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Conserved domains on  [gi|119594807|gb|EAW74401|]
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latent transforming growth factor beta binding protein 3, isoform CRA_a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 379-421 2.09e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 2.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 119594807  379 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 421
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-233 1.63e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119594807   194 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 233
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
235-275 1.92e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 119594807   235 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 275
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 110-144 2.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.33e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 119594807 110 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 144
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 549-584 1.10e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119594807  549 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 584
Cdd:pfam00683   1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
316-349 2.93e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 119594807   316 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 349
Cdd:smart00179   1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-315 4.65e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 4.65e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119594807   276 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 315
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
486-514 2.14e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 119594807   486 DVDECLDESNCRNG-VCENTRGGYRCACTP 514
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-186 9.28e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 9.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 119594807   153 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 186
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 379-421 2.09e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 2.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 119594807  379 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 421
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-233 1.63e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119594807   194 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 233
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
235-275 1.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 119594807   235 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 275
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 110-144 2.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.33e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 119594807 110 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 144
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
110-142 3.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 3.83e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119594807   110 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 142
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 549-584 1.10e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119594807  549 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 584
Cdd:pfam00683   1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 235-269 1.11e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.11e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 119594807 235 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 269
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 194-224 1.95e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.95e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 119594807 194 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 224
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
316-349 2.93e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 119594807   316 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 349
Cdd:smart00179   1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 316-349 4.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 119594807 316 DIDECSQdPSLCLPHGACKNLQGSYVCVCDEGFT 349
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-315 4.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 4.65e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119594807   276 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 315
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 276-315 1.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 119594807 276 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 315
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
486-514 2.14e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 119594807   486 DVDECLDESNCRNG-VCENTRGGYRCACTP 514
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
276-305 3.90e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119594807  276 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 305
Cdd:pfam07645   1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
235-264 3.98e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 3.98e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119594807  235 DVDEC-EAGDVCD-NGICSNTPGSFQCQCLSG 264
Cdd:pfam07645   1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 486-514 6.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 6.22e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 119594807 486 DVDECLDESNCRN-GVCENTRGGYRCACTP 514
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-186 9.28e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 9.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 119594807   153 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 186
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 379-421 2.09e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 47.66  E-value: 2.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 119594807  379 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 421
Cdd:pfam00683   3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
194-233 1.63e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 1.63e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119594807   194 DVNECAEGSPCSPG-WCENLPGSFRCTCAQGYApapDGRSC 233
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
235-275 1.92e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 119594807   235 DVDECEAGDVCDNG-ICSNTPGSFQCQCLSGYHlsrDRSHCE 275
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 110-144 2.33e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.33e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 119594807 110 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLK 144
Cdd:cd00054    1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
110-142 3.83e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 3.83e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119594807   110 DLNECAKPHLCGDGGFCINFPGHYKCNCYPGYR 142
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 549-584 1.10e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 39.95  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119594807  549 GMCAGPLAGpALTFDDCCCR-QGRGWGAQCRPCPPRG 584
Cdd:pfam00683   1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPG 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 235-269 1.11e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.11e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 119594807 235 DVDECEAGDVCDN-GICSNTPGSFQCQCLSGYHLSR 269
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 194-224 1.95e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 1.95e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 119594807 194 DVNECAEGSPCSP-GWCENLPGSFRCTCAQGY 224
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
316-349 2.93e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 2.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 119594807   316 DIDECSqDPSLCLPHGACKNLQGSYVCVCDEGFT 349
Cdd:smart00179   1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 316-349 4.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 119594807 316 DIDECSQdPSLCLPHGACKNLQGSYVCVCDEGFT 349
Cdd:cd00054    1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
276-315 4.65e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 4.65e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 119594807   276 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 315
Cdd:smart00179   1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 276-315 1.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 119594807 276 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 315
Cdd:cd00054    1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 189-232 1.60e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.45  E-value: 1.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 119594807 189 GGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDGRS 232
Cdd:cd01475  181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
486-514 2.14e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 119594807   486 DVDECLDESNCRNG-VCENTRGGYRCACTP 514
Cdd:smart00179   1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
276-305 3.90e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 3.90e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119594807  276 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 305
Cdd:pfam07645   1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
235-264 3.98e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 3.98e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 119594807  235 DVDEC-EAGDVCD-NGICSNTPGSFQCQCLSG 264
Cdd:pfam07645   1 DVDECaTGTHNCPaNTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 230-270 5.15e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 38.91  E-value: 5.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 119594807 230 GRSCLDVDECEAGD-VCDNgICSNTPGSFQCQCLSGYHLSRD 270
Cdd:cd01475  181 GKICVVPDLCATLShVCQQ-VCISTPGSYLCACTEGYALLED 221
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 486-514 6.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 6.22e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 119594807 486 DVDECLDESNCRN-GVCENTRGGYRCACTP 514
Cdd:cd00054    1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF smart00181
Epidermal growth factor-like domain;
238-270 7.95e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 34.41  E-value: 7.95e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 119594807   238 ECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRD 270
Cdd:smart00181   1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
153-186 9.28e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 34.53  E-value: 9.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 119594807   153 DIDECRDPSSC-PDGKCENKPGSFKCIaCQPGYRS 186
Cdd:smart00179   1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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