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Conserved domains on  [gi|119574812|gb|EAW54427|]
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cadherin-like 23, isoform CRA_a [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10638917)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 833-931 2.08e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 2.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  833 SYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNpgd 910
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|.
gi 119574812  911 vASNRRENSVQVVIQVLDVND 931
Cdd:cd11304    78 -GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-596 7.43e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 7.43e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  502 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVgNATIDREEQESYRLTVVATDRGTVP 580
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 119574812  581 LSGTAIVTILIDDIND 596
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 179-274 1.27e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 1.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  179 FEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKdvELDRETIAFYNLTICARDRGMPP 257
Cdd:cd11304     4 VSVPENAPpGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAK--PLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 119574812  258 LSSTMLVGIRVLDINDN 274
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1034 1.85e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  940 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEP 1016
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 119574812 1017 PLWGTTMLLVEVIDVNDN 1034
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-382 3.62e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 3.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  282 PMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 361
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90       100
                  ....*....|....*....|.
gi 119574812  362 PRIARRdydLLLIFLSDENDN 382
Cdd:cd11304    81 PLSSTA---TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 65-167 6.36e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 6.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   65 HYEVLLDEGpDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEiSHGRYTLIVTATDQC 144
Cdd:cd11304     1 SYEVSVPEN-APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE-EQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|...
gi 119574812  145 pilSHRLTSTTTVLVNVNDINDN 167
Cdd:cd11304    79 ---GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 728-825 2.41e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 2.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  728 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLeDSSAGKVIANQTVDYEEVHWLNFTVRASDNGSP 807
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 119574812  808 PRAAEIPVYLEIVDINDN 825
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1047-1145 5.52e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 5.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1047 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLktaGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 1126
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 119574812 1127 VPYETMQpLQVALEDIDDN 1145
Cdd:cd11304    81 PLSSTAT-VTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 607-716 7.49e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 7.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  607 TVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGivakddtdrlvPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 684
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVS-----------GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 119574812  685 LSVIDNASdlPERSVSvpnAKLTVNVLDVNDN 716
Cdd:cd11304    72 VTATDGGG--PPLSST---ATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 390-492 1.78e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  390 TYQAEVMENSPAGTPLTVLNgpilALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGviIDREafSPPILELLL 468
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVS----ATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKP--LDRE--EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 119574812  469 LAKDIGL--LNSTAHLLITILDDNDN 492
Cdd:cd11304    73 TATDGGGppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1162-1268 1.31e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1162 LTVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSwtP 1240
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG--P 80

                          90       100
                  ....*....|....*....|....*...
gi 119574812 1241 PRgpsptldlvadLTLQEVRVVLEDIND 1268
Cdd:cd11304    81 PL-----------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3-59 7.44e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 7.44e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 119574812      3 FRMDRISGEIATRpAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAP 59
Cdd:smart00112   26 FSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1277-1378 4.50e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.32  E-value: 4.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1277 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILaihyfralandSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFV 1356
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....
gi 119574812 1357 VDIVARDLAG--HNDTAIIGIYIL 1378
Cdd:cd11304    70 LTVTATDGGGppLSSTATVTITVL 93
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 833-931 2.08e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 2.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  833 SYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNpgd 910
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|.
gi 119574812  911 vASNRRENSVQVVIQVLDVND 931
Cdd:cd11304    78 -GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-596 7.43e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 7.43e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  502 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVgNATIDREEQESYRLTVVATDRGTVP 580
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 119574812  581 LSGTAIVTILIDDIND 596
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 179-274 1.27e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 1.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  179 FEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKdvELDRETIAFYNLTICARDRGMPP 257
Cdd:cd11304     4 VSVPENAPpGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAK--PLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 119574812  258 LSSTMLVGIRVLDINDN 274
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1034 1.85e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  940 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEP 1016
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 119574812 1017 PLWGTTMLLVEVIDVNDN 1034
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-382 3.62e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 3.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  282 PMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 361
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90       100
                  ....*....|....*....|.
gi 119574812  362 PRIARRdydLLLIFLSDENDN 382
Cdd:cd11304    81 PLSSTA---TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 65-167 6.36e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 6.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   65 HYEVLLDEGpDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEiSHGRYTLIVTATDQC 144
Cdd:cd11304     1 SYEVSVPEN-APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE-EQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|...
gi 119574812  145 pilSHRLTSTTTVLVNVNDINDN 167
Cdd:cd11304    79 ---GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 195-276 8.49e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 8.49e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    195 AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKdvELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDN 274
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 119574812    275 DP 276
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 728-825 2.41e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 2.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  728 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLeDSSAGKVIANQTVDYEEVHWLNFTVRASDNGSP 807
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 119574812  808 PRAAEIPVYLEIVDINDN 825
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1047-1145 5.52e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 5.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1047 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLktaGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 1126
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 119574812 1127 VPYETMQpLQVALEDIDDN 1145
Cdd:cd11304    81 PLSSTAT-VTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
178-269 1.53e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 1.53e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   178 PFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKdvELDRETIAFYNLTICARDRGMP 256
Cdd:pfam00028    2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTK--PLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 119574812   257 PLSSTMLVGIRVL 269
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 519-599 1.76e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 1.76e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    519 TATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVgNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDS 597
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 119574812    598 RP 599
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-169 3.64e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 3.64e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812     85 QALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEiSHGRYTLIVTATDQcpiLSHRLTSTTTVLVNVNDI 164
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDG---GGPPLSSTATVTITVLDV 76


                    ....*
gi 119574812    165 NDNVP 169
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
284-363 7.83e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 7.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   284 NITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 363
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 960-1036 2.34e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 2.34e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    960 ATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP 1036
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLdrEEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
502-591 3.03e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 3.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   502 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQDRFLIHLVTGVIRVgNATIDREEQESYRLTVVATDRGTVP 580
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 119574812   581 LSGTAIVTILI 591
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
941-1029 4.83e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 4.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   941 FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEPP 1017
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 119574812  1018 LWGTTMLLVEVI 1029
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 607-716 7.49e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 7.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  607 TVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGivakddtdrlvPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 684
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVS-----------GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 119574812  685 LSVIDNASdlPERSVSvpnAKLTVNVLDVNDN 716
Cdd:cd11304    72 VTATDGGG--PPLSST---ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 852-934 8.70e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 8.70e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    852 TATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNpgdvASNRRENSVQVVIQVLDV 929
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG----GGPPLSSTATVTITVLDV 76


                    ....*
gi 119574812    930 NDCRP 934
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 390-492 1.78e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  390 TYQAEVMENSPAGTPLTVLNgpilALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGviIDREafSPPILELLL 468
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVS----ATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKP--LDRE--EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 119574812  469 LAKDIGL--LNSTAHLLITILDDNDN 492
Cdd:cd11304    73 TATDGGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
834-927 1.07e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 1.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   834 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNpgdv 911
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*.
gi 119574812   912 ASNRRENSVQVVIQVL 927
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1162-1268 1.31e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1162 LTVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSwtP 1240
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG--P 80

                          90       100
                  ....*....|....*....|....*...
gi 119574812 1241 PRgpsptldlvadLTLQEVRVVLEDIND 1268
Cdd:cd11304    81 PL-----------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 302-384 1.60e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 1.60e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    302 ASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPriaRRDYDLLLIFLSDEND 381
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVTITVLDVND 78


                    ...
gi 119574812    382 NHP 384
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1064-1147 2.10e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 2.10e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   1064 ATDKDEGLNGAVRYSFLktaGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQpLQVALEDID 1143
Cdd:smart00112    2 ATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT-VTITVLDVN 77


                    ....
gi 119574812   1144 DNEP 1147
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
78-161 7.83e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 7.83e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    78 NTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEiSHGRYTLIVTATDQcpiLSHRLTSTTTV 157
Cdd:pfam00028   12 GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDS---GGPPLSSTATV 87


                   ....
gi 119574812   158 LVNV 161
Cdd:pfam00028   88 TITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 747-827 1.26e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 1.26e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    747 AVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSaGKVIANQTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNN 826
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPET-GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 119574812    827 P 827
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1048-1133 1.42e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 1.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  1048 HIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTaGNRDWefFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 1127
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*.
gi 119574812  1128 PYETMQ 1133
Cdd:pfam00028   81 LSSTAT 86
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3-59 7.44e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 7.44e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 119574812      3 FRMDRISGEIATRpAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAP 59
Cdd:smart00112   26 FSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1163-1246 1.79e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  1163 TVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKAsSNRSWTPP 1241
Cdd:pfam00028    4 SVPENAPVGTEVLTVT-ATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEA-TDSGGPPL 81


                   ....*
gi 119574812  1242 RGPSP 1246
Cdd:pfam00028   82 SSTAT 86
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3-57 2.13e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 2.13e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119574812    3 FRMDRISGEIATRpAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDN 57
Cdd:cd11304    45 FSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
731-819 5.61e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 5.61e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   731 RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLeDSSAGKVIANQTVDYEEVHWLNFTVRASDNGSPPRA 810
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI-DPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 119574812   811 AEIPVYLEI 819
Cdd:pfam00028   83 STATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 1.65e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    414 ALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGviIDREafSPPILELLLLAKDIG--LLNSTAHLLITILDDN 490
Cdd:smart00112    2 ATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKP--LDRE--EQPEYTLTVEATDGGgpPLSSTATVTITVLDVN 77


                    ....
gi 119574812    491 DNRP 494
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1180-1271 3.98e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 3.98e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   1180 AVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNrswtpprGPSPTLDLVadltlqE 1258
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDG-------GGPPLSSTA------T 68

                            90
                    ....*....|...
gi 119574812   1259 VRVVLEDINDQPP 1271
Cdd:smart00112   69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 624-718 6.82e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 6.82e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    624 TAIDHDL--NPKLEYHIVGivakddtdrlvPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASdlPERSVSV 701
Cdd:smart00112    1 SATDADSgeNGKVTYSILS-----------GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG--PPLSSTA 67

                            90
                    ....*....|....*..
gi 119574812    702 PnakLTVNVLDVNDNTP 718
Cdd:smart00112   68 T---VTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
606-711 8.23e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 8.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   606 QTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGivakddtdrlvPNQEDAFAVNINTGSVMVKSPMNRELVATYEV 683
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngRIFYSILG-----------GGPGGNFRIDPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|....*...
gi 119574812   684 TLSVIDNASDLPERSVSVpnaklTVNVL 711
Cdd:pfam00028   70 TVEATDSGGPPLSSTATV-----TITVL 92
Cadherin pfam00028
Cadherin domain;
391-506 1.11e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 1.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   391 YQAEVMENSPAGTPLTVLNgpilALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSgvIIDREafSPPILELLLL 469
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVT----ATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTK--PLDRE--SIGEYELTVE 72

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 119574812   470 AKdigllnstahllitildDNDNRPTFSPATLTVHLL 506
Cdd:pfam00028   73 AT-----------------DSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1277-1378 4.50e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.32  E-value: 4.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1277 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILaihyfralandSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFV 1356
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....
gi 119574812 1357 VDIVARDLAG--HNDTAIIGIYIL 1378
Cdd:cd11304    70 LTVTATDGGGppLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
3-51 1.39e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.39e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 119574812     3 FRMDRISGEIATRpAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTI 51
Cdd:pfam00028   44 FRIDPDTGDISTT-KPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1278-1378 9.10e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 9.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  1278 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILaihyfralandSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVV 1357
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|...
gi 119574812  1358 DIVARDLAGHN--DTAIIGIYIL 1378
Cdd:pfam00028   70 TVEATDSGGPPlsSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 833-931 2.08e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.26  E-value: 2.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  833 SYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNpgd 910
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                          90       100
                  ....*....|....*....|.
gi 119574812  911 vASNRRENSVQVVIQVLDVND 931
Cdd:cd11304    78 -GGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 502-596 7.43e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 7.43e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  502 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVgNATIDREEQESYRLTVVATDRGTVP 580
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*.
gi 119574812  581 LSGTAIVTILIDDIND 596
Cdd:cd11304    82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 179-274 1.27e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.95  E-value: 1.27e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  179 FEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKdvELDRETIAFYNLTICARDRGMPP 257
Cdd:cd11304     4 VSVPENAPpGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAK--PLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 119574812  258 LSSTMLVGIRVLDINDN 274
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1034 1.85e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 1.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  940 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEP 1016
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDreEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 119574812 1017 PLWGTTMLLVEVIDVNDN 1034
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 282-382 3.62e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 3.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  282 PMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 361
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90       100
                  ....*....|....*....|.
gi 119574812  362 PRIARRdydLLLIFLSDENDN 382
Cdd:cd11304    81 PLSSTA---TVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 65-167 6.36e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.24  E-value: 6.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   65 HYEVLLDEGpDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEiSHGRYTLIVTATDQC 144
Cdd:cd11304     1 SYEVSVPEN-APPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE-EQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|...
gi 119574812  145 pilSHRLTSTTTVLVNVNDINDN 167
Cdd:cd11304    79 ---GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 195-276 8.49e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 8.49e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    195 AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKdvELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDN 274
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 119574812    275 DP 276
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 728-825 2.41e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.84  E-value: 2.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  728 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLeDSSAGKVIANQTVDYEEVHWLNFTVRASDNGSP 807
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI-DPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 119574812  808 PRAAEIPVYLEIVDINDN 825
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1047-1145 5.52e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 5.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1047 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLktaGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 1126
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV---SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*....
gi 119574812 1127 VPYETMQpLQVALEDIDDN 1145
Cdd:cd11304    81 PLSSTAT-VTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
178-269 1.53e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.82  E-value: 1.53e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   178 PFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKdvELDRETIAFYNLTICARDRGMP 256
Cdd:pfam00028    2 SASVPENAPvGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTK--PLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 119574812   257 PLSSTMLVGIRVL 269
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 519-599 1.76e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 1.76e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    519 TATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVgNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDS 597
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITT-TKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 119574812    598 RP 599
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-169 3.64e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 89.33  E-value: 3.64e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812     85 QALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEiSHGRYTLIVTATDQcpiLSHRLTSTTTVLVNVNDI 164
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE-EQPEYTLTVEATDG---GGPPLSSTATVTITVLDV 76


                    ....*
gi 119574812    165 NDNVP 169
Cdd:smart00112   77 NDNAP 81
Cadherin pfam00028
Cadherin domain;
284-363 7.83e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.51  E-value: 7.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   284 NITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 363
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 960-1036 2.34e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 2.34e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    960 ATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP 1036
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDgLFSIDPETGEITTTKPLdrEEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
502-591 3.03e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.97  E-value: 3.03e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   502 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQDRFLIHLVTGVIRVgNATIDREEQESYRLTVVATDRGTVP 580
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlGGGPGGNFRIDPDTGDIST-TKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 119574812   581 LSGTAIVTILI 591
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
941-1029 4.83e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 4.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   941 FSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEPP 1017
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDreSIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 119574812  1018 LWGTTMLLVEVI 1029
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 607-716 7.49e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 7.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  607 TVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGivakddtdrlvPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 684
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSgeNGEVTYSIVS-----------GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                          90       100       110
                  ....*....|....*....|....*....|..
gi 119574812  685 LSVIDNASdlPERSVSvpnAKLTVNVLDVNDN 716
Cdd:cd11304    72 VTATDGGG--PPLSST---ATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 852-934 8.70e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 8.70e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    852 TATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNpgdvASNRRENSVQVVIQVLDV 929
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG----GGPPLSSTATVTITVLDV 76


                    ....*
gi 119574812    930 NDCRP 934
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 390-492 1.78e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.06  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  390 TYQAEVMENSPAGTPLTVLNgpilALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGviIDREafSPPILELLL 468
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVS----ATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKP--LDRE--EQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 119574812  469 LAKDIGL--LNSTAHLLITILDDNDN 492
Cdd:cd11304    73 TATDGGGppLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
834-927 1.07e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.35  E-value: 1.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   834 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNpgdv 911
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*.
gi 119574812   912 ASNRRENSVQVVIQVL 927
Cdd:pfam00028   77 GGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1162-1268 1.31e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1162 LTVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSwtP 1240
Cdd:cd11304     4 VSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGG--P 80

                          90       100
                  ....*....|....*....|....*...
gi 119574812 1241 PRgpsptldlvadLTLQEVRVVLEDIND 1268
Cdd:cd11304    81 PL-----------SSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 302-384 1.60e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.63  E-value: 1.60e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    302 ASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPriaRRDYDLLLIFLSDEND 381
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP---LSSTATVTITVLDVND 78


                    ...
gi 119574812    382 NHP 384
Cdd:smart00112   79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1064-1147 2.10e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 2.10e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   1064 ATDKDEGLNGAVRYSFLktaGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQpLQVALEDID 1143
Cdd:smart00112    2 ATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT-VTITVLDVN 77


                    ....
gi 119574812   1144 DNEP 1147
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
78-161 7.83e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 80.04  E-value: 7.83e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    78 NTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEiSHGRYTLIVTATDQcpiLSHRLTSTTTV 157
Cdd:pfam00028   12 GTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDS---GGPPLSSTATV 87


                   ....
gi 119574812   158 LVNV 161
Cdd:pfam00028   88 TITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 747-827 1.26e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.93  E-value: 1.26e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    747 AVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSaGKVIANQTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNN 826
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPET-GEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 119574812    827 P 827
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1048-1133 1.42e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.57  E-value: 1.42e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  1048 HIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTaGNRDWefFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 1127
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGN--FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80


                   ....*.
gi 119574812  1128 PYETMQ 1133
Cdd:pfam00028   81 LSSTAT 86
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3-59 7.44e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 7.44e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 119574812      3 FRMDRISGEIATRpAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAP 59
Cdd:smart00112   26 FSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1163-1246 1.79e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.71  E-value: 1.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  1163 TVPEHSPRGTLVGNVTgAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKAsSNRSWTPP 1241
Cdd:pfam00028    4 SVPENAPVGTEVLTVT-ATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEA-TDSGGPPL 81


                   ....*
gi 119574812  1242 RGPSP 1246
Cdd:pfam00028   82 SSTAT 86
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3-57 2.13e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 2.13e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 119574812    3 FRMDRISGEIATRpAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDN 57
Cdd:cd11304    45 FSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
731-819 5.61e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 5.61e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   731 RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLeDSSAGKVIANQTVDYEEVHWLNFTVRASDNGSPPRA 810
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI-DPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82


                   ....*....
gi 119574812   811 AEIPVYLEI 819
Cdd:pfam00028   83 STATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 414-494 1.65e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 61.60  E-value: 1.65e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    414 ALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGviIDREafSPPILELLLLAKDIG--LLNSTAHLLITILDDN 490
Cdd:smart00112    2 ATDADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKP--LDRE--EQPEYTLTVEATDGGgpPLSSTATVTITVLDVN 77


                    ....
gi 119574812    491 DNRP 494
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1180-1271 3.98e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 3.98e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   1180 AVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNrswtpprGPSPTLDLVadltlqE 1258
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDG-------GGPPLSSTA------T 68

                            90
                    ....*....|...
gi 119574812   1259 VRVVLEDINDQPP 1271
Cdd:smart00112   69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 624-718 6.82e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 6.82e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812    624 TAIDHDL--NPKLEYHIVGivakddtdrlvPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASdlPERSVSV 701
Cdd:smart00112    1 SATDADSgeNGKVTYSILS-----------GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG--PPLSSTA 67

                            90
                    ....*....|....*..
gi 119574812    702 PnakLTVNVLDVNDNTP 718
Cdd:smart00112   68 T---VTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
606-711 8.23e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.31  E-value: 8.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   606 QTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGivakddtdrlvPNQEDAFAVNINTGSVMVKSPMNRELVATYEV 683
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPngRIFYSILG-----------GGPGGNFRIDPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|....*...
gi 119574812   684 TLSVIDNASDLPERSVSVpnaklTVNVL 711
Cdd:pfam00028   70 TVEATDSGGPPLSSTATV-----TITVL 92
Cadherin pfam00028
Cadherin domain;
391-506 1.11e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.84  E-value: 1.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812   391 YQAEVMENSPAGTPLTVLNgpilALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSgvIIDREafSPPILELLLL 469
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVT----ATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTK--PLDRE--SIGEYELTVE 72

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 119574812   470 AKdigllnstahllitildDNDNRPTFSPATLTVHLL 506
Cdd:pfam00028   73 AT-----------------DSGGPPLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1277-1378 4.50e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 52.32  E-value: 4.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1277 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILaihyfralandSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFV 1356
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-----------SGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                          90       100
                  ....*....|....*....|....
gi 119574812 1357 VDIVARDLAG--HNDTAIIGIYIL 1378
Cdd:cd11304    70 LTVTATDGGGppLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
3-51 1.39e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 50.76  E-value: 1.39e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 119574812     3 FRMDRISGEIATRpAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTI 51
Cdd:pfam00028   44 FRIDPDTGDISTT-KPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1278-1378 9.10e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 9.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  1278 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILaihyfralandSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVV 1357
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDRESIGEYEL 69

                           90       100
                   ....*....|....*....|...
gi 119574812  1358 DIVARDLAGHN--DTAIIGIYIL 1378
Cdd:pfam00028   70 TVEATDSGGPPlsSTATVTITVL 92
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 609-676 4.81e-04

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 40.59  E-value: 4.81e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 119574812   609 SVLESAEPGTVIANItAIDHDLNP-KLEYHIVGIVAKDDTDRlvpnqedaFAVNINTGSVMVKSPMNRE 676
Cdd:pfam08266    5 SVPEETERGSFVGNL-AKDLGLEVgELAARGARVVSKGNKQY--------FQLNPETGDLLLNEKLDRE 64
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1042-1145 1.36e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 39.63  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812 1042 PNGTILHIREEIPLRSNVyevyATDKDEGLngAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS 1121
Cdd:cd00031     2 PDGSAVEGRSRGSFRVSI----PTDLIASS--GEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAA 75

                          90       100
                  ....*....|....*....|....
gi 119574812 1122 DLGQPVPYETMQpLQVALEDIDDN 1145
Cdd:cd00031    76 SLGANVPQTSSV-FSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 855-931 3.33e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.86  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119574812  855 DADSGNFALIeysLGDGESK----FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVAsnrrENSVQVVIQVLDVN 930
Cdd:cd00031    24 IASSGEIIKI---SAAGKEAlpswLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP----QTSSVFSIEVYDEN 96


                  .
gi 119574812  931 D 931
Cdd:cd00031    97 D 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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