proprotein convertase subtilisin/kexin type 5, isoform CRA_a [Homo sapiens]
Protein Classification
S8 family peptidase( domain architecture ID 13872968)
S8 family peptidase is a subtilisin-like serine protease containing an Asp/His/Ser catalytic triad that is not homologous to trypsin; similar to Homo sapiens furin, a ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| Peptidases_S8_Protein_convertases_Kexins_Furin-lik | cd04059 | Peptidase S8 family domain in Protein convertases; Protein convertases, whose members include ... |
126-420 | 3.56e-166 | |||||
Peptidase S8 family domain in Protein convertases; Protein convertases, whose members include furins and kexins, are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad that is not homologous to trypsin. Kexins are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein convertases. There is also strong sequence conservation. : Pssm-ID: 173789 [Multi-domain] Cd Length: 297 Bit Score: 485.91 E-value: 3.56e-166
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| P_proprotein | pfam01483 | Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein ... |
505-595 | 4.68e-39 | |||||
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain. : Pssm-ID: 460225 [Multi-domain] Cd Length: 86 Bit Score: 139.33 E-value: 4.68e-39
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| S8_pro-domain | pfam16470 | Peptidase S8 pro-domain; This domain is the pro-domain of several peptidases belonging to ... |
38-114 | 1.25e-36 | |||||
Peptidase S8 pro-domain; This domain is the pro-domain of several peptidases belonging to family S8. : Pssm-ID: 465126 Cd Length: 77 Bit Score: 132.34 E-value: 1.25e-36
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| GF_recep_IV super family | cl37890 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
635-744 | 7.25e-16 | |||||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). The actual alignment was detected with superfamily member pfam14843: Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 75.10 E-value: 7.25e-16
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| FU | smart00261 | Furin-like repeats; |
782-823 | 1.63e-09 | |||||
Furin-like repeats; : Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 54.05 E-value: 1.63e-09
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| FU | smart00261 | Furin-like repeats; |
833-867 | 2.45e-07 | |||||
Furin-like repeats; : Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 47.89 E-value: 2.45e-07
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| FU | smart00261 | Furin-like repeats; |
734-776 | 2.52e-05 | |||||
Furin-like repeats; : Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.11 E-value: 2.52e-05
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| PLAC | pfam08686 | PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ... |
873-910 | 9.06e-05 | |||||
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin. : Pssm-ID: 462560 Cd Length: 31 Bit Score: 40.21 E-value: 9.06e-05
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| Name | Accession | Description | Interval | E-value | |||||
| Peptidases_S8_Protein_convertases_Kexins_Furin-lik | cd04059 | Peptidase S8 family domain in Protein convertases; Protein convertases, whose members include ... |
126-420 | 3.56e-166 | |||||
Peptidase S8 family domain in Protein convertases; Protein convertases, whose members include furins and kexins, are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad that is not homologous to trypsin. Kexins are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein convertases. There is also strong sequence conservation. Pssm-ID: 173789 [Multi-domain] Cd Length: 297 Bit Score: 485.91 E-value: 3.56e-166
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| Peptidase_S8 | pfam00082 | Subtilase family; Subtilases are a family of serine proteases. They appear to have ... |
162-445 | 2.43e-66 | |||||
Subtilase family; Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567. Pssm-ID: 395035 [Multi-domain] Cd Length: 287 Bit Score: 223.88 E-value: 2.43e-66
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| P_proprotein | pfam01483 | Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein ... |
505-595 | 4.68e-39 | |||||
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain. Pssm-ID: 460225 [Multi-domain] Cd Length: 86 Bit Score: 139.33 E-value: 4.68e-39
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| S8_pro-domain | pfam16470 | Peptidase S8 pro-domain; This domain is the pro-domain of several peptidases belonging to ... |
38-114 | 1.25e-36 | |||||
Peptidase S8 pro-domain; This domain is the pro-domain of several peptidases belonging to family S8. Pssm-ID: 465126 Cd Length: 77 Bit Score: 132.34 E-value: 1.25e-36
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| AprE | COG1404 | Serine protease, subtilisin family [Posttranslational modification, protein turnover, ... |
154-420 | 1.51e-34 | |||||
Serine protease, subtilisin family [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 441014 [Multi-domain] Cd Length: 456 Bit Score: 138.31 E-value: 1.51e-34
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| COG4935 | COG4935 | Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
506-597 | 2.31e-18 | |||||
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 90.27 E-value: 2.31e-18
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| GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
635-744 | 7.25e-16 | |||||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 75.10 E-value: 7.25e-16
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| FU | smart00261 | Furin-like repeats; |
782-823 | 1.63e-09 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 54.05 E-value: 1.63e-09
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| PTZ00262 | PTZ00262 | subtilisin-like protease; Provisional |
167-411 | 3.97e-09 | |||||
subtilisin-like protease; Provisional Pssm-ID: 240338 [Multi-domain] Cd Length: 639 Bit Score: 60.37 E-value: 3.97e-09
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
784-825 | 1.21e-08 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 51.75 E-value: 1.21e-08
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
688-738 | 1.42e-08 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 51.37 E-value: 1.42e-08
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| FU | smart00261 | Furin-like repeats; |
683-729 | 7.00e-08 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 49.43 E-value: 7.00e-08
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| FU | smart00261 | Furin-like repeats; |
833-867 | 2.45e-07 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 47.89 E-value: 2.45e-07
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| GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
784-856 | 1.55e-06 | |||||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 48.14 E-value: 1.55e-06
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
837-867 | 3.34e-06 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 44.82 E-value: 3.34e-06
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| FU | smart00261 | Furin-like repeats; |
734-776 | 2.52e-05 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.11 E-value: 2.52e-05
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| PLAC | pfam08686 | PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ... |
873-910 | 9.06e-05 | |||||
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin. Pssm-ID: 462560 Cd Length: 31 Bit Score: 40.21 E-value: 9.06e-05
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
739-781 | 1.07e-04 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 40.58 E-value: 1.07e-04
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| Name | Accession | Description | Interval | E-value | |||||
| Peptidases_S8_Protein_convertases_Kexins_Furin-lik | cd04059 | Peptidase S8 family domain in Protein convertases; Protein convertases, whose members include ... |
126-420 | 3.56e-166 | |||||
Peptidase S8 family domain in Protein convertases; Protein convertases, whose members include furins and kexins, are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad that is not homologous to trypsin. Kexins are involved in the activation of peptide hormones, growth factors, and viral proteins. Furin cleaves cell surface vasoactive peptides and proteins involved in cardiovascular tissue remodeling in the TGN, at cell surface, or in endosomes but rarely in the ER. Furin also plays a key role in blood pressure regulation though the activation of transforming growth factor (TGF)-beta. High specificity is seen for cleavage after dibasic (Lys-Arg or Arg-Arg) or multiple basic residues in protein convertases. There is also strong sequence conservation. Pssm-ID: 173789 [Multi-domain] Cd Length: 297 Bit Score: 485.91 E-value: 3.56e-166
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| Peptidase_S8 | pfam00082 | Subtilase family; Subtilases are a family of serine proteases. They appear to have ... |
162-445 | 2.43e-66 | |||||
Subtilase family; Subtilases are a family of serine proteases. They appear to have independently and convergently evolved an Asp/Ser/His catalytic triad, like that found in the trypsin serine proteases (see pfam00089). Structure is an alpha/beta fold containing a 7-stranded parallel beta sheet, order 2314567. Pssm-ID: 395035 [Multi-domain] Cd Length: 287 Bit Score: 223.88 E-value: 2.43e-66
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| P_proprotein | pfam01483 | Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein ... |
505-595 | 4.68e-39 | |||||
Proprotein convertase P-domain; A unique feature of the eukaryotic subtilisin-like proprotein convertases is the presence of an additional highly conserved sequence of approximately 150 residues (P domain) located immediately downstream of the catalytic domain. Pssm-ID: 460225 [Multi-domain] Cd Length: 86 Bit Score: 139.33 E-value: 4.68e-39
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| S8_pro-domain | pfam16470 | Peptidase S8 pro-domain; This domain is the pro-domain of several peptidases belonging to ... |
38-114 | 1.25e-36 | |||||
Peptidase S8 pro-domain; This domain is the pro-domain of several peptidases belonging to family S8. Pssm-ID: 465126 Cd Length: 77 Bit Score: 132.34 E-value: 1.25e-36
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| Peptidases_S8_15 | cd07498 | Peptidase S8 family domain, uncharacterized subfamily 15; This family is a member of the ... |
165-418 | 7.38e-35 | |||||
Peptidase S8 family domain, uncharacterized subfamily 15; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173822 [Multi-domain] Cd Length: 242 Bit Score: 133.24 E-value: 7.38e-35
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| AprE | COG1404 | Serine protease, subtilisin family [Posttranslational modification, protein turnover, ... |
154-420 | 1.51e-34 | |||||
Serine protease, subtilisin family [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 441014 [Multi-domain] Cd Length: 456 Bit Score: 138.31 E-value: 1.51e-34
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| Peptidases_S8_S53 | cd00306 | Peptidase domain in the S8 and S53 families; Members of the peptidases S8 (subtilisin and ... |
165-418 | 2.34e-30 | |||||
Peptidase domain in the S8 and S53 families; Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) family include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values. Pssm-ID: 173787 [Multi-domain] Cd Length: 241 Bit Score: 120.38 E-value: 2.34e-30
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| Peptidases_S8_Subtilisin_like | cd07473 | Peptidase S8 family domain in Subtilisin-like proteins; This family is a member of the ... |
163-420 | 1.83e-26 | |||||
Peptidase S8 family domain in Subtilisin-like proteins; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173799 [Multi-domain] Cd Length: 259 Bit Score: 109.59 E-value: 1.83e-26
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| Peptidases_S8_Autotransporter_serine_protease_like | cd04848 | Peptidase S8 family domain in Autotransporter serine proteases; Autotransporter serine ... |
161-420 | 1.53e-22 | |||||
Peptidase S8 family domain in Autotransporter serine proteases; Autotransporter serine proteases belong to Peptidase S8 or Subtilase family. Subtilases, or subtilisin-like serine proteases, have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Autotransporters are a superfamily of outer membrane/secreted proteins of gram-negative bacteria. The presence of these subtilisin-like domains in these autotransporters are may enable them to be auto-catalytic and may also serve to allow them to act as a maturation protease cleaving other outer membrane proteins at the cell surface. Pssm-ID: 173794 [Multi-domain] Cd Length: 267 Bit Score: 98.17 E-value: 1.53e-22
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| Peptidases_S8_Thermitase_like | cd07484 | Peptidase S8 family domain in Thermitase-like proteins; Thermitase is a non-specific, ... |
127-420 | 4.08e-22 | |||||
Peptidase S8 family domain in Thermitase-like proteins; Thermitase is a non-specific, trypsin-related serine protease with a very high specific activity. It contains a subtilisin like domain. The tertiary structure of thermitase is similar to that of subtilisin BPN'. It contains a Asp/His/Ser catalytic triad. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values. Pssm-ID: 173810 [Multi-domain] Cd Length: 260 Bit Score: 96.95 E-value: 4.08e-22
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| Peptidases_S8_13 | cd07496 | Peptidase S8 family domain, uncharacterized subfamily 13; This family is a member of the ... |
164-407 | 9.69e-22 | |||||
Peptidase S8 family domain, uncharacterized subfamily 13; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173820 [Multi-domain] Cd Length: 285 Bit Score: 96.21 E-value: 9.69e-22
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| Peptidases_S8_Subtilisin_subset | cd07477 | Peptidase S8 family domain in Subtilisin proteins; This group is composed of many different ... |
164-418 | 8.51e-19 | |||||
Peptidase S8 family domain in Subtilisin proteins; This group is composed of many different subtilisins: Pro-TK-subtilisin, subtilisin Carlsberg, serine protease Pb92 subtilisin, and BPN subtilisins just to name a few. Pro-TK-subtilisin is a serine protease from the hyperthermophilic archaeon Thermococcus kodakaraensis and consists of a signal peptide, a propeptide, and a mature domain. TK-subtilisin is matured from pro-TK-subtilisin upon autoprocessing and degradation of the propeptide. Unlike other subtilisins though, the folding of the unprocessed form of pro-TK-subtilisin is induced by Ca2+ binding which is almost completed prior to autoprocessing. Ca2+ is required for activity unlike the bacterial subtilisins. The propeptide is not required for folding of the mature domain unlike the bacterial subtilases because of the stability produced from Ca2+ binding. Subtilisin Carlsberg is extremely similar in structure to subtilisin BPN'/Novo thought it has a 30% difference in amino acid sequence. The substrate binding regions are also similar and 2 possible Ca2+ binding sites have been identified recently. Subtilisin Carlsberg possesses the highest commercial importance as a proteolytic additive for detergents. Serine protease Pb92, the serine protease from the alkalophilic Bacillus strain PB92, also contains two calcium ions and the overall folding of the polypeptide chain closely resembles that of the subtilisins. Members of the peptidases S8 and S35 clan include endopeptidases, exopeptidases and also a tripeptidyl-peptidase. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The S53 family contains a catalytic triad Glu/Asp/Ser. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173803 [Multi-domain] Cd Length: 229 Bit Score: 86.43 E-value: 8.51e-19
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| COG4935 | COG4935 | Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
506-597 | 2.31e-18 | |||||
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 90.27 E-value: 2.31e-18
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| Peptidases_S8_Fervidolysin_like | cd07485 | Peptidase S8 family domain in Fervidolysin; Fervidolysin found in Fervidobacterium pennivorans ... |
155-404 | 2.38e-18 | |||||
Peptidase S8 family domain in Fervidolysin; Fervidolysin found in Fervidobacterium pennivorans is an extracellular subtilisin-like keratinase. It is contains a signal peptide, a propeptide, and a catalytic region. The tertiary structure of fervidolysin is similar to that of subtilisin. It contains a Asp/His/Ser catalytic triad and is a member of the peptidase S8 (subtilisin and kexin) family. The catalytic triad is similar to that found in trypsin-like proteases, but it does not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53, it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium; some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values. Pssm-ID: 173811 [Multi-domain] Cd Length: 273 Bit Score: 86.00 E-value: 2.38e-18
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| Peptidases_S8_1 | cd07487 | Peptidase S8 family domain, uncharacterized subfamily 1; This family is a member of the ... |
162-418 | 1.16e-17 | |||||
Peptidase S8 family domain, uncharacterized subfamily 1; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173812 [Multi-domain] Cd Length: 264 Bit Score: 83.79 E-value: 1.16e-17
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| GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
635-744 | 7.25e-16 | |||||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 75.10 E-value: 7.25e-16
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| Peptidases_S8_Kp43_protease | cd04842 | Peptidase S8 family domain in Kp43 proteases; Kp43 proteases are members of the peptidase S8 ... |
157-402 | 6.78e-15 | |||||
Peptidase S8 family domain in Kp43 proteases; Kp43 proteases are members of the peptidase S8 or Subtilase clan of proteases. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure (an example of convergent evolution). Kp43 is topologically similar to kexin and furin both of which are proprotein convertases, but differ in amino acids sequence and the position of its C-terminal barrel. Kp43 has 3 Ca2+ binding sites that differ from the corresponding sites in the other known subtilisin-like proteases. KP-43 protease is known to be an oxidation-resistant protease when compared with the other subtilisin-like proteases Pssm-ID: 173791 [Multi-domain] Cd Length: 293 Bit Score: 76.21 E-value: 6.78e-15
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| Peptidases_S8_subtilisin_Vpr-like | cd07474 | Peptidase S8 family domain in Vpr-like proteins; The maturation of the peptide antibiotic ... |
162-428 | 1.52e-14 | |||||
Peptidase S8 family domain in Vpr-like proteins; The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. Vpr was identified as one of the proteases, along with WprA, that are capable of processing subtilin. Asp, Ser, His triadPeptidases S8 or Subtilases are a serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173800 [Multi-domain] Cd Length: 295 Bit Score: 75.44 E-value: 1.52e-14
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| Peptidases_S8_PCSK9_ProteinaseK_like | cd04077 | Peptidase S8 family domain in ProteinaseK-like proteins; The peptidase S8 or Subtilase clan of ... |
160-419 | 9.37e-11 | |||||
Peptidase S8 family domain in ProteinaseK-like proteins; The peptidase S8 or Subtilase clan of proteases have a Asp/His/Ser catalytic triad that is not homologous to trypsin. This CD contains several members of this clan including: PCSK9 (Proprotein convertase subtilisin/kexin type 9), Proteinase_K, Proteinase_T, and other subtilisin-like serine proteases. PCSK9 posttranslationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR. Characterized Proteinases K are secreted endopeptidases with a high degree of sequence conservation. Proteinases K are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity. The number of calcium-binding motifs found in these differ. Proteinase T is a novel proteinase from the fungus Tritirachium album Limber. The amino acid sequence of proteinase T as deduced from the nucleotide sequence is about 56% identical to that of proteinase K. Pssm-ID: 173790 [Multi-domain] Cd Length: 255 Bit Score: 63.30 E-value: 9.37e-11
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| Peptidases_S8_5 | cd07489 | Peptidase S8 family domain, uncharacterized subfamily 5; gap in seq This family is a member of ... |
158-421 | 2.50e-10 | |||||
Peptidase S8 family domain, uncharacterized subfamily 5; gap in seq This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173814 [Multi-domain] Cd Length: 312 Bit Score: 62.62 E-value: 2.50e-10
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| VSP | pfam03302 | Giardia variant-specific surface protein; |
672-806 | 5.88e-10 | |||||
Giardia variant-specific surface protein; Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 62.29 E-value: 5.88e-10
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| Peptidases_S8_10 | cd07494 | Peptidase S8 family domain, uncharacterized subfamily 10; This family is a member of the ... |
150-428 | 6.41e-10 | |||||
Peptidase S8 family domain, uncharacterized subfamily 10; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173819 [Multi-domain] Cd Length: 298 Bit Score: 61.34 E-value: 6.41e-10
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| Peptidases_S8_6 | cd07490 | Peptidase S8 family domain, uncharacterized subfamily 6; This family is a member of the ... |
167-420 | 1.33e-09 | |||||
Peptidase S8 family domain, uncharacterized subfamily 6; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173815 [Multi-domain] Cd Length: 254 Bit Score: 59.87 E-value: 1.33e-09
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| FU | smart00261 | Furin-like repeats; |
782-823 | 1.63e-09 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 54.05 E-value: 1.63e-09
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| PTZ00262 | PTZ00262 | subtilisin-like protease; Provisional |
167-411 | 3.97e-09 | |||||
subtilisin-like protease; Provisional Pssm-ID: 240338 [Multi-domain] Cd Length: 639 Bit Score: 60.37 E-value: 3.97e-09
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| Furin-like | pfam00757 | Furin-like cysteine rich region; |
636-744 | 4.64e-09 | |||||
Furin-like cysteine rich region; Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 55.91 E-value: 4.64e-09
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| Peptidases_S8_12 | cd07480 | Peptidase S8 family domain, uncharacterized subfamily 12; This family is a member of the ... |
160-313 | 9.73e-09 | |||||
Peptidase S8 family domain, uncharacterized subfamily 12; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173806 [Multi-domain] Cd Length: 297 Bit Score: 57.77 E-value: 9.73e-09
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
784-825 | 1.21e-08 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 51.75 E-value: 1.21e-08
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
688-738 | 1.42e-08 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 51.37 E-value: 1.42e-08
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| Furin-like_2 | pfam15913 | Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
669-727 | 1.72e-08 | |||||
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation. Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 52.82 E-value: 1.72e-08
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| VSP | pfam03302 | Giardia variant-specific surface protein; |
623-867 | 2.40e-08 | |||||
Giardia variant-specific surface protein; Pssm-ID: 146106 [Multi-domain] Cd Length: 397 Bit Score: 57.29 E-value: 2.40e-08
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| Peptidases_S53 | cd04056 | Peptidase domain in the S53 family; Members of the peptidases S53 (sedolisin) family include ... |
159-403 | 2.65e-08 | |||||
Peptidase domain in the S53 family; Members of the peptidases S53 (sedolisin) family include endopeptidases and exopeptidases sedolisin, kumamolysin, and (PSCP) Pepstatin-insensitive Carboxyl Proteinase. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of Asn in subtilisin. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Characterized sedolisins include Kumamolisin, an extracellular calcium-dependent thermostable endopeptidase from Bacillus. The enzyme is synthesized with a 188 amino acid N-terminal preprotein region which is cleaved after the extraction into the extracellular space with low pH. One kumamolysin paralog, kumamolisin-As, is believed to be a collagenase. TPP1 is a serine protease that functions as a tripeptidyl exopeptidase as well as an endopeptidase. Less is known about PSCP from Pseudomonas which is thought to be an aspartic proteinase. Pssm-ID: 173788 [Multi-domain] Cd Length: 361 Bit Score: 56.94 E-value: 2.65e-08
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| PTZ00214 | PTZ00214 | high cysteine membrane protein Group 4; Provisional |
632-862 | 2.82e-08 | |||||
high cysteine membrane protein Group 4; Provisional Pssm-ID: 173479 [Multi-domain] Cd Length: 800 Bit Score: 57.62 E-value: 2.82e-08
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| FU | smart00261 | Furin-like repeats; |
683-729 | 7.00e-08 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 49.43 E-value: 7.00e-08
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
635-687 | 2.02e-07 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 48.28 E-value: 2.02e-07
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| FU | smart00261 | Furin-like repeats; |
833-867 | 2.45e-07 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 47.89 E-value: 2.45e-07
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| FU | smart00261 | Furin-like repeats; |
635-679 | 4.64e-07 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 47.12 E-value: 4.64e-07
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| Peptidases_S8_BacillopeptidaseF-like | cd07481 | Peptidase S8 family domain in BacillopeptidaseF-like proteins; Bacillus subtilis produces and ... |
162-404 | 1.40e-06 | |||||
Peptidase S8 family domain in BacillopeptidaseF-like proteins; Bacillus subtilis produces and secretes proteases and other types of exoenzymes at the end of the exponential phase of growth. The ones that make up this group is known as bacillopeptidase F, encoded by bpr, a serine protease with high esterolytic activity which is inhibited by PMSF. Like other members of the peptidases S8 family these have a Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Pssm-ID: 173807 [Multi-domain] Cd Length: 264 Bit Score: 50.84 E-value: 1.40e-06
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| GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
784-856 | 1.55e-06 | |||||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 48.14 E-value: 1.55e-06
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| Peptidases_S8_11 | cd04843 | Peptidase S8 family domain, uncharacterized subfamily 11; This family is a member of the ... |
150-400 | 3.06e-06 | |||||
Peptidase S8 family domain, uncharacterized subfamily 11; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173792 Cd Length: 277 Bit Score: 50.00 E-value: 3.06e-06
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
837-867 | 3.34e-06 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 44.82 E-value: 3.34e-06
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| Peptidases_S8_Lantibiotic_specific_protease | cd07482 | Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific ... |
164-407 | 4.66e-06 | |||||
Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Lantiobiotic (lanthionine-containing antibiotics) specific proteases are very similar in structure to serine proteases. Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides with antimicrobial activities against Gram-positive bacteria. The proteases that cleave the N-terminal leader peptides from lantiobiotics include: epiP, nsuP, mutP, and nisP. EpiP, from Staphylococcus, is thought to cleave matured epidermin. NsuP, a dehydratase from Streptococcus and NisP, a membrane-anchored subtilisin-like serine protease from Lactococcus cleave nisin. MutP is highly similar to epiP and nisP and is thought to process the prepeptide mutacin III of S. mutans. Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 the it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values. Pssm-ID: 173808 [Multi-domain] Cd Length: 294 Bit Score: 49.29 E-value: 4.66e-06
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| Furin-like_2 | pfam15913 | Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
693-774 | 5.36e-06 | |||||
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation. Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 45.88 E-value: 5.36e-06
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| Peptidases_S8_8 | cd07492 | Peptidase S8 family domain, uncharacterized subfamily 8; This family is a member of the ... |
167-420 | 6.92e-06 | |||||
Peptidase S8 family domain, uncharacterized subfamily 8; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173817 [Multi-domain] Cd Length: 222 Bit Score: 48.10 E-value: 6.92e-06
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| Peptidases_S53_like | cd05562 | Peptidase domain in the S53 family; Members of the peptidase S53 (sedolisin) family include ... |
381-453 | 8.54e-06 | |||||
Peptidase domain in the S53 family; Members of the peptidase S53 (sedolisin) family include endopeptidases and exopeptidases. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of Asn in subtilisin. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Characterized sedolisins include Kumamolisin, an extracellular calcium-dependent thermostable endopeptidase from Bacillus. The enzyme is synthesized with a 188 amino acid N-terminal preprotein region which is cleaved after the extraction into the extracellular space with low pH. One kumamolysin paralog, kumamolisin-As, is believed to be a collagenase. TPP1 is a serine protease that functions as a tripeptidyl exopeptidase as well as an endopeptidase. Less is known about PSCP from Pseudomonas which is thought to be an aspartic proteinase. Pssm-ID: 173798 [Multi-domain] Cd Length: 275 Bit Score: 48.44 E-value: 8.54e-06
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| FU | smart00261 | Furin-like repeats; |
734-776 | 2.52e-05 | |||||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 42.11 E-value: 2.52e-05
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| PLAC | pfam08686 | PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ... |
873-910 | 9.06e-05 | |||||
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin. Pssm-ID: 462560 Cd Length: 31 Bit Score: 40.21 E-value: 9.06e-05
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| FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
739-781 | 1.07e-04 | |||||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 40.58 E-value: 1.07e-04
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| Nar1 | COG4624 | Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; |
685-818 | 1.22e-04 | |||||
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion]; Pssm-ID: 443663 [Multi-domain] Cd Length: 450 Bit Score: 45.40 E-value: 1.22e-04
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| Peptidases_S8_14 | cd07497 | Peptidase S8 family domain, uncharacterized subfamily 14; This family is a member of the ... |
162-402 | 1.05e-03 | |||||
Peptidase S8 family domain, uncharacterized subfamily 14; This family is a member of the Peptidases S8 or Subtilases serine endo- and exo-peptidase clan. They have an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. The stability of subtilases may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. Some members of this clan contain disulfide bonds. These enzymes can be intra- and extracellular, some function at extreme temperatures and pH values. Pssm-ID: 173821 [Multi-domain] Cd Length: 311 Bit Score: 42.07 E-value: 1.05e-03
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| TNFRSF1A_teleost | cd15834 | Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) in teleosts; also known as ... |
674-793 | 3.45e-03 | |||||
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) in teleosts; also known as TNFR1; This subfamily of TNFRSF1 ((also known as type I TNFR, TNFR1, DR1, TNFRSF1A, CD120a, p55) is found in teleosts. It binds TNF-alpha, through the death domain (DD), and activates NF-kappaB, mediates apoptosis and activates signaling pathways controlling inflammatory, immune, and stress responses. It mediates signal transduction by interacting with antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRAF2 and TRADD that play regulatory roles. The human genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS), or periodic fever syndrome, is associated with germline mutations of the extracellular domains of this receptor, possibly due to impaired receptor clearance. Serum levels of TNFRSF1A are elevated in schizophrenia and bipolar disorder, and high levels are also associated with cognitive impairment and dementia. Knockout studies in zebrafish embryos have shown that a signaling balance between TNFRSF1A and TNFRSF1B is required for endothelial cell integrity. TNFRSF1A signals apoptosis through caspase-8, whereas TNFRSF1B signals survival via NF-kappaB in endothelial cells. Thus, this apoptotic pathway seems to be evolutionarily conserved, as TNFalpha promotes apoptosis of human endothelial cells and triggers caspase-2 and P53 activation in these cells via TNFRSF1A. Pssm-ID: 276930 [Multi-domain] Cd Length: 150 Bit Score: 39.01 E-value: 3.45e-03
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| Furin-like_2 | pfam15913 | Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ... |
787-867 | 3.71e-03 | |||||
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation. Pssm-ID: 464939 [Multi-domain] Cd Length: 102 Bit Score: 37.80 E-value: 3.71e-03
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