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Conserved domains on  [gi|119601499|gb|EAW81093|]
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presenilin 1 (Alzheimer disease 3), isoform CRA_c [Homo sapiens]

Protein Classification

A22B family peptidase( domain architecture ID 3497)

A22B family peptidase similar to Arabidopsis thaliana signal peptide peptidase-like 1, an intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Presenilin super family cl47627
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
 76-161 1.34e-44

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


The actual alignment was detected with superfamily member pfam01080:

Pssm-ID: 460052  Cd Length: 394  Bit Score: 151.61  E-value: 1.34e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601499   76 KYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT--RKDGQ-LIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVV 152
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSsqVNDEAsLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80


                  ....*....
gi 119601499  153 LYKYRCYKV 161
Cdd:pfam01080  81 LYKYRCYKV 89
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
 76-161 1.34e-44

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 151.61  E-value: 1.34e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601499   76 KYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT--RKDGQ-LIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVV 152
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSsqVNDEAsLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80


                  ....*....
gi 119601499  153 LYKYRCYKV 161
Cdd:pfam01080  81 LYKYRCYKV 89
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
 130-180 1.14e-05

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 44.16  E-value: 1.14e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 119601499   130 LHSILNAAIMISVIVVMTILLVVLYKYRCYKVsmrhrsLLSTLFFLWLGIL 180
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFKYLV------IVLVIYFSSLGVL 45
 
Name Accession Description Interval E-value
Presenilin pfam01080
Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It ...
 76-161 1.34e-44

Presenilin; Mutations in presenilin-1 are a major cause of early onset Alzheimer's disease. It has been found that presenilin-1 binds to beta-catenin in-vivo. This family also contains SPE proteins from C.elegans.


Pssm-ID: 460052  Cd Length: 394  Bit Score: 151.61  E-value: 1.34e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119601499   76 KYGAKHVIMLFVPVTLCMVVVVATIKSVSFYT--RKDGQ-LIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVV 152
Cdd:pfam01080   1 KYGAKQVIKLFVPVSLCMLLVVATIRSISFYSsqVNDEAsLVYTPFHEESDSTGTKLLNSLLNALIFIGVIVVMTFLLVL 80


                  ....*....
gi 119601499  153 LYKYRCYKV 161
Cdd:pfam01080  81 LYKYRCYKV 89
PSN smart00730
Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic ...
 130-180 1.14e-05

Presenilin, signal peptide peptidase, family; Presenilin 1 and presenilin 2 are polytopic membrane proteins, whose genes are mutated in some individuals with Alzheimer's disease. Distant homologues, present in eukaryotes and archaea, also contain conserved aspartic acid residues which are predicted to contribute to catalysis. At least one member of this family has been shown to possess signal peptide peptidase activity.


Pssm-ID: 214793  Cd Length: 249  Bit Score: 44.16  E-value: 1.14e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 119601499   130 LHSILNAAIMISVIVVMTILLVVLYKYRCYKVsmrhrsLLSTLFFLWLGIL 180
Cdd:smart00730   1 EYSLLNSLVAIVFPIVATFVLVLLYKFFKYLV------IVLVIYFSSLGVL 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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