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Conserved domains on  [gi|119590130|gb|EAW69724|]
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WD repeat domain 26, isoform CRA_e [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
137-431 1.38e-50

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 1.38e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 137 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDcsE 216
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 217 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 293
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 294 DTHQRIRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 369
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119590130 370 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
137-431 1.38e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 1.38e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 137 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDcsE 216
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 217 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 293
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 294 DTHQRIRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 369
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119590130 370 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-431 3.75e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 3.75e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 139 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDNYLVACGPDDCseLW 218
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 219 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 285
Cdd:cd00200   77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 286 DGKTVLASDTHQRIRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 364
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119590130 365 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 431
Cdd:cd00200  226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-431 7.12e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 119590130   395 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
395-431 4.35e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.35e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119590130  395 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 367-431 3.83e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 3.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119590130 367 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 431
Cdd:PTZ00420  85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
137-431 1.38e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 176.64  E-value: 1.38e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 137 TQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDcsE 216
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW----DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG--T 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 217 LWLWNVQTGELRTKMsQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLAS 293
Cdd:COG2319  186 VRLWDLATGKLLRTL-TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGhsGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 294 DTHQRIRGYnfeDLTDRNIVQ----EDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFG 369
Cdd:COG2319  265 SADGTVRLW---DLATGELLRtltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS 339

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 119590130 370 gHNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:COG2319  340 -PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
138-431 1.21e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.55  E-value: 1.21e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 138 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPdthlLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDcsEL 217
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 218 WLWNVQTGELRTKMSqSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLD-GNLLDSWEG--VRVQCLWCLSDGKTVLASD 294
Cdd:COG2319  145 RLWDLATGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGhtGAVRSVAFSPDGKLLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 295 THQRIRGYnfeDLTDRNIVQE----DHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTIhsCFGG 370
Cdd:COG2319  224 ADGTVRLW---DLATGKLLRTltghSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFSP 298

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 119590130 371 hNEDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:COG2319  299 -DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-431 3.75e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 155.96  E-value: 3.75e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 139 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLlktlEGHAYGVSYIAWSPDDNYLVACGPDDCseLW 218
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL----KGHTGPVRDVAASADGTYLASGSSDKT--IR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 219 LWNVQTGELRTKMSQsHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGNLLdSWEGVRVQCL----------WCLS--- 285
Cdd:cd00200   77 LWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSR---------DKTIK-VWDVETGKCLttlrghtdwvNSVAfsp 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 286 DGKTVLASDTHQRIRGYNFEDL-TDRNIVQEDHPIMSFTISKNGRLALLNVATQGVHLWDLQDRVLVRKYQGVTQGFYTI 364
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLRTGkCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 119590130 365 hsCFGGHNeDFIASGSEDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQIPsMMASASDDGTVRIW 431
Cdd:cd00200  226 --AFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
141-431 1.01e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 1.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 141 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDdcSELWLW 220
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLL----DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD--GTVRLW 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 221 NVQTGELRTKmSQSHEDSLTSVAWNPDGKRFVTGGQrgqfyqcdlDGnlldsweGVRvqcLWCLSDGKTVlasdthQRIR 300
Cdd:COG2319  106 DLATGLLLRT-LTGHTGAVRSVAFSPDGKTLASGSA---------DG-------TVR---LWDLATGKLL------RTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 301 GYnfedltdrnivqeDHPIMSFTISKNGRLallnvatqgvhlwdlqdrvlvrkyqgvtqgfytihscfgghnedfIASGS 380
Cdd:COG2319  160 GH-------------SGAVTSVAFSPDGKL---------------------------------------------LASGS 181

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 119590130 381 EDHKVYIWHKRSELPIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKLLASGSADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-256 7.26e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 7.26e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 135 CYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWqvdpDTHLLKLLKTLEGHAYGVSYIAWSPdDNYLVACGPDDC 214
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW----DLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDG 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 119590130 215 SeLWLWNVQTGELrTKMSQSHEDSLTSVAWNPDGKRFVTGGQ 256
Cdd:cd00200  242 T-IRVWDLRTGEC-VQTLSGHTNSVTSLAWSPDGKRLASGSA 281
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 141-268 5.73e-09

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 55.06  E-value: 5.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 141 LTEHCNEVWFCKFSNDGTKLA-TGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSyiaWSPDDNYLV-ACGPDDCSELW 218
Cdd:COG0823   26 LTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPS---WSPDGKRLAfVSRSDGRFDIY 102

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 119590130 219 LWNVQTGELRTkmsqsHEDSLTSVAWNPDGKRFV---TGGQRGQFYQCDLDGN 268
Cdd:COG0823  103 VLDLDGGAPRR-----LTDGPGSPSWSPDGRRIVfssDRGGRPDLYVVDLDGR 150
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 395-431 7.12e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 7.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 119590130   395 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
395-431 4.35e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 4.35e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 119590130  395 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 367-431 3.83e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 49.18  E-value: 3.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 119590130 367 CFgghnEDFIASGSEDHKVYIWHKRSEL--------PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 431
Cdd:PTZ00420  85 CF----SEILASGSEDLTIRVWEIPHNDesvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-172 1.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 119590130   139 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 172
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
139-175 2.25e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 2.25e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 119590130 139 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVD 175
Cdd:COG2319  366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
138-172 5.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 119590130  138 QQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIW 172
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 376-431 5.52e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 5.52e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119590130 376 IASGSEDHKVYIWHKRS-ELPIAELTGHTRTVNCVSWNPQipSMMASASDDGTVRIW 431
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDS--STLVSSSTDNTLKLW 687
PTZ00421 PTZ00421
coronin; Provisional
 156-283 7.93e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 7.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 156 DGTKLATGSKDTTVIIWQVDPDTHLLKLLK---TLEGHAYGVSYIAWSPD-DNYLVACGPDdcSELWLWNVQTGELRTKM 231
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIPEEGLTQNISDpivHLQGHTKKVGIVSFHPSaMNVLASAGAD--MVVNVWDVERGKAVEVI 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 119590130 232 SqSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCD-LDGNLLDSWE---GVRVQ-CLWC 283
Cdd:PTZ00421 165 K-CHSDQITSLEWNLDGSLLCTTSKDKKLNIIDpRDGTIVSSVEahaSAKSQrCLWA 220
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 152-249 8.17e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 45.03  E-value: 8.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130  152 KFSNDGTKLATGSKDTTviIW----------QVDPDthllkllktleGHAYGVSYIAWSPDDNYLV--ACGPDDCSELWL 219
Cdd:COG4946   395 VWSPDGKKIAFTDNRGR--LWvvdlasgkvrKVDTD-----------GYGDGISDLAWSPDSKWLAysKPGPNQLSQIFL 461

                          90       100       110
                  ....*....|....*....|....*....|
gi 119590130  220 WNVQTGELrTKMSQSHEDSlTSVAWNPDGK 249
Cdd:COG4946   462 YDVETGKT-VQLTDGRYDD-GSPAFSPDGK 489
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 395-431 1.05e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.05e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 119590130 395 PIAELTGHTRTVNCVSWNPQiPSMMASASDDGTVRIW 431
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVW 36
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 367-431 1.68e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.92  E-value: 1.68e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 119590130 367 CFGGHNEDFIASGSEDHKVYIWH-KRSELpIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 431
Cdd:PLN00181 539 CWNSYIKSQVASSNFEGVVQVWDvARSQL-VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 197-253 2.60e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 41.87  E-value: 2.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 119590130  197 IAWSPDDNYLVACGPDDCS-ELWLWNVQTgelRTKMSQSHEDSLTSVAWNPDGKRFVT 253
Cdd:pfam08662 106 IFWSPFGRLVLLAGFGNLAgDIEFWDVVN---KKKIATAEASNATLCEWSPDGRYFLT 160
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-173 3.01e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 3.01e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 119590130 139 QILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ 173
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 153-249 3.17e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.02  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130  153 FSNDGTKLA-----TGSKDttviIWQVDPDTHLLKLLKTLEGHAYgVSYIAWSPDDNYLVACgpDDCSELWLWNVQTGEL 227
Cdd:COG4946   350 WSPDGKSIAyfsdaSGEYE----LYIAPADGSGEPKQLTLGDLGR-VFNPVWSPDGKKIAFT--DNRGRLWVVDLASGKV 422

                          90       100
                  ....*....|....*....|..
gi 119590130  228 RTKMSQSHEDSLTSVAWNPDGK 249
Cdd:COG4946   423 RKVDTDGYGDGISDLAWSPDSK 444
PTZ00420 PTZ00420
coronin; Provisional
 395-431 3.69e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.55  E-value: 3.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 119590130 395 PIAELTGHTRTVNCVSWNPQIPSMMASASDDGTVRIW 431
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVW 102
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 215-329 4.90e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.73  E-value: 4.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130 215 SELWLWNVQTGELRTKMSQSHEDslTSVAWNPDGKRFV---TGGQRGQFYQCDLDGN---LLDSWEGVRVQCLWcLSDGK 288
Cdd:COG0823   11 SDIYVVDLDGGEPRRLTNSPGID--TSPAWSPDGRRIAftsDRGGGPQIYVVDADGGeprRLTFGGGYNASPSW-SPDGK 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 119590130 289 TVL---ASDTHQRIRGYNFEDLTDRNIVQEDHpimSFTISKNGR 329
Cdd:COG0823   88 RLAfvsRSDGRFDIYVLDLDGGAPRRLTDGPG---SPSWSPDGR 128
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 241-363 4.91e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.64  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119590130  241 SVAWNPDGKRFV-----TGGQrgQFYQCDLDG----------NLLDSWEGVrvqclwcLS-DGKTVLASDTHQRIRGYNF 304
Cdd:COG4946   347 LPAWSPDGKSIAyfsdaSGEY--ELYIAPADGsgepkqltlgDLGRVFNPV-------WSpDGKKIAFTDNRGRLWVVDL 417

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 119590130  305 EDLTDRNIVQE--DHPIMSFTISKNGR-LA---LLNVATQGVHLWDLQDRVLVRkyqgVTQGFYT 363
Cdd:COG4946   418 ASGKVRKVDTDgyGDGISDLAWSPDSKwLAyskPGPNQLSQIFLYDVETGKTVQ----LTDGRYD 478
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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