DEAD-like helicases superfamily;
2-97 8.15e-11

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 56.35  E-value: 8.15e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808     2 KQETAIKYMTDGCLLKHILGDP-NLTKFSVIILDEAHERT--LTTDILFGLLKKLfqekspnrKEHLKVVVMSATM--EL 76
Cdd:smart00487 103 SGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL--------PKNVQLLLLSATPpeEI 174

                           90       100
                   ....*....|....*....|.
gi 119614808    77 AKLSAFFGNCPIFDIPGRLYP 97
Cdd:smart00487 175 ENLLELFLNDPVFIDVGFTPL 195
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 6-91 1.07e-10

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 56.38  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808   6 AIKYMTDGCLLKHIlgDPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQeKSPNrkehLKVVVMSATMELAKLSAFFGN 85
Cdd:cd17972  156 SILFCTVGVLLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQ-AYPD----LRVILMSATIDTSMFCEYFFN 228


                 ....*.
gi 119614808  86 CPIFDI 91
Cdd:cd17972  229 CPVIEV 234
PHA02653 PHA02653
RNA helicase NPH-II; Provisional
 24-111 3.28e-07

RNA helicase NPH-II; Provisional


Pssm-ID: 177443 [Multi-domain]  Cd Length: 675  Bit Score: 47.28  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808  24 NLTKFSVIILDEAHERTLTTDILFGLLKKLfqeksPNRKEHLkvVVMSATME--LAKLSAFFGNcPIF-DIPG-RLYPVR 99
Cdd:PHA02653 288 KLFDYGTVIIDEVHEHDQIGDIIIAVARKH-----IDKIRSL--FLMTATLEddRDRIKEFFPN-PAFvHIPGgTLFPIS 359

                         90
                 ....*....|...
gi 119614808 100 EKFC-NLIGPRDR 111
Cdd:PHA02653 360 EVYVkNKYNPKNK 372
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 27-119 5.58e-04

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 37.90  E-value: 5.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119614808  27 KFSVIILDEAH----ERTLTTDILFGLlkklfqeKSPNRkehlkvVVMSAT-MELaKLSAFFGncpIFDI--PGRLYPV- 98
Cdd:COG0553  358 DWDLVILDEAQhiknPATKRAKAVRAL-------KARHR------LALTGTpVEN-RLEELWS---LLDFlnPGLLGSLk 420

                         90       100
                 ....*....|....*....|...
gi 119614808  99 --REKFCNLIGPRDRENTAYIQA 119
Cdd:COG0553  421 afRERFARPIEKGDEEALERLRR 443
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
 7-74 5.76e-04

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 37.22  E-value: 5.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119614808    7 IKYMTDGCLLKHILGDPNLTKFSVIILDEAHErtlTTDILFG-LLKKLFQEKSPNRkehlKVVVMSATM 74
Cdd:pfam00270  97 ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpDLEEILRRLPKKR----QILLLSATL 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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