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Conserved domains on  [gi|119594936|gb|EAW74530|]
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mitochondrial ribosomal protein L11, isoform CRA_e [Homo sapiens]

Protein Classification

39S ribosomal L11 family protein( domain architecture ID 12217913)

39S ribosomal L11 family protein similar to mitochondrial 39S ribosomal protein L11

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RL11 smart00649
Ribosomal protein L11/L12;
20-103 1.09e-38

Ribosomal protein L11/L12;


:

Pssm-ID: 197819  Cd Length: 132  Bit Score: 127.26  E-value: 1.09e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936    20 IRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDiKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEK 99
Cdd:smart00649   1 IKLQIPAGKANPAPPLGPALGQLGINIMEFCKEFNARTKD-KKGLPIPVKITVYNDKSFTFILKTPPASALLKKAAGIEK 79


                   ....
gi 119594936   100 GARQ 103
Cdd:smart00649  80 GSKK 83
 
Name Accession Description Interval E-value
RL11 smart00649
Ribosomal protein L11/L12;
20-103 1.09e-38

Ribosomal protein L11/L12;


Pssm-ID: 197819  Cd Length: 132  Bit Score: 127.26  E-value: 1.09e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936    20 IRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDiKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEK 99
Cdd:smart00649   1 IKLQIPAGKANPAPPLGPALGQLGINIMEFCKEFNARTKD-KKGLPIPVKITVYNDKSFTFILKTPPASALLKKAAGIEK 79


                   ....
gi 119594936   100 GARQ 103
Cdd:smart00649  80 GSKK 83
Ribosomal_L11 cd00349
Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S ...
 20-101 5.21e-38

Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal protein L12, which is distinct from the L12 involved in the formation of the L7/L12 stalk. The C-terminal domain (CTD) of L11 is essential for binding 23S rRNA, while the N-terminal domain (NTD) contains the binding site for the antibiotics thiostrepton and micrococcin. L11 and 23S rRNA form an essential part of the GTPase-associated region (GAR). Based on differences in the relative positions of the L11 NTD and CTD during the translational cycle, L11 is proposed to play a significant role in the binding of initiation factors, elongation factors, and release factors to the ribosome. Several factors, including the class I release factors RF1 and RF2, are known to interact directly with L11. In eukaryotes, L11 has been implicated in regulating the levels of ubiquinated p53 and MDM2 in the MDM2-p53 feedback loop, which is responsible for apoptosis in response to DNA damage. In bacteria, the "stringent response" to harsh conditions allows bacteria to survive, and ribosomes that lack L11 are deficient in stringent factor stimulation.


Pssm-ID: 100101  Cd Length: 131  Bit Score: 125.64  E-value: 5.21e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  20 IRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKeGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEK 99
Cdd:cd00349    1 IKLQVPAGKASPAPPLGPALGQLGVNIMKFCKEFNARTKDYK-GLPVPVKITVYNDRSFTFEVKTPPASALLKKAAGIEK 79


                 ..
gi 119594936 100 GA 101
Cdd:cd00349   80 GS 81
RplK COG0080
Ribosomal protein L11 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L11 ...
 15-101 8.20e-36

Ribosomal protein L11 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L11 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439850  Cd Length: 141  Bit Score: 120.19  E-value: 8.20e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  15 EVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDiKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAA 94
Cdd:COG0080    4 KVKGVIKLQVPAGKANPAPPVGPALGQHGVNIMEFCKEFNAKTKD-EKGMIVPVVITVYSDRSFTFIVKTPPASVLLKKA 82


                 ....*..
gi 119594936  95 AGIEKGA 101
Cdd:COG0080   83 AGIEKGS 89
L11_bact TIGR01632
50S ribosomal protein uL11, bacterial form; This model represents bacterial, chloroplast, and ...
 15-104 1.52e-35

50S ribosomal protein uL11, bacterial form; This model represents bacterial, chloroplast, and most mitochondrial forms of 50S ribosomal protein L11. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 233500  Cd Length: 140  Bit Score: 119.37  E-value: 1.52e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936   15 EVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAA 94
Cdd:TIGR01632   2 KIVGIIKLQVPAGQANPAPPVGPALGQRGVNIMEFCKQFNARTADYEPGLPVPVVITVYEDKSFTFIVKTPPVSYLLKKA 81

                          90
                  ....*....|
gi 119594936   95 AGIEKGARQT 104
Cdd:TIGR01632  82 AGVEKGSKNP 91
rplK PRK00140
50S ribosomal protein L11; Validated
 15-101 1.37e-32

50S ribosomal protein L11; Validated


Pssm-ID: 234661  Cd Length: 141  Bit Score: 112.15  E-value: 1.37e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  15 EVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKeGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAA 94
Cdd:PRK00140   4 KVVGYIKLQIPAGKANPAPPVGPALGQRGVNIMEFCKAFNARTQDQK-GLPIPVVITVYEDRSFTFITKTPPASVLLKKA 82


                 ....*..
gi 119594936  95 AGIEKGA 101
Cdd:PRK00140  83 AGIEKGS 89
Ribosomal_L11_N pfam03946
Ribosomal protein L11, N-terminal domain; The N-terminal domain of Ribosomal protein L11 ...
 20-78 1.16e-24

Ribosomal protein L11, N-terminal domain; The N-terminal domain of Ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain.


Pssm-ID: 461103  Cd Length: 58  Bit Score: 89.39  E-value: 1.16e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119594936   20 IRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKeGIPLPTKILVKPDRTF 78
Cdd:pfam03946   1 IKLQVPAGKATPAPPLGPALGPLGVNIMKFCKDFNAATKDYK-GLPVPVKITVYQDRSF 58
 
Name Accession Description Interval E-value
RL11 smart00649
Ribosomal protein L11/L12;
20-103 1.09e-38

Ribosomal protein L11/L12;


Pssm-ID: 197819  Cd Length: 132  Bit Score: 127.26  E-value: 1.09e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936    20 IRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDiKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEK 99
Cdd:smart00649   1 IKLQIPAGKANPAPPLGPALGQLGINIMEFCKEFNARTKD-KKGLPIPVKITVYNDKSFTFILKTPPASALLKKAAGIEK 79


                   ....
gi 119594936   100 GARQ 103
Cdd:smart00649  80 GSKK 83
Ribosomal_L11 cd00349
Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S ...
 20-101 5.21e-38

Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal protein L12, which is distinct from the L12 involved in the formation of the L7/L12 stalk. The C-terminal domain (CTD) of L11 is essential for binding 23S rRNA, while the N-terminal domain (NTD) contains the binding site for the antibiotics thiostrepton and micrococcin. L11 and 23S rRNA form an essential part of the GTPase-associated region (GAR). Based on differences in the relative positions of the L11 NTD and CTD during the translational cycle, L11 is proposed to play a significant role in the binding of initiation factors, elongation factors, and release factors to the ribosome. Several factors, including the class I release factors RF1 and RF2, are known to interact directly with L11. In eukaryotes, L11 has been implicated in regulating the levels of ubiquinated p53 and MDM2 in the MDM2-p53 feedback loop, which is responsible for apoptosis in response to DNA damage. In bacteria, the "stringent response" to harsh conditions allows bacteria to survive, and ribosomes that lack L11 are deficient in stringent factor stimulation.


Pssm-ID: 100101  Cd Length: 131  Bit Score: 125.64  E-value: 5.21e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  20 IRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKeGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEK 99
Cdd:cd00349    1 IKLQVPAGKASPAPPLGPALGQLGVNIMKFCKEFNARTKDYK-GLPVPVKITVYNDRSFTFEVKTPPASALLKKAAGIEK 79


                 ..
gi 119594936 100 GA 101
Cdd:cd00349   80 GS 81
RplK COG0080
Ribosomal protein L11 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L11 ...
 15-101 8.20e-36

Ribosomal protein L11 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L11 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439850  Cd Length: 141  Bit Score: 120.19  E-value: 8.20e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  15 EVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDiKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAA 94
Cdd:COG0080    4 KVKGVIKLQVPAGKANPAPPVGPALGQHGVNIMEFCKEFNAKTKD-EKGMIVPVVITVYSDRSFTFIVKTPPASVLLKKA 82


                 ....*..
gi 119594936  95 AGIEKGA 101
Cdd:COG0080   83 AGIEKGS 89
L11_bact TIGR01632
50S ribosomal protein uL11, bacterial form; This model represents bacterial, chloroplast, and ...
 15-104 1.52e-35

50S ribosomal protein uL11, bacterial form; This model represents bacterial, chloroplast, and most mitochondrial forms of 50S ribosomal protein L11. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 233500  Cd Length: 140  Bit Score: 119.37  E-value: 1.52e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936   15 EVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAA 94
Cdd:TIGR01632   2 KIVGIIKLQVPAGQANPAPPVGPALGQRGVNIMEFCKQFNARTADYEPGLPVPVVITVYEDKSFTFIVKTPPVSYLLKKA 81

                          90
                  ....*....|
gi 119594936   95 AGIEKGARQT 104
Cdd:TIGR01632  82 AGVEKGSKNP 91
rplK PRK00140
50S ribosomal protein L11; Validated
 15-101 1.37e-32

50S ribosomal protein L11; Validated


Pssm-ID: 234661  Cd Length: 141  Bit Score: 112.15  E-value: 1.37e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  15 EVGGVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKeGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAA 94
Cdd:PRK00140   4 KVVGYIKLQIPAGKANPAPPVGPALGQRGVNIMEFCKAFNARTQDQK-GLPIPVVITVYEDRSFTFITKTPPASVLLKKA 82


                 ....*..
gi 119594936  95 AGIEKGA 101
Cdd:PRK00140  83 AGIEKGS 89
Ribosomal_L11_N pfam03946
Ribosomal protein L11, N-terminal domain; The N-terminal domain of Ribosomal protein L11 ...
 20-78 1.16e-24

Ribosomal protein L11, N-terminal domain; The N-terminal domain of Ribosomal protein L11 adopts an alpha/beta fold and is followed by the RNA binding C-terminal domain.


Pssm-ID: 461103  Cd Length: 58  Bit Score: 89.39  E-value: 1.16e-24
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 119594936   20 IRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKeGIPLPTKILVKPDRTF 78
Cdd:pfam03946   1 IKLQVPAGKATPAPPLGPALGPLGVNIMKFCKDFNAATKDYK-GLPVPVKITVYQDRSF 58
rpl11 CHL00127
ribosomal protein L11; Validated
 18-101 2.22e-23

ribosomal protein L11; Validated


Pssm-ID: 177049  Cd Length: 140  Bit Score: 88.58  E-value: 2.22e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  18 GVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDiKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGI 97
Cdd:CHL00127   7 AIIKLALPAGKATPAPPVGPALGQHGVNINLFCKEYNARTKD-KIGLIIPVEISVYEDKSYTFILKTPPASVLLAKAAGI 85


                 ....
gi 119594936  98 EKGA 101
Cdd:CHL00127  86 KKGS 89
rpl11p PRK01143
50S ribosomal protein L11P; Validated
 18-101 8.12e-22

50S ribosomal protein L11P; Validated


Pssm-ID: 234908  Cd Length: 163  Bit Score: 84.95  E-value: 8.12e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  18 GVIRAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTKDIKeGIPLPTKILVKPD-RTFEIKIGQPTVSYFLKAAAG 96
Cdd:PRK01143   3 KVVEVLVEGGKATPGPPLGPALGPLGLNVKQVVQEINEKTKDFK-GMQVPVKVIVDTDtKKFEIEVGIPPTTALIKKELG 81


                 ....*
gi 119594936  97 IEKGA 101
Cdd:PRK01143  82 IEKGS 86
PRK14539 PRK14539
50S ribosomal protein L11/unknown domain fusion protein; Provisional
 11-101 2.27e-11

50S ribosomal protein L11/unknown domain fusion protein; Provisional


Pssm-ID: 184732  Cd Length: 196  Bit Score: 58.41  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  11 LRKPEVGGVIRAIVRAGLAMPGPPLGPVlgqrGVSINQFCKEFNERTKDiKEGIPLPTKILVKPDRTFEIKIGQPTVSYF 90
Cdd:PRK14539   1 MAKKEVVKVAKLQFNAGQAKPGPSLAGV----GINMPEFTKQFNDATRD-RGGEPVPVQITVYKDKSFDFKLFTAPASFK 75

                         90
                 ....*....|.
gi 119594936  91 LKAAAGIEKGA 101
Cdd:PRK14539  76 IKQAAKIKSGS 86
PTZ00321 PTZ00321
ribosomal protein L11; Provisional
 21-107 6.45e-08

ribosomal protein L11; Provisional


Pssm-ID: 240358 [Multi-domain]  Cd Length: 342  Bit Score: 49.98  E-value: 6.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119594936  21 RAIVRAGLAMPGPPLGPVLGQRGVSINQFCKEFNERTK-DIKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAagIEK 99
Cdd:PTZ00321  54 RFFIKAGKAATGPPVGQEFSKLGLKAMDFAKSFNDRTKpHFKDDVELIVRIQVYFDKSYLFTIEPPPTAWFILRA--LRK 131


                 ....*...
gi 119594936 100 GARQTASV 107
Cdd:PTZ00321 132 KRRETGPV 139
Ribosomal_L11 pfam00298
Ribosomal protein L11, RNA binding domain;
83-103 3.72e-03

Ribosomal protein L11, RNA binding domain;


Pssm-ID: 459750  Cd Length: 69  Bit Score: 33.85  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|.
gi 119594936   83 GQPTVSYFLKAAAGIEKGARQ 103
Cdd:pfam00298   1 KTPPASYLLKKAAGIEKGSGK 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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