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Conserved domains on  [gi|119591820|gb|EAW71414|]
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polymerase (RNA) III (DNA directed) polypeptide G (32kD) like, isoform CRA_c [Homo sapiens]

Protein Classification

RPC7 family DNA-directed RNA polymerase III subunit( domain architecture ID 10569492)

RPC7 family DNA-directed RNA polymerase III subunit is a peripheral component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
 37-156 8.34e-18

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


:

Pssm-ID: 463324  Cd Length: 213  Bit Score: 76.64  E-value: 8.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591820   37 PSPLFPPLeFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFIRPAV----------------PKRDVERYSDKYQMSGPI 100
Cdd:pfam11705  15 PSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTGSRTskstgpkgvktkatfdPFDGIERYSDKYLKKERI 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119591820  101 DNAIDWNP-DWRRLPREL------KIRVRKLQKERITILLPKRPPKTTEDK-----EETIQKLEVRRK 156
Cdd:pfam11705  94 LPSLDERPfVKEFFPKELwptldgDDVGIAKKKKKKLGLSKVKSLRNAEDEgeeeeEEEAKGLSLLEK 161
 
Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
 37-156 8.34e-18

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 76.64  E-value: 8.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591820   37 PSPLFPPLeFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFIRPAV----------------PKRDVERYSDKYQMSGPI 100
Cdd:pfam11705  15 PSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTGSRTskstgpkgvktkatfdPFDGIERYSDKYLKKERI 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119591820  101 DNAIDWNP-DWRRLPREL------KIRVRKLQKERITILLPKRPPKTTEDK-----EETIQKLEVRRK 156
Cdd:pfam11705  94 LPSLDERPfVKEFFPKELwptldgDDVGIAKKKKKKLGLSKVKSLRNAEDEgeeeeEEEAKGLSLLEK 161
 
Name Accession Description Interval E-value
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
 37-156 8.34e-18

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 76.64  E-value: 8.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119591820   37 PSPLFPPLeFRPVPLPSGEEGEYVLALKQELRGAMRQLPYFIRPAV----------------PKRDVERYSDKYQMSGPI 100
Cdd:pfam11705  15 PSPLFPPY-PLPVALPLTERERYQVALYLLFREQMHDGPFYTGSRTskstgpkgvktkatfdPFDGIERYSDKYLKKERI 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 119591820  101 DNAIDWNP-DWRRLPREL------KIRVRKLQKERITILLPKRPPKTTEDK-----EETIQKLEVRRK 156
Cdd:pfam11705  94 LPSLDERPfVKEFFPKELwptldgDDVGIAKKKKKKLGLSKVKSLRNAEDEgeeeeEEEAKGLSLLEK 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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